cdc3 (SPAC4A8.15c)

Gene Standard Namecdc3 ChromosomeI
Systematic IDSPAC4A8.15c Gene Start2579514
Synonyms Gene End2578956
Productprofilin Gene Length559
Feature Typeprotein coding CDS Start2579478
Name Description CDS End2578990
Characterisation Statuspublished CDS Length489

Ensembl Gene Location
  1. fas2
  2. sds22
  3. pts1
  4. SPAC4A8.14
  5. SPATRNAILE.02
  6. cdc3
  7. tif33
  8. SPNCRNA.840
  9. SPAC823.02
  10. ppk15
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000133elongated multinucleate cellMicroscopycdc3-124 (E43K)amino_acid_mutationPECO:0000004PMID:8207058
FYPO:0000252increased spontaneous diploidizationOthercdc3-313 (unknown)unknownNot specifiedPMID:8834798
FYPO:0000339mislocalized septumMicroscopycdc3-124 (E43K)amino_acid_mutationPECO:0000004PMID:8207058
FYPO:0000727abnormal actin filament organizationMicroscopycdc3+ (wild type)wild_typeOverexpressionPMID:8207058
FYPO:0000779dumbbell-shaped cellMicroscopycdc3-124 (E43K)amino_acid_mutationPECO:0000004PMID:8207058
Microscopycdc3delta (deletion)deletionPMID:8207058
Microscopycdc3+ (wild type)wild_typeOverexpressionPMID:8207058
FYPO:0000791abnormal actin cortical patch morphologyMicroscopycdc3-313 (unknown)unknownNot specifiedPECO:0000004PMID:8834798
FYPO:0001006multinucleate dumbbell-shaped cellMicroscopycdc3-124 (E43K)amino_acid_mutationEndogenousPECO:0000004PMID:958201
Microscopycdc3-6 (unknown)unknownEndogenousPECO:0000004PMID:958201
FYPO:0001007normal mitosisMicroscopycdc3-124 (E43K)amino_acid_mutationEndogenousPMID:8207058
FYPO:0001009abolished actomyosin contractile ring assemblyMicroscopycdc3+ (wild type)wild_typeOverexpressionPMID:8207058
Microscopycdc3delta (deletion)deletionPMID:8207058
Microscopycdc3-124 (E43K)amino_acid_mutationEndogenousPECO:0000004PMID:8207058
FYPO:0001011filamentous actin absentMicroscopycdc3delta (deletion)deletionPMID:8207058
FYPO:0002025inviable elongated multinucleate vegetative cell with abnormal septum morphologyMicroscopycdc3-313 (unknown)unknownNot specifiedPECO:0000004PMID:8834798
FYPO:0002061inviable vegetative cell populationMicroscopycdc3delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003785actin monomer bindingIDAPMID:11294914
GO:0005085guanyl-nucleotide exchange factor activityIDAPMID:11294914
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000915cytokinesis, actomyosin contractile ring assemblyIGIPMID:8207058
IMPPMID:8207058
IMPPMID:8834798
GO:0030041actin filament polymerizationIMPPMID:11231572
GO:0032220plasma membrane fusion involved in cytogamyIMPPMID:9490631
GO:0044396actin cortical patch organizationIMPPMID:8834798
GO:0071519actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assemblyNASGO_REF:0000001
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0005937mating projectionIDAPMID:9490631
GO:0030479actin cortical patchTASPMID:8978670
GO:0031097medial cortexIDAPMID:8207058
GO:0051285cell cortex of cell tipIDAPMID:8207058
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
125795142579466
225794162579084
325790272578956
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00235 IPR002097 Pfam Profilin 2 122 1
SM00392 IPR002097 SMART Profilin 1 127 1
PS00414 IPR002097 Prosite Patterns Profilin conserved site 1 8 1
G3DSA:3.30.450.30 Gene3D 1 127 2
SSF55770 IPR002097 SuperFamily 2 127 1
PR01640 IPR005455 PRINTS Profilin 49 63 1
PR01640 IPR005455 PRINTS Profilin 113 126 1
PR01640 IPR005455 PRINTS Profilin 1 12 1
PR01640 IPR005455 PRINTS Profilin 100 113 1
