prp10 (SPAC27F1.09c)

Gene Standard Nameprp10 ChromosomeI
Systematic IDSPAC27F1.09c Gene Start4336797
Synonymssap155 Gene End4333135
ProductU2 snRNP-associated protein Sap155 Gene Length3663
Feature Typeprotein coding CDS Start4336787
Name Descriptioncomplexed with Cdc5 CDS End4333170
Characterisation Statuspublished CDS Length3618

Ensembl Gene Location
  1. SPAC27F1.06c
  2. ost1
  3. pdt1
  4. prp10
  5. SPAC23D3.01
  6. rfc2
  7. SPAC23D3.03c
  8. gpd2
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001489inviable vegetative cellMicroscopyprp10delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003729mRNA bindingISOSGD:S000004901GO_REF:0000024
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000245spliceosomal complex assemblyISOSGD:S000004901GO_REF:0000024
GO:0045292mRNA cis splicing, via spliceosomeIMPPMID:9003295
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
IDAPMID:10759889
GO:0005681spliceosomal complexIEAUniProtKB:KW-0747GO_REF:0000037
GO:0005686U2 snRNPISOSGD:S000004901GO_REF:0000024
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
143367974336778
243367264336622
343365554333135

References

Region Start End Reference
three_prime_UTR43331694333135PMID:21511999
intron43367774336727PMID:9837997
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF08920 IPR015016 Pfam Splicing factor 3B subunit 1 187 307 1
G3DSA:1.25.10.10 IPR011989 Gene3D 504 585 83
G3DSA:1.25.10.10 IPR011989 Gene3D 710 1057 83
G3DSA:1.25.10.10 IPR011989 Gene3D 360 472 83
G3DSA:1.25.10.10 IPR011989 Gene3D 630 670 83
SSF48371 IPR016024 SuperFamily 361 448 130
SSF48371 IPR016024 SuperFamily 484 963 130
SSF48371 IPR016024 SuperFamily 1001 1154 130
Coil ncoils Rabaptin coiled-coil domain 4 30 974
PTHR12097 hmmpanther 1 1166 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:18257517
PMID:19547744
PMID:9585501

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000328HEAT repeatTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000328

Protein Properties

Ave. residue weight 113.79 Da
Charge -9.50
Isoelectric point 5.87
Molecular weight 132.68 kDa
Number of residues 1166
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
alternative splicing PMID:9837997
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide529.09PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide999.68PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide3.6PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC2A9.11cnuclear export factor (predicted) Negative GeneticPMID:22681890
SPCC736.07cunconventional prefoldin involved in translation initiation (predicted) Positive GeneticPMID:22681890
spf31DNAJ protein Spf31 (predicted) Negative GeneticPMID:22681890
nup85nucleoporin Nup85 Synthetic Growth DefectPMID:22240020
Synthetic Rescue
rex3exonuclease Rex3 (predicted) Negative GeneticPMID:22681890
prp2U2AF large subunit (U2AF-59) Synthetic LethalityPMID:9837997
SPAC977.13chydrolase, pseudogene Negative GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:22681890
prp12U2 snRNP-associated protein Sap130 (predicted) Synthetic Growth DefectPMID:11350031
SPBC29A10.16ccytochrome b5 (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
prp19ubiquitin-protein ligase E4 Affinity Capture-MSPMID:21386897
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Affinity Capture-MSPMID:15755920
cdc5cell division control protein, splicing factor Cdc5 Affinity Capture-MSPMID:15755920
cwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
dre4splicing associated factor Dre4 Affinity Capture-MSPMID:21386897
saf2splicing associated factor Saf2 Affinity Capture-MSPMID:21386897
prp2U2AF large subunit (U2AF-59) Two-hybridPMID:10923022
Reconstituted ComplexPMID:14730023
saf3splicing associated factor Saf3 Affinity Capture-MSPMID:21386897
prp5WD repeat protein Prp5 Affinity Capture-MSPMID:22064476
Reconstituted Complex
prp17splicing factor Prp17 Affinity Capture-MSPMID:21386897
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External References
Database Identifier Description
NBRP SPAC27F1.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC27F1.09c Retrieval of eukaryotic orthologs
BioGrid SPAC27F1.09c BioGRID Interaction Datasets
Bähler Lab SPAC27F1.09c Cell Cycle Expression Profile
Bähler Lab SPAC27F1.09c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC27F1.09c Pheromone response/mating expression profiles
Bähler Lab SPAC27F1.09c Environmental stress expression profiles
Bähler Lab SPAC27F1.09c Bähler Lab Transcriptome Viewer
Cyclebase SPAC27F1.09c Cell Cycle Data
PInt SPAC27F1.09c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC27F1.09c Entrez Gene
WikiGene2541619U2 snRNP-associated protein Sap155
Uniprot_genenamePRP10
EntrezGene2541619U2 snRNP-associated protein Sap155
SPD / RIKEN48/48E04Orfeome Localization Data
UniProtKB/SwissProtQ10178U2 snRNP component prp10
ModBaseQ10178Database of comparative protein structure models
Pfam Protein DomainsQ10178Pfam Domain Arrangement
RefSeq PeptideNP_594538U2 snRNP-associated protein Sap155
RefSeq mRNANM_001019967972h- U2 snRNP-associated protein Sap155 (prp10), mRNA
European Nucleotide ArchiveBAA87119ENA Protein Mapping
European Nucleotide ArchiveCAA93298ENA Protein Mapping
SPD / RIKEN48/48E04Orfeome Localization Data

Literature for prp10
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013