SPAC23A1.17


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC23A1.17 Feature Typeprotein coding
Synonyms Name Description
ProductWIP family cytoskeletal protein (predicted) Product Size1611aa, 170.53 kDa
Genomic Location Chromosome I, 4106702-4112044 (5343nt); CDS:4106827-4111662 (4836nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0017024myosin I bindingISOSGD:S000003557GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030036actin cytoskeleton organizationISOSGD:S000003557GO_REF:000002497
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030479actin cortical patchISOSGD:S000003557GO_REF:000002447
GO:0032153cell division siteIDAPMID:16823372292
GO:0051286cell tipIDAPMID:16823372186
GO:0005829cytosolIDAPMID:168233722317
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC23A1.17ΔNullPMID:204732893755
MicroscopySPAC23A1.17ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPAC23A1.17ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
141067024112044

UTRs

Region Start End Reference
five_prime_UTR41067024106826PMID:20118936
three_prime_UTR41116634112044PMID:21511999
five_prime_UTR41067024106826PMID:18641648
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00018 Pfam IPR001452 Src homology-3 domain 9 58 18
SM00326 SMART IPR001452 Src homology-3 domain 6 66 21
PS50002 Prosite Profiles IPR001452 Src homology-3 domain 3 67 21
G3DSA:2.30.30.40 Gene3D 4 64 21
SSF50044 SuperFamily IPR001452 3 67 21
Coil ncoils Rabaptin coiled-coil domain 398 419 975
Low complexity (SEG) seg 1436 1449
Low complexity (SEG) seg 1330 1350
Low complexity (SEG) seg 1290 1315
Low complexity (SEG) seg 1227 1278
Low complexity (SEG) seg 1021 1225
Low complexity (SEG) seg 1004 1015
Low complexity (SEG) seg 959 982
Low complexity (SEG) seg 747 762
Low complexity (SEG) seg 637 649
Low complexity (SEG) seg 472 494
Low complexity (SEG) seg 384 422
Low complexity (SEG) seg 362 375
Low complexity (SEG) seg 203 233

View domain organization at Pfam

Protein Properties

Ave. residue weight 105.85 Da
Charge -20.00
Isoelectric point 5.61
Molecular weight 170.53 kDa
Number of residues 1611
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
9392.78during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
11904.43during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
9.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Negative GeneticPMID:22681890
Phenotypic EnhancementPMID:19547744
tef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
cyk3cytokinesis protein Cyk3 (predicted) Affinity Capture-MSPMID:20603077
External References
Database Identifier Description
NBRP SPAC23A1.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC23A1.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC23A1.17 BioGRID Interaction Datasets
Expression Viewer SPAC23A1.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC23A1.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC23A1.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC23A1.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC23A1.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC23A1.17 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC23A1.17 Cell Cycle Data
GEO SPAC23A1.17 GEO profiles
PInt SPAC23A1.17 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542019SH3 domain-containing protein
EntrezGene2542019SH3 domain-containing protein
SPD / RIKEN48/48G09Orfeome Localization Data
UniProtKB/SwissProtO42854SH3 domain-containing protein C23A1.17
ModBaseO42854Database of comparative protein structure models
StringO42854Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594446SH3 domain-containing protein
RefSeq mRNANM_001019875972h- SH3 domain-containing protein (SPAC23A1.17), mRNA
European Nucleotide ArchiveCAA16991ENA Protein Mapping
UniParcUPI0000069573UniProt Archive

Literature for SPAC23A1.17

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014