ppt1 (SPAC56F8.04c)

Gene Standard Nameppt1 ChromosomeI
Systematic IDSPAC56F8.04c Gene Start1134356
Synonymscoq2 Gene End1133226
Productpara-hydroxybenzoate--polyprenyltransferase Ppt1 Gene Length1131
Feature Typeprotein coding CDS Start1134356
Name Description CDS End1133226
Characterisation Statuspublished CDS Length1131

Ensembl Gene Location
  1. SPAC56F8.02
  2. SPNCRNA.713
  3. SPNCRNA.714
  4. SPAC56F8.03
  5. ppt1
  6. mug64
  7. SPNCRNA.715
  8. alg10
  9. SPAC56F8.07
  10. mud1
  11. rrp8
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000087sensitive to hydrogen peroxideCell growth assayppt1delta (deletion)deletionPMID:11092853
Traceable Author Statementppt1delta (deletion)deletionPMID:18808426
FYPO:0000096sensitive to cadmiumCell growth assayppt1delta (deletion)deletionPECO:0000012PMID:18684775
FYPO:0000103sensitive to copperCell growth assayppt1delta (deletion)deletionPMID:11092853
Traceable Author Statementppt1delta (deletion)deletionPMID:18808426
FYPO:0000246antioxidant required for growthCell growth assayppt1delta (deletion)deletionPMID:11092853
Cell growth assayppt1delta (deletion)deletionPMID:11092853
Traceable Author Statementppt1delta (deletion)deletionPMID:18808426
Cell growth assayppt1delta (deletion)deletionPMID:11092853
FYPO:0000343increased hydrogen sulfide biosynthesisCell growth assayppt1delta (deletion)deletionPMID:11092853
FYPO:0000741increased cellular pigment accumulationCell growth assayppt1delta (deletion)deletionPECO:0000033, PECO:0000012PMID:18684775
is_bearer_of PATO:0000324
FYPO:0001161decreased aerobic cell population growth on glucose carbon sourceCell growth assayppt1delta (deletion)deletionPMID:11092853
FYPO:0001234slow cell population growthCell growth assayppt1delta (deletion)deletionPMID:11092853
FYPO:0001413increased cellular sulfide levelSubstance quantificationppt1delta (deletion)deletionPMID:11092853
Substance quantificationppt1delta (deletion)deletionPMID:11092853
Substance quantificationppt1delta (deletion)deletionPMID:11092853
FYPO:0001489inviable vegetative cellCell growth assayppt1delta (deletion)deletionPMID:11092853
FYPO:0001491viable vegetative cellMicroscopyppt1delta (deletion)deletionPMID:20473289
FYPO:0001712coenzyme Q10 absent from cellChromatography evidenceppt1delta (deletion)deletionPMID:11092853
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:00020834-hydroxybenzoate decaprenyltransferase activityIEAEC:2.5.1.39GO_REF:0000003
GO:00084124-hydroxybenzoate octaprenyltransferase activityIMPPMID:11092853
GO:0016209antioxidant activityIMPPMID:18808426
GO:00472934-hydroxybenzoate nonaprenyltransferase activityIEAEC:2.5.1.39GO_REF:0000003
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006119oxidative phosphorylationTASPMID:18808426
GO:0006744ubiquinone biosynthetic processIMPPMID:11092853
GO:0008299isoprenoid biosynthetic processIEAUniProtKB:KW-0414GO_REF:0000037
GO:0019646aerobic electron transport chainTASPMID:18808426
GO:0071276cellular response to cadmium ionIMPPMID:18684775
GO:0071585detoxification of cadmium ionIMPPMID:18684775
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005739mitochondrionIDAPMID:16823372
GO:0005743mitochondrial inner membraneIDAPMID:11092853
GO:0031305integral to mitochondrial inner membraneICGO:0005743, GO:0016021GO_REF:0000001
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111343561134332
211342831133226
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF01040 IPR000537 Pfam UbiA prenyltransferase family 81 339 2
TMhelix TMHMM 281 303 955
TMhelix TMHMM 229 251 955
TMhelix TMHMM 200 222 955
PS00943 IPR000537 Prosite Patterns UbiA prenyltransferase family 127 149 2
PTHR11048 hmmpanther 36 359 2
PTHR11048:SF2 hmmpanther 36 359 1
TIGR01474 IPR006370 tigrfam 4-hydroxybenzoate polyprenyl transferase 65 352 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.27 Da
Charge 14.50
Isoelectric point 9.70
Molecular weight 39.70 kDa
Number of residues 360
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide2698.7PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.45PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide2.7PMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by S. cerevisiae COQ2full PMID:11092853
Disease Association
DescriptionQualifierReference
coenzyme Q deficiency
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in bacteria
conserved in metazoa
conserved in vertebrates
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
dad3DASH complex subunit Dad3 Phenotypic EnhancementPMID:23365689
Synthetic Growth Defect
rad55RecA family ATPase Rad55/Rhp55 Phenotypic EnhancementPMID:23365689
dis2serine/threonine protein phosphatase PP1 Synthetic Growth DefectPMID:21965289
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External References
Database Identifier Description
NBRP SPAC56F8.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.04c Retrieval of eukaryotic orthologs
BioGrid SPAC56F8.04c BioGRID Interaction Datasets
Bähler Lab SPAC56F8.04c Cell Cycle Expression Profile
Bähler Lab SPAC56F8.04c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC56F8.04c Pheromone response/mating expression profiles
Bähler Lab SPAC56F8.04c Environmental stress expression profiles
Bähler Lab SPAC56F8.04c Bähler Lab Transcriptome Viewer
Cyclebase SPAC56F8.04c Cell Cycle Data
PInt SPAC56F8.04c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC56F8.04c Entrez Gene
IntEnz2.5.1.-
SPD / RIKEN16/16F05Orfeome Localization Data
WikiGene2543235para-hydroxybenzoate--polyprenyltransferase Coq2
Uniprot_genenameCOQ2
EntrezGene2543235para-hydroxybenzoate--polyprenyltransferase Coq2
UniProtKB/SwissProtQ102524-hydroxybenzoate polyprenyltransferase, mitochondrial
ModBaseQ10252Database of comparative protein structure models
Pfam Protein DomainsQ10252Pfam Domain Arrangement
RefSeq PeptideNP_593219para-hydroxybenzoate--polyprenyltransferase Coq2
RefSeq mRNANM_001018615972h- para-hydroxybenzoate--polyprenyltransferase Coq2 (coq2), mRNA
European Nucleotide ArchiveABF50674ENA Protein Mapping
European Nucleotide ArchiveBAB20425ENA Protein Mapping
European Nucleotide ArchiveCAA93575ENA Protein Mapping
SPD / RIKEN16/16F05Orfeome Localization Data

Literature for ppt1
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013