cfh1 (SPAC24B11.10c)


Gene Standard Namecfh1 Characterisation Statusconserved_unknown
Systematic IDSPAC24B11.10c Feature Typeprotein coding
Synonymschr3 Name DescriptionChs Four Homologue
Productchitin synthase regulatory factor-like Cfh1 (predicted) Product Size932aa, 103.18 kDa
Genomic Location Chromosome I, 221562-218260 (3303nt); CDS:221455-218657 (2799nt)

Ensembl Gene Location
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0032153cell division siteIDAPMID:16823372292
GO:0051286cell tipIDAPMID:16823372186
GO:0005829cytosolIDAPMID:168233722317
GO:0044732mitotic spindle pole bodyIDAPMID:16823372214
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopycfh1ΔNullPMID:204732893755
Microscopycfh1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001510viable vegetative cell, abnormal cell shape, normal cell sizeMicroscopycfh1ΔNullPECO:0000137, PECO:0000005PMID:23697806215
expressivity FYPO_EXT:0000003
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1221562218260

UTRs

Region Start End Reference
three_prime_UTR218656218260PMID:21511999
five_prime_UTR221562221456PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08238 Pfam IPR006597 Sel1-like 712 744 6
PF08238 Pfam IPR006597 Sel1-like 789 825 6
PF08238 Pfam IPR006597 Sel1-like 677 708 6
PF08238 Pfam IPR006597 Sel1-like 752 771 6
PF08238 Pfam IPR006597 Sel1-like 638 674 6
PF08238 Pfam IPR006597 Sel1-like 829 862 6
PF08238 Pfam IPR006597 Sel1-like 864 898 6
SM00671 SMART IPR006597 Sel1-like 751 788 7
SM00671 SMART IPR006597 Sel1-like 789 825 7
SM00671 SMART IPR006597 Sel1-like 638 674 7
SM00671 SMART IPR006597 Sel1-like 711 747 7
SM00671 SMART IPR006597 Sel1-like 826 863 7
SM00671 SMART IPR006597 Sel1-like 864 899 7
SM00671 SMART IPR006597 Sel1-like 675 710 7
PTHR11102:SF12 HMMPANTHER 8 908 3
PTHR11102 HMMPANTHER 8 908 7
G3DSA:1.25.40.10 Gene3D IPR011990 637 912 55
SSF81901 SuperFamily 656 903 9
Low complexity (SEG) seg 515 528
Low complexity (SEG) seg 495 510
Low complexity (SEG) seg 382 393
Low complexity (SEG) seg 236 248

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000212SEL1 repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000212

Protein Properties

Ave. residue weight 110.71 Da
Charge 31.00
Isoelectric point 9.54
Molecular weight 103.18 kDa
Number of residues 932
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3259.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
3185.27during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.8during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure may be incorrect15
possible splicing1
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
spa2GTPase activating protein Spa2 (predicted) Negative GeneticPMID:22681890
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
ppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC24B11.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24B11.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24B11.10c BioGRID Interaction Datasets
Expression Viewer SPAC24B11.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24B11.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24B11.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24B11.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24B11.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24B11.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC24B11.10c Cell Cycle Data
GEO SPAC24B11.10c GEO profiles
PInt SPAC24B11.10c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2541607chitin synthase regulatory factor Chr3 (predicted)
EntrezGene2541607chitin synthase regulatory factor Chr3 (predicted)
SPD / RIKEN29/29D12Orfeome Localization Data
UniProtKB/SwissProtQ09897Chitin synthase regulatory factor 3
ModBaseQ09897Database of comparative protein structure models
StringQ09897Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592847chitin synthase regulatory factor Chr3 (predicted)
RefSeq mRNANM_001018248972h- chitin synthase regulatory factor Chr3 (predicted) (chr3), mRNA
European Nucleotide ArchiveCAA91775ENA Protein Mapping
UniParcUPI000013A0D0UniProt Archive

Literature for cfh1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014