cdc25 (SPAC24H6.05)


Gene Standard Namecdc25 Characterisation Statuspublished
Systematic IDSPAC24H6.05 Feature Typeprotein coding
Synonymssal2 Name Description
ProductM phase inducer tyrosine phosphatase Cdc25 Product Size596aa, 66.57 kDa
Genomic Location Chromosome I, 482556-479228 (3329nt); CDS:481540-479750 (1791nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
phosphatase activity69
Annotation ExtensionEvidenceWith/FromReference
protein binding887
protein tyrosine phosphatase activity13
Annotation ExtensionEvidenceWith/FromReference
has substrate cdc2
GO Biological Process
GO Cellular Component
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
abolished cell population growth at high temperaturecdc25-22 (C532Y)38
decreased frequency of meiosis Icdc25-22 (C532Y)2
inviable vegetative cell populationcdc25+ (wild type)1455
cdc25Δ
sensitive to methyl methanesulfonatecdc25+ (wild type)331
viable vegetative cell populationcdc25-22 (C532Y)3850

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cyclecdc25Δ894
abnormal mitotic cell cycle arrest with replicated DNAcdc25-22 (C532Y)45
abnormal mitotic cell cycle regulation during cellular response to gamma radiationcdc25-22 (C532Y)9
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc25-22 (C532Y)15
cdc25+ (wild type)
abnormal sporulation resulting in formation of two-spore ascuscdc25-22 (C532Y)13
abolished meiosis IIcdc25-22 (C532Y)5
abolished protein localization to mitotic spindle pole body14
affects localization of far10cdc25-22 (C532Y)
abolished protein phosphatase activityC480S (C480S)5
cell cycle arrest in mitotic G2 phasecdc25-22 (C532Y)39
cut during cellular response to hydroxyureacdc25+ (wild type)44
decreased protein kinase activity56
affecting cdc2cdc25-22 (C532Y)
decreased protein level175
affecting mcm2cdc25-22 (C532Y)
decreased protein phosphorylation during vegetative growth104
affecting cdc25cdc25-9A (S99A, S148A, S178A, A192A, S204A, S206A, T226A, S234A, S359A)
decreased response to S-phase DNA damage checkpoint signalingcdc25+ (wild type)2
decreased RNA level during meiotic cell cycle7
affecting cdc25dF1234 (4 FLEX promoters deleted)
elongated vegetative cellcdc25Δ802
increased protein level during vegetative growth114
affecting cdc13cdc25-22 (C532Y)
inviable after spore germination with elongated germ tubecdc25Δ164
inviable elongated mononucleate aseptate cellcdc25-44
inviable elongated vegetative cellcdc25-22 (C532Y)420
normal activation of bipolar cell growthcdc25-22 (C532Y)3
normal horsetail movementprad21-cdc25 (rad21 promoter control)5
cdc25+ (wild type)
normal nucleus:cytoplasm ratiocdc25-22 (C532Y)6
normal protein localization to nucleus during vegetative growth83
affecting mcm5cdc25-22 (C532Y)
affecting mcm2cdc25-22 (C532Y)
normal protein phosphorylation during vegetative growth96
affecting pol1cdc25-22 (C532Y)
premature mitosiscdc25+ (wild type)5
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc25+ (wild type)4
small vegetative cellcdc25+ (wild type)88
two cell divisions prior to cell cycle arrest in mitotic G1 phase in response to pheromonecdc25-22 (C532Y)1
viable elongated vegetative cellcdc25-22 (C532Y)325
viable small vegetative cellcdc25+ (wild type)54

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
abnormal mitotic cell cycle arrest with unreplicated DNAcdc25+ (wild type), cdc10-V50 (H362Y)
abolished cell population growth at high temperaturewis1-DD (S469D, T473D), cdc25-22 (C532Y), S402A (S402A)
decreased cell population growth on glucose carbon sourcecdc25-22 (C532Y), cdc13+
decreased frequency of meiosismei4Δ, cdc25+ (wild type)
decreased vegetative cell population growthskb1+, cdc25-22 (C532Y)
skb1Δ, cdc25-22 (C532Y)
cdc25-22 (C532Y), shk1+
skb1+, cdc25-22 (C532Y), shk1+
cdc25-22 (C532Y), skb1+, shk1+
cdc2-3w (C67Y), skb1Δ, cdc25Δ
inviable cell populationcdc25-22 (C532Y), fkh2Δ
inviable vegetative cell populationcdc25-22 (C532Y), cdc13+
wis4Δ, cdc25-22 (C532Y), mcs4+
rhp6-788, cdc25-22 (C532Y)
mcs4Δ, cdc25-22 (C532Y)
cdc25-22 (C532Y), wee1-50, dis2+
cdc2-3w (C67Y), cdc25-22 (C532Y), mcs2-75
