rpl501 (SPAC3H5.12c)


Gene Standard Namerpl501 Characterisation Statusbiological_role_inferred
Systematic IDSPAC3H5.12c Feature Typeprotein coding
Synonymsrpl5, rpl5-1 Name Description
Product60S ribosomal protein L5 (predicted) Product Size294aa, 33.46 kDa
Genomic Location Chromosome I, 3410909-3411881 (973nt); CDS:3410951-3411835 (885nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00080975S rRNA bindingIEAIPR005485GO_REF:00000022
GO:0003735structural constituent of ribosomeISOSGD:S000006052GO_REF:0000024255
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0002181cytoplasmic translationNASGO_REF:0000051445
GO:0042254ribosome biogenesisISOSGD:S000006052GO_REF:0000024326
GO:0006412translationISOSGD:S000006052GO_REF:0000024597
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0022625cytosolic large ribosomal subunitISOSGD:S000006052GO_REF:000002482
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001701sensitive to bortezomib256
expressivity FYPO_EXT:0000002Cell growth assayrpl501ΔNullPECO:0000005, PECO:0000137PMID:21760946
FYPO:0002060viable vegetative cell populationMicroscopyrpl501ΔNullPMID:204732893760
Microscopyrpl501ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopyrpl501ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
134109093411881

UTRs

Region Coordinates Reference
five_prime_UTR3410909..3410950PMID:21511999
three_prime_UTR3411836..3411881PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00861 Pfam IPR005484 Ribosomal protein L18/L5 26 173 2
PF14204 Pfam IPR025607 Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal 193 287 2
PTHR23410 HMMPANTHER IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 2 294 2
3.30.420.100 Gene3D 12 252 2
SSF53137 SuperFamily 140 253 7
SSF53137 SuperFamily 12 112 7
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 84 104 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 165 184 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 145 164 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 43 62 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 20 39 2
PR00058 PRINTS IPR005485 Ribosomal protein L5 eukaryotic/L18 archaeal 207 227 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.81 Da
Charge 8.50
Isoelectric point 9.46
Molecular weight 33.46 kDa
Number of residues 294
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineIDAS167PMID:182575171663
present during cellular response to thiabendazole
present during cellular response to thiabendazoleIDAS10PMID:18257517
present during mitotic M phaseS9PMID:21712547
present during cellular response to thiabendazoleIDAS176PMID:18257517
present during mitotic M phaseS176PMID:21712547
present during mitotic M phaseS167PMID:21712547
MOD:00696phosphorylated residueNASPMID:182575171915
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
56167.62during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
330819.6during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
72during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
8.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3393
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Two-hybridPMID:19682301
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC3H5.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC3H5.12c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC3H5.12c BioGRID Interaction Datasets
Expression Viewer SPAC3H5.12c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC3H5.12c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC3H5.12c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC3H5.12c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC3H5.12c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC3H5.12c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC3H5.12c Cell Cycle Data
GEO SPAC3H5.12c GEO profiles
PInt SPAC3H5.12c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene254364260S ribosomal protein L5
EntrezGene254364260S ribosomal protein L5
UniProtKB/SwissProtP5282260S ribosomal protein L5-A
ModBaseP52822Database of comparative protein structure models
STRINGP52822Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_59418060S ribosomal protein L5
RefSeq mRNANM_001019604972h- 60S ribosomal protein L5 (rpl501), mRNA
European Nucleotide ArchiveAAB05674ENA Protein Mapping
European Nucleotide ArchiveAAB05674.1ENA Protein Mapping
European Nucleotide ArchiveCAB16596ENA Protein Mapping
European Nucleotide ArchiveCAB16596.1ENA Protein Mapping
UniParcUPI000013410DUniProt Archive

Literature for rpl501

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014