esc1 (SPAC56F8.16)

Gene Standard Nameesc1 Characterisation Statuspublished
Systematic IDSPAC56F8.16 Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Esc1 (predicted) Product Size413aa, 44.80 kDa
Genomic Location Chromosome I, 1153572-1156804 (3233nt); CDS:1154733-1155974 (1242nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
induction of conjugation upon carbon starvation1
Annotation ExtensionEvidenceWith/FromReference
induction of conjugation upon nitrogen starvation5
Annotation ExtensionEvidenceWith/FromReference
positive regulation of transcription from RNA polymerase II promoter75
Annotation ExtensionEvidenceWith/FromReference
regulation of protein kinase A signaling1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth on glucose carbon sourceesc1+ (wild type)380
decreased conjugation frequencyesc1Δ52
increased conjugation frequencyesc1+ (wild type)10
normal sporulation frequencyesc1Δ14
normal vegetative cell population growth rateesc1Δ80
viable vegetative cell populationesc1Δ3850

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic sister chromatid segregationesc1+ (wild type)281
viable elongated vegetative cellesc1+ (wild type)325
viable vegetative cell with normal cell morphologyesc1Δ3102
Target Of
FYPO affected by mutation in ste11 transcription factor Ste11
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR1153572..1154732PMID:21511999
3' UTR1155975..1156804PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00010 Pfam IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 385 4
SM00353 SMART IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 340 391 4
PS50888 Prosite Profiles IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 334 385 4
PTHR22934 HMMPANTHER 43 403 1 Gene3D IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 405 4
SSF47459 SuperFamily IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 333 404 4
Coil ncoils Predicted coiled-coil protein (DUF2205) 382 402 1055

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.47 Da
Charge 11.00
Codon Adaptation Index 0.45
Isoelectric point 9.36
Molecular weight 44.80 kDa
Number of residues 413
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for esc1 (SPAC56F8.16)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2835.02during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
9.6during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
4.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
orthologs cannot be distinguished124
conserved in fungi4607
conserved in eukaryotes4517
conserved in eukaryotes only2502

Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC56F8.16 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withSPAC30D11.14cRNA-binding protein (predicted) Two-hybridPMID:26771498
binds activation domain construct withesc1transcription factor Esc1 (predicted) Two-hybridPMID:26771498
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC56F8.16 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetically rescuespat1serine/threonine protein kinase Ran1/Pat1 Synthetic RescuePMID:8381348
overexpression rescuespka1cAMP-dependent protein kinase catalytic subunit Pka1 Dosage RescuePMID:16143612
overexpression rescuescyr1adenylate cyclase Dosage RescuePMID:16143612
External References
Database Identifier Description
NBRP SPAC56F8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.16 BioGRID Interaction Datasets
Expression Viewer SPAC56F8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.16 Transcriptome Viewer (Bähler Lab)
GEO SPAC56F8.16 GEO profiles
PInt SPAC56F8.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC56F8.16 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC56F8.16 Fission yeast phenotypic data & analysis
Cyclebase SPAC56F8.16.1 Cell Cycle Data
SPD / RIKEN19/19H01Orfeome Localization Data
UniProtKB/SwissProtQ04635Protein esc1
ModBaseQ04635Database of comparative protein structure models
STRINGQ04635Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593230transcription factor Esc1 (predicted)
RefSeq mRNANM_001018627972h- transcription factor Esc1 (predicted) (esc1), mRNA
European Nucleotide ArchiveX69389ENA EMBL mapping
European Nucleotide ArchiveCAA93587.1ENA Protein Mapping
UniParcUPI000012A1A6UniProt Archive

Literature for esc1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016