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
cdc25-22 (C532Y), sty2-1
mcs4-13, wee1-50, cdc25-22 (C532Y)
cdc25-22 (C532Y), pin1Δ
rhp6Δ, cdc25-22 (C532Y)
pyp3Δ, wee1-50, cdc25Δ
cdc25-22 (C532Y), wee1-6, dis2+
cdc2-1w (G146D), cdc25::ura4
cdc25-22 (C532Y), wee1-50, sds21+
win1-1, wee1-50, cdc25-22 (C532Y)
mcs1-77, wee1-50, cdc25-22 (C532Y)
cdc25-22 (C532Y), wis1Δ
hip3Δ, cdc25-22 (C532Y)
cdc25-22 (C532Y), fkh2Δ
cdc25-22 (C532Y), cdc2-3w (C67Y), dis2+
cdc25-22 (C532Y), wee1-50, dis3+
cdc25-22 (C532Y), sty1Δ
cdc25-22 (C532Y), cdc2-3w (C67Y), mcs2-75
cdc25-22 (C532Y), tor1Δ
cdc25-22 (C532Y), sty1-1
cdc25-22 (C532Y), wis4Δ
loss of viability at high temperaturewin1-1, wee1-50, cdc25-22 (C532Y)
cdc25-22 (C532Y), mcl1-1 (ntG372A)
sensitive to arsenatecdc2-3w (C67Y), cdc25Δ
slow vegetative cell population growthcdr1-76, cdc25-22 (C532Y)
cdr2-97, cdc25-22 (C532Y)
viable vegetative cell populationmcs1-77, wee1-50, cdc25-22 (C532Y)
cdc25::ura4, cdc2-3w (C67Y)
atf1Δ, cdc25Δ
mcs4-13, cdc2+, wee1-50, cdc25-22 (C532Y)
cdc25-22 (C532Y), D412E (D412E)
cdc25-22 (C532Y), wee1-6, dis2+
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
cdc25-22 (C532Y), cdc2-3w (C67Y), dis2+
wis4Δ, cdc25-22 (C532Y), wis1+ (wild type)
cdc25-22 (C532Y), wee1-50, dis3+
wee1Δ, cdc25-22 (C532Y)
ppa2+, wee1-50, cdc25-22 (C532Y)
tor1Δ, cdc25-22 (C532Y), gad8+
cdc25-22 (C532Y), wee1-50, sds21+
sds22+, wee1-50, cdc25-22 (C532Y)
cdc2-3w (C67Y), mcs6+, cdc25-22 (C532Y), mcs2-75
mcs4-13, wee1-50, cdc25-22 (C532Y)
wee1-50, pyp3+, cdc25::ura4
cdc25-22 (C532Y), wee1-50, sds23+
mcs4DN (D412N), cdc25-22 (C532Y)
cdc25-22 (C532Y), wee1-50, dis2+
cdc2-3w (C67Y), csk1+, cdc25-22 (C532Y), mcs2-75

Cell Phenotype

Term NameGenotypes
abnormal cell cycle arrest in mitotic S phasecdc25-22 (C532Y), cdt2-M1 (R50->stop)
abnormal cytoskeleton organizationcdc25-22 (C532Y), alp1-1315
abnormal mitotic cell cycle arrest with condensed chromosomescdc25-22 (C532Y), fin1+ (wild type)
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc25Δ, cdc2-3w (C67Y)
abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplicationcdc18+ (wild type), cdc25-22 (C532Y)
abnormal sporulation resulting in formation of two-spore ascuswee1-50, cdc25-22 (C532Y)
cdc2-1w (G146D), cdc25-22 (C532Y)
win1-1, wee1-50, cdc25-22 (C532Y)
cdr1+, cdc25-22 (C532Y)
abolished activation of bipolar cell growthcdc25-22 (C532Y), ssp1-31
aseptate mononucleate vegetative cellcdc25-22 (C532Y), skb1+
cut during cellular response to hydroxyureacdc25Δ, cdc2-3w (C67Y)
decreased response to S-phase DNA damage checkpoint signalingcdc25+ (wild type), cdc10-V50 (H362Y)
dispersed actin cortical patch localizationmor2-786, cdc25-22 (C532Y)
cdc25-22 (C532Y), pmo25-35 (T236A)
nak1-125 (T198I), cdc25-22 (C532Y)
elongated C-shaped vegetative cell with long curved cytoplasmic microtubulesklp6Δ, cdc25-22 (C532Y)
klp5Δ, cdc25-22 (C532Y)
klp6Δ, cdc25-22 (C532Y), klp5Δ
elongated mononucleate vegetative cellcut5-T401, cdc25-22 (C532Y)
increased cell wall thickness during vegetative growthcdc25-22 (C532Y), kin1Δ
increased duration of protein localization to mitotic spindle pole body
affects localization of cdc13cdc25-22 (C532Y), alp4-C(566-784) (1-565)
inviable after spore germination, multiple cell divisionship3Δ, cdc25-22 (C532Y)
mcs4-13, cdc25-22 (C532Y)
mcs1-77, cdc25-22 (C532Y)
inviable after spore germination, multiple cell divisions, elongated cellrhp6Δ, cdc25-22 (C532Y)
cdc25-22 (C532Y), tor1Δ
cdc25-22 (C532Y), gad8Δ
rhp6-788, cdc25-22 (C532Y)
inviable after spore germination, single or double cell division, elongated cellcdc25-22 (C532Y), sty1-1
cdc25-22 (C532Y), sty2-1
inviable after spore germination, without cell division, elongated cellcdc2-1w (G146D), cdc25::ura4
pyp3Δ, wee1-50, cdc25Δ
inviable elongated aseptate cellcdc25-22 (C532Y), atf1-bZIP (1-394)
inviable elongated mononucleate aseptate cellcdc25-, cut1-
cdc25-22 (C532Y), orb5-19
inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phasecdc25-22 (C532Y), alp4-C(566-784) (1-565)
inviable elongated vegetative cellwin1-1, cdc25-22 (C532Y)
cdc25-22 (C532Y), tor1Δ
