cfh1 (SPAC24B11.10c)

Gene Standard Namecfh1 Characterisation Statusconserved_unknown
Systematic IDSPAC24B11.10c Feature Typeprotein coding
Synonymschr3 Name DescriptionChs Four Homologue
Productchitin synthase regulatory factor-like Cfh1 (predicted) Product Size932aa, 103.18 kDa
Genomic Location Chromosome I, 221562-218260 (3303nt); CDS:221455-218657 (2799nt)

Ensembl Gene Location
GO Cellular Component
Term NameCount
cell division site301
Annotation ExtensionEvidenceWith/FromReference
cell tip190
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopycfh1ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell size215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Microscopycfh1ΔNullPECO:0000137, PECO:0000005PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08238 Pfam IPR006597 Sel1-like 829 862 6
PF08238 Pfam IPR006597 Sel1-like 638 674 6
PF08238 Pfam IPR006597 Sel1-like 677 708 6
PF08238 Pfam IPR006597 Sel1-like 864 898 6
PF08238 Pfam IPR006597 Sel1-like 752 771 6
PF08238 Pfam IPR006597 Sel1-like 789 825 6
PF08238 Pfam IPR006597 Sel1-like 712 744 6
SM00671 SMART IPR006597 Sel1-like 864 899 7
SM00671 SMART IPR006597 Sel1-like 751 788 7
SM00671 SMART IPR006597 Sel1-like 826 863 7
SM00671 SMART IPR006597 Sel1-like 675 710 7
SM00671 SMART IPR006597 Sel1-like 711 747 7
SM00671 SMART IPR006597 Sel1-like 638 674 7
SM00671 SMART IPR006597 Sel1-like 789 825 7
PTHR11102 HMMPANTHER 8 908 7
PTHR11102:SF12 HMMPANTHER 8 908 3 Gene3D IPR011990 Tetratricopeptide-like helical 637 912 62
SSF81901 SuperFamily 656 903 9

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000212SEL1 repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000212

Protein Properties

Ave. residue weight 110.71 Da
Charge 31.00
Isoelectric point 9.54
Molecular weight 103.18 kDa
Number of residues 932

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residueNASPMID:195477441922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10067during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
9197during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
9628during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
9299during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
9817during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
3185.27during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
3259.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
gene structure may be incorrect15
possible splicing1
Species Distribution
conserved in fungi4600
conserved in eukaryotes4514

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
spa2GTPase activating protein Spa2 (predicted) Negative GeneticPMID:22681890
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
ppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC24B11.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24B11.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24B11.10c BioGRID Interaction Datasets
Expression Viewer SPAC24B11.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24B11.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24B11.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24B11.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24B11.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24B11.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC24B11.10c Cell Cycle Data
GEO SPAC24B11.10c GEO profiles
PInt SPAC24B11.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24B11.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC24B11.10c Fission yeast phenotypic data & analysis
SPD / RIKEN29/29D12Orfeome Localization Data
UniProtKB/SwissProtQ09897Chitin synthase regulatory factor 3
ModBaseQ09897Database of comparative protein structure models
STRINGQ09897Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592847chitin synthase regulatory factor-like Chr3 (predicted)
RefSeq mRNANM_001018248972h- chitin synthase regulatory factor-like Chr3 (predicted) (chr3), mRNA
European Nucleotide ArchiveCAA91775.1ENA Protein Mapping
UniParcUPI000013A0D0UniProt Archive

Literature for cfh1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014