lsk1 (SPAC2F3.15)


Gene Standard Namelsk1 Characterisation Statuspublished
Systematic IDSPAC2F3.15 Feature Typeprotein coding
Synonymsctk1 Name DescriptionLatrunculin Sensitive Kinase
ProductP-TEFb-associated cyclin-dependent protein kinase Lsk1 Product Size593aa, 67.37 kDa
Genomic Location Chromosome I, 3953832-3956869 (3038nt); CDS:3954471-3956415 (1945nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding551
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein serine/threonine kinase activity5
Annotation ExtensionEvidenceWith/FromReference
RNA polymerase II carboxy-terminal domain kinase activity4
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
GO Cellular Component
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at high temperaturelsk1Δ186
decreased cell population growth at low temperaturelsk1Δ96
decreased conjugation frequencylsk1Δ52
decreased mating efficiencylsk1Δ276
decreased sporulation frequencylsk1Δ103
increased monopolar indexlsk1Δ39
normal growth during cellular response to salt stresslsk1Δ25
normal growth on caffeinelsk1Δ14
normal growth on glucose carbon sourcelsk1Δ318
normal growth on hydrogen peroxidelsk1Δ24
sensitive to cadmiumlsk1Δ321
sensitive to camptothecinlsk1Δ259
sensitive to carbendazimlsk1Δ27
sensitive to latrunculin AK306R (K306R)39
lsk1Δ
sensitive to thiabendazolelsk1Δ334
slow vegetative cell population growthlsk1Δ369
viable vegetative cell populationlsk1Δ3862

Cell Phenotype

Term NameGenotypesCount
abnormal actomyosin contractile ringlsk1Δ21
abnormal premeiotic DNA replicationlsk1Δ25
abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues2
affecting rpb1lsk1as (F353G)
affecting rpb1lsk1Δ
affecting rpb1K306R (K306R)
abolished protein localization to nucleus, with protein mislocalized to cytoplasm11
affects localization of lsc1K306R (K306R)
affects localization of lsc1lsk1Δ
abolished protein-protein interaction164
affecting lsk1 and lsc1K306R (K306R)
altered RNA level during vegetative growthlsk1Δ465
binucleate vegetative cell with fragmented septumlsk1Δ1
decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth5
affecting rpb1lsk1Δ
decreased protein localization to chromatin at RNA polymerase II promoter during vegetative growth2
affecting substrate ste11, affecting activity of rpb3lsk1Δ
decreased RNA level during vegetative growth204
affecting ste11lsk1Δ
delayed onset of cell cycle arrest in mitotic G1 phase in response to nitrogen starvationlsk1Δ13
elongated telomereslsk1Δ176
elongated tetranucleate vegetative cell with fragmented septumlsk1Δ2
increased protein localization to chromatin at RNA polymerase II promoter during vegetative growth3
affecting substrate sam1, affecting activity of rpb3lsk1Δ
affecting substrate act1, affecting activity of rpb3lsk1Δ
increased RNA level during vegetative growth356
affecting mug96lsk1Δ
affecting mug37lsk1Δ
normal actin cytoskeleton morphology during vegetative growthlsk1Δ17
normal actin cytoskeleton organizationlsk1Δ21
normal actomyosin contractile ring assemblylsk1Δ19
normal cell cycle regulation during cellular response to latrunculin Alsk1Δ1
normal cytokinesis checkpointlsk1Δ5
normal phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth2
affecting rpb1lsk1Δ
affecting rpb1K306R (K306R)
normal protein localization to nucleus during vegetative growth85
affecting lsk1K306R (K306R)
normal RNA level during vegetative growth137
affecting sam1lsk1Δ
protein mislocalized to cytoplasm during vegetative growth69
affects localization of lsg1lsk1Δ
viable vegetative cell with normal cell morphologylsk1Δ3103

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased cell population growth at high temperaturelsk1Δ, S2A (All CTD S2 residues mutated to Ala)
decreased cell population growth at low temperaturelsk1Δ, S2A (All CTD S2 residues mutated to Ala)
decreased cell population growth on glucose carbon sourcelsk1Δ, S2A (All CTD S2 residues mutated to Ala)
inviable vegetative cell populationclp1Δ, lsk1Δ, rng3-65
lsk1Δ, plo1-1
normal growth during cellular response to salt stresslsk1Δ, S2A (All CTD S2 residues mutated to Ala)
normal growth on hydrogen peroxidelsk1Δ, S2A (All CTD S2 residues mutated to Ala)
normal mating efficiencylsk1Δ, ste11+ (wild type)
sensitive to carbendazimlsk1Δ, S2A (All CTD S2 residues mutated to Ala)
sensitive to ethyl methanesulfonatelsk1Δ, S2A (All CTD S2 residues mutated to Ala)
sensitive to latrunculin Alsk1Δ, S2A (All CTD S2 residues mutated to Ala)
clp1Δ, lsk1Δ
sensitive to thiabendazolelsk1Δ, S2A (All CTD S2 residues mutated to Ala)
viable vegetative cell populationlsk1Δ, cdc16-116