win1-1, wee1-50, cdc25-22 (C532Y)
wee1-6, win1-1, cdc25-22 (C532Y)
inviable lemon-shaped cellcdc25-22 (C532Y), pmo25-2 (T613G)
cdc25-22 (C532Y), pmo25-35 (T236A)
mitosis with unreplicated DNAcdc25Δ, cdc2-3w (C67Y)
mitotic catastrophe with cutatf1+, cdc25-22 (C532Y)
mitotic G2/M transition delayatf1Δ, cdc25-22 (C532Y)
normal actin cortical patch localizationcdc25-22 (C532Y), orb5-19
normal cell cycle regulation during cellular response to hydroxyureawee1-50, cdc25Δ
cut5-T401, cdc25-22 (C532Y)
premature mitotic sister chromatid separationcdc25-22 (C532Y), hsk1-89 (L337P, E403K, L416P)
cdc25-22 (C532Y), rad21-K1
viable cell at high temperaturecdc2-E9 (D242N), wee1-50, cdc25+ (wild type)
cdc2-E8 (D213N), wee1-50, cdc25+ (wild type)
cdc25+ (wild type), wee1-50, cdc2-A21 (D90N)
viable elongated vegetative cellcdc2-3w (C67Y), win1-1, cdc25-22 (C532Y)
wee1-6, win1-1, cdc25-22 (C532Y)
cdc25-22 (C532Y), cdc2-3w (C67Y)
cdr2-97, cdc25-22 (C532Y)
mcs4-13, cdc25-22 (C532Y)
cdc2-3w (C67Y), tor1Δ, cdc25Δ
cdc25-22 (C532Y), wis4Δ
cdc25-22 (C532Y), shk1+
shk1+, cdc2-3w (C67Y), cdc25Δ
win1-1, wee1-50, cdc25-22 (C532Y)
cdc25-22 (C532Y), wee1-50
cdc25-22 (C532Y), win1-1
cdc25::ura4, cdc2-3w (C67Y)
cdr1-76, cdc25-22 (C532Y)
cdc2-3w (C67Y), skb1Δ, cdc25Δ
viable small vegetative cellcdc25-22 (C532Y), wee1-50
pyp3+, cdc25-22 (C532Y)
cdc25-22 (C532Y), wee1-6
viable vegetative cell with normal cell sizecdc2-3w (C67Y), cdc25-22 (C532Y)
wee1-50, cdc25-22 (C532Y)
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in cdc20 DNA polymerase epsilon catalytic subunit Pol2
FYPO affected by mutation in cdc25 M phase inducer tyrosine phosphatase Cdc25
FYPO affected by mutation in cdc6 DNA polymerase delta catalytic subunit Cdc6
FYPO affected by mutation in ckk2 calmodulin-dependent kinase kinase 2
FYPO affected by mutation in clp1 Cdc14-related protein phosphatase Clp1/Flp1
FYPO affected by mutation in cmk1 calcium/calmodulin-dependent protein kinase Cmk1
FYPO affected by mutation in crb2 DNA repair protein Rad9 homolog Crb2
FYPO affected by mutation in hsp9 heat shock protein Hsp9
FYPO affected by mutation in mei4 meiotic forkhead transcription factor Mei4
FYPO affected by mutation in mtf1 mitochondrial RNA polymerase specificity factor Mtf1
FYPO affected by mutation in pol1 DNA polymerase alpha catalytic subunit
FYPO affected by mutation in pub1 HECT-type ubiquitin-protein ligase E3 Pub1
FYPO affected by mutation in srk1 MAPK-activated protein kinase Srk1
FYPO localization affected by mutation in clp1 Cdc14-related protein phosphatase Clp1/Flp1
FYPO localization affected by mutation in srk1 MAPK-activated protein kinase Srk1
GO localized by sal3 karyopherin Sal3
GO regulated by mei4 meiotic forkhead transcription factor Mei4
GO regulated by srk1 MAPK-activated protein kinase Srk1
GO substrate of chk1 Chk1 protein kinase
GO substrate of clp1 Cdc14-related protein phosphatase Clp1/Flp1
GO substrate of mek1 Cds1/Rad53/Chk2 family protein kinase Mek1
GO substrate of pub1 HECT-type ubiquitin-protein ligase E3 Pub1
GO substrate of srk1 MAPK-activated protein kinase Srk1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons482556..482286, 482185..479228
Intron482285..482186
mRNA482556..479228
5' UTR482556..482286, 482185..481541PMID:21511999
CDS481540..479750
3' UTR479749..479228PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00581 Pfam IPR001763 Rhodanese-like domain 425 526 6
SM00450 SMART IPR001763 Rhodanese-like domain 419 530 6
PS50206 Prosite Profiles IPR001763 Rhodanese-like domain 429 533 7
PTHR10828 HMMPANTHER 390 573 2
PTHR10828:SF17 HMMPANTHER 390 573 1
3.40.250.10 Gene3D IPR001763 Rhodanese-like domain 408 542 8
SSF52821 SuperFamily IPR001763 Rhodanese-like domain 390 553 7
PR00716 PRINTS IPR000751 M-phase inducer phosphatase 504 525 1
PR00716 PRINTS IPR000751 M-phase inducer phosphatase 532 549 1
PR00716 PRINTS IPR000751 M-phase inducer phosphatase 413 433 1
PR00716 PRINTS IPR000751 M-phase inducer phosphatase 435 455 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.69 Da
Charge 12.50
Codon Adaptation Index 0.44
Isoelectric point 8.17
