abo1 (SPAC31G5.19)


Gene Standard Nameabo1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC31G5.19 Feature Typeprotein coding
Synonyms Name Description
ProductATPase with bromodomain protein (predicted) Product Size1190aa, 135.35 kDa
Genomic Location Chromosome I, 3023051-3028158 (5108nt); CDS:3024418-3027990 (3573nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
ATPase activity236
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
chromatin remodeling157
Annotation ExtensionEvidenceWith/FromReference
regulation of transcription from RNA polymerase II promoter288
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nuclear chromatin307
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
normal growth on amphotericin Babo1ΔNull17
sensitive to cobaltabo1ΔNull56
sensitive to doxorubicinabo1ΔNull91
sensitive to micafunginabo1ΔNull116
viable vegetative cell populationabo1ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
abnormal mitotic cell cycleabo1ΔNull833
viable elongated vegetative cellabo1ΔNull283
viable vegetative cell with abnormal cell shapeabo1ΔNull476
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3023051..3023169, 3023232..3028158
mRNA3023051..3028158
5' UTR3023051..3023169, 3023232..3024417PMID:21511999
CDS3024418..3027990
3' UTR3027991..3028158PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00004 Pfam IPR003959 ATPase, AAA-type, core 606 722 32
PF00004 Pfam IPR003959 ATPase, AAA-type, core 303 438 32
SM00382 SMART IPR003593 AAA+ ATPase domain 299 440 70
SM00382 SMART IPR003593 AAA+ ATPase domain 601 705 70
PS00674 Prosite Patterns IPR003960 ATPase, AAA-type, conserved site 408 426 19
PTHR23069:SF0 HMMPANTHER 23 1185 2
PTHR23069 HMMPANTHER 23 1185 2
1.20.920.10 Gene3D IPR001487 Bromodomain 864 911 10
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 264 446 288
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 590 745 288
1.10.8.60 Gene3D 447 529 35
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 591 751 294
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 264 529 294
SSF47370 SuperFamily IPR001487 Bromodomain 865 913 10

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000496bromodomainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000496
PBO:0000539AAA family ATPaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000539

Protein Properties

Ave. residue weight 113.74 Da
Charge -28.50
Isoelectric point 4.99
Molecular weight 135.35 kDa
Number of residues 1190
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS1047 1672
present during mitotic M phaseS212
present during mitotic M phase, cellular response to thiabendazoleS1047
present during mitotic M phaseS214
present during mitotic M phaseS972
present during cellular response to thiabendazoleS139
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S139 PMID:18257517
present during mitotic M phase experimental evidence S212 PMID:21712547
present during mitotic M phase experimental evidence S214 PMID:21712547
present during mitotic M phase experimental evidence S972 PMID:21712547
experimental evidence S1047 PMID:24763107
present during cellular response to thiabendazole IDA S1047 PMID:18257517
present during mitotic M phase experimental evidence S1047 PMID:21712547
phosphorylated residue 1926
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1598.58during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
801.32during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.94during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
affinity captured byprf1RNA polymerase II associated Paf1 complex (predicted) Affinity Capture-MSPMID:24385927
affinity captured bytpr1RNA polymerase II associated Paf1 complex subunit Tpr1 Affinity Capture-MSPMID:24385927
External References
Database Identifier Description
NBRP SPAC31G5.19 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC31G5.19 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC31G5.19 BioGRID Interaction Datasets
Expression Viewer SPAC31G5.19 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC31G5.19 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC31G5.19 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC31G5.19 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC31G5.19 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC31G5.19 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC31G5.19 Cell Cycle Data
GEO SPAC31G5.19 GEO profiles
PInt SPAC31G5.19 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC31G5.19 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC31G5.19 Fission yeast phenotypic data & analysis
SPD / RIKEN48/48D10Orfeome Localization Data
UniProtKB/SwissProtO14114Uncharacterized AAA domain-containing protein C31G5.19
ModBaseO14114Database of comparative protein structure models
STRINGO14114Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594020ATPase with bromodomain protein (predicted)
RefSeq mRNANM_001019446972h- ATPase with bromodomain protein (predicted) (SPAC31G5.19), mRNA
European Nucleotide ArchiveCAB11703.1ENA Protein Mapping
UniParcUPI0000069930UniProt Archive

Literature for abo1

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015