PR01640 IPR005455 PRINTS Profilin 25 38 1
PR01640 IPR005455 PRINTS Profilin 68 77 1
PR00392 IPR002097 PRINTS Profilin 61 75 1
PR00392 IPR002097 PRINTS Profilin 18 27 1
PR00392 IPR002097 PRINTS Profilin 37 57 1
PR00392 IPR002097 PRINTS Profilin 96 109 1
PR00392 IPR002097 PRINTS Profilin 3 12 1
PR00392 IPR002097 PRINTS Profilin 109 126 1
PTHR11604 IPR005455 hmmpanther Profilin 2 127 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 105.60 Da
Charge -0.50
Isoelectric point 5.82
Molecular weight 13.41 kDa
Number of residues 127
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide48285.67PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide60595.21PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide15PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic Growth DefectPMID:23297348
ain1alpha-actinin Synthetic LethalityPMID:11294907
acp1F-actin capping protein alpha subunit Synthetic LethalityPMID:16866873
arc1ARP2/3 actin-organizing complex subunit Sop2 Synthetic Growth DefectPMID:8978670
Synthetic Rescue
cdc12formin Cdc12 Synthetic LethalityPMID:9105045
cdc16two-component GAP Cdc16 Phenotypic EnhancementPMID:20805322
imp2contractile ring protein Imp2 Synthetic Growth DefectPMID:19139265
acp2F-actin capping protein beta subunit (predicted) Synthetic LethalityPMID:15743909
Synthetic LethalityPMID:16866873
Phenotypic Enhancement
sid2NDR kinase Sid2 Phenotypic SuppressionPMID:20805322
wee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:20805322
asp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Synthetic RescuePMID:10388810
ssp1serine/threonine protein kinase Ssp1 Phenotypic SuppressionPMID:10233158
adf1actin depolymerizing factor, cofilin Synthetic LethalityPMID:16467379
Phenotypic Enhancement
act1actin Act1 Synthetic Growth DefectPMID:10371213
Phenotypic SuppressionPMID:8207058
sec8exocyst complex subunit Sec8 Phenotypic EnhancementPMID:21148300
arp2ARP2/3 actin-organizing complex subunit Arp2 Synthetic RescuePMID:10588653
pom1DYRK family protein kinase Pom1 Synthetic LethalityPMID:9573052
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
mob2protein kinase activator Mob2 Co-localizationPMID:12456722
cdc12formin Cdc12 Reconstituted ComplexPMID:18305104
Co-localizationPMID:9105045
Reconstituted Complex
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External References
Database Identifier Description
NBRP SPAC4A8.15c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC4A8.15c Retrieval of eukaryotic orthologs
BioGrid SPAC4A8.15c BioGRID Interaction Datasets
Bähler Lab SPAC4A8.15c Cell Cycle Expression Profile
Bähler Lab SPAC4A8.15c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC4A8.15c Pheromone response/mating expression profiles
Bähler Lab SPAC4A8.15c Environmental stress expression profiles
Bähler Lab SPAC4A8.15c Bähler Lab Transcriptome Viewer
Cyclebase SPAC4A8.15c Cell Cycle Data
PInt SPAC4A8.15c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC4A8.15c Entrez Gene
WikiGene2543526profilin
Uniprot_genenameCDC3
EntrezGene2543526profilin
SPD / RIKEN41/41C06Orfeome Localization Data
UniProtKB/SwissProtP39825Profilin
ModBaseP39825Database of comparative protein structure models
Pfam Protein DomainsP39825Pfam Domain Arrangement
RefSeq PeptideNP_593827profilin
RefSeq mRNANM_001019256972h- profilin (cdc3), mRNA
European Nucleotide ArchiveCAB38578ENA Protein Mapping
UniParcUPI000013231DUniProt Archive

Literature for cdc3
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013