Molecular weight 66.57 kDa
Number of residues 596
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during cellular response to thiabendazoleS359
present during mitotic M phaseS583
present during mitotic M phaseS118
present during mitotic M phaseS577
present during mitotic M phaseS573
present during mitotic M phaseS15
present during mitotic M phaseS113
present during mitotic M phaseS3
S3, S15, S99, S113, S118, S120, S143, S172, S178, S192, S193, S202, S230, S334, S359
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S359 PMID:18257517
present during mitotic M phase experimental evidence S583 PMID:21712547
present during mitotic M phase experimental evidence S118 PMID:21712547
present during mitotic M phase experimental evidence S577 PMID:21712547
present during mitotic M phase experimental evidence S573 PMID:21712547
present during mitotic M phase experimental evidence S15 PMID:21712547
present during mitotic M phase experimental evidence S113 PMID:21712547
present during mitotic M phase experimental evidence S3 PMID:21712547
IDA S193 PMID:25720772
IDA S178 PMID:25720772
IDA S143 PMID:23297348
experimental evidence S3 PMID:24763107
IDA S202 PMID:25720772
IDA S230 PMID:25720772
IDA S334 PMID:25720772
experimental evidence S113 PMID:24763107
IDA S118 PMID:23297348
IDA S192 PMID:25720772
IDA S120 PMID:25720772
IDA S99 PMID:25720772
experimental evidence S15 PMID:24763107
IDA S118 PMID:25720772
IDA S359 PMID:25720772
IDA S172 PMID:25720772
IDA S113 PMID:25720772
O-phospho-L-threonine 1085
present during mitotic M phaseT110
present during mitotic M phaseT585
T357, T379
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T110 PMID:21712547
present during mitotic M phase experimental evidence T585 PMID:21712547
IDA T357 PMID:25720772
IDA T379 PMID:23297348
nitrosylation 1
added during cellular response to nitrosative stress
Annotation ExtensionEvidenceResidueReference
added during cellular response to nitrosative stress IDA PMID:22561704
phosphorylated residue 2511
added by srk1, added during mitotic G2 phase
added by srk1, added during cellular response to salt stress
Annotation ExtensionEvidenceResidueReference
added by srk1
added during mitotic G2 phase
IDA PMID:15629716
added by srk1
added during cellular response to salt stress
IDA PMID:15629716
IDA PMID:19547744
ubiquitinylated lysineK46, K48, K321 512
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence K48 PMID:26412298
mass spectrometry evidence K321 PMID:26412298
mass spectrometry evidence K46 PMID:26412298
IDA PMID:26412298
NAS PMID:8635463
O-phosphorylated residue 2457
removed by clp1
S113,S118, S172,S176, S332,S334
Annotation ExtensionEvidenceResidueReference
removed by clp1 IDA PMID:15128870
IDA S113,S118 PMID:25720772
IDA S332,S334 PMID:25720772
IDA S172,S176 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelincreased during GO:0098764Western blot evidencePMID:17804800
increased during GO:0071277Western blot evidencePMID:25081204
present during GO:0072690Western blot evidencePMID:25081204
RNA levelincreased during GO:0098764Northern assay evidencePMID:17804800

Quantitative Gene Expression

View graphical display of gene expression data for cdc25 (SPAC24H6.05)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by D. melanogaster twine PMID:1286615
Genome Organisation
DescriptionQualifierReferenceCount
alternative transcripts PMID:849310415
Misc
DescriptionQualifierReferenceCount
longer transcript expressed during cold shock due to altered 3'-end processing PMID:84931044
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC24H6.05 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
co-locates (via crystalisation or NMR) withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Co-crystal or NMR structurePMID:11812792
affinity captured byrad2414-3-3 protein Rad24 Affinity Capture-WesternPMID:15629716
affinity captured byrad2514-3-3 protein Rad25 Affinity Capture-WesternPMID:22182414
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
affinity captured bychk1Chk1 protein kinase Affinity Capture-WesternPMID:9278510
