ypa1 (SPAC4F10.04)


Gene Standard Nameypa1 Characterisation Statuspublished
Systematic IDSPAC4F10.04 Feature Typeprotein coding
Synonymsrrd1 Name DescriptionYeast Phosphatase Activator
Productprotein phosphatase type 2A regulator, PTPA family Ypa1 Product Size325aa, 37.17 kDa
Genomic Location Chromosome I, 4836136-4837590 (1455nt); CDS:4836395-4837415 (1021nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
peptidyl-prolyl cis-trans isomerase activity16
Annotation ExtensionEvidenceWith/FromReference
phosphatase activator activity5
Annotation ExtensionEvidenceWith/FromReference
protein phosphatase type 2A regulator activity7
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
regulation of protein phosphatase type 2A activity6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4209
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on glucose carbon sourceypa1ΔNull258
increased septation indexypa1ΔNull47
normal growth on terbinafineypa1ΔNull37
sensitive to amphotericin Bypa1ΔNull69
sensitive to bortezomibypa1ΔNull256
sensitive to cadmiumypa1ΔNull246
sensitive to clotrimazoleypa1ΔNull105
sensitive to doxorubicinypa1ΔNull91
sensitive to micafunginypa1ΔNull116
sensitive to rapamycinypa1ΔNull78
sensitive to terbinafineypa1ΔNull102
viable vegetative cell populationypa1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
abnormal actin cytoskeletonypa1ΔNull46
abnormal cell separation after cytokinesisypa1ΔNull83
abnormal microtubule cytoskeleton morphology during mitotic interphaseypa1ΔNull186
decreased phosphatase activity during cellular response to phosphate starvationypa1ΔNull10
microtubule bundles present in greater numbersypa1ΔNull23
vegetative cell lysisypa1ΔNull83
viable elongated vegetative cellypa1ΔNull301
viable vegetative cell with abnormal cell shapeypa1ΔNull482
viable vegetative cell, abnormal cell shape, normal cell sizeypa1ΔNull215
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4836136..4837267, 4837311..4837590
mRNA4836136..4837590
5' UTR4836136..4836394PMID:21511999
CDS4836395..4837267, 4837311..4837415
3' UTR4837416..4837590PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03095 Pfam IPR004327 Phosphotyrosyl phosphatase activator, PTPA 25 321 2
PTHR10012:SF0 HMMPANTHER 1 321 1
PTHR10012 HMMPANTHER IPR004327 Phosphotyrosyl phosphatase activator, PTPA 1 321 2
SSF140984 SuperFamily 20 320 2
PIRSF016325 PIRSF IPR004327 Phosphotyrosyl phosphatase activator, PTPA 14 325 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.37 Da
Charge 4.00
Isoelectric point 7.36
Molecular weight 37.17 kDa
Number of residues 325
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6230during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
6106during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4986during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
513.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.25during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withada1adenosine deaminase Ada1 Negative GeneticPMID:22681890
negative genetic interaction withade7phosphoribosylamidoimidazolesuccinocarboxamide synthase, SAICAR synthetase, Ade7 Negative GeneticPMID:22681890
negative genetic interaction withadn2transcription factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withadn3transcription factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withalg5dolichyl-phosphate beta-glucosyltransferase Alg5 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withalg6glucosyltransferase Alg6 Negative GeneticPMID:22681890
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
positive genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:18818364
positive genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:22681890
negative genetic interaction withapm3AP-3 adaptor complex subunit Apm3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withapm4AP-2 adaptor complex subunit Apm4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withapq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witharf6ADP-ribosylation factor, Arf family Arf6 Negative GeneticPMID:22681890
positive genetic interaction witharp6actin-like protein Arp6 Positive GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:18818364
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:22681890
positive genetic interaction withatg17autophagy associated protein kinase activator Atg17 Positive GeneticPMID:22681890
positive genetic interaction withatg1801WD repeat protein involved in autophagy Atg18a Positive GeneticPMID:18818364
negative genetic interaction withatg20autophagy associated sorting nexin Atg20 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withatg5autophagy associated protein Atg5 Positive GeneticPMID:22681890
positive genetic interaction withatg9autophagy associated protein Atg9 Positive GeneticPMID:22681890
negative genetic interaction withath1ataxin-2 homolog Negative GeneticPMID:22681890
positive genetic interaction withatp14F1-ATPase subunit H (predicted) Positive GeneticPMID:22681890
negative genetic interaction withaut12autophagy associated protein Aut12 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withaut12autophagy associated protein Aut12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withbio2biotin synthase Negative GeneticPMID:22681890
negative genetic interaction withblt1ubiquitin domain-like protein Blt1 Negative GeneticPMID:22681890
positive genetic interaction withbob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withbqt4bouquet formation protein Bqt4 Negative GeneticPMID:22681890
negative genetic interaction withbtb1BTB/POZ domain protein Btb1 Negative GeneticPMID:22681890
negative genetic interaction withbun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:18818364
