ppt1 (SPAC56F8.04c)


Gene Standard Nameppt1 Characterisation Statuspublished
Systematic IDSPAC56F8.04c Feature Typeprotein coding
Synonymscoq2 Name Description
Productpara-hydroxybenzoate--polyprenyltransferase Ppt1 Product Size360aa, 39.70 kDa
Genomic Location Chromosome I, 1134356-1133226 (1131nt); CDS:1134356-1133226 (1131nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00020834-hydroxybenzoate decaprenyltransferase activityIEA EC:2.5.1.39GO_REF:00000031
GO:00472934-hydroxybenzoate nonaprenyltransferase activityIEA EC:2.5.1.39GO_REF:00000031
GO:00084124-hydroxybenzoate octaprenyltransferase activityIMPPMID:110928531
GO:0016209antioxidant activityIMPPMID:1880842622
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0019646aerobic electron transport chainTASPMID:188084265
GO:0008299isoprenoid biosynthetic processIEAUniProtKB-KW:KW-0414GO_REF:000003714
GO:0006119oxidative phosphorylationTASPMID:1880842626
GO:0006744ubiquinone biosynthetic processIMPPMID:1109285311
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0031305integral component of mitochondrial inner membraneICGO:0016021, GO:0005743GO_REF:000000114
GO:0005743mitochondrial inner membraneIDAPMID:11092853155
GO:0005739mitochondrionIDAPMID:16823372756
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001934abolished cell population growth on glycerol carbon sourceCell growth assayppt1ΔNullPECO:0000072PMID:1866526857
FYPO:0000246antioxidant required for growthCell growth assayppt1ΔNullPECO:0000118, PECO:0000126, PECO:0000102PMID:110928534
Traceable Author Statementppt1ΔNullPMID:18808426
Cell growth assayppt1ΔNullPECO:0000179, PECO:0000126, PECO:0000102PMID:11092853
Cell growth assayppt1ΔNullPECO:0000183, PECO:0000103, PECO:0000126PMID:11092853
Cell growth assayppt1ΔNullPECO:0000005, PECO:0000179, PECO:0000126, PECO:0000102PMID:14695938
Cell growth assayppt1ΔNullPECO:0000005, PECO:0000179, PECO:0000126, PECO:0000102PMID:14695938
FYPO:0001407decreased cell population growth on glucose carbon sourceCell growth assayppt1ΔNullPECO:0000126, PECO:0000102PMID:1109285385
FYPO:0001355decreased vegetative cell population growthCell growth assayppt1ΔNullPECO:0000126PMID:18665268201
FYPO:0002061inviable vegetative cell populationCell growth assayppt1ΔNullPECO:0000005, PECO:0000126, PECO:0000102PMID:146959381309
FYPO:0000073resistance to caffeineCell growth assayppt1ΔNullPECO:0000137PMID:1967230618
expressivity FYPO_EXT:0000001
FYPO:0001701sensitive to bortezomibCell growth assayppt1ΔNullPECO:0000005, PECO:0000137PMID:21760946256
expressivity FYPO_EXT:0000003
FYPO:0000096sensitive to cadmiumcell growth assayppt1ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775244
expressivity FYPO_EXT:0000001
FYPO:0000103sensitive to copperTraceable Author Statementppt1ΔNullPMID:188084266
Cell growth assayppt1ΔNullPECO:0000103, PECO:0000137PMID:11092853
FYPO:0000087sensitive to hydrogen peroxideCell growth assayppt1ΔNullPECO:0000137PMID:19672306112
expressivity FYPO_EXT:0000003
expressivity FYPO_EXT:0000003cell growth assayppt1ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
Cell growth assayppt1ΔNullPECO:0000137PMID:18665268
Traceable Author Statementppt1ΔNullPMID:18808426
Cell growth assayppt1ΔNullPECO:0000103, PECO:0000137PMID:11092853
FYPO:0000271sensitive to salt stresscell growth assayppt1ΔNullPECO:0000207, PECO:0000137, PECO:0000102, PECO:0000005PMID:1868477573
expressivity FYPO_EXT:0000003
FYPO:0001234slow vegetative cell population growthCell growth assayppt1ΔNullPECO:0000137, PECO:0000103PMID:1109285340
