SPAC23A1.17


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC23A1.17 Feature Typeprotein coding
Synonyms Name Description
ProductWIP family cytoskeletal protein (predicted) Product Size1611aa, 170.53 kDa
Genomic Location Chromosome I, 4106702-4112044 (5343nt); CDS:4106827-4111662 (4836nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0017024myosin I bindingISOSGD:S000003557GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030036actin cytoskeleton organizationISOSGD:S000003557GO_REF:0000024102
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030479actin cortical patchISOSGD:S000003557GO_REF:000002447
GO:0032153cell division siteIDAPMID:16823372301
GO:0051286cell tipIDAPMID:16823372190
GO:0005829cytosolIDAPMID:168233722315
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC23A1.17ΔNullPECO:0000005, PECO:0000137PMID:236978063759
MicroscopySPAC23A1.17ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001MicroscopySPAC23A1.17ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
141067024112044

UTRs

Region Coordinates Reference
five_prime_UTR4106702..4106826PMID:20118936
five_prime_UTR4106702..4106826PMID:18641648
three_prime_UTR4111663..4112044PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00018 Pfam IPR001452 Src homology-3 domain 9 58 18
SM00326 SMART IPR001452 Src homology-3 domain 6 66 21
PS50002 Prosite Profiles IPR001452 Src homology-3 domain 3 67 21
2.30.30.40 Gene3D 4 64 21
SSF50044 SuperFamily IPR001452 Src homology-3 domain 3 67 21
Coil ncoils Rabaptin coiled-coil domain 398 419 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 105.85 Da
Charge -20.00
Isoelectric point 5.61
Molecular weight 170.53 kDa
Number of residues 1611
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS718PMID:217125471670
present during mitotic M phase
present during mitotic M phaseexperimental evidenceS916PMID:21712547
present during mitotic M phaseexperimental evidenceS699PMID:21712547
present during mitotic M phaseexperimental evidenceS959PMID:21712547
present during mitotic M phaseexperimental evidenceS768PMID:21712547
present during mitotic M phaseexperimental evidenceS589PMID:21712547
present during mitotic M phaseexperimental evidenceS501PMID:21712547
present during mitotic M phaseexperimental evidenceS712PMID:21712547
present during mitotic M phaseexperimental evidenceS1003PMID:21712547
present during mitotic M phaseexperimental evidenceS682PMID:21712547
experimental evidenceS718PMID:24763107
level fluctuates during mitotic cell cycleexperimental evidenceS712PMID:24763107
experimental evidenceS777PMID:24763107
present during mitotic M phaseexperimental evidenceS597PMID:21712547
experimental evidenceS682PMID:24763107
experimental evidenceS916PMID:24763107
experimental evidenceS146PMID:24763107
experimental evidenceS699PMID:24763107
experimental evidenceS343PMID:24763107
experimental evidenceS959PMID:24763107
present during mitotic M phaseexperimental evidenceS153PMID:21712547
present during mitotic M phaseexperimental evidenceS159PMID:21712547
present during mitotic M phaseexperimental evidenceS155PMID:21712547
present during mitotic M phaseexperimental evidenceS777PMID:21712547
present during mitotic M phaseexperimental evidenceS343PMID:21712547
present during mitotic M phaseexperimental evidenceS692PMID:21712547
present during mitotic M phaseexperimental evidenceS678PMID:21712547
MOD:00047O-phospho-L-threonineexperimental evidenceT715PMID:24763107692
level fluctuates during mitotic cell cycle
experimental evidenceT685PMID:24763107
experimental evidenceT458PMID:24763107
present during mitotic M phaseexperimental evidenceT775PMID:21712547
present during mitotic M phaseexperimental evidenceT685PMID:21712547
present during mitotic M phaseexperimental evidenceT748PMID:21712547
present during mitotic M phaseexperimental evidenceT336PMID:21712547
present during mitotic M phaseexperimental evidenceT579PMID:21712547
present during mitotic M phaseexperimental evidenceT1002PMID:21712547
present during mitotic M phaseexperimental evidenceT587PMID:21712547
present during mitotic M phaseexperimental evidenceT715PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441922
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
13937during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
13956during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
14614during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
14504during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
9392.78during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
14514during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
11904.43during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
Phenotypic EnhancementPMID:19547744
tef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cyk3cytokinesis protein Cyk3 (predicted) Affinity Capture-MSPMID:20603077
External References
Database Identifier Description
NBRP SPAC23A1.17 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC23A1.17 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC23A1.17 BioGRID Interaction Datasets
Expression Viewer SPAC23A1.17 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC23A1.17 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC23A1.17 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC23A1.17 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC23A1.17 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC23A1.17 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC23A1.17 Cell Cycle Data
GEO SPAC23A1.17 GEO profiles
PInt SPAC23A1.17 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC23A1.17 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC23A1.17 Fission yeast phenotypic data & analysis
SPD / RIKEN48/48G09Orfeome Localization Data
UniProtKB/SwissProtO42854SH3 domain-containing protein C23A1.17
ModBaseO42854Database of comparative protein structure models
STRINGO42854Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594446SH3 domain-containing protein
RefSeq mRNANM_001019875972h- SH3 domain-containing protein (SPAC23A1.17), mRNA
European Nucleotide ArchiveCAA16991.1ENA Protein Mapping
UniParcUPI0000069573UniProt Archive

Literature for SPAC23A1.17

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014