affinity captured byclp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-WesternPMID:15128870
affinity captured bymtl1TRAMP/MTREC complex subunit, ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
affinity captured byhsp9heat shock protein Hsp9 Affinity Capture-WesternPMID:22182414
modified bycds1replication checkpoint kinase Cds1 Biochemical ActivityPMID:10198041
modified bysrk1MAPK-activated protein kinase Srk1 Biochemical ActivityPMID:18272791
modified bychk1Chk1 protein kinase Biochemical ActivityPMID:9774107
modified bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:22665807
binds DNA-binding domain construct withsec18secretory pathway protein Sec18 (predicted) Two-hybridPMID:26771498
binds DNA-binding domain construct withclp1Cdc14-related protein phosphatase Clp1/Flp1 Two-hybridPMID:17538026
affinity capturesrad2414-3-3 protein Rad24 Affinity Capture-WesternPMID:10523629
affinity captureschk1Chk1 protein kinase Affinity Capture-WesternPMID:20639859
affinity capturessrk1MAPK-activated protein kinase Srk1 Affinity Capture-WesternPMID:15629716
affinity capturesclp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-WesternPMID:14765109
modifiessrk1MAPK-activated protein kinase Srk1 Biochemical ActivityPMID:15629716
forms complex withrad2414-3-3 protein Rad24 Reconstituted ComplexPMID:10523629
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC24H6.05 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
phenotype enhanced bypmo25mo25 family protein Pmo25 Phenotypic EnhancementPMID:16325501
phenotype enhanced bymug134endosulfine Igo1 Phenotypic EnhancementPMID:26776736
phenotype enhanced bypyp2tyrosine phosphatase Pyp2 Phenotypic EnhancementPMID:1464319
phenotype enhanced bymcs4response regulator Mcs4 Phenotypic EnhancementPMID:9136929
phenotype enhanced bycpc2RACK1 ortholog Cpc2 Phenotypic EnhancementPMID:20974849
phenotype enhanced byklp6kinesin-8 family plus-end microtubule motor Klp6 Phenotypic EnhancementPMID:11739790
phenotype enhanced byres2MBF transcription factor complex subunit Res2 Phenotypic EnhancementPMID:11029045
phenotype enhanced bycdr2serine/threonine protein kinase Cdr2 Phenotypic EnhancementPMID:24508166
phenotype enhanced bywee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:10233158
phenotype enhanced byres1MBF transcription factor complex subunit Res1 Phenotypic EnhancementPMID:11029045
phenotype enhanced bynak1PAK-related kinase Nak1 Phenotypic EnhancementPMID:16096637
phenotype enhanced bychk1Chk1 protein kinase Phenotypic EnhancementPMID:10637286
phenotype enhanced byrep2MBF transcription factor activator Rep2 Phenotypic EnhancementPMID:11029045
phenotype enhanced byrad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22682874
phenotype enhanced byklp5kinesin-8 family plus-end microtubule motor Klp5 Phenotypic EnhancementPMID:11870212
phenotype enhanced bymor2morphogenesis protein Mor2 Phenotypic EnhancementPMID:16096637
phenotype enhanced byatf1transcription factor, Atf-CREB family Atf1 Phenotypic EnhancementPMID:24728197
phenotype enhanced bycdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11029045
phenotype enhanced byfor3formin For3 Phenotypic EnhancementPMID:23185032
phenotype enhanced bycds1replication checkpoint kinase Cds1 Phenotypic EnhancementPMID:22682874
phenotype enhanced bywin1MAP kinase kinase kinase Win1 Phenotypic EnhancementPMID:3442828
rescued by overexpression ofcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Dosage RescuePMID:1464318
rescued by overexpression ofwis1MAP kinase kinase Wis1 Dosage RescuePMID:8557102
rescued by overexpression ofsty1MAP kinase Sty1 Dosage RescuePMID:8557102
rescued by overexpression ofcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Dosage RescuePMID:3796591
rescued by overexpression ofhsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
rescued by overexpression ofmek1Cds1/Rad53/Chk2 family protein kinase Mek1 Dosage RescuePMID:12482912
rescued by overexpression offin1serine/threonine protein kinase, NIMA related Fin1 Dosage RescuePMID:12065422
rescued by overexpression ofdis33'-5' exoribonuclease subunit Dis3 Dosage RescuePMID:1944266
