esc1 (SPAC56F8.16)


Gene Standard Nameesc1 Characterisation Statuspublished
Systematic IDSPAC56F8.16 Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Esc1 (predicted) Product Size413aa, 44.80 kDa
Genomic Location Chromosome I, 1153572-1156804 (3233nt); CDS:1154733-1155974 (1242nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
induction of conjugation upon carbon starvation1
Annotation ExtensionEvidenceWith/FromReference
induction of conjugation upon nitrogen starvation6
Annotation ExtensionEvidenceWith/FromReference
positive regulation of transcription from RNA polymerase II promoter89
Annotation ExtensionEvidenceWith/FromReference
regulation of protein kinase A signaling1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth on glucose carbon sourceesc1+ (wild type)Overexpression258
decreased conjugation frequencyesc1ΔNull44
increased conjugation frequencyesc1+ (wild type)Overexpression11
normal vegetative cell population growth rateesc1ΔNull70
viable vegetative cell populationesc1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
abnormal mitotic sister chromatid segregationesc1+ (wild type)Overexpression210
normal sporulation frequencyesc1ΔNull9
viable elongated vegetative cellesc1+ (wild type)Overexpression301
viable vegetative cell with normal cell morphologyesc1ΔNull3094
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in ste11 transcription factor Ste11
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1153572..1156804
mRNA1153572..1156804
5' UTR1153572..1154732PMID:21511999
CDS1154733..1155974
3' UTR1155975..1156804PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00010 Pfam IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 385 4
SM00353 SMART IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 340 391 4
PS50888 Prosite Profiles IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 334 385 4
PTHR22934 HMMPANTHER 1 409 2
4.10.280.10 Gene3D IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 405 4
SSF47459 SuperFamily IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 333 404 4
Coil ncoils Rabaptin coiled-coil domain 382 403 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.47 Da
Charge 11.00
Isoelectric point 9.36
Molecular weight 44.80 kDa
Number of residues 413
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2835.02during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.6during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
4.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
orthologs cannot be distinguished129
conserved in fungi4603
conserved in eukaryotes4514
conserved in eukaryotes only2501
Orthologs

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
overexpression rescuescyr1adenylate cyclase Dosage RescuePMID:16143612
synthetically rescuespat1serine/threonine protein kinase Ran1/Pat1 Synthetic RescuePMID:8381348
overexpression rescuespka1cAMP-dependent protein kinase catalytic subunit Pka1 Dosage RescuePMID:16143612
External References
Database Identifier Description
NBRP SPAC56F8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.16 BioGRID Interaction Datasets
Expression Viewer SPAC56F8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.16 Transcriptome Viewer (Bähler Lab)
GEO SPAC56F8.16 GEO profiles
PInt SPAC56F8.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC56F8.16 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC56F8.16 Fission yeast phenotypic data & analysis
Cyclebase SPAC56F8.16.1 Cell Cycle Data
SPD / RIKEN19/19H01Orfeome Localization Data
UniProtKB/SwissProtQ04635Protein esc1
ModBaseQ04635Database of comparative protein structure models
STRINGQ04635Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593230transcription factor Esc1 (predicted)
RefSeq mRNANM_001018627972h- transcription factor Esc1 (predicted) (esc1), mRNA
European Nucleotide ArchiveX69389ENA EMBL mapping
European Nucleotide ArchiveCAA93587.1ENA Protein Mapping
UniParcUPI000012A1A6UniProt Archive

Literature for esc1

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015