mga2 (SPAC26H5.05)

Gene Standard Namemga2 Characterisation Statusbiological_role_inferred
Systematic IDSPAC26H5.05 Feature Typeprotein coding
Synonyms Name Description
ProductIPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Product Size1151aa, 127.70 kDa
Genomic Location Chromosome I, 4125000-4128805 (3806nt); CDS:4125212-4128667 (3456nt)

Ensembl Gene Location
GO Biological Process
GO Cellular Component
Term NameCount
endoplasmic reticulum membrane205
Annotation ExtensionEvidenceWith/FromReference
fungal-type vacuole133
Annotation ExtensionEvidenceWith/FromReference
integral component of cytoplasmic side of endoplasmic reticulum membrane4
Annotation ExtensionEvidenceWith/FromReference
protein complex1367
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on glucose carbon sourcemga2ΔNull154
increased septation indexmga2ΔNull39
sensitive to cadmium246
expressivity FYPO_EXT:0000003mga2ΔNull
sensitive to camptothecinmga2ΔNull214
expressivity FYPO_EXT:0000003mga2ΔNull
sensitive to cobalt56
expressivity FYPO_EXT:0000003mga2ΔNull
sensitive to tacrolimus81
expressivity FYPO_EXT:0000003mga2ΔNull
sensitive to thiabendazolemga2ΔNull185
viable vegetative cell populationmga2ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
abnormal actin cytoskeletonmga2ΔNull43
abnormal microtubule cytoskeletonmga2ΔNull225
single microtubule bundlemga2ΔNull10
viable stubby vegetative cell70
penetrance FYPO_EXT:0000003, expressivity FYPO_EXT:0000001mga2ΔNull
viable vegetative cell with abnormal cell shape472
penetrance FYPO_EXT:0000001mga2ΔNull
viable vegetative cell, abnormal cell shape, normal cell size215
penetrance FYPO_EXT:0000001, expressivity FYPO_EXT:0000003mga2ΔNull
Target Of
FYPO affected by mutation in plo1 Polo kinase Plo1 PMID:12615979
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01833 Pfam IPR002909 IPT domain 658 739 1
PF12796 Pfam IPR020683 Ankyrin repeat-containing domain 858 922 10
SM00429 SMART IPR002909 IPT domain 657 740 1
SM00248 SMART IPR002110 Ankyrin repeat 894 923 14
SM00248 SMART IPR002110 Ankyrin repeat 801 830 14
SM00248 SMART IPR002110 Ankyrin repeat 861 890 14
TMhelix TMHMM 1115 1137 959
PS50088 Prosite Profiles IPR002110 Ankyrin repeat 894 926 13
PS50088 Prosite Profiles IPR002110 Ankyrin repeat 861 893 13
PS50297 Prosite Profiles IPR020683 Ankyrin repeat-containing domain 861 935 15
PTHR24142:SF4 HMMPANTHER 116 1088 1
PTHR24142 HMMPANTHER 116 1088 3 Gene3D IPR020683 Ankyrin repeat-containing domain 854 938 15 Gene3D IPR013783 Immunoglobulin-like fold 654 742 3
SSF48403 SuperFamily IPR020683 Ankyrin repeat-containing domain 801 935 15
SSF81296 SuperFamily IPR014756 Immunoglobulin E-set 654 733 14

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000453ankyrin repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000453

Protein Properties

Ave. residue weight 110.95 Da
Charge -16.00
Isoelectric point 5.33
Molecular weight 127.70 kDa
Number of residues 1151