rescued by overexpression ofpyp3protein-tyrosine phosphatase Pyp3 Dosage RescuePMID:1464318
rescued by overexpression ofstp1protein tyrosine phosphatase Stp1 Dosage RescuePMID:7961734
rescued by overexpression ofchk1Chk1 protein kinase Dosage RescuePMID:9832516
rescued by overexpression ofsds21serine/threonine protein phosphatase PP1 subfamily, Sds21 Dosage RescuePMID:1944266
rescued by overexpression ofrad2414-3-3 protein Rad24 Dosage RescuePMID:9832516
rescued by overexpression ofrad2514-3-3 protein Rad25 Dosage RescuePMID:9832516
rescued by overexpression ofmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Dosage RescuePMID:8557037
rescued by overexpression ofgad8AGC family protein kinase Gad8 Dosage RescuePMID:19546237
rescued by overexpression ofcmk2MAPK-activated protein kinase Cmk2 Dosage RescuePMID:12135745
rescued by overexpression ofdis2serine/threonine protein phosphatase PP1, Dis2 Dosage RescuePMID:1944266
rescued by overexpression ofsum3translation initiation RNA helicase Sum3 Dosage RescuePMID:9832516
synthetically rescuesrae1RNA export factor, nucleoporin Rae1 Synthetic RescuePMID:7706287
synthetically rescuessrk1MAPK-activated protein kinase Srk1 Synthetic RescuePMID:15629716
synthetically rescuesams2cell cycle regulated GATA-type transcription factor Ams2 Synthetic RescuePMID:18077559
synthetically rescuescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic RescuePMID:24861625
synthetically rescueschk1Chk1 protein kinase Synthetic RescuePMID:8497322
synthetic lethal withfkh2forkhead transcription factor Fkh2 Synthetic LethalityPMID:25908789
synthetic lethal withsty1MAP kinase Sty1 Synthetic LethalityPMID:8824588
synthetic lethal withwis1MAP kinase kinase Wis1 Synthetic LethalityPMID:7657164
synthetic lethal withpyp1tyrosine phosphatase Pyp1 Synthetic LethalityPMID:1464319
synthetic lethal withres2MBF transcription factor complex subunit Res2 Synthetic LethalityPMID:2474475
synthetic lethal withpub1HECT-type ubiquitin-protein ligase E3 Pub1 Synthetic LethalityPMID:8635463
synthetic lethal withmcs4response regulator Mcs4 Synthetic LethalityPMID:9136929
synthetic lethal withdnt1nucleolar protein Dnt1 Synthetic LethalityPMID:24006256
synthetic lethal withkms2spindle pole body protein Kms2 Synthetic LethalityPMID:24963130
synthetic lethal withcpc2RACK1 ortholog Cpc2 Synthetic LethalityPMID:20974849
synthetic lethal withcdc13G2/M B-type cyclin Cdc13 Synthetic LethalityPMID:8455610
synthetic lethal withslp1substrate-specific mitotic metaphase/anaphase APC coactivator Slp1 Synthetic LethalityPMID:9001228
synthetic lethal withrhp6Rad6 homolog, ubiquitin conjugating enzyme E2 Rhp6 Synthetic LethalityPMID:10224243
synthetic lethal withtor1serine/threonine protein kinase Tor1 Synthetic LethalityPMID:19546237
synthetic lethal withcdr2serine/threonine protein kinase Cdr2 Synthetic LethalityPMID:9843577
synthetic lethal withact1actin Act1 Synthetic LethalityPMID:8292390
synthetic lethal withhip1hira protein, histone chaperone Hip1 Synthetic LethalityPMID:15121850
synthetic lethal withmis3rRNA processing protein Mis3 Synthetic LethalityPMID:10947840
synthetic lethal withsal3karyopherin Sal3 Synthetic LethalityPMID:12399381
synthetic lethal withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic LethalityPMID:9843572
synthetic lethal withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic LethalityPMID:15128870
synthetic lethal withcut12spindle pole body protein Cut12 Synthetic LethalityPMID:9531532
rescuesssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Phenotypic SuppressionPMID:7628434
rescuespol1DNA polymerase alpha catalytic subunit Phenotypic SuppressionPMID:9693370
rescuescdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:9013342
rescuesslm9hira protein Slm9 Phenotypic SuppressionPMID:10835386
rescuescmk1calcium/calmodulin-dependent protein kinase Cmk1 Phenotypic SuppressionPMID:25081204
rescueswee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:9473044
rescuesrad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
