bbc1 (SPAC23A1.17)


Gene Standard Namebbc1 Characterisation Statusbiological role inferred
Systematic IDSPAC23A1.17 Feature Typeprotein coding
Synonyms Name Description
ProductWIP family cytoskeletal protein Bbc1 (predicted) Product Size1611aa, 170.53 kDa
Genomic Location Chromosome I, 4106702-4112044 (5343nt); CDS:4106827-4111662 (4836nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
myosin I binding1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
actin cytoskeleton organization97
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
actin cortical patch47
Annotation ExtensionEvidenceWith/FromReference
cell division site317
Annotation ExtensionEvidenceWith/FromReference
cell tip209
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationbbc1Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologybbc1Δ3102
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4106702..4112044
mRNA4106702..4112044
5' UTR4106702..4106826PMID:18641648
5' UTR4106702..4106826PMID:20118936
CDS4106827..4111662
3' UTR4111663..4112044PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00018 Pfam IPR001452 SH3 domain 9 58 20
SM00326 SMART IPR001452 SH3 domain 6 66 21
PS50002 Prosite Profiles IPR001452 SH3 domain 3 67 21
PTHR15175 HMMPANTHER 7 76 1
PTHR15175:SF4 HMMPANTHER 7 76 1
2.30.30.40 Gene3D CheW-like domain 4 64 21
SSF50044 SuperFamily IPR001452 SH3 domain 3 67 21
Coil ncoils Predicted coiled-coil protein (DUF2205) 398 418 1055

