pex13 (SPAC3C7.10)


Gene Standard Namepex13 Characterisation Statusbiological role inferred
Systematic IDSPAC3C7.10 Feature Typeprotein coding
Synonyms Name Description
Productperoxin 13 (predicted) Product Size288aa, 32.05 kDa
Genomic Location Chromosome I, 2084966-2086433 (1468nt); CDS:2085248-2086114 (867nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
protein import into peroxisome matrix6
Annotation ExtensionEvidenceWith/FromReference
protein import into peroxisome matrix, docking1
Annotation ExtensionEvidenceWith/FromReference
protein targeting to peroxisome11
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4213
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane966
Annotation ExtensionEvidenceWith/FromReference
peroxisomal membrane13
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationpex13Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologypex13Δ3102
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2084966..2086433
mRNA2084966..2086433
5' UTR2084966..2085247PMID:21511999
CDS2085248..2086114
3' UTR2086115..2086433PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04088 Pfam IPR007223 Peroxin 13, N-terminal 84 201 1
PF00018 Pfam IPR001452 SH3 domain 228 280 20
SM00326 SMART IPR001452 SH3 domain 225 287 21
TMhelix TMHMM 177 199 950
PS50002 Prosite Profiles IPR001452 SH3 domain 222 288 21
PTHR19332 HMMPANTHER 47 288 1
PTHR19332:SF3 HMMPANTHER 47 288 1
2.30.30.40 Gene3D CheW-like domain 212 287 21
SSF50044 SuperFamily IPR001452 SH3 domain 222 287 21
PR00452 PRINTS IPR001452 SH3 domain 274 286 12
PR00452 PRINTS IPR001452 SH3 domain 240 255 12
PR00452 PRINTS IPR001452 SH3 domain 262 271 12

View domain organization at Pfam

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 111.30 Da
Charge 5.00
Codon Adaptation Index 0.37
Isoelectric point 8.71
Molecular weight 32.05 kDa
Number of residues 288
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for pex13 (SPAC3C7.10)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1494.32during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1665during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.49during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
Zellweger syndrome10
metabolic disorders143
peroxisomal metabolism disorders12
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC3C7.10 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withpex19Pex19 protein (predicted) Two-hybridPMID:26771498
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC3C7.10 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withpar1protein phosphatase PP2A regulatory subunit B-56 Par1 Negative GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withmis4cohesin loading factor (adherin) Mis4 Negative GeneticPMID:23050226
negative genetic interaction withvps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
positive genetic interaction withSPAC1A6.03clysophospholipase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withspc34DASH complex subunit Spc34 Positive GeneticPMID:22681890
positive genetic interaction withurk1uridine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withask1DASH complex subunit Ask1 Positive GeneticPMID:22681890
positive genetic interaction withppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withppm1leucine carboxyl methyltransferase, involved in regulation of autophagy Ppm1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withxap5xap-5-like protein Positive GeneticPMID:24957674
positive genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc4 Positive GeneticPMID:21504829
positive genetic interaction withsty1MAP kinase Sty1 Positive GeneticPMID:22681890
positive genetic interaction withdam1DASH complex subunit Dam1 Positive GeneticPMID:22681890
positive genetic interaction withdad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
positive genetic interaction withspc19DASH complex subunit Spc19 Positive GeneticPMID:22681890
positive genetic interaction withSPAC1B3.02ctranscription elongation factor, Elf1 family (predicted) Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC3C7.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC3C7.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC3C7.10 BioGRID Interaction Datasets
Expression Viewer SPAC3C7.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC3C7.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC3C7.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC3C7.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC3C7.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC3C7.10 Transcriptome Viewer (Bähler Lab)
GEO SPAC3C7.10 GEO profiles
PInt SPAC3C7.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC3C7.10 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC3C7.10 Fission yeast phenotypic data & analysis
Cyclebase SPAC3C7.10.1 Cell Cycle Data
SPD / RIKEN11/11F07Orfeome Localization Data
UniProtKB/SwissProtO14136Peroxisomal membrane protein pex13
ModBaseO14136Database of comparative protein structure models
STRINGO14136Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593611peroxin 13 (predicted)
RefSeq mRNANM_001019042972h- peroxin 13 (predicted) (pex13), mRNA
European Nucleotide ArchiveCAB16740.1ENA Protein Mapping
UniParcUPI000006A79BUniProt Archive

Literature for pex13

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016