rrn10 (SPAC22E12.08)

Gene Standard Namerrn10 Characterisation Statuspublished
Systematic IDSPAC22E12.08 Feature Typeprotein coding
Synonyms Name Description
ProductRNA polymerase I upstream activation factor complex subunit Rrn10 Product Size97aa, 11.01 kDa
Genomic Location Chromosome I, 5033373-5034586 (1214nt); CDS:5033478-5033823 (346nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
rDNA binding6
Annotation ExtensionEvidenceWith/FromReference
transcription factor activity, RNA polymerase I upstream control element sequence-specific binding3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
transcription from RNA polymerase I promoter31
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
RNA polymerase I upstream activating factor complex4
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationrrn10Δ1468

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cyclerrn10Δ903
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellsrrn10Δ88
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons5033373..5033603, 5033656..5034586
5' UTR5033373..5033477PMID:21511999
CDS5033478..5033603, 5033656..5033823
3' UTR5033824..5034586PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF05234 Pfam IPR022793 RNA polymerase I-specific transcription initiation factor Rrn10 2 97 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.54 Da
Charge -12.00
Codon Adaptation Index 0.41
Isoelectric point 3.90
Molecular weight 11.01 kDa
Number of residues 97
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for rrn10 (SPAC22E12.08)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.51during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi only552
conserved in fungi4608
conserved in eukaryotes4516

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC22E12.08 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withspp27RNA polymerase I upstream activation factor complex subunit Spp27 Two-hybridPMID:12490702
binds activation domain construct withacr1upstream activation factor complex subunit Acr1 Two-hybridPMID:26771498
binds activation domain construct withSPBP8B7.17cphosphomethylpyrimidine kinase (predicted) Two-hybridPMID:26771498
co-fractionates withspp27RNA polymerase I upstream activation factor complex subunit Spp27 Co-fractionationPMID:12490702
co-fractionates withrrn5RNA polymerase I upstream activation factor complex subunit Rrn5 Co-fractionationPMID:12490702
External References
Database Identifier Description
NBRP SPAC22E12.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22E12.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC22E12.08 BioGRID Interaction Datasets
Expression Viewer SPAC22E12.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC22E12.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC22E12.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC22E12.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC22E12.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC22E12.08 Transcriptome Viewer (Bähler Lab)
GEO SPAC22E12.08 GEO profiles
PInt SPAC22E12.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC22E12.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC22E12.08 Fission yeast phenotypic data & analysis
Cyclebase SPAC22E12.08.1 Cell Cycle Data
SPD / RIKEN02/02B04Orfeome Localization Data
UniProtKB/SwissProtQ10360RNA polymerase I-specific transcription initiation factor rrn10
ModBaseQ10360Database of comparative protein structure models
STRINGQ10360Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594834RNA polymerase I upstream activation factor complex subunit Rrn10
RefSeq mRNANM_001020263972h- RNA polymerase I upstream activation factor complex subunit Rrn10 (rrn10), mRNA
European Nucleotide ArchiveCAA93895.1ENA Protein Mapping
UniParcUPI000013A905UniProt Archive

Literature for rrn10

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017