Cell Phenotype

Term NameGenotypes
abnormal actomyosin contractile ringlsk1Δ, clp1Δ
abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during nitrogen starvation
affecting rpb1wis1+ (wild type), lsk1Δ
decreased chromatin binding during cellular response to nitrogen starvation
affecting substrate ste11, affecting activity of lsk1lsk1Δ, ste11-D5'-UTR (2137 OF 2181 5' UTR deleted)
elongated tetranucleate vegetative celllsk1Δ, plo1-1
normal RNA level
affecting ste11lsk1Δ, mei2-L-SATA
affecting ste11lsk1Δ, pat1-114
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in lsk1 P-TEFb-associated cyclin-dependent protein kinase Lsk1
FYPO affected by mutation in rpb1 RNA polymerase II large subunit Rpb1
FYPO affected by mutation in ste11 transcription factor Ste11
FYPO localization affected by mutation in lsc1 Lsk1 associated cyclin
GO regulated by lsc1 Lsk1 associated cyclin
GO substrate of sty1 MAP kinase Sty1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3953832..3955418, 3955465..3955555, 3955622..3956300, 3956352..3956869
Intron3955419..3955464, 3955556..3955621, 3956301..3956351
mRNA3953832..3956869
5' UTR3953832..3954470PMID:21511999
CDS3954471..3955418, 3955465..3955555, 3955622..3956300, 3956352..3956415
3' UTR3956416..3956869PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 277 561 108
SM00220 SMART IPR000719 Protein kinase domain 277 561 107
PS50011 Prosite Profiles IPR000719 Protein kinase domain 277 561 108
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 283 306 70
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 395 407 91
PTHR24056 HMMPANTHER 230 593 9
PTHR24056:SF39 HMMPANTHER 230 593 1
3.30.200.20 Gene3D Immunoglobulin-like fold 275 356 111
1.10.510.10 Gene3D Immunoglobulin-like fold 357 562 112
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 269 565 127

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.60 Da
Charge 46.00
Codon Adaptation Index 0.37
Isoelectric point 10.60
Molecular weight 67.37 kDa
Number of residues 593
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2293
added by sty1, added during cellular response to nitrogen starvationS109
present during cellular response to thiabendazole, mitotic M phaseS104
present during mitotic M phaseS185
present during cellular response to thiabendazole, mitotic M phaseS109
present during mitotic M phaseS112
present during mitotic M phaseS114
present during mitotic M phaseS189
present during mitotic M phaseS190
present during mitotic M phaseS56
present during mitotic M phaseS191
present during mitotic M phaseS58
level fluctuates during mitotic cell cycleS112
S31, S56, S59, S60, S109, S167
Annotation ExtensionEvidenceResidueReference
added by sty1
added during cellular response to nitrogen starvation
IDA S109 PMID:22144909
present during cellular response to thiabendazole IDA S104 PMID:18257517
present during mitotic M phase experimental evidence S185 PMID:21712547
present during mitotic M phase experimental evidence S109 PMID:21712547
present during mitotic M phase experimental evidence S112 PMID:21712547
present during cellular response to thiabendazole IDA S109 PMID:18257517
present during mitotic M phase experimental evidence S114 PMID:21712547
present during mitotic M phase experimental evidence S104 PMID:21712547
present during mitotic M phase experimental evidence S189 PMID:21712547
present during mitotic M phase experimental evidence S190 PMID:21712547
present during mitotic M phase experimental evidence S56 PMID:21712547
present during mitotic M phase experimental evidence S191 PMID:21712547
present during mitotic M phase experimental evidence S58 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S112 PMID:24763107
IDA S167 PMID:25720772
IDA S56 PMID:25720772
IDA S31 PMID:25720772
IDA S60 PMID:25720772
IDA S59 PMID:25720772
experimental evidence S109 PMID:24763107
phosphorylated residue 2515
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS52,S59, S56,S58, S56,S59, S56,S60, S59,S60, S104,S109, S104,S109,S112, S104,S109,S114, S104,S109,Y116, S104,S112, S109,S112, S109,Y116, S112,S114, S112,S114,Y116, S189,S190, S189,S191, S190,S191, Y9,S18 2461
Annotation ExtensionEvidenceResidueReference
IDA S189,S191 PMID:25720772
IDA S104,S109,S112 PMID:25720772
IDA S112,S114 PMID:25720772
IDA S109,S112 PMID:25720772
IDA S52,S59 PMID:25720772
IDA S104,S109,S114 PMID:25720772
IDA S56,S58 PMID:25720772
IDA S109,Y116 PMID:25720772
IDA S59,S60 PMID:25720772
IDA S190,S191 PMID:25720772
IDA S56,S60 PMID:25720772
IDA S112,S114,Y116 PMID:25720772
IDA S56,S59 PMID:25720772
IDA S104,S109,Y116 PMID:25720772
IDA S104,S112 PMID:25720772
IDA S189,S190 PMID:25720772
IDA S104,S109 PMID:25720772
IDA Y9,S18 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelpresent during GO:0072690Western blot evidencePMID:22144909
unchanged during GO:0006995Western blot evidencePMID:22144909

