pop100 (SPAC25B8.16)

Gene Standard Namepop100 Characterisation Statusbiological_role_inferred
Systematic IDSPAC25B8.16 Feature Typeprotein coding
Synonyms Name Description
ProductRNase P and RNase MRP subunit (predicted) Product Size698aa, 79.93 kDa
Genomic Location Chromosome I, 4187325-4189859 (2535nt); CDS:4187547-4189643 (2097nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ribonuclease MRP activity7
Annotation ExtensionEvidenceWith/FromReference
ribonuclease P activity10
Annotation ExtensionEvidenceWith/FromReference
tRNA binding22
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mRNA cleavage20
Annotation ExtensionEvidenceWith/FromReference
rRNA processing195
Annotation ExtensionEvidenceWith/FromReference
tRNA 5'-leader removal3
Annotation ExtensionEvidenceWith/FromReference
tRNA processing102
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nucleolar ribonuclease P complex9
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
ribonuclease MRP complex10
Annotation ExtensionEvidenceWith/FromReference
ribonuclease P complex10
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
inviable vegetative cell populationpop100ΔNull1428

Cell Phenotype

Term NameAlleleExpressionCount
abnormal mitotic cell cyclepop100ΔNull808
inviable after spore germination with elongated germ tubepop100ΔNull163
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellspop100ΔNull87
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06978 Pfam IPR009723 Ribonuclease P/MRP, subunit POP1 43 234 1
PF08170 Pfam IPR012590 POPLD 472 568 1
PTHR22731 HMMPANTHER 38 648 1
PTHR22731:SF3 HMMPANTHER 38 648 1
SSF103025 SuperFamily 456 522 3
SSF103025 SuperFamily 180 366 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.51 Da
Charge 41.00
Isoelectric point 10.03
Molecular weight 79.93 kDa
Number of residues 698
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
992.91during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.9during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPAC25B8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC25B8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC25B8.16 BioGRID Interaction Datasets
Expression Viewer SPAC25B8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC25B8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC25B8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC25B8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC25B8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC25B8.16 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC25B8.16 Cell Cycle Data
GEO SPAC25B8.16 GEO profiles
PInt SPAC25B8.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC25B8.16 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC25B8.16 Fission yeast phenotypic data & analysis
SPD / RIKEN27/27H04Orfeome Localization Data
UniProtKB/SwissProtQ9UTA4Ribonucleases P/MRP protein subunit pop1
ModBaseQ9UTA4Database of comparative protein structure models
STRINGQ9UTA4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594476RNase P and RNase MRP subunit (predicted)
RefSeq mRNANM_001019905972h- RNase P and RNase MRP subunit (predicted) (SPAC25B8.16), mRNA
European Nucleotide ArchiveBAA87135.1ENA Protein Mapping
European Nucleotide ArchiveCAB61782.1ENA Protein Mapping
UniParcUPI000006BCD8UniProt Archive

Literature for pop100

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015