ppt1 (SPAC56F8.04c)


Gene Standard Nameppt1 Characterisation Statuspublished
Systematic IDSPAC56F8.04c Feature Typeprotein coding
Synonymscoq2 Name Description
Productpara-hydroxybenzoate--polyprenyltransferase Ppt1 Product Size360aa, 39.70 kDa
Genomic Location Chromosome I, 1134356-1133226 (1131nt); CDS:1134356-1133226 (1131nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
4-hydroxybenzoate decaprenyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
4-hydroxybenzoate nonaprenyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
4-hydroxybenzoate octaprenyltransferase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
isoprenoid biosynthetic process16
Annotation ExtensionEvidenceWith/FromReference
ubiquinone biosynthetic process11
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of mitochondrial inner membrane16
Annotation ExtensionEvidenceWith/FromReference
mitochondrial inner membrane163
Annotation ExtensionEvidenceWith/FromReference
mitochondrion761
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viability depends on conditions

Population Phenotype

Term NameAlleleExpressionCount
abolished cell population growth on glycerol carbon sourceppt1ΔNull66
decreased cell population growth on glucose carbon sourceppt1ΔNull154
decreased vegetative cell population growthppt1ΔNull403
growth auxotrophic for antioxidantppt1ΔNull3
inviable vegetative cell populationppt1ΔNull1428
resistance to caffeineppt1ΔNull26
sensitive to bortezomibppt1ΔNull256
sensitive to cadmiumppt1ΔNull246
sensitive to copperppt1ΔNull9
sensitive to doxorubicinppt1ΔNull91
sensitive to hydrogen peroxideppt1ΔNull137
ppt1ΔNull
sensitive to salt stressppt1ΔNull86
slow vegetative cell population growthppt1ΔNull318
viable vegetative cell populationppt1ΔNull3783

Cell Phenotype

Term NameAlleleExpressionCount
coenzyme Q10 absent from cellppt1ΔNull4
increased cellular pigment accumulation during cellular response to cadmium ion14
colour PATO:0000324ppt1ΔNull
increased cellular sulfide levelppt1ΔNull8
increased hydrogen sulfide biosynthesisppt1ΔNull4
inviable vegetative cellppt1ΔNull1271
viable vegetative cellppt1ΔNull3615
viable vegetative cell with normal cell morphologyppt1ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111343561134332
211342831133226

UTRs

Region Coordinates Reference
exon1134356..1134332,1134283..1133226
mRNA1134356..1133226
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01040 Pfam IPR000537 UbiA prenyltransferase family 81 338 2
TMhelix TMHMM 200 222 959
TMhelix TMHMM 281 303 959
TMhelix TMHMM 229 251 959
PS00943 Prosite Patterns IPR000537 UbiA prenyltransferase family 127 149 2
PTHR11048:SF7 HMMPANTHER 40 354 1
PTHR11048 HMMPANTHER 40 354 2
TIGR01474 tigrfam IPR006370 4-hydroxybenzoate polyprenyl transferase 65 352 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.27 Da
Charge 14.50
Isoelectric point 9.70
Molecular weight 39.70 kDa
Number of residues 360
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2698.7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.45during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by S. cerevisiae COQ2full PMID:11092853
Disease Association
DescriptionQualifierReferenceCount
coenzyme Q deficiency2
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
conserved in metazoa3432
conserved in vertebrates3407
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
phenotype enhanced bydad3DASH complex subunit Dad3 Phenotypic EnhancementPMID:23365689
synthetic growth defect withdad3DASH complex subunit Dad3 Synthetic Growth DefectPMID:23365689
synthetic growth defect withdis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Synthetic Growth DefectPMID:21965289
enhances phenotype ofrad55RecA family ATPase Rad55/Rhp55 Phenotypic EnhancementPMID:23365689
External References
Database Identifier Description
NBRP SPAC56F8.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.04c BioGRID Interaction Datasets
Expression Viewer SPAC56F8.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC56F8.04c Cell Cycle Data
GEO SPAC56F8.04c GEO profiles
PInt SPAC56F8.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC56F8.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC56F8.04c Fission yeast phenotypic data & analysis
SPD / RIKEN16/16F05Orfeome Localization Data
IntEnz2.5.1.-Integrated relational Enzyme database
Rhea2.5.1.-Annotated reactions database
UniProtKB/SwissProtQ102524-hydroxybenzoate polyprenyltransferase, mitochondrial
ModBaseQ10252Database of comparative protein structure models
STRINGQ10252Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593219para-hydroxybenzoate--polyprenyltransferase Ppt1
RefSeq mRNANM_001018615972h- para-hydroxybenzoate--polyprenyltransferase Ppt1 (ppt1), mRNA
European Nucleotide ArchiveABF50674.1ENA Protein Mapping
European Nucleotide ArchiveBAB20425.1ENA Protein Mapping
European Nucleotide ArchiveCAA93575.2ENA Protein Mapping
UniParcUPI0001B062B3UniProt Archive

Literature for ppt1

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015