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS333, S479, S557 1670
present during mitotic M phaseS6
present during mitotic M phaseS41
present during mitotic M phaseS48
present during mitotic M phaseS617
present during mitotic M phaseS557
present during mitotic M phaseS542
present during mitotic M phaseS616
present during mitotic M phaseS479
present during mitotic M phaseS49
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S6 PMID:21712547
present during mitotic M phase experimental evidence S41 PMID:21712547
present during mitotic M phase experimental evidence S48 PMID:21712547
present during mitotic M phase experimental evidence S49 PMID:21712547
experimental evidence S333 PMID:24763107
experimental evidence S479 PMID:24763107
present during mitotic M phase experimental evidence S479 PMID:21712547
present during mitotic M phase experimental evidence S542 PMID:21712547
experimental evidence S557 PMID:24763107
present during mitotic M phase experimental evidence S557 PMID:21712547
present during mitotic M phase experimental evidence S616 PMID:21712547
present during mitotic M phase experimental evidence S617 PMID:21712547
O-phospho-L-threonine 693
present during mitotic M phaseT650
present during mitotic M phaseT481
present during mitotic M phaseT636
Annotation ExtensionEvidenceResidueReference
experimental evidence T481 PMID:24763107
present during mitotic M phase experimental evidence T481 PMID:21712547
present during mitotic M phase experimental evidence T636 PMID:21712547
present during mitotic M phase experimental evidence T650 PMID:21712547
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
268during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
225during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
205during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
1454.75during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
373.17during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.4during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Miscellaneous Functional Group
membrane-tethered transcription factor4
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi only619
conserved in fungi4604
conserved in eukaryotes4516

