arg11 (SPAC4G9.09c)


Gene Standard Namearg11 Characterisation Statuspublished
Systematic IDSPAC4G9.09c Feature Typeprotein coding
Synonyms Name Description
ProductN-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase Product Size885aa, 97.70 kDa
Genomic Location Chromosome I, 2272911-2269908 (3004nt); CDS:2272676-2270019 (2658nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0003942N-acetyl-gamma-glutamyl-phosphate reductase activityIMPPMID:13133662
GO:0051287NAD bindingIEAIPR000534GO_REF:000000223
GO:0003991acetylglutamate kinase activityIGIUniProtKB:P31318PMID:13133661
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006526arginine biosynthetic processIMPPMID:131336612
GO:0006592ornithine biosynthetic processISSUniProtKB:P31318GO_REF:00000014
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005759mitochondrial matrixIDAPMID:1313366152
GO:0005739mitochondrionIDAPMID:16823372758
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001934abolished cell population growth on glycerol carbon sourceCell growth assayarg11ΔNullPECO:0000072PMID:1866526861
FYPO:0001355decreased vegetative cell population growthCell growth assayarg11ΔNullPECO:0000126PMID:18665268305
FYPO:0000087sensitive to hydrogen peroxideCell growth assayarg11ΔNullPECO:0000137PMID:18665268121
FYPO:0002060viable vegetative cell populationMicroscopyarg11ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopyarg11ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopyarg11ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
122729112269908

UTRs

Region Coordinates Reference
five_prime_UTR2272911..2272677PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04768 Pfam IPR006855 Domain of unknown function DUF619 327 490 2
PF01118 Pfam IPR000534 Semialdehyde dehydrogenase, NAD-binding 572 693 2
PF00696 Pfam IPR001048 Aspartate/glutamate/uridylate kinase 94 311 3
SM00859 SMART IPR000534 Semialdehyde dehydrogenase, NAD-binding 572 694 2
PS01224 Prosite Patterns IPR023013 N-acetyl-gamma-glutamyl-phosphate reductase, active site 698 714 1
PTHR23342:SF0 HMMPANTHER 58 867 1
PTHR23342 HMMPANTHER 58 867 2
3.40.1160.10 Gene3D IPR001048 Aspartate/glutamate/uridylate kinase 91 343 3
3.30.360.10 Gene3D 709 857 13
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 569 708 99
SSF53633 SuperFamily IPR001048 Aspartate/glutamate/uridylate kinase 67 344 3
SSF55347 SuperFamily 703 857 12
SSF51735 SuperFamily 570 720 88
PIRSF036440 PIRSF IPR011241 NAGK-NAGSA, bifunctional 1 885 1
TIGR00761 tigrfam IPR004662 Acetylglutamate kinase 94 319 1
TIGR01850 tigrfam IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 572 883 1

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0100011cleaved_peptide_region292

Protein Properties

Ave. residue weight 110.40 Da
Charge 30.00
Isoelectric point 9.77
Molecular weight 97.70 kDa
Number of residues 885
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS836PMID:217125471663
present during mitotic M phase
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
67388during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
63584during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
64389during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
70759during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
67667during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
33200.01during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
26527.97during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
8.5during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Genome Organisation
DescriptionQualifierReferenceCount
divergently orientated to functionally related gene10
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3393
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:22681890
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
saf4splicing associated factor Saf4 Negative GeneticPMID:22681890
bun107WD repeat protein, human WDR48 family Bun107 Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
pof9F-box protein Pof9 Negative GeneticPMID:22681890
SPCC1919.05Ski complex TPR repeat subunit Ski3 (predicted) Negative GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
cdc37Hsp90 co-chaperone Cdc37 Negative GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Positive GeneticPMID:22681890
ubp4ubiquitin C-terminal hydrolase Ubp4 Negative GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Negative GeneticPMID:22681890
cdk11serine/threonine protein kinase cdk11 Negative GeneticPMID:22681890
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
pfd1prefoldin subunit 1 (predicted) Negative GeneticPMID:22681890
mlo3RNA binding protein Mlo3 Negative GeneticPMID:22681890
atp11F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
pub3HECT-type ubiquitin-protein ligase Pub3 (predicted) Negative GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor Reb1 Negative GeneticPMID:22681890
sre1sterol regulatory element binding protein, transcription factor Sre1 Negative GeneticPMID:21504829
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
ppm1leucine carboxyl methyltransferase Ppm1 (predicted) Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
ubp2ubiquitin C-terminal hydrolase Ubp2 Positive GeneticPMID:22681890
SPBC18H10.05WD repeat protein, human WDR44 family Negative GeneticPMID:22681890
lsb5cortical component Lsb5 (predicted) Positive GeneticPMID:22681890
SPBC336.05csmall RNA 2'-O-methyltransferase activity (predicted) Positive GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC4G9.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC4G9.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC4G9.09c BioGRID Interaction Datasets
Expression Viewer SPAC4G9.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC4G9.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC4G9.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC4G9.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC4G9.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC4G9.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC4G9.09c Cell Cycle Data
GEO SPAC4G9.09c GEO profiles
PInt SPAC4G9.09c Protein-Protein Interaction Predictor (Bähler Lab)
KEGGMAP00220KEGG Pathway Database
IntEnz1.2.1.38Integrated relational Enzyme database
Rhea1.2.1.38Annotated reactions database
IntEnz2.7.2.8Integrated relational Enzyme database
Rhea2.7.2.8Annotated reactions database
WikiGene2543391N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase
EntrezGene2543391N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase
SPD / RIKEN47/47A09Orfeome Localization Data
UniProtKB/SwissProtP31318Protein arg11, mitochondrial
ModBaseP31318Database of comparative protein structure models
STRINGP31318Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593691N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase
RefSeq mRNANM_001019123972h- N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase (arg11), mRNA
European Nucleotide ArchiveCAA45132ENA Protein Mapping
European Nucleotide ArchiveCAA45132.1ENA Protein Mapping
European Nucleotide ArchiveCAA93559ENA Protein Mapping
European Nucleotide ArchiveCAA93559.1ENA Protein Mapping
UniParcUPI0000125D42UniProt Archive

Literature for arg11

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014