mpc2 (SPAC24B11.09)


Gene Standard Namempc2 Characterisation Statusbiological_role_inferred
Systematic IDSPAC24B11.09 Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial pyruvate transmembrane transporter Mpc2 (predicted) Product Size118aa, 13.54 kDa
Genomic Location Chromosome I, 214093-216962 (2870nt); CDS:216483-216839 (357nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0050833pyruvate transmembrane transporter activity2
contributes_toISOSGD:S000003475GO_REF:0000024
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:1902361mitochondrial pyruvate transmembrane transportISOSGD:S000003475GO_REF:00000012
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmIDAPMID:168233724204
GO:0031305integral component of mitochondrial inner membraneISOSGD:S000003475GO_REF:000002414
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopympc2ΔNullPECO:0000005, PECO:0000137PMID:236978063751
Microscopympc2ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell size215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopympc2ΔNullPECO:0000137, PECO:0000004PMID:23697806
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopympc2ΔNullPECO:0000137, PECO:0000005PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1214093216962
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03650 Pfam IPR005336 Mitochondrial pyruvate carrier 1 113 2
TMhelix TMHMM 72 94 959
PTHR14154 HMMPANTHER 1 118 2
PTHR14154:SF2 HMMPANTHER 1 118 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.71 Da
Charge 13.00
Isoelectric point 11.51
Molecular weight 13.54 kDa
Number of residues 118
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
10669during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2971.31during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
12during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
jmj4Jmj4 protein (predicted) Positive GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
rik1silencing protein Rik1 Positive GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
ubp4ubiquitin C-terminal hydrolase Ubp4 Negative GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
cdk11serine/threonine protein kinase cdk11 Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC24B11.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24B11.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24B11.09 BioGRID Interaction Datasets
Expression Viewer SPAC24B11.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24B11.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24B11.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24B11.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24B11.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24B11.09 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC24B11.09 Cell Cycle Data
GEO SPAC24B11.09 GEO profiles
PInt SPAC24B11.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24B11.09 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN02/02D06Orfeome Localization Data
UniProtKB/SwissProtQ09896Probable mitochondrial pyruvate carrier 1
ModBaseQ09896Database of comparative protein structure models
STRINGQ09896Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592846hypothetical protein SPAC24B11.09
RefSeq mRNANM_001018247972h- hypothetical protein (SPAC24B11.09), mRNA
European Nucleotide ArchiveCAA91774.1ENA Protein Mapping
UniParcUPI000013A0CEUniProt Archive

Literature for mpc2

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014