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
duo1DASH complex subunit Duo1 Two-hybridPMID:23695164
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
plo1Polo kinase Plo1 Two-hybridPMID:12615979
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
pph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:18818364
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
shg1Set1C complex subunit Shg1 Positive GeneticPMID:22681890
SPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Negative GeneticPMID:22681890
hht2histone H3 h3.2 Positive GeneticPMID:18818364
alp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
peg1CLASP family microtubule-associated protein Negative GeneticPMID:18818364
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
SPAC4G9.20cmitochondrial carrier with solute carrier repeats, organic acid transmembrane transporter (predicted) Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:18818364
brl1ubiquitin-protein ligase E3 Brl1 Phenotypic SuppressionPMID:19547744
ptf1Mst2 histone acetytransferase acytyltransferase complex, predicted phosphoric monoester hydrolase Ptf1 Negative GeneticPMID:18818364
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
tma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
utp16U3 snoRNP-associated protein Utp16 (predicted) Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
psl1cyclin pho85 family Psl1 (predicted) Positive GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
atb2tubulin alpha 2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme E2 Ubc6 (predicted) Negative GeneticPMID:18818364
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
eaf1RNA polymerase II transcription elongation factor SpEAF Positive GeneticPMID:18818364
leo1RNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:18818364
nap1nucleosome assembly protein Nap1 Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:18818364
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:18818364
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:18818364
pyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
efc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
lea1U2 snRNP-associated protein Lea1 (predicted) Negative GeneticPMID:22681890
caf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:18818364
gim3prefoldin subunit 4, Gim3 (predicted) Negative GeneticPMID:18818364
gst1glutathione S-transferase Gst1 Negative GeneticPMID:22681890
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
rok1ATP-dependent RNA helicase Rok1 (predicted) Positive GeneticPMID:18818364
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Phenotypic EnhancementPMID:19547744
pli1SUMO E3 ligase Pli1 Negative GeneticPMID:18818364
pfd1prefoldin subunit 1 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC3H1.05CAAX prenyl protease (predicted) Phenotypic EnhancementPMID:19547744
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
atp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:18818364
psy2protein phosphatase PP4 complex subunit Psy2 (predicted) Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
kap113karyopherin Kap113 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
gim4prefoldin subunit 2, Gim4(predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
srk1MAPK-activated protein kinase Srk1 Negative GeneticPMID:22681890
nhp6High-mobility group non-histone chromatin protein (predicted) Negative GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:18818364
ivn1CDC50 domain protein, implicated in signal transduction (predicted) Phenotypic SuppressionPMID:19547744
vms1Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ER associated ubiquitin-dependent protein catabolic process Vms1 (predicted) Phenotypic SuppressionPMID:19547744
doa10ER-localized ubiquitin-protein ligase E3 Doa10 (predicted) Phenotypic EnhancementPMID:19547744
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
SPCC645.13transcription elongation regulator (predicted) Negative GeneticPMID:18818364
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
mst2histone acetyltransferase Mst2 Negative GeneticPMID:18818364
fhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mmb1mitochondrial microtubule binder Mmb1 Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
SPBC1861.07elongin C (predicted) Positive GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:18818364
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:18818364
SPBP4H10.16cphosphatase activator (predicted) Positive GeneticPMID:22681890
srp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Positive GeneticPMID:18818364
pdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
SPBC21C3.19SBDS family protein Rtc3 (predicted) Positive GeneticPMID:22681890
gda1guanosine-diphosphatase Gda1 Positive GeneticPMID:18818364
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
gas4sporulation specific 1,3-beta-glucanosyltransferase Gas4 Phenotypic SuppressionPMID:19547744
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
jmj4Jmj4 protein (predicted) Positive GeneticPMID:22681890
set5histone lysine methyltransferase Set5 (predicted) Negative GeneticPMID:18818364
ubc13ubiquitin conjugating enzyme E2 Ubc13 Negative GeneticPMID:18818364
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
ptp4phosphatidate cytidylyltransferase Ptp4 (predicted) Phenotypic EnhancementPMID:19547744
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
cia1histone chaperone Cia1 Negative GeneticPMID:18818364
get1GET complex subunit Get1 (predicted) Phenotypic SuppressionPMID:19547744
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Positive GeneticPMID:18818364
pho24-nitrophenylphosphatase Negative GeneticPMID:18818364
pnn1pinin ortholog, involved in splicing Pnn1 (predicted) Negative GeneticPMID:18818364
SPBC16H5.04pho88 family protein (predicted) Phenotypic EnhancementPMID:19547744
hhp2serine/threonine protein kinase Hhp2 Negative GeneticPMID:18818364
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
srb7mediator complex subunit Srb7 Negative GeneticPMID:18818364
cyp4cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp4 (predicted) Positive GeneticPMID:22681890
rnf10ubiquitin-protein ligase E3 implicated in transcription (predicted) Positive GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Negative GeneticPMID:18818364
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
xap5xap-5-like protein Positive GeneticPMID:24957674
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Phenotypic SuppressionPMID:19547744
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPAC589.06cpho88 family protein (predicted) Phenotypic EnhancementPMID:19547744
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:18818364
alp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
Phenotypic EnhancementPMID:19547744
swr1SNF2 family ATP-dependent DNA helicase Swr1 Negative GeneticPMID:22681890
ptc3protein phosphatase 2c homolog 3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sac12inositol polyphosphate phosphatase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
mug154conserved fungal protein Positive GeneticPMID:18818364
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
syj1inositol-polyphosphate 5-phosphatase (synaptojanin homolog 1) Positive GeneticPMID:18818364
rsv2transcription factor Rsv2 Negative GeneticPMID:18818364
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
med13mediator complex subunit Srb9 Phenotypic EnhancementPMID:19547744
eri1double-strand siRNA ribonuclease Eri1 Negative GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
res2MBF transcription factor complex subunit Res2 Positive GeneticPMID:18818364
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:18818364
cxr1mRNA processing factor Positive GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
nsk1Clp1-interacting, microtubule plus-end binding Nsk1 Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC26H5.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC26H5.05 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC26H5.05 BioGRID Interaction Datasets
Expression Viewer SPAC26H5.05 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC26H5.05 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC26H5.05 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC26H5.05 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC26H5.05 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC26H5.05 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC26H5.05 Cell Cycle Data
GEO SPAC26H5.05 GEO profiles
PInt SPAC26H5.05 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC26H5.05 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC26H5.05 Fission yeast phenotypic data & analysis
SPD / RIKEN48/48D01Orfeome Localization Data
UniProtKB/SwissProtO13987Ankyrin and IPT/TIG repeat-containing protein C26H5.05
ModBaseO13987Database of comparative protein structure models
STRINGO13987Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594452IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted)
RefSeq mRNANM_001019881972h- IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) (SPAC26H5.05), mRNA
European Nucleotide ArchiveCAB16191.1ENA Protein Mapping
UniParcUPI0000069C0AUniProt Archive

Literature for mga2

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015