lsk1 (SPAC2F3.15)

Gene Standard Namelsk1 ChromosomeI
Systematic IDSPAC2F3.15 Gene Start3953832
Synonyms Gene End3956869
ProductP-TEFb-associated cyclin-dependent protein kinase Lsk1 Gene Length3038
Feature Typeprotein coding CDS Start3954471
Name DescriptionLatrunculin Sensitive Kinase CDS End3956415
Characterisation Statuspublished CDS Length1945

Ensembl Gene Location
  1. SPAC2F3.11
  2. SPAC2F3.13c
  3. plp1
  4. saf2
  5. SPNCRNA.239
  6. SPNCRNA.240
  7. lsk1
  8. SPAC2F3.16
  9. SPAC11G7.01
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000082sensitive to high temperatureCell growth assaylsk1delta (deletion)deletionNot specifiedPECO:0000102, PECO:0000137PMID:22912768
FYPO:0000107sensitive to latrunculin Ano_name (unrecorded)unrecordedPMID:15537703
FYPO:0002060viable vegetative cell populationMicroscopylsk1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIlsc1PMID:17502918
GO:0005524ATP bindingIEAUniProtKB:KW-0067GO_REF:0000037
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity
has_direct_input cdc25IDAPMID:19328067
has_direct_input cdc25IDAPMID:17502918
GO:0097472cyclin-dependent protein kinase activityTASPMID:15537703
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0031031positive regulation of septation initiation signaling cascadeIGIplo1PMID:15537703
GO:0031565cytokinesis checkpointIMPPMID:17502918
GO:0031566actomyosin contractile ring maintenanceIMPPMID:15537703
different_pathwayIGIclp1PMID:15537703
GO:0051519activation of bipolar cell growthIMPPMID:20501954
GO:0070816phosphorylation of RNA polymerase II C-terminal domainIMPPMID:19328067
IMPPMID:17502918
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:17502918
IDAPMID:16823372
IDAPMID:15537703
GO:0005730nucleolusIDAPMID:16823372
GO:0008024positive transcription elongation factor complex bNASGO_REF:0000001
GO:0032806carboxy-terminal domain protein kinase complexIPIlsc1PMID:17502918
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
139538323955418
239554653955555
339556223956300
439563523956869

References

Region Start End Reference
three_prime_UTR39564163956869PMID:21511999
five_prime_UTR39538323954470PMID:21511999
three_prime_UTR39564163956869PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00069 IPR000719 Pfam Protein kinase, catalytic domain 277 561 109
SM00220 IPR002290 SMART Serine/threonine- / dual specificity protein kinase, catalytic domain 277 561 74
PS50011 IPR000719 Prosite Profiles Protein kinase, catalytic domain 277 561 110
PS00108 IPR008271 Prosite Patterns Serine/threonine-protein kinase, active site 395 407 97
PS00107 IPR017441 Prosite Patterns Protein kinase, ATP binding site 283 306 73
G3DSA:3.30.200.20 Gene3D 275 356 108
G3DSA:1.10.510.10 Gene3D 357 562 111
SSF56112 IPR011009 SuperFamily 269 565 127
PTHR24056:SF39 hmmpanther 2 590 1
PTHR24056 hmmpanther 2 590 11