Quantitative Gene Expression

View graphical display of gene expression data for lsk1 (SPAC2F3.15)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
141during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2during GO:0072690PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.53during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC2F3.15 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captureslsc1Lsk1 associated cyclin Affinity Capture-WesternPMID:17502918
affinity captureslsg1Lsk1 complex gamma subunit Lsg1 Affinity Capture-WesternPMID:21931816
modifiesrpb1RNA polymerase II large subunit Rpb1 Biochemical ActivityPMID:20605454
modified bysty1MAP kinase Sty1 Biochemical ActivityPMID:22144909
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC2F3.15 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
rescued byact1actin Act1 Phenotypic SuppressionPMID:15537703
rescued byste11transcription factor Ste11 Phenotypic SuppressionPMID:20605454
rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:15537703
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withdbr1RNA lariat debranching enzyme Dbr1 Negative GeneticPMID:18818364
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
negative genetic interaction withimp1importin alpha Negative GeneticPMID:22681890
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
negative genetic interaction withSPBC17D1.05Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withgim4prefoldin subunit 2, Gim4(predicted) Negative GeneticPMID:22681890
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
negative genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Negative GeneticPMID:18818364
negative genetic interaction withmal3microtubule plus-end binding protein, EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction witherp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsvp26Sed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withdsk1SR protein-specific kinase Dsk1 Negative GeneticPMID:18818364
negative genetic interaction withspt2non-specific DNA binding protein Spt2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
negative genetic interaction withatd1aldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withklp6kinesin-8 family plus-end microtubule motor Klp6 Negative GeneticPMID:18818364
negative genetic interaction withhta1histone H2A alpha Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withubp7ubiquitin C-terminal hydrolase Ubp7 Negative GeneticPMID:18818364
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
negative genetic interaction withrud3Golgi matrix protein Rud3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withswc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:18818364
negative genetic interaction withftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
negative genetic interaction withdcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
negative genetic interaction withjmj1histone demethylase Jmj1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withbdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
negative genetic interaction withpdt1Nramp family manganese ion transmembrane transporter Negative GeneticPMID:22681890
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
negative genetic interaction withadn1adhesion defective protein Negative GeneticPMID:22681890
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction witharp6actin-like protein Arp6 Negative GeneticPMID:18818364
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
negative genetic interaction withSPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:18818364
negative genetic interaction withwhi2G-patch RNA-binding protein, involved in splicing (predicted) Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction withhip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
negative genetic interaction withgfh1gamma tubulin complex subunit Gfh1 Negative GeneticPMID:18818364
negative genetic interaction withSPAP27G11.11cdubious Negative GeneticPMID:22681890
negative genetic interaction withswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Negative GeneticPMID:22681890
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:18818364
negative genetic interaction withccr1NADPH-cytochrome p450 reductase Negative GeneticPMID:22681890
negative genetic interaction withrsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
negative genetic interaction withmed6mediator complex subunit Med6 Negative GeneticPMID:18818364
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withmed20mediator complex subunit Med20 Negative GeneticPMID:18818364
negative genetic interaction withsnt2Lid2 complex PHD finger subunit Snt2 Negative GeneticPMID:18818364
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
negative genetic interaction withyaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
negative genetic interaction withrev3DNA polymerase zeta catalytic subunit Rev3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withspn4mitotic septin Spn4 Negative GeneticPMID:22681890
negative genetic interaction withubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Negative GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withtea2kinesin family plus-end microtubule motor Tea2 Negative GeneticPMID:18818364