rescuescdr2serine/threonine protein kinase Cdr2 Phenotypic SuppressionPMID:9843572
rescueswis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescuescut1separase/separin Phenotypic SuppressionPMID:16453724
rescuestif45translation initiation factor eIF4E, 4F complex subunit Phenotypic SuppressionPMID:10462529
rescuesfin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
rescuessep1forkhead transcription factor Sep1 Phenotypic SuppressionPMID:9473044
enhances phenotype offkh2forkhead transcription factor Fkh2 Phenotypic EnhancementPMID:22451489
enhances phenotype ofwis4MAP kinase kinase kinase Wis4 Phenotypic EnhancementPMID:9136929
enhances phenotype ofcdr2serine/threonine protein kinase Cdr2 Phenotypic EnhancementPMID:24508166
enhances phenotype ofmcs4response regulator Mcs4 Phenotypic EnhancementPMID:9383051
enhances phenotype ofssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Phenotypic EnhancementPMID:24451546
enhances phenotype ofklp5kinesin-8 family plus-end microtubule motor Klp5 Phenotypic EnhancementPMID:11870212
enhances phenotype offor3formin For3 Phenotypic EnhancementPMID:20362451
enhances phenotype ofpof3F-box protein Pof3 Phenotypic EnhancementPMID:11809834
enhances phenotype ofwee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:9013342
enhances phenotype ofnod1medial cortical node Gef2-related protein protein Nod1 Phenotypic EnhancementPMID:23349808
enhances phenotype ofclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:22665807
enhances phenotype ofsts5RNB-like protein Phenotypic EnhancementPMID:8886983
enhances phenotype ofpyp3protein-tyrosine phosphatase Pyp3 Phenotypic EnhancementPMID:7961734
enhances phenotype ofddb1damaged DNA binding protein Ddb1 Phenotypic EnhancementPMID:14701809
enhances phenotype ofkms2spindle pole body protein Kms2 Phenotypic EnhancementPMID:24963130
enhances phenotype ofcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic EnhancementPMID:2004705
rescued bywis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescued bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Phenotypic SuppressionPMID:3796591
rescued bywee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:3796591
rescued byrad3ATR checkpoint kinase Rad3 Phenotypic SuppressionPMID:10637286
rescued byrad2414-3-3 protein Rad24 Phenotypic SuppressionPMID:11166180
rescued bycdc18MCM loader Phenotypic SuppressionPMID:11532929
rescued bymik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
rescued bychk1Chk1 protein kinase Phenotypic SuppressionPMID:10637286
rescued byskb1type II protein arginine N-methyltransferase Skb1 Phenotypic SuppressionPMID:23615447
rescued byatf1transcription factor, Atf-CREB family Atf1 Phenotypic SuppressionPMID:24728197
overexpression rescuesmei4meiotic forkhead transcription factor Mei4 Dosage RescuePMID:25492408
overexpression rescuescut12spindle pole body protein Cut12 Dosage RescuePMID:17409062
overexpression rescuesact1actin Act1 Dosage RescuePMID:8292390
synthetic growth defect withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:2004705
synthetic growth defect withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic Growth DefectPMID:15911625
synthetic growth defect withblt1ubiquitin domain-like protein Blt1 Synthetic Growth DefectPMID:24790095
synthetic growth defect withpin1peptidyl-prolyl cis-trans isomerase Pin1 Synthetic Growth DefectPMID:11707530
synthetic growth defect withrpn1219S proteasome regulatory subunit Rpn12 Synthetic Growth DefectPMID:8621436
synthetic growth defect withcut12spindle pole body protein Cut12 Synthetic Growth DefectPMID:12065422
synthetic growth defect withslm9hira protein Slm9 Synthetic Growth DefectPMID:9843572
synthetic growth defect withcdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
synthetic growth defect withcdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic Growth DefectPMID:20444100
synthetic growth defect withelp3elongator complex subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
synthetic growth defect withatf1transcription factor, Atf-CREB family Atf1 Synthetic Growth DefectPMID:24728197
