uch1 (SPAC27F1.03c)

Gene Standard Nameuch1 Characterisation Statuspublished
Systematic IDSPAC27F1.03c Feature Typeprotein coding
Synonyms Name Description
Productubiquitin C-terminal hydrolase Uch1 Product Size222aa, 24.91 kDa
Genomic Location Chromosome I, 4321579-4320716 (864nt); CDS:4321475-4320807 (669nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004221ubiquitin thiolesterase activityISMPFAM:PF01088GO_REF:00000015
GO:0004843ubiquitin-specific protease activityIDAPMID:2083865126
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016579protein deubiquitinationIDAPMID:2083865124
GO:0006511ubiquitin-dependent protein catabolic processIEAIPR001578GO_REF:0000002173
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000502proteasome complexIEAUniProtKB-KW:KW-0647GO_REF:000003743
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001023normal growth on cisplatinCell growth assayuch1ΔNullPECO:0000137, PECO:0000103, PECO:0000005PMID:2124741636
FYPO:0002060viable vegetative cell populationMicroscopyuch1ΔNullPECO:0000005, PECO:0000137PMID:236978063730

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyuch1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01088 Pfam IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 2 208 2
PS00140 Prosite Patterns IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 77 93 1
PTHR10589 HMMPANTHER IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 2 221 2
PTHR10589:SF17 HMMPANTHER 2 221 1
3.40.532.10 Gene3D IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 2 220 2
SSF54001 SuperFamily 1 220 30
PR00707 PRINTS IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 77 94 2
PR00707 PRINTS IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 173 183 2
PR00707 PRINTS IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 39 51 2
PR00707 PRINTS IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 153 164 2
PR00707 PRINTS IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 4 21 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.22 Da
Charge -13.00
Isoelectric point 4.47
Molecular weight 24.91 kDa
Number of residues 222
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
54022during GO:0000080PECO:0000005,
mass spectrometry evidencePMID:24763107
60094during GO:0000084PECO:0000005,
mass spectrometry evidencePMID:24763107
47941during GO:0000085PECO:0000005,
mass spectrometry evidencePMID:24763107
55320during GO:0000087PECO:0000005,
mass spectrometry evidencePMID:24763107
52101during GO:0072690PECO:0000005,
mass spectrometry evidencePMID:24763107
11536.93during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
5420.48during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.7during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
0.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633
Species Distribution
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
nep1NEDD8 protease Nep1 Phenotypic EnhancementPMID:23496905
set1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
elp5elongator complex subunit Elp5 (predicted) Positive GeneticPMID:18818364
nep2NEDD8 protease Nep2 Phenotypic EnhancementPMID:23496905
SPAC227.06Rab GTPase binding (predicted) Negative GeneticPMID:22681890
pam17TIM23 translocase complex-associated motor subunit Pam17 (predicted) Positive GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
sap145U2 snRNP-associated protein Sap145 Negative GeneticPMID:22681890
lys4homocitrate synthase Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
msh1mitochondrial MutS protein Msh1 (predicted) Positive GeneticPMID:18818364
csn5COP9/signalosome complex subunit Csn5 Phenotypic EnhancementPMID:23496905
uch2ubiquitin C-terminal hydrolase Uch2 Phenotypic EnhancementPMID:23496905
mug129sequence orphan Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
pex6peroxin-6 (predicted) Positive GeneticPMID:22681890
atb2tubulin alpha 2 Positive GeneticPMID:22681890
gma12alpha-1,2-galactosyltransferase Gma12 Positive GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Positive GeneticPMID:22681890
emc1ER membrane protein complex subunit Emc1 (predicted) Negative GeneticPMID:22681890
zrg17cation diffusion family zinc membrane transporter Zrg17 Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Positive GeneticPMID:18818364
fra2transcriptional repressor protein BolA domain (predicted) Negative GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:18818364
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
fhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ned8ubiquitin-like protein modifier Ned8 Reconstituted ComplexPMID:23496905
External References
Database Identifier Description
NBRP SPAC27F1.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC27F1.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC27F1.03c BioGRID Interaction Datasets
Expression Viewer SPAC27F1.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC27F1.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC27F1.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC27F1.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC27F1.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC27F1.03c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC27F1.03c Cell Cycle Data
GEO SPAC27F1.03c GEO profiles
PInt SPAC27F1.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC27F1.03c Peptides identified in tandem mass spectrometry proteomics experiments
WikiGene2541733ubiquitin C-terminal hydrolase Uch1
EntrezGene2541733ubiquitin C-terminal hydrolase Uch1
SPD / RIKEN42/42H03Orfeome Localization Data
UniProtKB/SwissProtQ10171Probable ubiquitin carboxyl-terminal hydrolase 1
ModBaseQ10171Database of comparative protein structure models
STRINGQ10171Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594531ubiquitin C-terminal hydrolase Uch1
RefSeq mRNANM_001019960972h- ubiquitin C-terminal hydrolase Uch1 (uch1), mRNA
European Nucleotide ArchiveCAA93292ENA Protein Mapping
European Nucleotide ArchiveCAA93292.1ENA Protein Mapping
UniParcUPI00001379D1UniProt Archive

Literature for uch1

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014