SPAC4F10.16c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC4F10.16c Feature Typeprotein coding
Synonyms Name Description
ProductP-type ATPase (predicted) Product Size1367aa, 154.28 kDa
Genomic Location Chromosome I, 4869888-4863739 (6150nt); CDS:4868110-4863961 (4150nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0000287magnesium ion bindingIEAIPR006539GO_REF:000000248
GO:0004012phospholipid-translocating ATPase activityISOSGD:S000000968GO_REF:00000246
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006897endocytosisISOSGD:S000000968GO_REF:000002465
GO:0006886intracellular protein transportISOSGD:S000000968GO_REF:0000024332
GO:0045332phospholipid translocationISOSGD:S000000968GO_REF:00000245
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
GO:0005886plasma membraneISOSGD:S000000968GO_REF:0000024243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPAC4F10.16cΔNullPECO:0000005, PECO:0000137PMID:236978063755
MicroscopySPAC4F10.16cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPAC4F10.16cΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
148698884864584
248645374863739

UTRs

Region Start End Reference
three_prime_UTR48639604863739PMID:21511999
five_prime_UTR48698884868111PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00122 Pfam IPR008250 P-type ATPase, A domain 298 560 14
PF12710 Pfam 597 1044 7
TMhelix TMHMM 1175 1197 959
TMhelix TMHMM 1212 1234 959
TMhelix TMHMM 1058 1080 959
TMhelix TMHMM 532 554 959
TMhelix TMHMM 485 507 959
TMhelix TMHMM 1093 1112 959
TMhelix TMHMM 1280 1302 959
TMhelix TMHMM 1127 1145 959
TMhelix TMHMM 1241 1260 959
PS00154 Prosite Patterns IPR018303 Cation-transporting P-type ATPase 600 606 14
PTHR24092 HMMPANTHER IPR006539 Cation-transporting P-type ATPase, subfamily IV 18 1320 5
PTHR24092:SF14 HMMPANTHER IPR026871 18 1320 2
G3DSA:3.40.50.1000 Gene3D IPR023214 1004 1089 33
G3DSA:3.40.50.1000 Gene3D IPR023214 879 935 33
G3DSA:2.70.150.10 Gene3D IPR008250 433 469 12
G3DSA:2.70.150.10 Gene3D IPR008250 318 381 12
G3DSA:2.70.150.10 Gene3D IPR008250 155 223 12
G3DSA:3.40.1110.10 Gene3D IPR023299 690 878 13
G3DSA:3.40.1110.10 Gene3D IPR023299 590 635 13
SSF81660 SuperFamily IPR023299 605 631 11
SSF81660 SuperFamily IPR023299 681 847 11
SSF81665 SuperFamily 470 592 14
SSF81665 SuperFamily 1082 1310 14
SSF81665 SuperFamily 126 215 14
SSF81653 SuperFamily 428 468 14
SSF81653 SuperFamily 316 379 14
SSF56784 SuperFamily IPR023214 864 927 41
SSF56784 SuperFamily IPR023214 976 1081 41
Low complexity (SEG) seg 1329 1333
PR00119 PRINTS IPR001757 Cation-transporting P-type ATPase 598 612 14
PR00119 PRINTS IPR001757 Cation-transporting P-type ATPase 1033 1052 14
TIGR01652 tigrfam IPR006539 Cation-transporting P-type ATPase, subfamily IV 128 1317 5
TIGR01494 tigrfam IPR001757 Cation-transporting P-type ATPase 1003 1114 14

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 112.86 Da
Charge 4.00
Isoelectric point 6.71
Molecular weight 154.28 kDa
Number of residues 1367
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.82during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
top1DNA topoisomerase I Positive GeneticPMID:22681890
SPBC660.05WW domain containing conserved fungal protein Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
crp79poly(A) binding protein Crp79 Affinity Capture-RNAPMID:20531409
External References
Database Identifier Description
NBRP SPAC4F10.16c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC4F10.16c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC4F10.16c BioGRID Interaction Datasets
Expression Viewer SPAC4F10.16c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC4F10.16c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC4F10.16c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC4F10.16c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC4F10.16c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC4F10.16c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC4F10.16c Cell Cycle Data
GEO SPAC4F10.16c GEO profiles
PInt SPAC4F10.16c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2543523P-type ATPase (predicted)
EntrezGene2543523P-type ATPase (predicted)
IntEnz3.6.3.1Integrated relational Enzyme database
Rhea3.6.3.1Annotated reactions database
SPD / RIKEN30/30F11Orfeome Localization Data
UniProtKB/SwissProtO36028Putative phospholipid-transporting ATPase C4F10.16c
ModBaseO36028Database of comparative protein structure models
StringO36028Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594759P-type ATPase (predicted)
RefSeq PeptideNP_594760conserved fungal protein
RefSeq mRNANM_001020186972h- P-type ATPase (predicted) (SPAC4F10.16c), mRNA
RefSeq mRNANM_001020187972h- conserved fungal protein (SPAC4F10.17), mRNA
European Nucleotide ArchiveCAB11719ENA Protein Mapping
UniParcUPI000006AA59UniProt Archive

Literature for SPAC4F10.16c

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014