FYPO:0002060viable vegetative cell populationMicroscopyppt1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopyppt1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001712coenzyme Q10 absent from cellChromatography evidenceppt1ΔNullPECO:0000126PMID:110928532
FYPO:0002723increased cellular pigment accumulation during cellular response to cadmiumcell growth assayppt1ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:1868477514
colour PATO:0000324
FYPO:0001413increased cellular sulfide levelSubstance quantificationppt1ΔNullPECO:0000183, PECO:0000126PMID:110928533
Substance quantificationppt1ΔNullPMID:11092853
Substance quantificationppt1ΔNullPMID:11092853
FYPO:0000343increased hydrogen sulfide biosynthesisCell growth assayppt1ΔNullPMID:110928534
Substance quantification evidenceppt1ΔNullPMID:14695938
FYPO:0001489inviable vegetative cellCell growth assayppt1ΔNullPECO:0000126, PECO:0000103PMID:11092853934
FYPO:0001491viable vegetative cellCell growth assayppt1ΔNullPECO:0000005, PECO:0000179, PECO:0000126, PECO:0000102PMID:146959383271
Cell growth assayppt1ΔNullPECO:0000005, PECO:0000118, PECO:0000126, PECO:0000102PMID:14695938
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyppt1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111343561134332
211342831133226
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01040 Pfam IPR000537 UbiA prenyltransferase family 81 338 2
TMhelix TMHMM 200 222 959
TMhelix TMHMM 229 251 959
TMhelix TMHMM 281 303 959
PS00943 Prosite Patterns IPR000537 UbiA prenyltransferase family 127 149 2
PTHR11048:SF2 HMMPANTHER 2 359 1
PTHR11048 HMMPANTHER 2 359 2
Low complexity (SEG) seg 280 294
TIGR01474 tigrfam IPR006370 4-hydroxybenzoate polyprenyl transferase 65 352 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.27 Da
Charge 14.50
Isoelectric point 9.70
Molecular weight 39.70 kDa
Number of residues 360
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2698.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReferenceCount
functionally complemented by S. cerevisiae COQ2full PMID:110928531
Disease Association
DescriptionQualifierReferenceCount
coenzyme Q deficiency2
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rad55RecA family ATPase Rad55/Rhp55 Phenotypic EnhancementPMID:23365689
dis2serine/threonine protein phosphatase PP1 Synthetic Growth DefectPMID:21965289
dad3DASH complex subunit Dad3 Phenotypic EnhancementPMID:23365689
Synthetic Growth Defect
External References
Database Identifier Description
NBRP SPAC56F8.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.04c BioGRID Interaction Datasets
Expression Viewer SPAC56F8.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC56F8.04c Cell Cycle Data
GEO SPAC56F8.04c GEO profiles
PInt SPAC56F8.04c Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN16/16F05Orfeome Localization Data
IntEnz2.5.1.-Integrated relational Enzyme database
Rhea2.5.1.-Annotated reactions database
WikiGene2543235para-hydroxybenzoate--polyprenyltransferase Coq2
EntrezGene2543235para-hydroxybenzoate--polyprenyltransferase Coq2
UniProtKB/SwissProtQ102524-hydroxybenzoate polyprenyltransferase, mitochondrial
ModBaseQ10252Database of comparative protein structure models
StringQ10252Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593219para-hydroxybenzoate--polyprenyltransferase Coq2
RefSeq mRNANM_001018615972h- para-hydroxybenzoate--polyprenyltransferase Coq2 (coq2), mRNA
European Nucleotide ArchiveABF50674ENA Protein Mapping
European Nucleotide ArchiveBAB20425ENA Protein Mapping
European Nucleotide ArchiveCAA93575ENA Protein Mapping
UniParcUPI0001B062B3UniProt Archive

Literature for ppt1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014