spo3 (SPAC607.10)

Gene Standard Namespo3 Characterisation Statuspublished
Systematic IDSPAC607.10 Feature Typeprotein coding
Synonyms Name Description
Productsporulation protein Spo3 Product Size1028aa, 119.41 kDa
Genomic Location Chromosome I, 2052799-2057177 (4379nt); CDS:2053945-2057031 (3087nt)

Ensembl Gene Location
GO Biological Process

GO Slim Terms

ascospore formation

Term NameCount
ascospore formation68
Annotation ExtensionEvidenceWith/FromReference
ascospore-type prospore assembly20
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
plasma membrane249
Annotation ExtensionEvidenceWith/FromReference
prospore membrane26
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
increased cell population growth ratespo3ΔNull246
viable vegetative cell populationspo3ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
abnormal forespore membrane formationspo3ΔNull25
abnormal sporulation resulting in formation of ascus containing anucleate sporesspo3Not specified10
abolished sporulationspo3Not specified54
spo3-B3Not specified
normal meiosisspo3-B3Not specified140
normal mitotic spindle pole bodyspo3Not specified9
spindle pole body absent from cell after meiosis IIspo3Not specified9
viable vegetative cell with normal cell morphologyspo3ΔNull3092
Target Of
FYPO affected by mutation in npg1 GTPase regulator Rng2-like (predicted) PMID:25146394
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR2052799..2053944PMID:21511999
3' UTR2057032..2057177PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
SignalP-noTM signalp 1 19 212

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 116.16 Da
Charge 2.50
Isoelectric point 6.75
Molecular weight 119.41 kDa
Number of residues 1028
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0034293experimental evidencePMID:PMPB:0

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.1during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.25during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
Schizosaccharomyces specific220

Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
enhances phenotype ofdma1mitotic spindle checkpoint ubiquitin ligase Dma1 Phenotypic EnhancementPMID:20980623
phenotype enhanced bynpg1GTPase regulator Rng2-like (predicted) Phenotypic EnhancementPMID:25146394
rescuespsy1SNARE Psy1 Phenotypic SuppressionPMID:11739793
positive genetic interaction withres1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC607.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC607.10 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC607.10 BioGRID Interaction Datasets
Expression Viewer SPAC607.10 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC607.10 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC607.10 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC607.10 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC607.10 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC607.10 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC607.10 Cell Cycle Data
GEO SPAC607.10 GEO profiles
PInt SPAC607.10 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC607.10 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC607.10 Fission yeast phenotypic data & analysis
SPD / RIKEN29/29H12Orfeome Localization Data
UniProtKB/SwissProtQ9US08Sporulation-specific protein 3
ModBaseQ9US08Database of comparative protein structure models
STRINGQ9US08Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593599sporulation protein Spo3
RefSeq mRNANM_001019030972h- sporulation protein Spo3 (spo3), mRNA
European Nucleotide ArchiveCAB63797.1ENA Protein Mapping
UniParcUPI0000135E5AUniProt Archive

Literature for spo3

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015