myp2 (SPAC4A8.05c)

Gene Standard Namemyp2 ChromosomeI
Systematic IDSPAC4A8.05c Gene Start2553696
Synonymsmyo3 Gene End2547260
Productmyosin II heavy chain Myo3 Gene Length6437
Feature Typeprotein coding CDS Start2553665
Name Description CDS End2547351
Characterisation Statuspublished CDS Length6315

Ensembl Gene Location
  1. ptc4
  2. SPNCRNA.834
  3. isp6
  4. SPNCRNA.835
  5. myp2
  6. SPNCRNA.836
  7. SPAC4A8.06c
  8. SPNCRNA.837
  9. SPAC4A8.07c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000015branched cellmyp2delta (deletion)deletionPMID:9398685
FYPO:0000223elongated multiseptate cellsmyp2delta (deletion)deletionPMID:9398685
FYPO:0002060viable vegetative cell populationMicroscopymyp2delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003774motor activityISMPFAM:PF00063GO_REF:0000001
GO:0003779actin bindingICGO:0016460GO_REF:0000001
GO:0005515protein bindingIPIcdc4PMID:10769212
IPIrlc1PMID:11069761
GO:0005524ATP bindingISMPFAM:PF00063GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000910cytokinesisIMPPMID:9398685
GO:0000915cytokinesis, actomyosin contractile ring assemblyTASPMID:12589679
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005739mitochondrionIDAPMID:16823372
GO:0005826actomyosin contractile ringIDAPMID:9398685
GO:0016460myosin II complexTASPMID:9398685
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
125536962547260

References

Region Start End Reference
three_prime_UTR25473502547260PMID:21511999
five_prime_UTR25536962553666PMID:21511999
three_prime_UTR25473502547260PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF02736 IPR004009 Pfam Myosin, N-terminal, SH3-like 37 76 2
PF00063 IPR001609 Pfam Myosin head, motor domain 91 755 5
SM00242 IPR001609 SMART Myosin head, motor domain 83 768 5
G3DSA:4.10.270.10 Gene3D 766 829 2
SSF50084 IPR008989 SuperFamily 37 69 1
SSF52540 SuperFamily 61 824 294
Coil ncoils Rabaptin coiled-coil domain 1170 1198 974
Coil ncoils Rabaptin coiled-coil domain 1931 1952 974
Coil ncoils Rabaptin coiled-coil domain 988 1083 974
Coil ncoils Rabaptin coiled-coil domain 1329 1350 974
Coil ncoils Rabaptin coiled-coil domain 1665 1686 974
Coil ncoils Rabaptin coiled-coil domain 1480 1501 974
Coil ncoils Rabaptin coiled-coil domain 890 939 974
Coil ncoils Rabaptin coiled-coil domain 1215 1236 974
Coil ncoils Rabaptin coiled-coil domain 1820 1876 974
Coil ncoils Rabaptin coiled-coil domain 1623 1644 974
Coil ncoils Rabaptin coiled-coil domain 1121 1163 974
Coil ncoils Rabaptin coiled-coil domain 838 866 974
Coil ncoils Rabaptin coiled-coil domain 1729 1764 974
Coil ncoils Rabaptin coiled-coil domain 2003 2048 974
Coil ncoils Rabaptin coiled-coil domain 2052 2080 974
PR00193 IPR001609 PRINTS Myosin head, motor domain 119 138 5
PR00193 IPR001609 PRINTS Myosin head, motor domain 222 249 5
PR00193 IPR001609 PRINTS Myosin head, motor domain 507 535 5
PR00193 IPR001609 PRINTS Myosin head, motor domain 175 200 5
PR00193 IPR001609 PRINTS Myosin head, motor domain 453 481 5
PTHR13140 hmmpanther 12 2091 8
PTHR13140:SF23 hmmpanther 12 2091 2

