abo1 (SPAC31G5.19)


Gene Standard Nameabo1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC31G5.19 Feature Typeprotein coding
Synonyms Name Description
ProductATPase with bromodomain protein (predicted) Product Size1190aa, 135.35 kDa
Genomic Location Chromosome I, 3023051-3028158 (5108nt); CDS:3024418-3027990 (3573nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037558
GO:0016887ATPase activityNASGO_REF:0000051232
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingNASGO_REF:0000051151
GO:0006357regulation of transcription from RNA polymerase II promoterISOSGD:S000003502GO_REF:0000024262
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000790nuclear chromatinISMPFAM:PF00439GO_REF:0000001278
GO:0005634nucleusIDAPMID:168233722737
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000980normal growth on amphotericin BCell growth assayabo1ΔNullPECO:0000137, PECO:0000005PMID:2373802117
FYPO:0001245sensitive to cobalt56
expressivity FYPO_EXT:0000003Cell growth assayabo1ΔNullPECO:0000201, PECO:0000005PMID:22806344
FYPO:0003559sensitive to doxorubicin91
expressivity FYPO_EXT:0000001Cell growth assayabo1ΔNullPECO:0000137, PECO:0000142PMID:23365689
FYPO:0002641sensitive to micafungin116
expressivity FYPO_EXT:0000002Cell growth assayabo1ΔNullPECO:0000137, PECO:0000005PMID:23738021
FYPO:0002060viable vegetative cell populationMicroscopyabo1ΔNullPMID:204732893751
Microscopyabo1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopyabo1ΔNullPECO:0000005, PECO:0000137PMID:23697806640
FYPO:0001492viable elongated vegetative cell197
penetrance FYPO_EXT:0000001Microscopyabo1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
130230513023169
230232323028158
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00004 Pfam IPR003959 ATPase, AAA-type, core 303 438 32
PF00004 Pfam IPR003959 ATPase, AAA-type, core 606 722 32
SM00382 SMART IPR003593 AAA+ ATPase domain 299 440 70
SM00382 SMART IPR003593 AAA+ ATPase domain 601 705 70
PS00674 Prosite Patterns IPR003960 ATPase, AAA-type, conserved site 408 426 19
PTHR23069:SF0 HMMPANTHER 1 1188 2
PTHR23069 HMMPANTHER 1 1188 2
3.40.50.300 Gene3D 590 745 288
1.10.8.60 Gene3D 447 529 35
3.40.50.300 Gene3D 264 446 288
1.20.920.10 Gene3D IPR001487 Bromodomain 864 911 10
SSF47370 SuperFamily IPR001487 Bromodomain 865 913 10
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 591 751 294
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 264 529 294

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000496bromodomainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000496
PBO:0000539AAA family ATPaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000539

Protein Properties

Ave. residue weight 113.74 Da
Charge -28.50
Isoelectric point 4.99
Molecular weight 135.35 kDa
Number of residues 1190
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS1047PMID:247631071670
present during mitotic M phaseS1047PMID:21712547
present during mitotic M phaseS972PMID:21712547
present during mitotic M phaseS214PMID:21712547
present during mitotic M phaseS212PMID:21712547
present during cellular response to thiabendazoleIDAS139PMID:18257517
present during cellular response to thiabendazoleIDAS1047PMID:18257517
MOD:00696phosphorylated residueNASPMID:182575171922
NASPMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1598.58during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
801.32during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.94during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
prf1RNA polymerase II associated Paf1 complex (predicted) Affinity Capture-MSPMID:24385927
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
tpr1RNA polymerase II associated Paf1 complex subunit Tpr1 Affinity Capture-MSPMID:24385927
External References
Database Identifier Description
NBRP SPAC31G5.19 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC31G5.19 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC31G5.19 BioGRID Interaction Datasets
Expression Viewer SPAC31G5.19 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC31G5.19 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC31G5.19 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC31G5.19 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC31G5.19 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC31G5.19 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC31G5.19 Cell Cycle Data
GEO SPAC31G5.19 GEO profiles
PInt SPAC31G5.19 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC31G5.19 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN48/48D10Orfeome Localization Data
UniProtKB/SwissProtO14114Uncharacterized AAA domain-containing protein C31G5.19
ModBaseO14114Database of comparative protein structure models
STRINGO14114Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594020ATPase with bromodomain protein (predicted)
RefSeq mRNANM_001019446972h- ATPase with bromodomain protein (predicted) (SPAC31G5.19), mRNA
European Nucleotide ArchiveCAB11703.1ENA Protein Mapping
UniParcUPI0000069930UniProt Archive

Literature for abo1

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014