positive genetic interaction withcbp1CENP-B homolog Positive GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcsr102sec14 cytosolic factor family phosphatidylinositol transmembrane transporter (predicted) Negative GeneticPMID:22681890
positive genetic interaction withcta3P-type ATPase, potassium exporting Cta3 Positive GeneticPMID:22681890
positive genetic interaction withctl1choline transmembrane transporter family protein Ctl1 Positive GeneticPMID:22681890
synthetically rescuescut3condensin complex subunit Cut3 Synthetic RescuePMID:24945319
negative genetic interaction withcwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
negative genetic interaction withcxr1mRNA processing factor Negative GeneticPMID:22681890
negative genetic interaction withcyp7cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withdbl1double strand break localizing Dbl1 Negative GeneticPMID:22681890
negative genetic interaction withdbl6double strand break localizing protein Dbl6 Negative GeneticPMID:22681890
positive genetic interaction withdbl8tRNA-splicing endonuclease positive effector Dbl8 Positive GeneticPMID:22681890
negative genetic interaction withdeg1tRNA-pseudouridine synthase Deg1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withdga1diacylglycerol O-acyltransferase Dga1 Negative GeneticPMID:22681890
negative genetic interaction withdlc1dynein light chain Dlc1 Negative GeneticPMID:22681890
negative genetic interaction withent3ENTH/VHS domain protein Ent3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
negative genetic interaction witherd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
negative genetic interaction witherg28Erg28 protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction witherg5C-22 sterol desaturase Erg5 Negative GeneticPMID:18818364
negative genetic interaction witherg5C-22 sterol desaturase Erg5 Negative GeneticPMID:22681890
negative genetic interaction witherp2COPII-coated vesicle component Erp2/3/4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withest1telomerase regulator Est1 Negative GeneticPMID:18818364
negative genetic interaction withexg3glucan 1,3-beta-glucosidase Exg3 Negative GeneticPMID:22681890
negative genetic interaction withexo70exocyst complex subunit Exo70 Negative GeneticPMID:22681890
positive genetic interaction withfbh1DNA helicase I, ubiquitin ligase F-box adaptor Fbh1 Positive GeneticPMID:18818364
negative genetic interaction withfcf2rRNA processing protein Fcf2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
negative genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
negative genetic interaction withfis1mitochondrial fission protein Fis1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfsv1SNARE Fsv1 Negative GeneticPMID:22681890
negative genetic interaction withgcd10tRNA (m1A) methyltransferase Gcd10 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgdh1NADP-specific glutamate dehydrogenase Gdh1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgit5heterotrimeric G protein beta subunit Git5 Negative GeneticPMID:22681890
negative genetic interaction withgld1mitochondrial glycerol dehydrogenase Gld1 Negative GeneticPMID:22681890
negative genetic interaction withgmh6alpha-1,2-galactosyltransferase Gmh6 Negative GeneticPMID:22681890
negative genetic interaction withgos1SNARE Gos1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgpa2heterotrimeric G protein alpha-2 subunit Gpa2 Negative GeneticPMID:22681890
negative genetic interaction withgpd3glyceraldehyde 3-phosphate dehydrogenase Gpd3 Negative GeneticPMID:22681890
negative genetic interaction withhac12-hydroxyacyl-CoA lyase Hac1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withhem2porphobilinogen synthase Hem2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withhif2Set3 complex subunit Hif2 Negative GeneticPMID:18818364
negative genetic interaction withhmt1vacuolar transmembrane transporter Hmt1 Negative GeneticPMID:22681890
negative genetic interaction withhob3BAR adaptor protein Hob3 Negative GeneticPMID:22681890
negative genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:18818364
positive genetic interaction withidp1isocitrate dehydrogenase Idp1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withilv1acetolactate synthase catalytic subunit Negative GeneticPMID:22681890
negative genetic interaction withimp1importin alpha Negative GeneticPMID:22681890
negative genetic interaction withire1serine/threonine protein kinase, sensor for unfolded proteins in the ER Ire1 Negative GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
negative genetic interaction withknk1AAA family ATPase kink, Knk1 Negative GeneticPMID:22681890
negative genetic interaction withlag1sphingosine N-acyltransferase Lag1 Negative GeneticPMID:22681890
negative genetic interaction withleo1RNA polymerase II associated Paf1 complex (predicted) Negative GeneticPMID:18818364
negative genetic interaction withleo1RNA polymerase II associated Paf1 complex (predicted) Negative GeneticPMID:22681890
negative genetic interaction withliz1pantothenate transmembrane transporter Liz1 Negative GeneticPMID:22681890
negative genetic interaction withlon1Lon protease homolog Lon1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withlub1WD repeat protein Lub1 Negative GeneticPMID:22681890
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withmad3mitotic spindle checkpoint protein Mad3 Negative GeneticPMID:22681890
negative genetic interaction withmam3cell agglutination protein Mam3 Negative GeneticPMID:22681890
negative genetic interaction withmbx1MADS-box transcription factor Mbx1 Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
