cfh1 (SPAC24B11.10c)


Gene Standard Namecfh1 Characterisation Statusconserved_unknown
Systematic IDSPAC24B11.10c Feature Typeprotein coding
Synonymschr3 Name DescriptionChs Four Homologue
Productchitin synthase regulatory factor-like Cfh1 (predicted) Product Size932aa, 103.18 kDa
Genomic Location Chromosome I, 221562-218260 (3303nt); CDS:221455-218657 (2799nt)

Ensembl Gene Location
GO Cellular Component
Term NameCount
cell division site305
Annotation ExtensionEvidenceWith/FromReference
cell tip194
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationcfh1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell, abnormal cell shape, normal cell sizecfh1ΔNull215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons221562..218260
mRNA221562..218260
5' UTR221562..221456PMID:21511999
CDS221455..218657
3' UTR218656..218260PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08238 Pfam IPR006597 Sel1-like 752 771 6
PF08238 Pfam IPR006597 Sel1-like 638 674 6
PF08238 Pfam IPR006597 Sel1-like 677 708 6
PF08238 Pfam IPR006597 Sel1-like 829 862 6
PF08238 Pfam IPR006597 Sel1-like 712 744 6
PF08238 Pfam IPR006597 Sel1-like 789 825 6
PF08238 Pfam IPR006597 Sel1-like 864 898 6
SM00671 SMART IPR006597 Sel1-like 864 899 7
SM00671 SMART IPR006597 Sel1-like 751 788 7
SM00671 SMART IPR006597 Sel1-like 826 863 7
SM00671 SMART IPR006597 Sel1-like 711 747 7
SM00671 SMART IPR006597 Sel1-like 675 710 7
SM00671 SMART IPR006597 Sel1-like 638 674 7
SM00671 SMART IPR006597 Sel1-like 789 825 7
PTHR11102:SF54 HMMPANTHER 188 908 1
PTHR11102 HMMPANTHER 188 908 7
1.25.40.10 Gene3D IPR011990 Tetratricopeptide-like helical domain 637 912 62
SSF81901 SuperFamily 656 903 9

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000212SEL1 repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000212

Protein Properties

Ave. residue weight 110.71 Da
Charge 31.00
Isoelectric point 9.54
Molecular weight 103.18 kDa
Number of residues 932
Modifications

Protein Modifications

Term NameResidueCount
phosphorylated residue 1927
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10067during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9197during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9628during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9299during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9817during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3185.27during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
3259.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure may be incorrect15
possible splicing1
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4603
conserved in eukaryotes4514
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withpck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
positive genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
negative genetic interaction withppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
positive genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
negative genetic interaction withspa2cell polarity protein Spa2 Negative GeneticPMID:22681890
negative genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC24B11.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24B11.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24B11.10c BioGRID Interaction Datasets
Expression Viewer SPAC24B11.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24B11.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24B11.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24B11.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24B11.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24B11.10c Transcriptome Viewer (Bähler Lab)
GEO SPAC24B11.10c GEO profiles
PInt SPAC24B11.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24B11.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC24B11.10c Fission yeast phenotypic data & analysis
Cyclebase SPAC24B11.10c.1 Cell Cycle Data
SPD / RIKEN29/29D12Orfeome Localization Data
UniProtKB/SwissProtQ09897Chitin synthase regulatory factor 3
ModBaseQ09897Database of comparative protein structure models
STRINGQ09897Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592847chitin synthase regulatory factor-like Chr3 (predicted)
RefSeq mRNANM_001018248972h- chitin synthase regulatory factor-like Chr3 (predicted) (chr3), mRNA
European Nucleotide ArchiveCAA91775.1ENA Protein Mapping
UniParcUPI000013A0D0UniProt Archive

Literature for cfh1

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015