esc1 (SPAC56F8.16)

Gene Standard Nameesc1 Characterisation Statuspublished
Systematic IDSPAC56F8.16 Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Esc1 (predicted) Product Size413aa, 44.80 kDa
Genomic Location Chromosome I, 1153572-1156804 (3233nt); CDS:1154733-1155974 (1242nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingNASGO_REF:000005191
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityTASPMID:838134891
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030154cell differentiationIEAUniProtKB-KW:KW-0221GO_REF:0000037102
GO:0031141induction of conjugation upon carbon starvationIMPPMID:83813481
GO:0031142induction of conjugation upon nitrogen starvationIMPPMID:83813487
GO:0045944positive regulation of transcription from RNA polymerase II promoterICGO:0000978GO_REF:000000187
GO:0010738regulation of protein kinase A signalingIMPPMID:83813481
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001420normal vegetative cell population growth rateCell growth assayesc1ΔNullPMID:838134851
FYPO:0002060viable vegetative cell populationMicroscopyesc1ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000303decreased conjugation frequencyMicroscopyesc1ΔNullPMID:838134836
FYPO:0000761increased conjugation frequencyMicroscopyesc1+ (wild type)OverexpressionPMID:838134810
FYPO:0002052normal sporulation frequencyMicroscopyesc1ΔNullPMID:83813488
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyesc1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
FYPO affected by mutation in ste11 transcription factor Ste11 PMID:8381348
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00010 Pfam IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 385 4
SM00353 SMART IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 340 391 4
PS50888 Prosite Profiles IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 334 385 4
PTHR22934 HMMPANTHER 1 412 2 Gene3D IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 405 4
SSF47459 SuperFamily IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 333 404 4
Coil ncoils Rabaptin coiled-coil domain 382 403 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.47 Da
Charge 11.00
Isoelectric point 9.36
Molecular weight 44.80 kDa
Number of residues 413
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2835.02during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
4.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
orthologs cannot be distinguished130
conserved in fungi4600
conserved in eukaryotes4514
conserved in eukaryotes only2497

Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
pka1cAMP-dependent protein kinase catalytic subunit Pka1 Dosage RescuePMID:16143612
cyr1adenylate cyclase Dosage RescuePMID:16143612
ran1serine/threonine protein kinase Ran1 Phenotypic SuppressionPMID:8381348
External References
Database Identifier Description
NBRP SPAC56F8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.16 BioGRID Interaction Datasets
Expression Viewer SPAC56F8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.16 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC56F8.16 Cell Cycle Data
GEO SPAC56F8.16 GEO profiles
PInt SPAC56F8.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC56F8.16 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC56F8.16 Fission yeast phenotypic data & analysis
SPD / RIKEN19/19H01Orfeome Localization Data
UniProtKB/SwissProtQ04635Protein esc1
ModBaseQ04635Database of comparative protein structure models
STRINGQ04635Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593230transcription factor Esc1 (predicted)
RefSeq mRNANM_001018627972h- transcription factor Esc1 (predicted) (esc1), mRNA
European Nucleotide ArchiveX69389ENA EMBL mapping
European Nucleotide ArchiveCAA93587.1ENA Protein Mapping
UniParcUPI000012A1A6UniProt Archive

Literature for esc1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014