Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC25B8.16 Feature Typeprotein coding
Synonyms Name Description
ProductRNase P and RNase MRP subunit (predicted) Product Size698aa, 79.93 kDa
Genomic Location Chromosome I, 4187325-4189859 (2535nt); CDS:4187547-4189643 (2097nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000171ribonuclease MRP activity7
GO:0004526ribonuclease P activity10
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006379mRNA cleavageISOSGD:S000005165GO_REF:000002420
GO:0006364rRNA processingISOSGD:S000005165GO_REF:0000024193
GO:0001682tRNA 5'-leader removalIEAIPR009723GO_REF:00000023
GO:0008033tRNA processingISOSGD:S000005165GO_REF:0000024102
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005655nucleolar ribonuclease P complexISOSGD:S000005165GO_REF:00000249
GO:0000172ribonuclease MRP complexISOSGD:S000005165GO_REF:000002410
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPAC25B8.16ΔNullPMID:204732891337
MicroscopySPAC25B8.16ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopySPAC25B8.16ΔNullPECO:0000005, PECO:0000137PMID:23697806640
FYPO:0000314inviable after spore germination with elongated germ tube163
penetrance FYPO_EXT:0000001MicroscopySPAC25B8.16ΔNullPECO:0000005, PECO:0000137PMID:23697806
FYPO:0002262inviable after spore germination, multiple cell divisions, elongated cellMicroscopySPAC25B8.16ΔNullPECO:0000005, PECO:0000137PMID:2369780695
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08170 Pfam IPR012590 POPLD 472 568 1
PF06978 Pfam IPR009723 Ribonuclease P/MRP, subunit POP1 43 234 1
PTHR22731 HMMPANTHER 7 645 1
SSF103025 SuperFamily 180 366 3
SSF103025 SuperFamily 456 522 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.51 Da
Charge 41.00
Isoelectric point 10.03
Molecular weight 79.93 kDa
Number of residues 698
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
992.91during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.9during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPAC25B8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC25B8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC25B8.16 BioGRID Interaction Datasets
Expression Viewer SPAC25B8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC25B8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC25B8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC25B8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC25B8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC25B8.16 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC25B8.16 Cell Cycle Data
GEO SPAC25B8.16 GEO profiles
PInt SPAC25B8.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC25B8.16 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN27/27H04Orfeome Localization Data
UniProtKB/SwissProtQ9UTA4Ribonucleases P/MRP protein subunit pop1
ModBaseQ9UTA4Database of comparative protein structure models
STRINGQ9UTA4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594476RNase P and RNase MRP subunit (predicted)
RefSeq mRNANM_001019905972h- RNase P and RNase MRP subunit (predicted) (SPAC25B8.16), mRNA
European Nucleotide ArchiveBAA87135.1ENA Protein Mapping
European Nucleotide ArchiveCAB61782.1ENA Protein Mapping
UniParcUPI000006BCD8UniProt Archive

Literature for SPAC25B8.16

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014