negative genetic interaction withrpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:18818364
negative genetic interaction withcaa1cytoplasmic aspartate aminotransferase Caa1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:18818364
negative genetic interaction withcsn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
negative genetic interaction withfar8SIP/FAR complex striatin subunit, Far8/Csc3 Negative GeneticPMID:22681890
positive genetic interaction withtrs8502TRAPP complex subunit Trs85b (predicted) Positive GeneticPMID:18818364
positive genetic interaction withmtg1mitochondrial GTPase involved in translation Mtg1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpmk1MAP kinase Pmk1 Positive GeneticPMID:18818364
positive genetic interaction withvht1vitamin H transmembrane transporter Vht1 Positive GeneticPMID:22681890
positive genetic interaction withSPAC144.05ATP-dependent DNA helicase/ ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withsdh3succinate dehydrogenase (ubiquinone) cytochrome b subunit (predicted) Positive GeneticPMID:22681890
positive genetic interaction withdef1RNAPII degradation factor Def1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsat1Golgi membrane exchange factor subunit Sat1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withhmt2sulfide-quinone oxidoreductase Positive GeneticPMID:22681890
positive genetic interaction withtim18TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:18818364
positive genetic interaction withSPAC22H10.09Schizosaccharomyces specific protein Positive GeneticPMID:22681890
positive genetic interaction withSPCC777.02transcription factor (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:18818364
positive genetic interaction withshk2PAK-related kinase Shk2 Positive GeneticPMID:18818364
positive genetic interaction withcoq10mitochondrial ubiquinone binding protein Coq10 Positive GeneticPMID:22681890
positive genetic interaction withlsg1Lsk1 complex gamma subunit Lsg1 Positive GeneticPMID:22681890
positive genetic interaction withest1telomerase regulator Est1 Positive GeneticPMID:18818364
positive genetic interaction withilv1acetolactate synthase catalytic subunit Positive GeneticPMID:22681890
positive genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Positive GeneticPMID:18818364
positive genetic interaction withdph1UBA domain protein Dph1 Positive GeneticPMID:18818364
positive genetic interaction withset6histone lysine methyltransferase Set6 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrad2FEN-1 endonuclease Rad2 Positive GeneticPMID:18818364
positive genetic interaction withura3mitochondrial dihydroorotate dehydrogenase Ura3 Positive GeneticPMID:22681890
positive genetic interaction withies2Ino80 complex subunit Ies2 Positive GeneticPMID:18818364
positive genetic interaction withleo1RNA polymerase II associated Paf1 complex (predicted) Positive GeneticPMID:18818364
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withnud3nuclear distribution protein NUDC homolog Positive GeneticPMID:22681890
positive genetic interaction withsck2serine/threonine protein kinase Sck2 Positive GeneticPMID:24463365
positive genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Positive GeneticPMID:18818364
positive genetic interaction withpex11peroxisomal biogenesis factor 11 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Positive GeneticPMID:18818364
positive genetic interaction withsec63ER protein translocation subcomplex subunit Sec63 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withdpe1dipeptidyl peptidase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Positive GeneticPMID:22681890
positive genetic interaction withSPBC8D2.12cmitochondrial translational activator of cytochrome C oxidase I (predicted) Positive GeneticPMID:22681890
positive genetic interaction withdad2DASH complex subunit Dad2 Positive GeneticPMID:18818364
positive genetic interaction withmgr2TIM23 translocase complex subunit Mgr2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withaut12autophagy associated protein Aut12 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withpdp2PWWP domain protein Pdp2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withppk6serine/threonine protein kinase Ppk6 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrcd1CCR4-NOT complex RNA-binding protein subunit Rcd1 Positive GeneticPMID:22681890
positive genetic interaction withcsk1cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1 Positive GeneticPMID:22681890
positive genetic interaction withser2phosphoserine phosphatase Ser2 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withelp1elongator subunit Elp1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withvrp1verprolin Positive GeneticPMID:18818364
positive genetic interaction withSPAC12B10.01cHECT-type ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withshy1cytochrome c oxidase assembly protein Shy1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtrm112eRF1 methyltransferase complex and tRNA (m2G10) methyltransferase complex regulatory subunit Trm112 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withelp6elongator complex subunit Elp6 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withlub1WD repeat protein Lub1 Positive GeneticPMID:22681890
