rrn10 (SPAC22E12.08)

Gene Standard Namerrn10 Characterisation Statuspublished
Systematic IDSPAC22E12.08 Feature Typeprotein coding
Synonyms Name Description
ProductRNA polymerase I upstream activation factor complex subunit Rrn10 Product Size97aa, 11.01 kDa
Genomic Location Chromosome I, 5033373-5034586 (1214nt); CDS:5033478-5033823 (346nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0001168RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activityIDAPMID:124907023
GO:0000182rDNA bindingTASPMID:124907026
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0045943positive regulation of transcription from RNA polymerase I promoterIMPPMID:124907025
GO:0006356regulation of transcription from RNA polymerase I promoterIDAPMID:1249070211
GO:0006360transcription from RNA polymerase I promoterIDAPMID:1249070234
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000500RNA polymerase I upstream activating factor complexNASGO_REF:00000514
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyrrn10ΔNullPECO:0000005, PECO:0000137PMID:236978061338

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopyrrn10ΔNullPECO:0000005, PECO:0000137PMID:23697806686
FYPO:0003529inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells87
penetrance FYPO_EXT:0000001Microscopyrrn10ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05234 Pfam IPR022793 UAF complex subunit Rrn10 2 97 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.54 Da
Charge -12.00
Isoelectric point 3.90
Molecular weight 11.01 kDa
Number of residues 97
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.51during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi only623
conserved in fungi4600
conserved in eukaryotes4514

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
spp27RNA polymerase I upstream activation factor complex subunit Spp27 Co-fractionationPMID:12490702
rrn5RNA polymerase I upstream activation factor complex subunit Rrn5 Co-fractionationPMID:12490702
External References
Database Identifier Description
NBRP SPAC22E12.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22E12.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22E12.08 BioGRID Interaction Datasets
Expression Viewer SPAC22E12.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22E12.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22E12.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22E12.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22E12.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22E12.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC22E12.08 Cell Cycle Data
GEO SPAC22E12.08 GEO profiles
PInt SPAC22E12.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC22E12.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC22E12.08 Fission yeast phenotypic data & analysis
SPD / RIKEN02/02B04Orfeome Localization Data
UniProtKB/SwissProtQ10360RNA polymerase I-specific transcription initiation factor rrn10
ModBaseQ10360Database of comparative protein structure models
STRINGQ10360Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594834RNA polymerase I upstream activation factor complex subunit Rrn10
RefSeq mRNANM_001020263972h- RNA polymerase I upstream activation factor complex subunit Rrn10 (rrn10), mRNA
European Nucleotide ArchiveCAA93895.1ENA Protein Mapping
UniParcUPI000013A905UniProt Archive

Literature for rrn10

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014