mpc2 (SPAC24B11.09)


Gene Standard Namempc2 Characterisation Statusbiological_role_inferred
Systematic IDSPAC24B11.09 Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial pyruvate transmembrane transporter Mpc2 (predicted) Product Size118aa, 13.54 kDa
Genomic Location Chromosome I, 214093-216962 (2870nt); CDS:216483-216839 (357nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
pyruvate transmembrane transporter activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mitochondrial pyruvate transmembrane transport2
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4208
Annotation ExtensionEvidenceWith/FromReference
integral component of mitochondrial inner membrane16
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationmpc2ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell, abnormal cell shape, normal cell sizempc2ΔNull215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons214093..216962
mRNA214093..216962
5' UTR214093..216482PMID:21511999
CDS216483..216839
3' UTR216840..216962AU013763
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03650 Pfam IPR005336 Mitochondrial pyruvate carrier 1 113 2
TMhelix TMHMM 72 94 959
PTHR14154:SF2 HMMPANTHER 1 108 1
PTHR14154 HMMPANTHER 1 108 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.71 Da
Charge 13.00
Isoelectric point 11.51
Molecular weight 13.54 kDa
Number of residues 118
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10669during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2971.31during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
12during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
negative genetic interaction withcdk11serine/threonine protein kinase cdk11 Negative GeneticPMID:22681890
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
negative genetic interaction withdsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
negative genetic interaction withdsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:22681890
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
positive genetic interaction withjmj4Jmj4 protein (predicted) Positive GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withpek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
negative genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
negative genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
positive genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withraf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
positive genetic interaction withrik1silencing protein Rik1 Positive GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withubp4ubiquitin C-terminal hydrolase Ubp4 Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC24B11.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24B11.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24B11.09 BioGRID Interaction Datasets
Expression Viewer SPAC24B11.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24B11.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24B11.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24B11.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24B11.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24B11.09 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC24B11.09 Cell Cycle Data
GEO SPAC24B11.09 GEO profiles
PInt SPAC24B11.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24B11.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC24B11.09 Fission yeast phenotypic data & analysis
SPD / RIKEN02/02D06Orfeome Localization Data
UniProtKB/SwissProtQ09896Probable mitochondrial pyruvate carrier 1
ModBaseQ09896Database of comparative protein structure models
STRINGQ09896Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592846hypothetical protein SPAC24B11.09
RefSeq mRNANM_001018247972h- hypothetical protein (SPAC24B11.09), mRNA
European Nucleotide ArchiveCAA91774.1ENA Protein Mapping
UniParcUPI000013A0CEUniProt Archive

Literature for mpc2

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015