synthetic growth defect withres2MBF transcription factor complex subunit Res2 Synthetic Growth DefectPMID:11029045
synthetic growth defect withctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
synthetic growth defect withmik1mitotic inhibitor kinase Mik1 Synthetic Growth DefectPMID:22806395
synthetic growth defect withwee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:23333317
synthetic growth defect withtor1serine/threonine protein kinase Tor1 Synthetic Growth DefectPMID:18235227
synthetic growth defect withssp1Ca2+/calmodulin-dependent (CaMMK)-like protein kinase Ssp1 Synthetic Growth DefectPMID:24451546
synthetic growth defect withhsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Synthetic Growth DefectPMID:11027263
synthetic growth defect withgad8AGC family protein kinase Gad8 Synthetic Growth DefectPMID:18235227
synthetically rescued bywis1MAP kinase kinase Wis1 Synthetic RescuePMID:15917811
synthetically rescued bycut12spindle pole body protein Cut12 Synthetic RescuePMID:15917811
synthetically rescued byskb1type II protein arginine N-methyltransferase Skb1 Synthetic RescuePMID:9843966
synthetically rescued bypyp1tyrosine phosphatase Pyp1 Synthetic RescuePMID:1464319
synthetically rescued bywee1M phase inhibitor protein kinase Wee1 Synthetic RescuePMID:9843572
synthetically rescued bycdc2cyclin-dependent protein kinase Cdk1/Cdc2 Synthetic RescuePMID:7217015
synthetically rescued bycig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:8455610
synthetically rescued byppa2serine/threonine protein phosphatase Ppa2 Synthetic RescuePMID:8389306
synthetically rescued bypyp2tyrosine phosphatase Pyp2 Synthetic RescuePMID:1464319
synthetically rescued bynif1SEL1 repeat protein Nif1 Synthetic RescuePMID:23615447
synthetically rescued bympr1histidine-containing response regulator phosphotransferase Mpr1 Synthetic RescuePMID:10940030
synthetically rescued bydis2serine/threonine protein phosphatase PP1, Dis2 Synthetic RescuePMID:23333317
negative genetic interaction withgar2nucleolar protein required for rRNA processing Negative GeneticPMID:22681890
inviable in presence of overexpressedpyp1tyrosine phosphatase Pyp1 Dosage LethalityPMID:7937842
inviable in presence of overexpressedcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Dosage LethalityPMID:8515818
inviable in presence of overexpressedpyp2tyrosine phosphatase Pyp2 Dosage LethalityPMID:7937842
growth defect in presence of overexpressedshk1PAK-related kinase Shk1 Dosage Growth DefectPMID:9843966
growth defect in presence of overexpressedskb1type II protein arginine N-methyltransferase Skb1 Dosage Growth DefectPMID:9843966
External References
Database Identifier Description
NBRP SPAC24H6.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC24H6.05 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC24H6.05 BioGRID Interaction Datasets
Expression Viewer SPAC24H6.05 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC24H6.05 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC24H6.05 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC24H6.05 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC24H6.05 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC24H6.05 Transcriptome Viewer (Bähler Lab)
GEO SPAC24H6.05 GEO profiles
PInt SPAC24H6.05 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC24H6.05 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC24H6.05 Fission yeast phenotypic data & analysis
Cyclebase SPAC24H6.05.1 Cell Cycle Data
IntEnz3.1.3.48Integrated relational Enzyme database
Rhea3.1.3.48Annotated reactions database
SPD / RIKEN40/40F12Orfeome Localization Data
UniProtKB/SwissProtP06652M-phase inducer phosphatase
ModBaseP06652Database of comparative protein structure models
STRINGP06652Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592947M phase inducer phosphatase Cdc25
European Nucleotide ArchiveAAA35294.1ENA Protein Mapping
European Nucleotide ArchiveCAA90849.1ENA Protein Mapping
UniParcUPI000012F47FUniProt Archive

Literature for cdc25

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016