View domain organization at Pfam

Protein Properties

Ave. residue weight 105.85 Da
Charge -20.00
Codon Adaptation Index 0.39
Isoelectric point 5.61
Molecular weight 170.53 kDa
Number of residues 1611
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during mitotic M phaseS589
present during mitotic M phaseS712
present during mitotic M phaseS501
present during mitotic M phaseS777
present during mitotic M phaseS699
present during mitotic M phaseS916
present during mitotic M phaseS692
present during mitotic M phaseS718
present during mitotic M phaseS959
present during mitotic M phaseS682
present during mitotic M phaseS155
present during mitotic M phaseS159
present during mitotic M phaseS153
present during mitotic M phaseS597
present during mitotic M phaseS1003
present during mitotic M phaseS343
present during mitotic M phaseS678
present during mitotic M phaseS768
S94, S100, S146, S159, S265, S343, S477, S478, S483, S501, S682, S692, S699, S718, S768, S777, S799, S805, S916, S959, S1248, S1266
level fluctuates during mitotic cell cycleS712
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S589 PMID:21712547
present during mitotic M phase experimental evidence S712 PMID:21712547
present during mitotic M phase experimental evidence S501 PMID:21712547
present during mitotic M phase experimental evidence S777 PMID:21712547
present during mitotic M phase experimental evidence S699 PMID:21712547
present during mitotic M phase experimental evidence S916 PMID:21712547
present during mitotic M phase experimental evidence S692 PMID:21712547
present during mitotic M phase experimental evidence S718 PMID:21712547
present during mitotic M phase experimental evidence S959 PMID:21712547
present during mitotic M phase experimental evidence S682 PMID:21712547
present during mitotic M phase experimental evidence S155 PMID:21712547
present during mitotic M phase experimental evidence S159 PMID:21712547
present during mitotic M phase experimental evidence S153 PMID:21712547
present during mitotic M phase experimental evidence S597 PMID:21712547
present during mitotic M phase experimental evidence S1003 PMID:21712547
present during mitotic M phase experimental evidence S343 PMID:21712547
present during mitotic M phase experimental evidence S678 PMID:21712547
present during mitotic M phase experimental evidence S768 PMID:21712547
experimental evidence S959 PMID:24763107
IDA S805 PMID:25720772
experimental evidence S682 PMID:24763107
level fluctuates during mitotic cell cycle experimental evidence S712 PMID:24763107
IDA S501 PMID:25720772
experimental evidence S777 PMID:24763107
IDA S343 PMID:25720772
IDA S265 PMID:25720772
IDA S94 PMID:25720772
IDA S1266 PMID:25720772
IDA S692 PMID:25720772
IDA S768 PMID:25720772
experimental evidence S916 PMID:24763107
IDA S483 PMID:25720772
IDA S477 PMID:25720772
experimental evidence S343 PMID:24763107
experimental evidence S146 PMID:24763107
IDA S718 PMID:25720772
IDA S478 PMID:25720772
IDA S777 PMID:25720772
experimental evidence S718 PMID:24763107
IDA S1248 PMID:25720772
IDA S799 PMID:25720772
experimental evidence S699 PMID:24763107
IDA S100 PMID:25720772
IDA S159 PMID:25720772
O-phospho-L-threonine 1085
present during mitotic M phaseT336
present during mitotic M phaseT775
present during mitotic M phaseT579
present during mitotic M phaseT748
present during mitotic M phaseT685
present during mitotic M phaseT1002
present during mitotic M phaseT587
present during mitotic M phaseT715
level fluctuates during mitotic cell cycleT715
T458, T685, T775
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T336 PMID:21712547
present during mitotic M phase experimental evidence T775 PMID:21712547
present during mitotic M phase experimental evidence T579 PMID:21712547
present during mitotic M phase experimental evidence T748 PMID:21712547
present during mitotic M phase experimental evidence T685 PMID:21712547
present during mitotic M phase experimental evidence T1002 PMID:21712547
present during mitotic M phase experimental evidence T587 PMID:21712547
present during mitotic M phase experimental evidence T715 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence T715 PMID:24763107
experimental evidence T458 PMID:24763107
experimental evidence T685 PMID:24763107
IDA T775 PMID:25720772
O4'-phospho-L-tyrosineY97 281
Annotation ExtensionEvidenceResidueReference
IDA Y97 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS86,S90, S93,S94, S93,S94,S100, S94,S100, S94,T102, S153,S159, S155,S159, S267,T270, S478,S501, S483,S501, S484,S501, S768,S777, S768,T775, S768,T775,S777, S799,S802, S799,T803, S1243,S1248, S1244,S1248, S1254,S1261,S1266, S1254,S1266, S1255,S1258, S1258,S1264, S1258,S1264,S1266, S1258,S1266, S1261,S1264,S1266, S1261,S1266, S1261,S1266,S1270, S1261,S1266,S1274, S1261,T1268,S1270, S1264,S1266, S1264,S1269, S1266,T1268, S1266,T1268,S1269, S1330,S1333, T715,S718, T748,S751, T775,S777 2457
Annotation ExtensionEvidenceResidueReference
IDA S1254,S1266 PMID:25720772
IDA S1261,S1264,S1266 PMID:25720772
IDA S94,S100 PMID:25720772
IDA S768,T775 PMID:25720772
IDA S1261,S1266,S1274 PMID:25720772
IDA S1258,S1264 PMID:25720772
IDA T775,S777 PMID:25720772
IDA S153,S159 PMID:25720772
IDA S1243,S1248 PMID:25720772
IDA S1264,S1266 PMID:25720772
IDA S483,S501 PMID:25720772
IDA T748,S751 PMID:25720772
IDA S94,T102 PMID:25720772
IDA S1254,S1261,S1266 PMID:25720772
IDA S1261,S1266 PMID:25720772
IDA S93,S94 PMID:25720772
IDA S1258,S1264,S1266 PMID:25720772
IDA S1266,T1268,S1269 PMID:25720772
IDA S1261,S1266,S1270 PMID:25720772
IDA S799,S802 PMID:25720772
IDA S267,T270 PMID:25720772
IDA S768,S777 PMID:25720772
IDA S484,S501 PMID:25720772
IDA S1261,T1268,S1270 PMID:25720772
IDA S155,S159 PMID:25720772
IDA S1258,S1266 PMID:25720772
IDA S768,T775,S777 PMID:25720772
IDA T715,S718 PMID:25720772
IDA S1255,S1258 PMID:25720772
IDA S93,S94,S100 PMID:25720772
IDA S1264,S1269 PMID:25720772
IDA S86,S90 PMID:25720772
IDA S1330,S1333 PMID:25720772
IDA S799,T803 PMID:25720772
IDA S478,S501 PMID:25720772
IDA S1266,T1268 PMID:25720772
IDA S1244,S1248 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for bbc1 (SPAC23A1.17)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
13937during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
13956during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
14614during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
14504during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
14514during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
9392.78during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
11904.43during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.2during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC23A1.17 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycyk3cytokinesis protein Cyk3 (predicted) Affinity Capture-MSPMID:20603077
modified bydsk1SR protein-specific kinase Dsk1 Biochemical ActivityPMID:26167880
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC23A1.17 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
phenotype enhanced byelp3elongator complex subunit Elp3 (predicted) Phenotypic EnhancementPMID:19547744
External References
Database Identifier Description
NBRP SPAC23A1.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC23A1.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC23A1.17 BioGRID Interaction Datasets
Expression Viewer SPAC23A1.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC23A1.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC23A1.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC23A1.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC23A1.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC23A1.17 Transcriptome Viewer (Bähler Lab)
GEO SPAC23A1.17 GEO profiles
PInt SPAC23A1.17 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC23A1.17 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC23A1.17 Fission yeast phenotypic data & analysis
Cyclebase SPAC23A1.17.1 Cell Cycle Data
SPD / RIKEN48/48G09Orfeome Localization Data
UniProtKB/SwissProtO42854SH3 domain-containing protein C23A1.17
ModBaseO42854Database of comparative protein structure models
STRINGO42854Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594446SH3 domain-containing protein
RefSeq mRNANM_001019875972h- SH3 domain-containing protein (SPAC23A1.17), mRNA
European Nucleotide ArchiveCAA16991.1ENA Protein Mapping
UniParcUPI0000069573UniProt Archive

Literature for bbc1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016