vps4 (SPAC2G11.06)

Gene Standard Namevps4 ChromosomeI
Systematic IDSPAC2G11.06 Gene Start817996
Synonyms Gene End819739
ProductAAA family ATPase Vps4 (predicted) Gene Length1744
Feature Typeprotein coding CDS Start818117
Name Description CDS End819650
Characterisation Statusbiological_role_inferred CDS Length1534

Ensembl Gene Location
  1. urb2
  2. vps45
  3. SPAC2G11.04
  4. rim20
  5. vps4
  6. SPNCRNA.688
  7. ptc3
  8. smn1
  9. SPAC2G11.09
  10. SPAC2G11.10c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencevps4delta (deletion)deletionPMID:20537132
FYPO:0000268sensitive to UVcompetitive growth assay evidencevps4delta (deletion)deletionPMID:20537132
FYPO:0001475fragmented spindle pole bodyMicroscopyvps4delta (deletion)deletionPMID:22682253
FYPO:0002060viable vegetative cell populationMicroscopyvps4delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005524ATP bindingISMIPR003593GO_REF:0000001
GO:0016887ATPase activityISMIPR003593GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0043328protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayIMPPMID:17660439
GO:0045053protein retention in Golgi apparatusISSUniProtKB:P52917GO_REF:0000001
GO:0045324late endosome to vacuole transportIMPPMID:17660439
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005737cytoplasmIDAPMID:16823372
ISSUniProtKB:P52917GO_REF:0000001
GO:0005829cytosolIDAPMID:16823372
GO:0010008endosome membraneIEASL-0100GO_REF:0000039
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1817996818140
2818207818318
3818429818915
4818975819739

References

Region Start End Reference
three_prime_UTR819651819739PMID:21511999
three_prime_UTR819651819739PMID:21511999
five_prime_UTR817996818116PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00004 IPR003959 Pfam ATPase, AAA-type, core 165 294 32
PF04212 IPR007330 Pfam MIT 7 74 1
PF09336 IPR015415 Pfam Vps4 oligomerisation, C-terminal 369 429 3
SM00745 IPR007330 SMART MIT 3 80 1
SM00382 IPR003593 SMART AAA+ ATPase domain 161 296 73
PS00674 IPR003960 Prosite Patterns ATPase, AAA-type, conserved site 266 285 19
G3DSA:1.10.8.60 Gene3D 303 412 34
G3DSA:1.20.58.280 Gene3D 1 79 2
G3DSA:3.40.50.300 Gene3D 122 302 279
SSF52540 SuperFamily 124 425 294
SSF116846 SuperFamily 1 91 2
PTHR23074 hmmpanther 1 432 4
PTHR23074:SF3 hmmpanther 1 432 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000539AAA family ATPaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000539

Protein Properties

Ave. residue weight 112.04 Da
Charge 0.50
Isoelectric point 6.70
Molecular weight 48.40 kDa
Number of residues 432
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide3374.46PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1244.11PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.65PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.3PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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External References
Database Identifier Description
NBRP SPAC2G11.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC2G11.06 Retrieval of eukaryotic orthologs
BioGrid SPAC2G11.06 BioGRID Interaction Datasets
Bähler Lab SPAC2G11.06 Cell Cycle Expression Profile
Bähler Lab SPAC2G11.06 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC2G11.06 Pheromone response/mating expression profiles
Bähler Lab SPAC2G11.06 Environmental stress expression profiles
Bähler Lab SPAC2G11.06 Bähler Lab Transcriptome Viewer
Cyclebase SPAC2G11.06 Cell Cycle Data
PInt SPAC2G11.06 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC2G11.06 Entrez Gene
WikiGene2542054AAA family ATPase Vps4 (predicted)
Uniprot_genenameVPS4
EntrezGene2542054AAA family ATPase Vps4 (predicted)
SPD / RIKEN24/24H04Orfeome Localization Data
UniProtKB/SwissProtQ09803Suppressor protein of bem1/bed5 double mutants
ModBaseQ09803Database of comparative protein structure models
Pfam Protein DomainsQ09803Pfam Domain Arrangement
RefSeq PeptideNP_593086AAA family ATPase Vps4 (predicted)
RefSeq mRNANM_001018484972h- AAA family ATPase Vps4 (predicted) (vps4), mRNA
European Nucleotide ArchiveAAA35347ENA Protein Mapping
European Nucleotide ArchiveCAA91171ENA Protein Mapping
UniParcUPI00001359D4UniProt Archive

Literature for vps4
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013