bgs2 (SPAC24C9.07c)


Gene Standard Namebgs2 Characterisation Statuspublished
Systematic IDSPAC24C9.07c Feature Typeprotein coding
Synonymsmeu21, pgs2 Name DescriptionMeiotic Expression Upregulated,
Beta Glucan Synthase
Product1,3-beta-glucan synthase subunit Bgs2 Product Size1894aa, 219.18 kDa
Genomic Location Chromosome I, 3059282-3053214 (6069nt); CDS:3059282-3053598 (5685nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
1,3-beta-D-glucan synthase activity5
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ascospore formation60
Annotation ExtensionEvidenceWith/FromReference
ascospore wall (1->3)-beta-D-glucan biosynthetic process2
Annotation ExtensionEvidenceWith/FromReference
fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process10
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
1,3-beta-D-glucan synthase complex5
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane963
Annotation ExtensionEvidenceWith/FromReference
prospore membrane30
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
inviable spore populationbgs2Δ20
bgs2::his3
normal growth on Calcofluor Whitebgs2+5
bgs2::his3
normal growth on echinocandinbgs2::his38
bgs2+
normal growth on papulacandin Bbgs2+2
bgs2::his3
normal vegetative cell population growth ratebgs2+78
bgs2::his3
normal viability in stationary phasebgs2::his329
viable spore populationbgs2+/bgs2- (heterozygous diploid)46
viable vegetative cell populationbgs2Δ3837

Cell Phenotype

Term NameGenotypesCount
abnormal ascospore wall assemblybgs2::his33
abnormal spore shapebgs2Δ10
abolished sporulationbgs2::his354
decreased 1,3-beta-D-glucan synthase activity during sporulationbgs2::his31
irregular ascospore wallbgs2Δ2
normal 1,3-beta-D-glucan synthase activity during vegetative growthbgs2+2
bgs2::his3
normal conjugationbgs2Δ49
normal conjugation frequencybgs2::his314
normal meiosis Ibgs2Δ7
bgs2::his3
normal meiosis IIbgs2Δ6
bgs2::his3
spore lysisbgs2Δ4
viable vegetative cell with normal cell morphologybgs2::his33100
bgs2Δ
bgs2+

FYPO Multi-allele Phenotypes

Cell Phenotype

Term NameGenotypes
abolished sporulationbgs4+ (wild type), bgs2::his3
bgs1+ (wild type), bgs2::his3
bgs3+ (wild type), bgs2::his3
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3059282..3053214
3' UTR3053597..3053214PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF14288 Pfam IPR026899 1,3-beta-glucan synthase subunit FKS1-like, domain-1 335 441 4
PF02364 Pfam IPR003440 Glycosyl transferase, family 48 844 1665 4
TMhelix TMHMM 1637 1659 953
TMhelix TMHMM 1476 1498 953
TMhelix TMHMM 732 754 953
TMhelix TMHMM 1339 1361 953
TMhelix TMHMM 1775 1797 953
TMhelix TMHMM 1596 1618 953
TMhelix TMHMM 530 552 953
TMhelix TMHMM 1835 1857 953
TMhelix TMHMM 1708 1730 953
TMhelix TMHMM 602 624 953
TMhelix TMHMM 1394 1411 953
TMhelix TMHMM 565 587 953
TMhelix TMHMM 657 679 953
TMhelix TMHMM 703 725 953
TMhelix TMHMM 1503 1525 953
TMhelix TMHMM 1674 1696 953
PTHR12741 HMMPANTHER 175 273 5
PTHR12741 HMMPANTHER 1579 1600 5
PTHR12741 HMMPANTHER 958 1563 5
PTHR12741 HMMPANTHER 321 935 5
PTHR12741 HMMPANTHER 1616 1873 5
PTHR12741:SF7 HMMPANTHER 175 273 4
PTHR12741:SF7 HMMPANTHER 1579 1600 4
PTHR12741:SF7 HMMPANTHER 958 1563 4
PTHR12741:SF7 HMMPANTHER 321 935 4
PTHR12741:SF7 HMMPANTHER 1616 1873 4

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 115.73 Da
Charge 4.50
Codon Adaptation Index 0.38
Isoelectric point 6.71
Molecular weight 219.18 kDa
Number of residues 1894
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelabsent during GO:0034605Northern assay evidencePMID:11069657
present during GO:0030437Northern assay evidencePMID:11069657
absent during GO:0072690Northern assay evidencePMID:11069657
absent during GO:0071277Northern assay evidencePMID:11069657
present during GO:0034293experimental evidencePMID:11069657

Quantitative Gene Expression

View graphical display of gene expression data for bgs2 (SPAC24C9.07c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3072during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.48during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
not functionally complemented by S. cerevisiae FKS2 PMID:11069657
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi only618
conserved in fungi4605
conserved in eukaryotes4515
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC24C9.07c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
enhances phenotype ofres1MBF transcription factor complex subunit Res1 Phenotypic EnhancementPMID:19547744
External References
Database Identifier Description
NBRP SPAC24C9.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24C9.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24C9.07c BioGRID Interaction Datasets
Expression Viewer SPAC24C9.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24C9.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24C9.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24C9.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24C9.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24C9.07c Transcriptome Viewer (Bähler Lab)
GEO SPAC24C9.07c GEO profiles
PInt SPAC24C9.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24C9.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC24C9.07c Fission yeast phenotypic data & analysis
Cyclebase SPAC24C9.07c.1 Cell Cycle Data
IntEnz2.4.1.34Integrated relational Enzyme database
Rhea2.4.1.34Annotated reactions database
SPD / RIKEN39/39E08Orfeome Localization Data
UniProtKB/SwissProtO139671,3-beta-glucan synthase component bgs2
ModBaseO13967Database of comparative protein structure models
STRINGO13967Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_5940321,3-beta-glucan synthase subunit Bgs2
RefSeq mRNANM_001019457972h- 1,3-beta-glucan synthase subunit Bgs2 (bgs2), mRNA
MetaCycPWY-67731,3-beta-D-glucan biosynthesis
KEGG00500+2.4.1.34Starch and sucrose metabolism

Literature for bgs2

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016