vps53 (SPAC3A12.15)

Gene Standard Namevps53 Characterisation Statusbiological_role_inferred
Systematic IDSPAC3A12.15 Feature Typeprotein coding
Synonyms Name Description
ProductGARP complex subunit Vps53 (predicted) Product Size756aa, 87.51 kDa
Genomic Location Chromosome I, 1446480-1449286 (2807nt); CDS:1446703-1448973 (2271nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006896Golgi to vacuole transportISOSGD:S000003566GO_REF:000002418
GO:0006886intracellular protein transportICGO:0042147GO_REF:0000001332
GO:0042147retrograde transport, endosome to GolgiISOSGD:S000003566GO_REF:000002423
GO:0016192vesicle-mediated transportISOSGD:S000003566GO_REF:0000024299
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000938GARP complexISOSGD:S000003566GO_REF:00000244
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyvps53ΔNullPMID:204732891309
Microscopyvps53ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002451inviable vegetative cell with abnormal cell shapeMicroscopyvps53ΔNullPECO:0000005, PECO:0000137PMID:23697806441
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04100 Pfam IPR007234 Vps53-like, N-terminal 17 393 1
PTHR12820 HMMPANTHER 18 712 1
PTHR12820:SF0 HMMPANTHER 18 712 1
Coil ncoils Rabaptin coiled-coil domain 46 67 975
Low complexity (SEG) seg 307 319
Low complexity (SEG) seg 40 52

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.75 Da
Charge 4.00
Isoelectric point 7.55
Molecular weight 87.51 kDa
Number of residues 756
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
643.36during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.4during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.35during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAC3A12.15 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC3A12.15 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC3A12.15 BioGRID Interaction Datasets
Expression Viewer SPAC3A12.15 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC3A12.15 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC3A12.15 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC3A12.15 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC3A12.15 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC3A12.15 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC3A12.15 Cell Cycle Data
GEO SPAC3A12.15 GEO profiles
PInt SPAC3A12.15 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN28/28B07Orfeome Localization Data
WikiGene2542930GARP complex subunit Vps53 (predicted)
EntrezGene2542930GARP complex subunit Vps53 (predicted)
UniProtKB/SwissProtP87129Vacuolar protein sorting-associated protein 53
ModBaseP87129Database of comparative protein structure models
StringP87129Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593341GARP complex subunit Vps53 (predicted)
RefSeq mRNANM_001018773972h- GARP complex subunit Vps53 (predicted) (vps53), mRNA
European Nucleotide ArchiveCAB08743ENA Protein Mapping
UniParcUPI000013AA01UniProt Archive

Literature for vps53

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014