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744

Protein Properties

Ave. residue weight 115.29 Da
Charge 2.00
Isoelectric point 6.60
Molecular weight 242.57 kDa
Number of residues 2104
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000201,
PECO:0000005		single_cell6100PMID:16224022
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide495.04PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.55PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.9PMID:23101633
Disease Association
DescriptionQualifierReference
cancer
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
SPCC613.03conserved fungal protein Negative GeneticPMID:22681890
sec63ER protein translocation subcomplex subunit Sec63 (predicted) Negative GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Positive GeneticPMID:18818364
bst1GPI inositol deacylase Bst1 (predicted) Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
imp2contractile ring protein Imp2 Synthetic LethalityPMID:19139265
vps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
mid1medial ring protein Mid1 Negative GeneticPMID:22681890
erp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
SPAC6G9.14RNA-binding protein (predicted) Negative GeneticPMID:22681890
act1actin Act1 Synthetic Growth DefectPMID:9459302
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
csc4SIP/FAR complex subunit, Csc4 Negative GeneticPMID:22681890
cis4cation diffusion family zinc membrane transporter Cis4 Negative GeneticPMID:22681890
cdc8tropomyosin Synthetic Growth DefectPMID:9459302
chs2chitin synthase homolog Chs2 Synthetic LethalityPMID:16772338
rsv2transcription factor Rsv2 Positive GeneticPMID:18818364
gef2RhoGEF Gef2 Phenotypic EnhancementPMID:22298427
SPBP8B7.02sequence orphan Negative GeneticPMID:22681890
vps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:22681890
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Synthetic LethalityPMID:9398685
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:18818364
zrg17cation diffusion family zinc membrane transporter Zrg17 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Synthetic LethalityPMID:19139265
myo2myosin II heavy chain Synthetic Growth DefectPMID:10637292
Synthetic Growth DefectPMID:10769212
Synthetic LethalityPMID:22275432
Synthetic LethalityPMID:16772338
Dosage RescuePMID:20110347
trx2mitochondrial thioredoxin Trx2 Negative GeneticPMID:22681890
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Negative GeneticPMID:22681890
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:23087209
Phenotypic Enhancement
pmr1P-type ATPase, calcium transporting Pmr1 Negative GeneticPMID:22681890
far8SIP/FAR complex striatin subunit, Far8/Csc3 Negative GeneticPMID:22681890
cdc4myosin II light chain Synthetic LethalityPMID:20739711
ppb1calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1 Synthetic RescuePMID:12136004
Synthetic Lethality
cdc14SIN component Cdc14 Synthetic LethalityPMID:9398685
cdc16two-component GAP Cdc16 Synthetic LethalityPMID:9398685
cay1cactin, spliceosome complex subunit (predicted) Negative GeneticPMID:18818364
spo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
kin1microtubule affinity-regulating kinase Kin1 Phenotypic EnhancementPMID:23294323
Positive GeneticPMID:22681890
ubp4ubiquitin C-terminal hydrolase Ubp4 Negative GeneticPMID:22681890
gyp1GTPase activating protein Gyp1 (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
cdc4myosin II light chain Two-hybridPMID:10769212
Affinity Capture-Western
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
myo1myosin type I Affinity Capture-RNAPMID:19805578
chs2chitin synthase homolog Chs2 Co-localizationPMID:16772338
Affinity Capture-Western
rng2IQGAP Affinity Capture-RNAPMID:19805578
mcp7meiosis specific coiled-coil protein Mcp7 Affinity Capture-RNAPMID:19805578
mto1MT organizer Mto1 Affinity Capture-WesternPMID:20970338
myo2myosin II heavy chain Affinity Capture-RNAPMID:19805578
myo52myosin type V Affinity Capture-RNAPMID:19805578
rlc1myosin II regulatory light chain Rlc1 Affinity Capture-WesternPMID:11069761
myo51myosin type V Affinity Capture-RNAPMID:19805578
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External References
Database Identifier Description
NBRP SPAC4A8.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC4A8.05c Retrieval of eukaryotic orthologs
BioGrid SPAC4A8.05c BioGRID Interaction Datasets
Bähler Lab SPAC4A8.05c Cell Cycle Expression Profile
Bähler Lab SPAC4A8.05c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC4A8.05c Pheromone response/mating expression profiles
Bähler Lab SPAC4A8.05c Environmental stress expression profiles
Bähler Lab SPAC4A8.05c Bähler Lab Transcriptome Viewer
Cyclebase SPAC4A8.05c Cell Cycle Data
PInt SPAC4A8.05c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC4A8.05c Entrez Gene
WikiGene2543576myosin II heavy chain Myo3
Uniprot_genenameMYO3
EntrezGene2543576myosin II heavy chain Myo3
SPD / RIKEN34/34C05Orfeome Localization Data
UniProtKB/SwissProtO14157Myosin type-2 heavy chain 2
ModBaseO14157Database of comparative protein structure models
Pfam Protein DomainsO14157Pfam Domain Arrangement
RefSeq PeptideNP_593816myosin II heavy chain Myo3
RefSeq mRNANM_001019246972h- myosin II heavy chain Myo3 (myp2), mRNA
European Nucleotide ArchiveAAC04615ENA Protein Mapping
European Nucleotide ArchiveBAA24579ENA Protein Mapping
European Nucleotide ArchiveBAA87116ENA Protein Mapping
European Nucleotide ArchiveCAB11475ENA Protein Mapping
UniParcUPI000012FBD6UniProt Archive

Literature for myp2
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013