rpl501 (SPAC3H5.12c)

Gene Standard Namerpl501 Characterisation Statusbiological_role_inferred
Systematic IDSPAC3H5.12c Feature Typeprotein coding
Synonymsrpl5, rpl5-1 Name Description
Product60S ribosomal protein L5 (predicted) Product Size294aa, 33.46 kDa
Genomic Location Chromosome I, 3410909-3411881 (973nt); CDS:3410951-3411835 (885nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00080975S rRNA bindingIEAIPR005485GO_REF:00000022
GO:0003735structural constituent of ribosomeISOSGD:S000006052GO_REF:0000024255
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0002181cytoplasmic translationNASGO_REF:0000051446
GO:0042254ribosome biogenesisISOSGD:S000006052GO_REF:0000024338
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0022625cytosolic large ribosomal subunitISOSGD:S000006052GO_REF:000002482
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001701sensitive to bortezomib256
expressivity FYPO_EXT:0000002Cell growth assayrpl501ΔNullPECO:0000005, PECO:0000137PMID:21760946
FYPO:0002060viable vegetative cell populationMicroscopyrpl501ΔNullPMID:204732893751
Microscopyrpl501ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyrpl501ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF14204 Pfam IPR025607 Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal 193 287 2
PF00861 Pfam IPR005484 Ribosomal protein L18/L5 26 173 2
PTHR23410:SF8 HMMPANTHER 2 290 2
PTHR23410 HMMPANTHER IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 2 290 2
3.30.420.100 Gene3D 12 252 2
SSF53137 SuperFamily 140 253 7
SSF53137 SuperFamily 12 112 7
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 43 62 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 207 227 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 145 164 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 84 104 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 20 39 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 165 184 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.81 Da
Charge 8.50
Isoelectric point 9.46
Molecular weight 33.46 kDa
Number of residues 294

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS176PMID:217125471670
present during mitotic M phase
present during cellular response to thiabendazoleIDAS176PMID:18257517
present during cellular response to thiabendazoleIDAS167PMID:18257517
present during cellular response to thiabendazoleIDAS10PMID:18257517
present during mitotic M phaseexperimental evidenceS167PMID:21712547
present during mitotic M phaseexperimental evidenceS9PMID:21712547
MOD:00696phosphorylated residueNASPMID:182575171922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
330819.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
56167.62during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
72during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
8.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in bacteria1002
conserved in metazoa3428
conserved in vertebrates3402

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Two-hybridPMID:19682301
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC3H5.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC3H5.12c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC3H5.12c BioGRID Interaction Datasets
Expression Viewer SPAC3H5.12c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC3H5.12c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC3H5.12c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC3H5.12c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC3H5.12c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC3H5.12c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC3H5.12c Cell Cycle Data
GEO SPAC3H5.12c GEO profiles
PInt SPAC3H5.12c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC3H5.12c Peptides identified in tandem mass spectrometry proteomics experiments
UniProtKB/SwissProtP5282260S ribosomal protein L5-A
ModBaseP52822Database of comparative protein structure models
STRINGP52822Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_59418060S ribosomal protein L5
RefSeq mRNANM_001019604972h- 60S ribosomal protein L5 (rpl501), mRNA
European Nucleotide ArchiveAAB05674.1ENA Protein Mapping
European Nucleotide ArchiveCAB16596.1ENA Protein Mapping
MetaCycPWY-6123Inosine-5'-phosphate biosynthesis I
MetaCycPWY-6124Inosine-5'-phosphate biosynthesis II
MetaCycPWY-7234Inosine-5'-phosphate biosynthesis III
UniParcUPI000013410DUniProt Archive
UniPathwayUPA00074Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2

Literature for rpl501

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014