mga2 (SPAC26H5.05)

Gene Standard Namemga2 ChromosomeI
Systematic IDSPAC26H5.05 Gene Start4125000
Synonyms Gene End4128805
ProductIPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Gene Length3806
Feature Typeprotein coding CDS Start4125212
Name Description CDS End4128667
Characterisation Statusbiological_role_inferred CDS Length3456

Ensembl Gene Location
  1. pcf2
  2. SPNCRNA.959
  3. SPAC26H5.04
  4. SPNCRNA.960
  5. mga2
  6. SPNCRNA.961
  7. pot1
  8. SPAC26H5.07c
  9. bgl2
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000085sensitive to camptothecincompetitive growth assay evidencemga2delta (deletion)deletionPMID:20537132
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidencemga2delta (deletion)deletionPMID:20537132
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencemga2delta (deletion)deletionPMID:20537132
FYPO:0000269sensitive to microtubule depolymerizing drugscompetitive growth assay evidencemga2delta (deletion)deletionPMID:20537132
FYPO:0001491viable vegetative cellMicroscopymga2delta (deletion)deletionPMID:20473289
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0036083positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoterISOSGD:S000001503GO_REF:0000024
GO:0045944positive regulation of transcription from RNA polymerase II promoterISOSGD:S000001503GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000324fungal-type vacuoleIDAPMID:16823372
GO:0005774vacuolar membraneIEASL-0271GO_REF:0000039
GO:0005789endoplasmic reticulum membraneISOSGD:S000001503GO_REF:0000024
GO:0043234protein complexNASGO_REF:0000051
GO:0071458integral to cytosolic side of endoplasmic reticulum membraneICGO:0045944, GO:0005789GO_REF:0000001
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
141250004128805

References

Region Start End Reference
three_prime_UTR41286684128805PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00023 IPR002110 Pfam Ankyrin repeat 895 923 11
PF01833 IPR002909 Pfam Cell surface receptor IPT/TIG 658 739 1
SM00429 IPR002909 SMART Cell surface receptor IPT/TIG 657 740 1
SM00248 IPR002110 SMART Ankyrin repeat 894 923 14
SM00248 IPR002110 SMART Ankyrin repeat 801 830 14
SM00248 IPR002110 SMART Ankyrin repeat 861 890 14
TMhelix TMHMM 1115 1137 955
PS50088 IPR002110 Prosite Profiles Ankyrin repeat 861 893 13
PS50088 IPR002110 Prosite Profiles Ankyrin repeat 894 926 13
PS50297 IPR020683 Prosite Profiles Ankyrin repeat-containing domain 861 935 15
G3DSA:2.60.40.10 IPR013783 Gene3D 654 742 2
G3DSA:1.25.40.20 IPR020683 Gene3D 854 938 15
SSF81296 IPR014756 SuperFamily 654 733 14
SSF48403 IPR020683 SuperFamily 801 935 15

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000453ankyrin repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000453

