pex13 (SPAC3C7.10)


Gene Standard Namepex13 Characterisation Statusbiological_role_inferred
Systematic IDSPAC3C7.10 Feature Typeprotein coding
Synonyms Name Description
Productperoxin 13 (predicted) Product Size288aa, 32.05 kDa
Genomic Location Chromosome I, 2084966-2086433 (1468nt); CDS:2085248-2086114 (867nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
protein import into peroxisome matrix5
Annotation ExtensionEvidenceWith/FromReference
protein import into peroxisome matrix, docking1
Annotation ExtensionEvidenceWith/FromReference
protein targeting to peroxisome11
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4205
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
peroxisomal membrane14
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopypex13ΔNullPMID:204732893759
Microscopypex13ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopypex13ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
120849662086433

UTRs

Region Coordinates Reference
five_prime_UTR2084966..2085247PMID:21511999
three_prime_UTR2086115..2086433PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04088 Pfam IPR007223 Peroxin 13, N-terminal 78 203 1
PF00018 Pfam IPR001452 Src homology-3 domain 228 280 18
SM00326 SMART IPR001452 Src homology-3 domain 225 287 21
TMhelix TMHMM 177 199 959
PS50002 Prosite Profiles IPR001452 Src homology-3 domain 222 288 21
PTHR19332 HMMPANTHER 47 288 1
2.30.30.40 Gene3D 212 287 21
SSF50044 SuperFamily IPR001452 Src homology-3 domain 222 287 21
PR00452 PRINTS IPR001452 Src homology-3 domain 262 271 12
PR00452 PRINTS IPR001452 Src homology-3 domain 240 255 12
PR00452 PRINTS IPR001452 Src homology-3 domain 274 286 12

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 111.30 Da
Charge 5.00
Isoelectric point 8.71
Molecular weight 32.05 kDa
Number of residues 288
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1494.32during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1665during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.49during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
peroxisomal defects8
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Positive GeneticPMID:21504829
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
ppm1leucine carboxyl methyltransferase Ppm1 (predicted) Positive GeneticPMID:22681890
sty1MAP kinase Sty1 Positive GeneticPMID:22681890
SPAC1A6.03cphospholipase (predicted) Positive GeneticPMID:22681890
xap5xap-5-like protein Positive GeneticPMID:24957674
ask1DASH complex subunit Ask1 Positive GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Positive GeneticPMID:22681890
spc34DASH complex subunit Spc34 Positive GeneticPMID:22681890
SPAC1B3.02ctranscription elongation factor, Elf1 family (predicted) Positive GeneticPMID:22681890
dam1DASH complex subunit Dam1 Positive GeneticPMID:22681890
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC3C7.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC3C7.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC3C7.10 BioGRID Interaction Datasets
Expression Viewer SPAC3C7.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC3C7.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC3C7.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC3C7.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC3C7.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC3C7.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC3C7.10 Cell Cycle Data
GEO SPAC3C7.10 GEO profiles
PInt SPAC3C7.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC3C7.10 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC3C7.10 Fission yeast phenotypic data & analysis
SPD / RIKEN11/11F07Orfeome Localization Data
UniProtKB/SwissProtO14136Peroxisomal membrane protein pex13
ModBaseO14136Database of comparative protein structure models
STRINGO14136Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593611peroxin 13 (predicted)
RefSeq mRNANM_001019042972h- peroxin 13 (predicted) (pex13), mRNA
European Nucleotide ArchiveCAB16740.1ENA Protein Mapping
UniParcUPI000006A79BUniProt Archive

Literature for pex13

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014