cfh1 (SPAC24B11.10c)


Gene Standard Namecfh1 Characterisation Statusconserved unknown
Systematic IDSPAC24B11.10c Feature Typeprotein coding
Synonymschr3 Name DescriptionChs Four Homologue
Productchitin synthase regulatory factor-like Cfh1 (predicted) Product Size932aa, 103.18 kDa
Genomic Location Chromosome I, 221562-218260 (3303nt); CDS:221455-218657 (2799nt)

Ensembl Gene Location
GO Cellular Component
Term NameCount
cell division site317
Annotation ExtensionEvidenceWith/FromReference
cell tip209
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body220
Annotation ExtensionEvidenceWith/FromReference
nucleus2700
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationcfh1Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell, abnormal cell shape, normal cell sizecfh1Δ215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons221562..218260
mRNA221562..218260
5' UTR221562..221456PMID:21511999
CDS221455..218657
3' UTR218656..218260PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08238 Pfam IPR006597 Sel1-like repeat 789 825 6
PF08238 Pfam IPR006597 Sel1-like repeat 712 744 6
PF08238 Pfam IPR006597 Sel1-like repeat 828 862 6
PF08238 Pfam IPR006597 Sel1-like repeat 676 709 6
PF08238 Pfam IPR006597 Sel1-like repeat 638 674 6
PF08238 Pfam IPR006597 Sel1-like repeat 864 898 6
SM00671 SMART IPR006597 Sel1-like repeat 638 674 7
SM00671 SMART IPR006597 Sel1-like repeat 826 863 7
SM00671 SMART IPR006597 Sel1-like repeat 711 747 7
SM00671 SMART IPR006597 Sel1-like repeat 675 710 7
SM00671 SMART IPR006597 Sel1-like repeat 864 899 7
SM00671 SMART IPR006597 Sel1-like repeat 789 825 7
SM00671 SMART IPR006597 Sel1-like repeat 751 788 7
PTHR11102:SF83 HMMPANTHER 611 932 1
PTHR11102:SF83 HMMPANTHER 92 129 1
PTHR11102 HMMPANTHER 611 932 7
PTHR11102 HMMPANTHER 92 129 7
1.25.40.10 Gene3D IPR011990 Tetratricopeptide-like helical domain 637 912 62
SSF81901 SuperFamily 656 903 9

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000212SEL1 repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000212

Protein Properties

Ave. residue weight 110.71 Da
Charge 31.00
Codon Adaptation Index 0.38
Isoelectric point 9.54
Molecular weight 103.18 kDa
Number of residues 932
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS40, S41, S42, S43, S156, S273, S328, S389, S393, S467, S498, S516, S519, S524, S525 2289
Annotation ExtensionEvidenceResidueReference
IDA S40 PMID:25720772
IDA S389 PMID:25720772
IDA S156 PMID:25720772
IDA S525 PMID:25720772
IDA S516 PMID:25720772
IDA S328 PMID:25720772
IDA S467 PMID:25720772
IDA S42 PMID:25720772
IDA S519 PMID:25720772
IDA S524 PMID:25720772
IDA S393 PMID:25720772
IDA S43 PMID:25720772
IDA S273 PMID:25720772
IDA S41 PMID:25720772
IDA S498 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS156,S161, S156,S163, S275,S284,S285, S308,T313,T317, S386,S389, S386,S389,S393, S386,S389,Y397, S386,S393, S389,S393, S467,S471, S467,S481, S467,T468, S467,T468,S479, S467,T468,S481, S467,T477, S467,T477,S481, S471,S481, S471,T477, S471,T477,S481, T313,S315,T317, T468,S481, T468,T477,S481, T477,S481 2457
Annotation ExtensionEvidenceResidueReference
IDA T313,S315,T317 PMID:25720772
IDA S275,S284,S285 PMID:25720772
IDA S467,T468 PMID:25720772
IDA S386,S393 PMID:25720772
IDA S467,T477,S481 PMID:25720772
IDA T477,S481 PMID:25720772
IDA S467,T477 PMID:25720772
IDA T468,S481 PMID:25720772
IDA S467,T468,S481 PMID:25720772
IDA S471,T477,S481 PMID:25720772
IDA S471,T477 PMID:25720772
IDA S386,S389 PMID:25720772
IDA S386,S389,Y397 PMID:25720772
IDA S471,S481 PMID:25720772
IDA S467,S471 PMID:25720772
IDA S386,S389,S393 PMID:25720772
IDA S389,S393 PMID:25720772
IDA S467,S481 PMID:25720772
IDA S156,S161 PMID:25720772
IDA S308,T313,T317 PMID:25720772
IDA T468,T477,S481 PMID:25720772
IDA S156,S163 PMID:25720772
IDA S467,T468,S479 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for cfh1 (SPAC24B11.10c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10067during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
9197during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
9628during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
9299during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
3185.27during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
9817during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
3259.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure may be incorrect15
possible splicing1
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC24B11.10c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byrng10coiled-coil protein involved in septum formation Rng10 Affinity Capture-MSPMID:27168121
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC24B11.10c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
positive genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
negative genetic interaction withppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
negative genetic interaction withspa2cell polarity protein Spa2 Negative GeneticPMID:22681890
negative genetic interaction withpck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC24B11.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24B11.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24B11.10c BioGRID Interaction Datasets
Expression Viewer SPAC24B11.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24B11.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24B11.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24B11.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24B11.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24B11.10c Transcriptome Viewer (Bähler Lab)
GEO SPAC24B11.10c GEO profiles
PInt SPAC24B11.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24B11.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC24B11.10c Fission yeast phenotypic data & analysis
Cyclebase SPAC24B11.10c.1 Cell Cycle Data
SPD / RIKEN29/29D12Orfeome Localization Data
UniProtKB/SwissProtQ09897Chitin synthase regulatory factor 3
ModBaseQ09897Database of comparative protein structure models
STRINGQ09897Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592847chitin synthase regulatory factor-like Chr3 (predicted)
RefSeq mRNANM_001018248972h- chitin synthase regulatory factor-like Chr3 (predicted) (chr3), mRNA
European Nucleotide ArchiveCAA91775.1ENA Protein Mapping
UniParcUPI000013A0D0UniProt Archive

Literature for cfh1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016