esc1 (SPAC56F8.16)


Gene Standard Nameesc1 Characterisation Statuspublished
Systematic IDSPAC56F8.16 Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Esc1 (predicted) Product Size413aa, 44.80 kDa
Genomic Location Chromosome I, 1153572-1156804 (3233nt); CDS:1154733-1155974 (1242nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingNASGO_REF:000005194
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityTASPMID:838134891
GO:0046983protein dimerization activityIEAIPR011598GO_REF:000000253
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030154cell differentiationIEAUniProtKB-KW:KW-0221GO_REF:000003791
GO:0031141induction of conjugation upon carbon starvationIMPPMID:83813481
GO:0031142induction of conjugation upon nitrogen starvationIMPPMID:83813487
GO:0045944positive regulation of transcription from RNA polymerase II promoterICGO:0000978GO_REF:000000182
GO:0010738regulation of protein kinase A signalingIMPPMID:83813481
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001420normal vegetative cell population growth rateCell growth assayesc1ΔNullPMID:838134841
FYPO:0002060viable vegetative cell populationMicroscopyesc1ΔNullPECO:0000005, PECO:0000137PMID:236978063730
Microscopyesc1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000303decreased conjugation frequencyMicroscopyesc1ΔNullPMID:838134823
FYPO:0000761increased conjugation frequencyMicroscopyesc1+ (wild type)OverexpressionPMID:83813489
FYPO:0002052normal sporulation frequencyMicroscopyesc1ΔNullPMID:83813487
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyesc1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in ste11 transcription factor Ste11 PMID:8381348
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
111535721156804

UTRs

Region Coordinates Reference
five_prime_UTR1153572..1154732PMID:21511999
three_prime_UTR1155975..1156804PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00010 Pfam IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 385 4
SM00353 SMART IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 340 391 4
PS50888 Prosite Profiles IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 334 385 4
PTHR22934 HMMPANTHER 1 409 2
4.10.280.10 Gene3D IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 336 405 4
SSF47459 SuperFamily IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain 333 404 4
Coil ncoils Rabaptin coiled-coil domain 382 403 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.47 Da
Charge 11.00
Isoelectric point 9.36
Molecular weight 44.80 kDa
Number of residues 413
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
2835.02during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
9.6during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
4.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
orthologs cannot be distinguished132
conserved in fungi4569
conserved in eukaryotes4482
conserved in eukaryotes only2487
Orthologs

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
pka1cAMP-dependent protein kinase catalytic subunit Pka1 Dosage RescuePMID:16143612
cyr1adenylate cyclase Dosage RescuePMID:16143612
ran1serine/threonine protein kinase Ran1 Phenotypic SuppressionPMID:8381348
External References
Database Identifier Description
NBRP SPAC56F8.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC56F8.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC56F8.16 BioGRID Interaction Datasets
Expression Viewer SPAC56F8.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC56F8.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC56F8.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC56F8.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC56F8.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC56F8.16 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC56F8.16 Cell Cycle Data
GEO SPAC56F8.16 GEO profiles
PInt SPAC56F8.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC56F8.16 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN19/19H01Orfeome Localization Data
WikiGene2543286transcription factor Esc1 (predicted)
EntrezGene2543286transcription factor Esc1 (predicted)
UniProtKB/SwissProtQ04635Protein esc1
ModBaseQ04635Database of comparative protein structure models
STRINGQ04635Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593230transcription factor Esc1 (predicted)
RefSeq mRNANM_001018627972h- transcription factor Esc1 (predicted) (esc1), mRNA
European Nucleotide ArchiveX69389ENA EMBL mapping
European Nucleotide ArchiveCAA49186ENA Protein Mapping
European Nucleotide ArchiveCAA93587ENA Protein Mapping
European Nucleotide ArchiveCAA93587.1ENA Protein Mapping
UniParcUPI000012A1A6UniProt Archive

Literature for esc1

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014