med13 (SPAC589.02c)

Synonyms srb9, spTrap240 ChromosomeI
Productmediator complex subunit Srb9 Gene Start3098883
Feature Typeprotein coding Gene End3095075
Name Description CDS Start3098883
Characterisation Statuspublished CDS End3095075

Ensembl Gene Location
dad1 nse2 taz1 SPNCRNA.885 mug74 > med13 < SPNCRNA.886 SPAC589.03c SPAC589.04 SPAC589.05c SPAC589.06c atg18 SPNCRNA.560
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
130988833098878
230987813098626
330985903095075

Protein Feature Information
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Protein Features

Ensembl protein image with mapped locations of structural domains
Feature ID Database Description Start End Score All Genes
PF06333 Pfam Mediator complex, subunit Med13 875 1079 48.2 1
TMHMM tmhmm Double transmembrane domain 15 35 0.88583 1312

Protein Properties

Ave. residue weight 113.68 Da
Charge -49.50
Isoelectric point 4.54
Molecular weight 139.26 kDa
Number of residues 1225
Sequence
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Fission Yeast Phenotype

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Term IDDescriptionSourceAll Genes
FYPO:0000124viableTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000124

Gene Ontology Annotations

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Biological Process
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0006357regulation of transcription from RNA polymerase II promoterIC GO:0000119GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0006357

Cellular Component
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0005634nucleusIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005634
GO:0005829cytosolIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005829
GO:0016592mediator complexIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0016592
IEAGO_REF:0000002

Molecular Function
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0001104RNA polymerase II transcription cofactor activityIEAGO_REF:0000002Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0001104

Gene Expression

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DescriptionSourceAll Genes
transcriptionally represses genes involved in cell surface adhesion Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001046

Species Distribution

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DescriptionSourceAll Genes
conserved in FungiTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000057
conserved in Eukaryotes onlyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000096
conserved in VertebratesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000095
conserved in EukaryotesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000058
predominantly uniformly single copy (one to one)Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000104
conserved in MetazoaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000094

Manually Curated Orthologs

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SpeciesGeneDescription

Interactions

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Genetic Interactions from BioGRID

Gene Feature Evidence Source
ptc2protein phosphatase 2C Ptc2 Negative Genetic
SPAC323.03csequence orphan Negative Genetic
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Phenotypic Enhancement
pho24-nitrophenylphosphatase Negative Genetic
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive Genetic
rpl160160S ribosomal protein L13/L16 (predicted) Negative Genetic
sre2membrane-tethered transcription factor (predicted) Negative Genetic
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative Genetic
pmp1dual-specificity MAP kinase phosphatase Pmp1 Negative Genetic
dsc1ubiquitin-protein ligase E3 (predicted) Negative Genetic
Negative Genetic
hip1hira protein, histone chaperone Hip1 Negative Genetic
rik1silencing protein Rik1 Negative Genetic
rxt2histone deacetylase complex subunit Rxt2 Phenotypic Enhancement
SPAC26H5.05IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Phenotypic Enhancement
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative Genetic
res2MBF transcription factor complex subunit Res2 Negative Genetic
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative Genetic
SPBC56F2.08cRNA-binding protein (predicted) Negative Genetic
SPAC1952.06cDUF1716 family protein Positive Genetic
arp42SWI/SNF and RSC complex subunit Arp42 Positive Genetic
hrp1ATP-dependent DNA helicase Hrp1 Negative Genetic
reb1RNA polymerase I transcription termination factor Reb1 Negative Genetic
hip4histone promoter control protein Hip4 Negative Genetic

Physical Interactions from BioGRID

Gene Feature Evidence Source
srb11cyclin CycC, Srb mediator subunit Srb11 Affinity Capture-MS
srb4mediator complex subunit Srb4 Affinity Capture-MS
Affinity Capture-Western
med8mediator complex subunit Med8 Affinity Capture-MS
pmc1mediator complex subunit Pmc1 Affinity Capture-MS
srb8mediator complex subunit Srb8 Affinity Capture-MS
Affinity Capture-MS
med15mediator complex subunit Med15 (predicted) Affinity Capture-MS
Affinity Capture-Western
pmc3mediator complex subunit Pmc3/Med27 Affinity Capture-Western
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Affinity Capture-MS
med7mediator complex subunit Med7 Affinity Capture-MS
Affinity Capture-MS
sep11mediator complex subunit Pmc6 Affinity Capture-MS
hrp1ATP-dependent DNA helicase Hrp1 Affinity Capture-Western

External References

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Database Identifier Description
NBRP SPAC589.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC589.02c Retrieval of eukaryotic orthologs
BioGrid SPAC589.02c BioGRID Interaction Datasets
Bähler Lab SPAC589.02c Cell Cycle Expression Profile
Bähler Lab SPAC589.02c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC589.02c Pheromone response/mating expression profiles
Bähler Lab SPAC589.02c Environmental stress expression profiles
Bähler Lab SPAC589.02c Bähler Lab Transcriptome Viewer
Cyclebase SPAC589.02c Cell Cycle Data
Entrez Gene SPAC589.02c Link to Entrez Gene
SPD / RIKEN49/49G12Orfeome Localization Data
UniProtKB/SwissProtQ9HE02Mediator of RNA polymerase II transcription subunit 13
ArrayExpressQ9HE02Link to ArrayExpress
RefSeq PeptideNP_594050mediator complex subunit Srb9
RefSeq mRNANM_001019474972h- mediator complex subunit Srb9 (med13), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAC19759ENA Protein Mapping
UniParcUPI0001B062B6UniProt Archive

Literature for med13

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Search: UK PMC or PubMed