etr1 (SPAC26F1.04c)

Gene Standard Nameetr1 Characterisation Statusbiological role inferred
Systematic IDSPAC26F1.04c Feature Typeprotein coding
Synonyms Name Description
Productenoyl-[acyl-carrier protein] reductase (predicted) Product Size372aa, 41.23 kDa
Genomic Location Chromosome I, 5177808-5179736 (1929nt); CDS:5178325-5179443 (1119nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
enoyl-[acyl-carrier-protein] reductase activity2
Annotation ExtensionEvidenceWith/FromReference
trans-2-enoyl-CoA reductase (NADPH) activity2
Annotation ExtensionEvidenceWith/FromReference
zinc ion binding225
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
fatty acid biosynthetic process29
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
resistance to hydrogen peroxideetr1Δ75
sensitive to caffeine during vegetative growthetr1Δ110
sensitive to rapamycinetr1Δ80
viable vegetative cell populationetr1Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyetr1Δ3103
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR5177808..5178324PMID:21511999
3' UTR5179444..5179736PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00107 Pfam IPR013149 Alcohol dehydrogenase, C-terminal 186 318 11
SM00829 SMART IPR020843 Polyketide synthase, enoylreductase domain 30 368 10
PTHR11695:SF590 HMMPANTHER 36 372 1
PTHR11695 HMMPANTHER IPR002085 Alcohol dehydrogenase superfamily, zinc-type 36 372 12 Gene3D IPR016040 NAD(P)-binding domain 156 333 100 Gene3D IPR011032 GroES-like 16 117 12
SSF51735 SuperFamily IPR016040 NAD(P)-binding domain 148 331 88
SSF50129 SuperFamily IPR011032 GroES-like 20 191 13
Coil ncoils Predicted coiled-coil protein (DUF2205) 211 231 1049

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.83 Da
Charge 11.50
Codon Adaptation Index 0.46
Isoelectric point 9.41
Molecular weight 41.23 kDa
Number of residues 372

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS12, S13 2293
Annotation ExtensionEvidenceResidueReference
IDA S12 PMID:25720772
IDA S13 PMID:25720772
phosphorylated residue 2515
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS12,S15, S12,T14 2461
Annotation ExtensionEvidenceResidueReference
IDA S12,S15 PMID:25720772
IDA S12,T14 PMID:25720772
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for etr1 (SPAC26F1.04c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
71098during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
67634during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
64189during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
73878during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3406.58during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
72179during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
8213.21during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAC26F1.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC26F1.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC26F1.04c BioGRID Interaction Datasets
Expression Viewer SPAC26F1.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC26F1.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC26F1.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC26F1.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC26F1.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC26F1.04c Transcriptome Viewer (Bähler Lab)
GEO SPAC26F1.04c GEO profiles
PInt SPAC26F1.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC26F1.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC26F1.04c Fission yeast phenotypic data & analysis
Cyclebase SPAC26F1.04c.1 Cell Cycle Data
IntEnz1.3.1.-Integrated relational Enzyme database
Rhea1.3.1.-Annotated reactions database
SPD / RIKEN17/17F03Orfeome Localization Data
UniProtKB/SwissProtQ10488Probable trans-2-enoyl-CoA reductase, mitochondrial
ModBaseQ10488Database of comparative protein structure models
STRINGQ10488Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594891enoyl-
RefSeq mRNANM_001020320972h- enoyl-[acyl-carrier protein] reductase (predicted) (etr1), mRNA
European Nucleotide ArchiveCAA97361.1ENA Protein Mapping
UniParcUPI000012F564UniProt Archive

Literature for etr1

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017