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744
PMID:18257517

Protein Properties

Ave. residue weight 113.60 Da
Charge 46.00
Isoelectric point 10.60
Molecular weight 67.37 kDa
Number of residues 593
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide141PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.53PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide2PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rhn1RNA polymerase II transcription termination factor homolog Synthetic Growth DefectPMID:22912768
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
wpl1Wings apart-like homolog Wpl1 Positive GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
gfh1gamma tubulin complex subunit Gfh1 Negative GeneticPMID:18818364
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
shy1SURF-family protein Shy1 (predicted) Positive GeneticPMID:22681890
hmt2sulfide-quinone oxidoreductase Positive GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
atp11F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
fhl1forkhead transcription factor Fhl1 Positive GeneticPMID:22681890
elp6elongator complex subunit Elp6 (predicted) Positive GeneticPMID:18818364
ubp7ubiquitin C-terminal hydrolase Ubp7 Negative GeneticPMID:18818364
aut12autophagy associated protein Aut12 (predicted) Positive GeneticPMID:18818364
hta1histone H2A alpha Negative GeneticPMID:18818364
SPBC215.07cPWWP domain protein (predicted) Positive GeneticPMID:22681890
vrp1verprolin Positive GeneticPMID:18818364
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ubc13ubiquitin conjugating enzyme Ubc13 Positive GeneticPMID:18818364
snr13-hydroxyisobutyryl-CoA hydrolase snr1 Positive GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
ura3dihydroorotate dehydrogenase Ura3 Positive GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Positive GeneticPMID:22681890
mgr2mitochondrial membrane protein Mgr2 (predicted) Positive GeneticPMID:22681890
dad2DASH complex subunit Dad2 Positive GeneticPMID:18818364
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
reb1RNA polymerase I transcription termination factor Reb1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
def1RNAPII degradation factor Def1 (predicted) Positive GeneticPMID:22681890
frp1ferric-chelate reductase Frp1 Positive GeneticPMID:22681890
pex11peroxisomal biogenesis factor 11 (predicted) Positive GeneticPMID:22681890
SPAC227.10prefoldin subunit 2 (predicted) Negative GeneticPMID:22681890
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
SPBC19F8.02nuclear distribution protein NUDC homolog Positive GeneticPMID:22681890
pzh1serine/threonine protein phosphatase Pzh1 Positive GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
jmj1histone demethylase Jmj1 (predicted) Negative GeneticPMID:18818364
spn4septin Spn4 Negative GeneticPMID:22681890
pdt1Nramp family manganese ion transporter Negative GeneticPMID:22681890
coq10mitochondrial ubiquinone binding protein Coq10 Positive GeneticPMID:22681890
cdc16two-component GAP Cdc16 Synthetic RescuePMID:15537703
Synthetic RescuePMID:17502918
SPAC12B10.01cubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
imp1importin alpha Negative GeneticPMID:22681890
ctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:18818364
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
sec63ER protein translocation subcomplex subunit Sec63 (predicted) Positive GeneticPMID:22681890
mis17kinetochore protein Mis17 Synthetic RescuePMID:21445296
ppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:18818364
SPCC777.02transcription factor (predicted) Positive GeneticPMID:22681890
SPAC3A11.10cdipeptidyl peptidase (predicted) Positive GeneticPMID:22681890
SPBC21B10.08csequence orphan Positive GeneticPMID:22681890
SPAC20H4.08phosphatase activator (predicted) Negative GeneticPMID:18818364
ser2phosphoserine phosphatase Ser2 (predicted) Positive GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Positive GeneticPMID:18818364
SPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
SPCC1672.04cmitochondrial copper chaperone (predicted) Positive GeneticPMID:22681890
wis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:22144909
rev3DNA polymerase zeta catalytic subunit Rev3 (predicted) Negative GeneticPMID:18818364
elp1elongator subunit Elp1 (predicted) Positive GeneticPMID:18818364
dbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
ste11transcription factor Ste11 Phenotypic SuppressionPMID:22144909
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:18818364
dph1UBA domain protein Dph1 Positive GeneticPMID:18818364
pyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:18818364
dsk1SR protein-specific kinase Dsk1 Negative GeneticPMID:18818364
rpl70260S ribosomal protein L7 Positive GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
sdh3succinate dehydrogenase (ubiquinone) cytochrome b subunit (predicted) Positive GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cdc14SIN component Cdc14 Synthetic RescuePMID:15537703
SPAC144.05ATP-dependent DNA helicase (predicted) Positive GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
msh6MutS protein homolog Negative GeneticPMID:18818364
ssu72phosphoric ester hydrolase Ssu72 (predicted) Positive GeneticPMID:18818364
mal3EB1 family Mal3 Negative GeneticPMID:18818364
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
clp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:15537703
Phenotypic Enhancement
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
sid1PAK-related GC kinase Sid1 Synthetic RescuePMID:15537703
rad2FEN-1 endonuclease Rad2 Positive GeneticPMID:18818364
sol1SWI/SNF complex subunit Sol1 Positive GeneticPMID:22681890
set6histone lysine methyltransferase Set6 (predicted) Positive GeneticPMID:22681890