negative genetic interaction withmed20mediator complex subunit Med20 Negative GeneticPMID:18818364
negative genetic interaction withmed6mediator complex subunit Med6 Negative GeneticPMID:18818364
positive genetic interaction withmex67mRNA export receptor, Tap, nucleoporin Mex67 Positive GeneticPMID:22681890
negative genetic interaction withmfm2M-factor precursor Mfm2 Negative GeneticPMID:22681890
positive genetic interaction withmgr2TIM23 translocase complex subunit Mgr2 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withmid1medial ring protein Mid1 Negative GeneticPMID:22681890
positive genetic interaction withmms19Dos2 silencing complex subunit Mms19 Positive GeneticPMID:18818364
negative genetic interaction withmoc3transcription factor Moc3 Negative GeneticPMID:22681890
negative genetic interaction withmpc1mitochondrial pyruvate transmembrane transporter subunit Mpc1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmst2histone acetyltransferase Mst2 Negative GeneticPMID:18818364
negative genetic interaction withmsy1MS calcium ion channel protein Msy1 Negative GeneticPMID:22681890
negative genetic interaction withmug113T5orf172 family protein Negative GeneticPMID:22681890
negative genetic interaction withmug33Tea1-interacting protein involved in exocytosis Negative GeneticPMID:22681890
negative genetic interaction withmug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmyh1adenine DNA glycosylase Myh1 Negative GeneticPMID:22681890
negative genetic interaction withnap1nucleosome assembly protein Nap1 Negative GeneticPMID:18818364
negative genetic interaction withnap1nucleosome assembly protein Nap1 Negative GeneticPMID:22681890
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
negative genetic interaction withnot2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withnto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withoca2serine/threonine protein kinase Oca2 Negative GeneticPMID:22681890
positive genetic interaction withpac10prefoldin subunit 3 Pac10 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
negative genetic interaction withpar1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
negative genetic interaction withpck1protein kinase C (PKC)-like Pck1 Negative GeneticPMID:22681890
negative genetic interaction withpds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
negative genetic interaction withpds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:22681890
negative genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
negative genetic interaction withplh1phospholipid-diacylglycerol acyltransferase Plh1 Negative GeneticPMID:22681890
negative genetic interaction withpmp1dual-specificity MAP kinase phosphatase Pmp1 Negative GeneticPMID:18818364
negative genetic interaction withpmp1dual-specificity MAP kinase phosphatase Pmp1 Negative GeneticPMID:22681890
negative genetic interaction withpmr1P-type ATPase, calcium transporting Pmr1 Negative GeneticPMID:22681890
positive genetic interaction withpnk1DNA kinase/phosphatase Pnk1 Positive GeneticPMID:18818364
negative genetic interaction withpof15F-box protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
negative genetic interaction withpom2DYRK family protein kinase Pom2 Negative GeneticPMID:22681890
synthetic growth defect withppa2serine/threonine protein phosphatase Ppa2 Synthetic Growth DefectPMID:22267499
negative genetic interaction withppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
negative genetic interaction withppk33serine/threonine protein kinase Ppk33 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
positive genetic interaction withppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
negative genetic interaction withpsh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
negative genetic interaction withpso2DNA 5' exonuclease (predicted) Negative GeneticPMID:22681890
negative genetic interaction withptl2triacylglycerol lipase ptl2 Negative GeneticPMID:22681890
negative genetic interaction withpuc1cyclin Puc1 Negative GeneticPMID:22681890
negative genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
negative genetic interaction withrap1telomere binding protein Rap1 Negative GeneticPMID:18818364
negative genetic interaction withrds1conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withrec11meiotic cohesin complex subunit Rec11 Negative GeneticPMID:22681890
negative genetic interaction withrep1MBF transcription factor activator Rep1 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
negative genetic interaction withrga8Rho-type GTPase activating protein Rga8 Negative GeneticPMID:22681890
negative genetic interaction withrhp23Rad23 homolog Rhp23 Negative GeneticPMID:22681890
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:18818364
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:22681890
negative genetic interaction withrod1arrestin/PY protein involved in ubiquitin-mediated endocytosis Rod1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrog1acylglycerol lipase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrpl10260S ribosomal protein L10a Positive GeneticPMID:22681890
positive genetic interaction withrpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrpl200160S ribosomal protein L20a (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpl230160S ribosomal protein L23 Negative GeneticPMID:22681890
positive genetic interaction withrpl240160S ribosomal protein L24 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrpp20160S acidic ribosomal protein A2 Negative GeneticPMID:22681890
positive genetic interaction withrps00140S ribosomal protein S0A (p40) Positive GeneticPMID:22681890
