SPAC4A8.07c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC4A8.07c Feature Typeprotein coding
Synonyms Name Description
Productsphingoid long chain base kinase (predicted) Product Size458aa, 51.29 kDa
Genomic Location Chromosome I, 2558444-2556600 (1845nt); CDS:2558297-2556773 (1525nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0017050D-erythro-sphingosine kinase activityISOSGD:S000005697GO_REF:00000241
GO:0003951NAD+ kinase activityIEAIPR016064GO_REF:00000025
GO:0004143diacylglycerol kinase activityIEAIPR001206GO_REF:00000021
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0019722calcium-mediated signalingISOSGD:S000005697GO_REF:00000246
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathwayIEAIPR001206GO_REF:00000021
GO:0046520sphingoid biosynthetic processISOSGD:S000005697GO_REF:00000242
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusISOSGD:S000005697GO_REF:0000024355
GO:0005783endoplasmic reticulumISOSGD:S000005697GO_REF:0000024594
GO:0031902late endosome membraneIEASL-0151GO_REF:00000398
GO:0005886plasma membraneIEAUniProtKB-KW:KW-1003GO_REF:0000037243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC4A8.07cΔNullPECO:0000005, PECO:0000137PMID:236978063755
MicroscopySPAC4A8.07cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPAC4A8.07cΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
125584442558183
225581232557938
325578482556600

UTRs

Region Start End Reference
three_prime_UTR25567722556600PMID:21511999
five_prime_UTR25584442558298PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00781 Pfam IPR001206 Diacylglycerol kinase, catalytic domain 108 223 1
SM00046 SMART IPR001206 Diacylglycerol kinase, catalytic domain 107 265 1
PS50146 Prosite Profiles IPR001206 Diacylglycerol kinase, catalytic domain 103 241 1
PTHR12358:SF8 HMMPANTHER 85 448 1
PTHR12358 HMMPANTHER 85 448 2
SSF111331 SuperFamily IPR016064 105 293 5
SSF111331 SuperFamily IPR016064 331 449 5

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.98 Da
Charge 3.50
Isoelectric point 7.06
Molecular weight 51.29 kDa
Number of residues 458
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2767.91during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
3541.23during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.57during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC4A8.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC4A8.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC4A8.07c BioGRID Interaction Datasets
Expression Viewer SPAC4A8.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC4A8.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC4A8.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC4A8.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC4A8.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC4A8.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC4A8.07c Cell Cycle Data
GEO SPAC4A8.07c GEO profiles
PInt SPAC4A8.07c Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz2.7.1.107Integrated relational Enzyme database
Rhea2.7.1.107Annotated reactions database
WikiGene2543328sphingoid long chain base kinase (predicted)
EntrezGene2543328sphingoid long chain base kinase (predicted)
SPD / RIKEN24/24G05Orfeome Localization Data
UniProtKB/SwissProtO14159Sphingoid long chain base kinase 4
ModBaseO14159Database of comparative protein structure models
StringO14159Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593818sphingoid long chain base kinase (predicted)
RefSeq mRNANM_001019248972h- sphingoid long chain base kinase (predicted) (SPAC4A8.07c), mRNA
European Nucleotide ArchiveCAB11477ENA Protein Mapping
UniParcUPI0000069FBCUniProt Archive

Literature for SPAC4A8.07c

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014