etr1 (SPAC26F1.04c)


Gene Standard Nameetr1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC26F1.04c Feature Typeprotein coding
Synonyms Name Description
Productenoyl-[acyl-carrier protein] reductase (predicted) Product Size372aa, 41.23 kDa
Genomic Location Chromosome I, 5177808-5179736 (1929nt); CDS:5178325-5179443 (1119nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
alcohol dehydrogenase activity, zinc-dependent4
Annotation ExtensionEvidenceWith/FromReference
enoyl-[acyl-carrier-protein] reductase activity2
Annotation ExtensionEvidenceWith/FromReference
trans-2-enoyl-CoA reductase (NADPH) activity2
Annotation ExtensionEvidenceWith/FromReference
zinc ion binding248
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
aerobic respiration46
Annotation ExtensionEvidenceWith/FromReference
fatty acid biosynthetic process30
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4206
Annotation ExtensionEvidenceWith/FromReference
mitochondrion761
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
resistance to hydrogen peroxideetr1ΔNull72
sensitive to caffeineetr1ΔNull108
viable vegetative cell populationetr1ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyetr1ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
151778085179736

UTRs

Region Coordinates Reference
five_prime_UTR5177808..5178324PMID:21511999
three_prime_UTR5179444..5179736PMID:21511999
mRNA5177808..5179736
exon5178325..5179443
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00107 Pfam IPR013149 Alcohol dehydrogenase, C-terminal 186 319 12
SM00829 SMART IPR020843 Polyketide synthase, enoylreductase domain 30 368 10
PTHR11695 HMMPANTHER IPR002085 Alcohol dehydrogenase superfamily, zinc-type 20 370 11
PTHR11695:SF15 HMMPANTHER 20 370 1
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 156 333 100
3.90.180.10 Gene3D IPR011032 GroES (chaperonin 10)-like 16 117 12
SSF50129 SuperFamily IPR011032 GroES (chaperonin 10)-like 20 191 13
SSF51735 SuperFamily 148 331 88
Coil ncoils Rabaptin coiled-coil domain 211 232 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.83 Da
Charge 11.50
Isoelectric point 9.41
Molecular weight 41.23 kDa
Number of residues 372
Modifications

Protein Modifications

Term NameResidueCount
phosphorylated residue 1923
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
71098during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
67634during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
64189during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
73878during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3406.58during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
72179during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8213.21during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC26F1.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC26F1.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC26F1.04c BioGRID Interaction Datasets
Expression Viewer SPAC26F1.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC26F1.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC26F1.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC26F1.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC26F1.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC26F1.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC26F1.04c Cell Cycle Data
GEO SPAC26F1.04c GEO profiles
PInt SPAC26F1.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC26F1.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC26F1.04c Fission yeast phenotypic data & analysis
IntEnz1.3.1.-Integrated relational Enzyme database
Rhea1.3.1.-Annotated reactions database
SPD / RIKEN17/17F03Orfeome Localization Data
UniProtKB/SwissProtQ10488Probable trans-2-enoyl-CoA reductase, mitochondrial
ModBaseQ10488Database of comparative protein structure models
STRINGQ10488Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594891enoyl-
RefSeq mRNANM_001020320972h- enoyl-[acyl-carrier protein] reductase (predicted) (etr1), mRNA
European Nucleotide ArchiveCAA97361.1ENA Protein Mapping
UniParcUPI000012F564UniProt Archive

Literature for etr1

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015