bbc1 (SPAC23A1.17)


Gene Standard Namebbc1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC23A1.17 Feature Typeprotein coding
Synonyms Name Description
ProductWIP family cytoskeletal protein Bbc1 (predicted) Product Size1611aa, 170.53 kDa
Genomic Location Chromosome I, 4106702-4112044 (5343nt); CDS:4106827-4111662 (4836nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
myosin I binding1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
actin cytoskeleton organization102
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
actin cortical patch47
Annotation ExtensionEvidenceWith/FromReference
cell division site305
Annotation ExtensionEvidenceWith/FromReference
cell tip194
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationbbc1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologybbc1ΔNull3094
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4106702..4112044
mRNA4106702..4112044
5' UTR4106702..4106826PMID:20118936
5' UTR4106702..4106826PMID:18641648
CDS4106827..4111662
3' UTR4111663..4112044PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00018 Pfam IPR001452 SH3 domain 9 58 18
SM00326 SMART IPR001452 SH3 domain 6 66 21
PS50002 Prosite Profiles IPR001452 SH3 domain 3 67 21
2.30.30.40 Gene3D 4 64 21
SSF50044 SuperFamily IPR001452 SH3 domain 3 67 21
Coil ncoils Rabaptin coiled-coil domain 398 419 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 105.85 Da
Charge -20.00
Isoelectric point 5.61
Molecular weight 170.53 kDa
Number of residues 1611
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS768
present during mitotic M phaseS597
present during mitotic M phaseS718
present during mitotic M phaseS678
level fluctuates during mitotic cell cycleS712
present during mitotic M phaseS682
present during mitotic M phaseS692
present during mitotic M phaseS916
present during mitotic M phaseS501
present during mitotic M phaseS712
present during mitotic M phaseS159
present during mitotic M phaseS777
S146, S343, S682, S699, S718, S777, S916, S959
present during mitotic M phaseS343
present during mitotic M phaseS1003
present during mitotic M phaseS589
present during mitotic M phaseS959
present during mitotic M phaseS153
present during mitotic M phaseS699
present during mitotic M phaseS155
Annotation ExtensionEvidenceResidueReference
experimental evidence S146 PMID:24763107
present during mitotic M phase experimental evidence S153 PMID:21712547
present during mitotic M phase experimental evidence S155 PMID:21712547
present during mitotic M phase experimental evidence S159 PMID:21712547
experimental evidence S343 PMID:24763107
present during mitotic M phase experimental evidence S343 PMID:21712547
present during mitotic M phase experimental evidence S501 PMID:21712547
present during mitotic M phase experimental evidence S589 PMID:21712547
present during mitotic M phase experimental evidence S597 PMID:21712547
present during mitotic M phase experimental evidence S678 PMID:21712547
experimental evidence S682 PMID:24763107
present during mitotic M phase experimental evidence S682 PMID:21712547
present during mitotic M phase experimental evidence S692 PMID:21712547
experimental evidence S699 PMID:24763107
present during mitotic M phase experimental evidence S699 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S712 PMID:24763107
present during mitotic M phase experimental evidence S712 PMID:21712547
experimental evidence S718 PMID:24763107
present during mitotic M phase experimental evidence S718 PMID:21712547
present during mitotic M phase experimental evidence S768 PMID:21712547
experimental evidence S777 PMID:24763107
present during mitotic M phase experimental evidence S777 PMID:21712547
experimental evidence S916 PMID:24763107
present during mitotic M phase experimental evidence S916 PMID:21712547
experimental evidence S959 PMID:24763107
present during mitotic M phase experimental evidence S959 PMID:21712547
present during mitotic M phase experimental evidence S1003 PMID:21712547
O-phospho-L-threonine 698
present during mitotic M phaseT685
level fluctuates during mitotic cell cycleT715
present during mitotic M phaseT336
present during mitotic M phaseT1002
present during mitotic M phaseT579
present during mitotic M phaseT715
T458, T685
present during mitotic M phaseT775
present during mitotic M phaseT748
present during mitotic M phaseT587
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T336 PMID:21712547
experimental evidence T458 PMID:24763107
present during mitotic M phase experimental evidence T579 PMID:21712547
present during mitotic M phase experimental evidence T587 PMID:21712547
experimental evidence T685 PMID:24763107
present during mitotic M phase experimental evidence T685 PMID:21712547
present during mitotic M phase experimental evidence T715 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence T715 PMID:24763107
present during mitotic M phase experimental evidence T748 PMID:21712547
present during mitotic M phase experimental evidence T775 PMID:21712547
present during mitotic M phase experimental evidence T1002 PMID:21712547
phosphorylated residue 1927
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
13937during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
13956during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
14614during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
14504during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9392.78during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
14514during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
11904.43during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
2.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycyk3cytokinesis protein Cyk3 (predicted) Affinity Capture-MSPMID:20603077
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
phenotype enhanced byelp3elongator complex subunit Elp3 (predicted) Phenotypic EnhancementPMID:19547744
negative genetic interaction withtef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC23A1.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC23A1.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC23A1.17 BioGRID Interaction Datasets
Expression Viewer SPAC23A1.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC23A1.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC23A1.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC23A1.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC23A1.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC23A1.17 Transcriptome Viewer (Bähler Lab)
GEO SPAC23A1.17 GEO profiles
PInt SPAC23A1.17 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC23A1.17 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC23A1.17 Fission yeast phenotypic data & analysis
Cyclebase SPAC23A1.17.1 Cell Cycle Data
SPD / RIKEN48/48G09Orfeome Localization Data
UniProtKB/SwissProtO42854SH3 domain-containing protein C23A1.17
ModBaseO42854Database of comparative protein structure models
STRINGO42854Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594446SH3 domain-containing protein
RefSeq mRNANM_001019875972h- SH3 domain-containing protein (SPAC23A1.17), mRNA
European Nucleotide ArchiveCAA16991.1ENA Protein Mapping
UniParcUPI0000069573UniProt Archive

Literature for bbc1

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015