Protein Properties

Ave. residue weight 110.95 Da
Charge -16.00
Isoelectric point 5.33
Molecular weight 127.70 kDa
Number of residues 1151
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1454.75PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide373.17PMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide4.4PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.5PMID:23101633
Miscellaneous Functional Group
DescriptionQualifierReference
membrane-tethered transcription factor
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBP8B7.23ubiquitin-protein ligase E3 implicated in transcription (predicted) Positive GeneticPMID:22681890
SPBC26H8.05cserine/threonine protein phosphatase (predicted) Negative GeneticPMID:18818364
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
hhp2serine/threonine protein kinase Hhp2 Negative GeneticPMID:18818364
pli1SUMO E3 ligase Pli1 Negative GeneticPMID:18818364
atb2tubulin alpha 2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mst2histone acetyltransferase Mst2 Negative GeneticPMID:18818364
pek1MAP kinase kinase Pek1 Positive GeneticPMID:18818364
atp11F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:18818364
fhl1fork head transcription factor Fhl1 Negative GeneticPMID:22681890
mug154conserved fungal protein Positive GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
nap1nucleosome assembly protein Nap1 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
ubc13ubiquitin conjugating enzyme Ubc13 Negative GeneticPMID:18818364
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:18818364
spf1Set1C PHD Finger protein Spf1 Positive GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:18818364
brl1ubiquitin-protein ligase E3 Brl1 Phenotypic SuppressionPMID:19547744
lea1U2 snRNP-associated protein Lea1 (predicted) Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC227.10prefoldin subunit 2 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
caf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Negative GeneticPMID:22681890
gas4sporulation specific 1,3-beta-glucanosyltransferase Gas4 Phenotypic SuppressionPMID:19547744
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
alp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
srp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
psl1cyclin pho85 family (predicted) Positive GeneticPMID:22681890
pck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Negative GeneticPMID:18818364
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:18818364
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
ivn1CDC50 domain protein, implicated in signal transduction (predicted) Phenotypic SuppressionPMID:19547744
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
peg1CLASP family microtubule-associated protein Negative GeneticPMID:18818364
pho24-nitrophenylphosphatase Negative GeneticPMID:18818364
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
efc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Positive GeneticPMID:22681890
doa10ER-localized ubiquitin ligase Doa10 (predicted) Phenotypic EnhancementPMID:19547744
pfd1prefoldin subunit 1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pnn1pinin ortholog, involved in splicing Pnn1 (predicted) Negative GeneticPMID:18818364
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
nhp6High-mobility group non-histone chromatin protein (predicted) Negative GeneticPMID:22681890
gst1glutathione S-transferase Gst1 Negative GeneticPMID:22681890
kap113karyopherin Kap113 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rsv2transcription factor Rsv2 Negative GeneticPMID:18818364
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:18818364
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:18818364
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
jmj4Jmj4 protein (predicted) Positive GeneticPMID:22681890
SPBP8B7.10cU3 snoRNP-associated protein Utp16 (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
pyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
hht2histone H3 h3.2 Positive GeneticPMID:18818364
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
cyp4cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp4 (predicted) Positive GeneticPMID:22681890
srk1MAPK-activated protein kinase Srk1 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mmb1mitochondria microtubule binder Mmb1 Negative GeneticPMID:22681890
SPBC16H5.04pho88 family protein (predicted) Phenotypic EnhancementPMID:19547744
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
SPAC227.05prefoldin subunit 4 (predicted) Negative GeneticPMID:18818364
gda1guanosine-diphosphatase Gda1 Positive GeneticPMID:18818364
SPAC3H1.05CAAX prenyl protease (predicted) Phenotypic EnhancementPMID:19547744
SPBP4H10.16cphosphatase activator (predicted) Positive GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
rok1ATP-dependent RNA helicase Rok1 (predicted) Positive GeneticPMID:18818364
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:18818364
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:18818364
med13mediator complex subunit Srb9 Phenotypic EnhancementPMID:19547744
SPBC216.01cDNA damage response protein (predicted) Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
eaf1RNA polymerase II transcription elongation factor SpEAF Positive GeneticPMID:18818364
SPBC23E6.01cmRNA processing factor (predicted) Positive GeneticPMID:22681890
alp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
SPBC1861.07elongin C (predicted) Positive GeneticPMID:22681890
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Phenotypic SuppressionPMID:19547744
atg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
ptc3protein phosphatase 2c homolog 3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Negative GeneticPMID:18818364
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
gsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
get1GET complex subunit Get1 (predicted) Phenotypic SuppressionPMID:19547744
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:18818364
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
syj1inositol-polyphosphate 5-phosphatase (synaptojanin homolog 1) Positive GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
SPBC21C3.19SBDS family protein Rtc3 (predicted) Positive GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
shg1Set1C complex subunit Shg1 Positive GeneticPMID:22681890
res2MBF transcription factor complex subunit Res2 Positive GeneticPMID:18818364
set5histone lysine methyltransferase Set5 (predicted) Negative GeneticPMID:18818364
SPBC13E7.08cRNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:18818364
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
SPAC3C7.01cinositol polyphosphate phosphatase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic EnhancementPMID:19547744
Negative GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
SPCC645.13transcription elongation regulator (predicted) Negative GeneticPMID:18818364
pdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
fft3fun thirty related protein Fft3 Positive GeneticPMID:18818364
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:18818364
swd1Set1C complex subunit Swd1 Positive GeneticPMID:18818364
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Negative GeneticPMID:22681890
SPCC1827.04ankyrin repeat protein, unknown biological role Phenotypic SuppressionPMID:19547744
mre11Mre11 nuclease Negative GeneticPMID:18818364
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:18818364
ptp4phosphatidate cytidylyltransferase Ptp4 (predicted) Phenotypic EnhancementPMID:19547744
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
cia1histone chaperone Cia1 Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
nsk1Clp1-interacting protein Nsk1 Negative GeneticPMID:22681890
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Phenotypic EnhancementPMID:19547744
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:18818364
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:18818364
SPAC4G9.20cmitochondrial carrier with solute carrier repeats, organic acid transmembrane transporter (predicted) Negative GeneticPMID:22681890
ptf1phosphoric monoester hydrolase (predicted) Negative GeneticPMID:18818364
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
SPAC589.06cpho88 family protein (predicted) Phenotypic EnhancementPMID:19547744
eri1double-strand siRNA ribonuclease Eri1 Negative GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
srb7mediator complex subunit Srb7 Negative GeneticPMID:18818364
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
plo1Polo kinase Plo1 Two-hybridPMID:12615979
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External References
Database Identifier Description
NBRP SPAC26H5.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC26H5.05 Retrieval of eukaryotic orthologs
BioGrid SPAC26H5.05 BioGRID Interaction Datasets
Bähler Lab SPAC26H5.05 Cell Cycle Expression Profile
Bähler Lab SPAC26H5.05 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC26H5.05 Pheromone response/mating expression profiles
Bähler Lab SPAC26H5.05 Environmental stress expression profiles
Bähler Lab SPAC26H5.05 Bähler Lab Transcriptome Viewer
Cyclebase SPAC26H5.05 Cell Cycle Data
PInt SPAC26H5.05 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC26H5.05 Entrez Gene
SPD / RIKEN48/48D01Orfeome Localization Data
WikiGene2542701IPT/TIG ankyrin repeat protein
EntrezGene2542701IPT/TIG ankyrin repeat protein
UniProtKB/SwissProtO13987Ankyrin and IPT/TIG repeat-containing protein C26H5.05
ModBaseO13987Database of comparative protein structure models
Pfam Protein DomainsO13987Pfam Domain Arrangement
RefSeq PeptideNP_594452IPT/TIG ankyrin repeat protein
RefSeq mRNANM_001019881972h- IPT/TIG ankyrin repeat protein (SPAC26H5.05), mRNA
European Nucleotide ArchiveCAB16191ENA Protein Mapping
SPD / RIKEN48/48D01Orfeome Localization Data

Literature for mga2
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013