positive genetic interaction withrpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withare2acyl-coA-sterol acyltransferase Are2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC21B10.08cantibiotic biosynthesis monooxygenase-like domain (predicted) Positive GeneticPMID:22681890
positive genetic interaction withwpl1cohesin loading/unloading factor (WAPL) Wpl1 Positive GeneticPMID:18818364
positive genetic interaction withSPAC105.02cankyrin repeat protein, human PPP1R16A ortholog Positive GeneticPMID:22681890
positive genetic interaction withtfs1transcription elongation factor TFIIS Positive GeneticPMID:18818364
positive genetic interaction withppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
positive genetic interaction withsol1SWI/SNF complex subunit Sol1 Positive GeneticPMID:22681890
positive genetic interaction withrpl70260S ribosomal protein L7b involved in cytoplasmic translation Positive GeneticPMID:22681890
positive genetic interaction withsnr13-hydroxyisobutyryl-CoA hydrolase snr1 Positive GeneticPMID:22681890
positive genetic interaction withswc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
positive genetic interaction withcox19mitochondrial respiratory chain complex IV assembly protein Cox19 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
positive genetic interaction withsnf5SWI/SNF complex subunit Snf5 Positive GeneticPMID:22681890
positive genetic interaction withSPBC16H5.12cconserved fungal protein Positive GeneticPMID:22681890
positive genetic interaction withzfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Positive GeneticPMID:22681890
positive genetic interaction withubc13ubiquitin conjugating enzyme E2 Ubc13 Positive GeneticPMID:18818364
positive genetic interaction withebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withckb2CK2 family regulatory subunit Ckb2 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withdad1DASH complex subunit Dad1 Positive GeneticPMID:18818364
positive genetic interaction withfhl1forkhead transcription factor Fhl1 Positive GeneticPMID:22681890
positive genetic interaction withmpc1mitochondrial pyruvate transmembrane transporter subunit Mpc1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withfrp1ferric-chelate reductase Frp1 Positive GeneticPMID:22681890
synthetically rescuescdc16two-component GAP Cdc16 Synthetic RescuePMID:17502918
synthetically rescuesmis17kinetochore protein, CENP-U ortholog Mis17 Synthetic RescuePMID:21445296
synthetically rescuesmei2RNA-binding protein involved in meiosis Mei2 Synthetic RescuePMID:22144909
synthetically rescuessid1PAK-related GC kinase Sid1 Synthetic RescuePMID:15537703
synthetically rescuescdc14SIN component Cdc14 Synthetic RescuePMID:15537703
rescueswis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:22144909
rescuespat1serine/threonine protein kinase Ran1/Pat1 Phenotypic SuppressionPMID:22144909
rescuesmei2RNA-binding protein involved in meiosis Mei2 Phenotypic SuppressionPMID:22144909
synthetic growth defect withcdk9P-TEFb-associated cyclin-dependent protein kinase Cdk9 Synthetic Growth DefectPMID:22876190
synthetic growth defect withrhn1RNA polymerase II transcription termination factor homolog Synthetic Growth DefectPMID:22912768
synthetic lethal withplo1Polo kinase Plo1 Synthetic LethalityPMID:15537703
synthetic lethal withcia1histone chaperone Cia1 Synthetic LethalityPMID:22291963
phenotype enhanced byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:15537703
enhances phenotype ofset3histone lysine methyltransferase Set3 Phenotypic EnhancementPMID:22347452
External References
Database Identifier Description
NBRP SPAC2F3.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC2F3.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC2F3.15 BioGRID Interaction Datasets
Expression Viewer SPAC2F3.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC2F3.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC2F3.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC2F3.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC2F3.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC2F3.15 Transcriptome Viewer (Bähler Lab)
GEO SPAC2F3.15 GEO profiles
PInt SPAC2F3.15 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC2F3.15 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC2F3.15 Fission yeast phenotypic data & analysis
Cyclebase SPAC2F3.15.1 Cell Cycle Data
SPD / RIKEN46/46B09Orfeome Localization Data
UniProtKB/SwissProtO14098CTD kinase subunit alpha
ModBaseO14098Database of comparative protein structure models
STRINGO14098Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594393P-TEFb-associated cyclin-dependent protein kinase Lsk1
RefSeq mRNANM_001019816972h- P-TEFb-associated cyclin-dependent protein kinase Lsk1 (lsk1), mRNA
European Nucleotide ArchiveCAB16269.1ENA Protein Mapping
UniParcUPI000006A971UniProt Archive

Literature for lsk1

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Release Version: PomBase:30_62 - 30 Jan 2017