negative genetic interaction withrps190240S ribosomal protein S19 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpt419S proteasome regulatory subunit Rpt4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
negative genetic interaction withsat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
negative genetic interaction withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Negative GeneticPMID:22681890
negative genetic interaction withser3D-3 phosphoglycerate dehydrogenase Ser3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:25076038
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:22681890
negative genetic interaction withshm1serine hydroxymethyltransferase Shm1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withskb5Shk1 kinase binding protein 5 Negative GeneticPMID:22681890
negative genetic interaction withski2Ski complex RNA helicase Ski2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsno1glutamine aminotransferase subunit Sno1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC10F6.13caspartate aminotransferase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC1296.01cphosphoacetylglucosamine mutase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC1399.02transmembrane transporter (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC1705.02human 4F5S homolog Negative GeneticPMID:22681890
negative genetic interaction withSPAC17H9.04cRNA-binding protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.14Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC1A6.03cphospholipase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC212.01cS. pombe specific DUF999 family protein 2 Negative GeneticPMID:22681890
negative genetic interaction withSPAC212.06cDNA helicase in rearranged telomeric region, truncated Negative GeneticPMID:22681890
negative genetic interaction withSPAC22H10.02conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC23C4.09cDNA-binding TFAR19-related protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC24H6.13DUF221 family protein implicated in Golgi to plasma membrane transport (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC3G9.11cpyruvate decarboxylase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC3H5.08cWD repeat protein, human WDR44 family Negative GeneticPMID:22681890
negative genetic interaction withSPAC4A8.14ribose-phosphate pyrophosphokinase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC9.02cpolyamine N-acetyltransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC926.06cleucine-rich repeat protein, unknown role Negative GeneticPMID:22681890
negative genetic interaction withSPAP32A8.02xylose and arabinose reductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAPB1A10.08Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAPB1A10.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAPB21F2.02Dopey family protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAPJ695.01cS. pombe specific UPF0321 family protein 3 Negative GeneticPMID:22681890
negative genetic interaction withSPBC106.12cTHO complex subunit (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC115.03gfo/idh/mocA family oxidoreductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1198.08dipeptidase Dug1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC12C2.03cmethionine synthase reductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1348.01S. pombe specific DUF999 protein family 5 Negative GeneticPMID:22681890
negative genetic interaction withSPBC1652.01ribosomal RNA processing element (RRPE)-binding protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1683.03ctransmembrane transporter (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.12cconserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBC1773.17cglyoxylate reductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1778.05chuman LAMTOR2 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBC21B10.07glycosyl hydrolase family (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC21B10.08cantibiotic biosynthesis monooxygenase-like domain (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC21C3.06Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC28E12.02RNA-binding protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC2G5.01ER protein involved in ER-nucleus signaling (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
negative genetic interaction withSPBC365.16conserved protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC651.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC6B1.03cPal1 family protein Negative GeneticPMID:22681890
rescuesSPBC713.07cvacuolar polyphosphatase (predicted) Phenotypic SuppressionPMID:21169418
negative genetic interaction withSPBC8E4.05cfumarate lyase superfamily Negative GeneticPMID:22681890
negative genetic interaction withSPBCPT2R1.01cS. pombe specific DUF999 protein family 9 Negative GeneticPMID:22681890
negative genetic interaction withSPBP35G2.14RNA-binding protein Negative GeneticPMID:22681890
negative genetic interaction withSPBP4H10.17ccarboxyl methyl esterase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBP4H10.17ccarboxyl methyl esterase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withspc34DASH complex subunit Spc34 Positive GeneticPMID:18818364
negative genetic interaction withSPCC1393.08transcription factor, zf-GATA type (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC1442.02central kinetochore associated family protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC18.13tRNA (guanine-N7-)-methyltransferase subunit Trm82 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC1827.03cacetyl-CoA ligase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC188.10cNegative GeneticPMID:22681890
