esc1 (SPAC56F8.16)

Gene Standard Nameesc1 Characterisation Statuspublished
Systematic IDSPAC56F8.16 Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Esc1 (predicted) Product Size413aa, 44.80 kDa
Genomic Location Chromosome I, 1153572-1156804 (3233nt); CDS:1154733-1155974 (1242nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingNASGO_REF:000005196
GO:0046983protein dimerization activityIEAIPR011598GO_REF:0000002109
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030154cell differentiationIEAUniProtKB-KW:KW-0221GO_REF:0000037121
GO:0031142induction of conjugation upon nitrogen starvationIMPPMID:838134811
GO:0045893positive regulation of transcription, DNA-templatedIMPPMID:838134898
GO:0006357regulation of transcription from RNA polymerase II promoterNASGO_REF:0000051264
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyesc1ΔNullPMID:204732893755
Microscopyesc1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyesc1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00010 Pfam IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 385 4
SM00353 SMART IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 340 391 4
PS50888 Prosite Profiles IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 334 385 4
PTHR22934 HMMPANTHER 1 412 2
G3DSA: Gene3D IPR011598 336 405 4
SSF47459 SuperFamily IPR011598 333 404 4
Coil ncoils Rabaptin coiled-coil domain 382 403 975
Low complexity (SEG) seg 23 42
Low complexity (SEG) seg 86 103
Low complexity (SEG) seg 116 126
Low complexity (SEG) seg 150 199

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.47 Da
Charge 11.00
Isoelectric point 9.36
Molecular weight 44.80 kDa
Number of residues 413
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
2835.02during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
9.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
4.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
orthologs cannot be distinguished132
conserved in fungi4564
conserved in eukaryotes4482
conserved in eukaryotes only2485

Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
pka1cAMP-dependent protein kinase catalytic subunit Pka1 Dosage RescuePMID:16143612
cyr1adenylate cyclase Dosage RescuePMID:16143612
External References
Database Identifier Description
NBRP SPAC56F8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.16 BioGRID Interaction Datasets
Expression Viewer SPAC56F8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.16 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC56F8.16 Cell Cycle Data
GEO SPAC56F8.16 GEO profiles
PInt SPAC56F8.16 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN19/19H01Orfeome Localization Data
WikiGene2543286transcription factor Esc1 (predicted)
EntrezGene2543286transcription factor Esc1 (predicted)
UniProtKB/SwissProtQ04635Protein esc1
ModBaseQ04635Database of comparative protein structure models
StringQ04635Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593230transcription factor Esc1 (predicted)
RefSeq mRNANM_001018627972h- transcription factor Esc1 (predicted) (esc1), mRNA
European Nucleotide ArchiveCAA49186ENA Protein Mapping
European Nucleotide ArchiveCAA93587ENA Protein Mapping
UniParcUPI000012A1A6UniProt Archive

Literature for esc1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014