kap114 (SPAC22H10.03c)

Gene Standard Namekap114 ChromosomeI
Systematic IDSPAC22H10.03c Gene Start2376572
Synonyms Gene End2373052
Productkaryopherin Kap14 Gene Length3521
Feature Typeprotein coding CDS Start2376385
Name Description CDS End2373144
Characterisation Statuspublished CDS Length3242

Ensembl Gene Location
  1. pck1
  2. SPNCRNA.818
  3. SPNCRNA.192
  4. SPNCRNA.819
  5. SPAC22H10.02
  6. kap114
  7. SPNCRNA.820
  8. ppa3
  9. SPAC22H10.05c
  10. SPNCRNA.821
  11. SPAC22H10.06c
  12. zym1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001491viable vegetative cellkap114delta (deletion)deletionPMID:15116432
Microscopykap114delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005525GTP bindingNASGO_REF:0000001
GO:0008565protein transporter activityIEAIPR001494GO_REF:0000002
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006605protein targetingNASGO_REF:0000051
GO:0006913nucleocytoplasmic transportNASGO_REF:0000051
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:15116432
IDAPMID:16823372
GO:0005635nuclear envelopeIDAPMID:16823372
GO:0005643nuclear poreIEAIPR001494GO_REF:0000002
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
123765722376280
223762232374002
323739612373792
423737442373626
523735832373413
623733762373303
723732632373052

References

Region Start End Reference
five_prime_UTR23765722376386PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF03810 IPR001494 Pfam Importin-beta, N-terminal 24 100 8
SM00913 IPR001494 SMART Importin-beta, N-terminal 24 100 9
PS50166 IPR001494 Prosite Profiles Importin-beta, N-terminal 24 100 8
G3DSA:1.25.10.10 IPR011989 Gene3D 945 989 83
G3DSA:1.25.10.10 IPR011989 Gene3D 880 891 83
G3DSA:1.25.10.10 IPR011989 Gene3D 5 848 83
SSF48371 IPR016024 SuperFamily 5 989 130
PTHR10997:SF9 hmmpanther 1 990 1
PTHR10997 hmmpanther 1 990 4

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000561importin familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000561

Protein Properties

Ave. residue weight 112.65 Da
Charge -66.00
Isoelectric point 4.19
Molecular weight 111.86 kDa
Number of residues 993
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2356.72PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide6390.62PMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.9PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.56PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated PMID:21511999
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
ptn1phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1 Negative GeneticPMID:22681890
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
ser2phosphoserine phosphatase Ser2 (predicted) Negative GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Positive GeneticPMID:22681890
SPBC23E6.01cmRNA processing factor (predicted) Positive GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
amo1nuclear rim protein Amo1 Positive GeneticPMID:18818364
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
med7mediator complex subunit Med7 Negative GeneticPMID:22681890
vps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:22681890
SPBC1861.07elongin C (predicted) Negative GeneticPMID:22681890
sts5RNB-like protein Positive GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
tim13TIM22 inner membrane protein import complex subunit Tim13 (predicted) Negative GeneticPMID:18818364
SPBC2D10.093-hydroxyisobutyryl-CoA hydrolase (predicted) Positive GeneticPMID:22681890
SPBP35G2.14RNA-binding protein Negative GeneticPMID:22681890
rho3Rho family GTPase Rho3 Positive GeneticPMID:22681890
lub1WD repeat protein Lub1 Positive GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:22681890
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:18818364
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
sap114splicing factor Sap114 Negative GeneticPMID:22681890
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
SPAC3A12.13ctranslation initiation factor eIF3j (p35) Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Positive GeneticPMID:18818364
SPCC63.03DNAJ domain protein, DNAJC11 family Positive GeneticPMID:22681890
git5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
atp14F1-ATPase subunit H (predicted) Positive GeneticPMID:22681890
SPAC31A2.12arrestin/PY protein 1 (predicted) Negative GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
SPAC23H4.16csequence orphan Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPAC22H10.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC22H10.03c Retrieval of eukaryotic orthologs
BioGrid SPAC22H10.03c BioGRID Interaction Datasets
Bähler Lab SPAC22H10.03c Cell Cycle Expression Profile
Bähler Lab SPAC22H10.03c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC22H10.03c Pheromone response/mating expression profiles
Bähler Lab SPAC22H10.03c Environmental stress expression profiles
Bähler Lab SPAC22H10.03c Bähler Lab Transcriptome Viewer
Cyclebase SPAC22H10.03c Cell Cycle Data
PInt SPAC22H10.03c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC22H10.03c Entrez Gene
SPD / RIKEN48/48B05Orfeome Localization Data
WikiGene2541885karyopherin Kap14
Uniprot_genenameKAP114
EntrezGene2541885karyopherin Kap14
UniProtKB/SwissProtQ10297Importin subunit beta-5
ModBaseQ10297Database of comparative protein structure models
Pfam Protein DomainsQ10297Pfam Domain Arrangement
RefSeq PeptideNP_593739karyopherin Kap14
RefSeq mRNANM_001019170972h- karyopherin Kap14 (kap114), mRNA
European Nucleotide ArchiveCAA93604ENA Protein Mapping
SPD / RIKEN48/48B05Orfeome Localization Data

Literature for kap114
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013