Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC3A11.07 Feature Typeprotein coding
Synonyms Name Description
ProductNADH dehydrogenase (predicted) Product Size551aa, 61.67 kDa
Genomic Location Chromosome I, 3456694-3459197 (2504nt); CDS:3457273-3458928 (1656nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003954NADH dehydrogenase activityISSUniProtKB:P40215GO_REF:00000013
GO:0050660flavin adenine dinucleotide bindingIEAIPR001327GO_REF:000000234
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006116NADH oxidationISSUniProtKB:P40215GO_REF:00000017
GO:0006091generation of precursor metabolites and energyNASGO_REF:0000051115
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005743mitochondrial inner membraneISSUniProtKB:P40215GO_REF:0000001155
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC3A11.07ΔNullPMID:204732893755
MicroscopySPAC3A11.07ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPAC3A11.07ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Target Of
regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1 PMID:16537923
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00070 Pfam IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain 256 343 6
PF07992 Pfam IPR023753 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 94 411 9
PTHR22915 HMMPANTHER 32 551 2
PTHR22915:SF4 HMMPANTHER 32 551 2
G3DSA: Gene3D 256 432 29
G3DSA: Gene3D 89 221 29
SSF51905 SuperFamily 92 307 26
SSF51905 SuperFamily 251 430 26
Low complexity (SEG) seg 21 34
Low complexity (SEG) seg 255 266
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 195 213 7
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 388 410 7
PR00368 PRINTS IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase 256 274 7

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.93 Da
Charge 18.00
Isoelectric point 9.28
Molecular weight 61.67 kDa
Number of residues 551
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
46048.16during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
47384.69during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
25during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4564
conserved in eukaryotes4482

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
bzz1diacylglycerol binding protein Bzz1 (predicted) Positive GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
SPBPB10D8.02carylsulfatase (predicted) Positive GeneticPMID:22681890
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Positive GeneticPMID:22681890
tea5pseudokinase Tea5 Negative GeneticPMID:22681890
rsc4RSC complex subunit Rsc4 Positive GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
ago1argonaute Positive GeneticPMID:22681890
knd1Cullin-associated NEDD8-dissociated protein Knd1 (predicted) Positive GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC3A11.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC3A11.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC3A11.07 BioGRID Interaction Datasets
Expression Viewer SPAC3A11.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC3A11.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC3A11.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC3A11.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC3A11.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC3A11.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC3A11.07 Cell Cycle Data
GEO SPAC3A11.07 GEO profiles
PInt SPAC3A11.07 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2543119NADH dehydrogenase
EntrezGene2543119NADH dehydrogenase
SPD / RIKEN34/34G01Orfeome Localization Data
UniProtKB/SwissProtO14121Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial
ModBaseO14121Database of comparative protein structure models
StringO14121Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594196NADH dehydrogenase
RefSeq mRNANM_001019620972h- NADH dehydrogenase (SPAC3A11.07), mRNA
European Nucleotide ArchiveCAB16382ENA Protein Mapping
UniParcUPI000006A719UniProt Archive

Literature for SPAC3A11.07

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014