SPAC5H10.09c

Gene Standard NameUnassigned ChromosomeI
Systematic IDSPAC5H10.09c Gene Start161822
Synonyms Gene End160977
Product3-methyl-2-oxobutanoatehydroxymethyltransferase (predicted) Gene Length846
Feature Typeprotein coding CDS Start161780
Name Description CDS End160977
Characterisation Statusbiological_role_inferred CDS Length804

Ensembl Gene Location
  1. SPAC5H10.04
  2. SPAC5H10.05c
  3. adh4
  4. SPAC5H10.07
  5. pan6
  6. SPAC5H10.09c
  7. SPNCRNA.614
  8. SPNCRNA.615
  9. SPAC5H10.10
  10. gmh1
  11. SPAC5H10.12c
  12. SPNCRNA.616
  13. gmh2
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001491viable vegetative cellMicroscopySPAC5H10.09cdelta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:00038643-methyl-2-oxobutanoate hydroxymethyltransferase activityISSUniProtKB:P38122GO_REF:0000001
GO:0008168methyltransferase activityIEAUniProtKB:KW-0489GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0015940pantothenate biosynthetic processISSUniProtKB:P38122GO_REF:0000001
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005739mitochondrionIDAPMID:16823372
ISSUniProtKB:P38122GO_REF:0000001
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1161822160977

References

Region Start End Reference
five_prime_UTR161822161781PMID:20118936
five_prime_UTR161822161781PMID:18641648
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF02548 IPR003700 Pfam Ketopantoate hydroxymethyltransferase 4 263 1
G3DSA:3.20.20.60 IPR015813 Gene3D 4 267 3
SSF51621 IPR015813 SuperFamily 6 266 3
PIRSF000388 IPR003700 PIRSF Ketopantoate hydroxymethyltransferase 1 267 1
PTHR20881 IPR003700 hmmpanther Ketopantoate hydroxymethyltransferase 2 267 1
TIGR00222 IPR003700 tigrfam Ketopantoate hydroxymethyltransferase 4 267 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.03 Da
Charge 5.00
Isoelectric point 8.46
Molecular weight 29.11 kDa
Number of residues 267
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1019.41PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide3179.4PMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.6PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.23PMID:23101633
Warning
DescriptionQualifierReference
co-expressed with adjacent geneInferred from Sequence or Structural Similarity
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in bacteria
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPCC16C4.106-phosphogluconolactonase (predicted) Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:22681890
pca1metacaspase Pca1 Positive GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
SPBC713.07cvacuolar polyphosphatase (predicted) Negative GeneticPMID:22681890
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
rem1meiosis-specific cyclin Rem1 Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
SPBC839.03cneddylation protein Dcn1 (predicted) Positive GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
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External References
Database Identifier Description
NBRP SPAC5H10.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC5H10.09c Retrieval of eukaryotic orthologs
BioGrid SPAC5H10.09c BioGRID Interaction Datasets
Bähler Lab SPAC5H10.09c Cell Cycle Expression Profile
Bähler Lab SPAC5H10.09c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC5H10.09c Pheromone response/mating expression profiles
Bähler Lab SPAC5H10.09c Environmental stress expression profiles
Bähler Lab SPAC5H10.09c Bähler Lab Transcriptome Viewer
Cyclebase SPAC5H10.09c Cell Cycle Data
PInt SPAC5H10.09c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC5H10.09c Entrez Gene
WikiGene25427313-methyl-2-oxobutanoatehydroxymethyltransferase (predicted)
EntrezGene25427313-methyl-2-oxobutanoatehydroxymethyltransferase (predicted)
IntEnz2.1.2.11
SPD / RIKEN10/10B09Orfeome Localization Data
UniProtKB/SwissProtQ09672Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase
ModBaseQ09672Database of comparative protein structure models
Pfam Protein DomainsQ09672Pfam Domain Arrangement
RefSeq PeptideNP_5928223-methyl-2-oxobutanoatehydroxymethyltransferase (predicted)
RefSeq mRNANM_001018222972h- 3-methyl-2-oxobutanoatehydroxymethyltransferase (predicted) (SPAC5H10.09c), mRNA
European Nucleotide ArchiveCAA89959ENA Protein Mapping
SPD / RIKEN10/10B09Orfeome Localization Data

Literature for SPAC5H10.09c
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013