est1telomerase regulator Est1 Positive GeneticPMID:18818364
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
dcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:18818364
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
SPAP27G11.11cdubious Negative GeneticPMID:22681890
lsg1Lsk1 complex gamma subunit (predicted) Positive GeneticPMID:22681890
pmk1MAP kinase Pmk1 Positive GeneticPMID:18818364
SPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Positive GeneticPMID:18818364
lub1WD repeat protein Lub1 Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
spt2non-specific DNA binding protein Spt2 (predicted) Negative GeneticPMID:18818364
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:18818364
csk1cyclin-dependent kinase activating kinase Csk1 Positive GeneticPMID:22681890
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
SPBC17D1.05sequence orphan Negative GeneticPMID:22681890
are2acyl-coA-sterol acyltransferase Are2 (predicted) Positive GeneticPMID:22681890
far8SIP/FAR complex striatin subunit, Far8/Csc3 Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Phenotypic EnhancementPMID:22347452
SPAC22H10.09sequence orphan Positive GeneticPMID:22681890
ilv1acetolactate synthase catalytic subunit Positive GeneticPMID:22681890
SPAC9E9.09caldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
SPBC13E7.08cRNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:18818364
plo1Polo kinase Plo1 Synthetic LethalityPMID:15537703
vht1vitamin H transporter Vth1 Positive GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ies2Ino80 complex subunit Ies2 Positive GeneticPMID:18818364
rud3Golgi matrix protein Rud3 (predicted) Negative GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Negative GeneticPMID:18818364
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Positive GeneticPMID:22681890
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Positive GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
mtg1mitochondrial GTPase involved in translation Mtg1 (predicted) Positive GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
ran1serine/threonine protein kinase Ran1 Phenotypic SuppressionPMID:22144909
SPBC8D2.12cmitochondrial translational activator of cytochrome C oxidase I (predicted) Positive GeneticPMID:22681890
med20mediator complex subunit Med20 Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
adn1adhesion defective protein, predicted transcriptional regulator (predicted) Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Positive GeneticPMID:18818364
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC824.04WD repeat protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
mpc1mitochondrial pyruvate transmembrane transporter subunit Mpc1 Positive GeneticPMID:22681890
ppk6serine/threonine protein kinase Ppk6 (predicted) Positive GeneticPMID:22681890
SPBC16H5.12cconserved fungal protein Positive GeneticPMID:22681890
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:18818364
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Positive GeneticPMID:18818364
cia1histone chaperone Cia1 Synthetic LethalityPMID:22291963
nrc1bromodomain protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
ckb2CK2 family regulatory subunit (predicted) Positive GeneticPMID:18818364
shk2PAK-related kinase Shk2 Positive GeneticPMID:18818364
SPCC1795.10cSed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:22681890
cdk9P-TEFb-associated cyclin-dependent protein kinase Cdk9 Synthetic Growth DefectPMID:22876190
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Positive GeneticPMID:22681890
rik1silencing protein Rik1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ccr1NADPH-cytochrome p450 reductase Negative GeneticPMID:22681890
SPAC105.02cankyrin repeat protein, implicated in meiosis Positive GeneticPMID:22681890
mei2RNA-binding protein involved in meiosis Mei2 Phenotypic SuppressionPMID:22144909
Synthetic Rescue
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
SPBC1734.07cTRAPP complex subunit Trs85 (predicted) Positive GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rpb1RNA polymerase II large subunit Rpb1 Biochemical ActivityPMID:20605454
lsc1Lsk1 associated cyclin Co-localizationPMID:17502918
Affinity Capture-Western
lsg1Lsk1 complex gamma subunit (predicted) Affinity Capture-WesternPMID:21931816
sty1MAP kinase Sty1 Biochemical ActivityPMID:22144909
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External References
Database Identifier Description
NBRP SPAC2F3.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC2F3.15 Retrieval of eukaryotic orthologs
BioGrid SPAC2F3.15 BioGRID Interaction Datasets
Bähler Lab SPAC2F3.15 Cell Cycle Expression Profile
Bähler Lab SPAC2F3.15 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC2F3.15 Pheromone response/mating expression profiles
Bähler Lab SPAC2F3.15 Environmental stress expression profiles
Bähler Lab SPAC2F3.15 Bähler Lab Transcriptome Viewer
Cyclebase SPAC2F3.15 Cell Cycle Data
PInt SPAC2F3.15 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC2F3.15 Entrez Gene
WikiGene2541672P-TEFb-associated cyclin-dependent protein kinase Lsk1
Uniprot_genenameLSK1
EntrezGene2541672P-TEFb-associated cyclin-dependent protein kinase Lsk1
UniProtKB/SwissProtO14098CTD kinase subunit alpha
ModBaseO14098Database of comparative protein structure models
Pfam Protein DomainsO14098Pfam Domain Arrangement
RefSeq PeptideNP_594393P-TEFb-associated cyclin-dependent protein kinase Lsk1
RefSeq mRNANM_001019816972h- P-TEFb-associated cyclin-dependent protein kinase Lsk1 (lsk1), mRNA
European Nucleotide ArchiveCAB16269ENA Protein Mapping
SPD / RIKEN46/46B09Orfeome Localization Data
UniParcUPI000006A971UniProt Archive

Literature for lsk1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013