negative genetic interaction withSPCC18B5.10cTREX complex subunit Tex1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPCC24B10.18human Leydig cell tumor 10 kDa protein homolog Negative GeneticPMID:22681890
negative genetic interaction withSPCC285.10cSPRY domain protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC306.11Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC4B3.02cGolgi transport protein Got1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC550.11karyopherin (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC569.04Schizosaccharomyces pombe specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC584.01csulfite reductase NADPH flavoprotein subunit (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC584.15carrestin involved in ubiquitin-dependent endocytosis Negative GeneticPMID:22681890
negative genetic interaction withSPCC594.01DUF1769 family protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC663.15cconserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withspf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
negative genetic interaction withspn3mitotic septin Spn3 Negative GeneticPMID:22681890
negative genetic interaction withsrb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
negative genetic interaction withsrk1MAPK-activated protein kinase Srk1 Negative GeneticPMID:22681890
negative genetic interaction withsro7Lgl family protein Sro7 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withssa1heat shock protein Ssa1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
positive genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
positive genetic interaction withswd22mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22 Positive GeneticPMID:18818364
negative genetic interaction withswd3WD repeat protein Swd3 Negative GeneticPMID:18818364
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
negative genetic interaction withtad1tRNA specific adenosine-37 deaminase Tad1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtal1transaldolase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:18818364
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:22681890
negative genetic interaction withtcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
negative genetic interaction withtef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
negative genetic interaction withtos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtrk1potassium ion transmembrane transporter Trk1 Negative GeneticPMID:22681890
positive genetic interaction withtrm10tRNA m(1)G methyltransferase Trm10 Positive GeneticPMID:18818364
negative genetic interaction withtrs130TRAPP complex subunit Trs130 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtsc1hamartin Negative GeneticPMID:22681890
negative genetic interaction withtsc2tuberin Negative GeneticPMID:22681890
negative genetic interaction withucp6UBA domain protein Ucp6 Negative GeneticPMID:22681890
negative genetic interaction withulp1SUMO deconjugating enzyme Ulp1 Negative GeneticPMID:22681890
negative genetic interaction withura3dihydroorotate dehydrogenase Ura3 Negative GeneticPMID:22681890
negative genetic interaction withvac7Vac7 ortholog (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withvps1dynamin family protein Vps1 Negative GeneticPMID:22681890
negative genetic interaction withvps1301chorein homolog Vps13a (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvps3CORVET complex subunit, GTPase regulator Vps3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvps38phophatidylinositol 3-kinase complex subunit Vps38 Negative GeneticPMID:22681890
negative genetic interaction withvps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvsl1vacuolar SNARE Vsl1/Vam7 Negative GeneticPMID:22681890
negative genetic interaction withwbp4WW domain-binding protein Wbp4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withwtf21wtf element Wtf21 Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withyox1MBF complex corepressor Yox1 Negative GeneticPMID:22681890
synthetic lethal withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Synthetic LethalityPMID:22267499
negative genetic interaction withyps1aspartic protease, yapsin Yps1 Negative GeneticPMID:22681890
negative genetic interaction withzhf1zinc ion transmembrane transporter Zhf1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC4F10.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC4F10.04 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC4F10.04 BioGRID Interaction Datasets
Expression Viewer SPAC4F10.04 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC4F10.04 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC4F10.04 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC4F10.04 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC4F10.04 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC4F10.04 Transcriptome Viewer (Bähler Lab)
GEO SPAC4F10.04 GEO profiles
PInt SPAC4F10.04 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC4F10.04 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC4F10.04 Fission yeast phenotypic data & analysis
Cyclebase SPAC4F10.04.1 Cell Cycle Data
SPD / RIKEN15/15C06Orfeome Localization Data
UniProtKB/SwissProtO36016Serine/threonine-protein phosphatase 2A activator 1
ModBaseO36016Database of comparative protein structure models
STRINGO36016Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594747protein phosphatase type 2A, intrinsic regulator (predicted)
RefSeq mRNANM_001020174972h- protein phosphatase type 2A, intrinsic regulator (predicted) (SPAC4F10.04), mRNA
European Nucleotide ArchiveCAB11707.1ENA Protein Mapping
UniParcUPI00000699B2UniProt Archive

Literature for ypa1

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Release Version: PomBase:26_52 - 11 May 2015