erg25 (SPAC630.08c)


Gene Standard Nameerg25 Characterisation Statusbiological_role_inferred
Systematic IDSPAC630.08c Feature Typeprotein coding
Synonyms Name Description
ProductC-4 methylsterol oxidase Erg25 (predicted) Product Size300aa, 35.80 kDa
Genomic Location Chromosome I, 361266-359638 (1629nt); CDS:360962-360060 (903nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000254C-4 methylsterol oxidase activityISSUniProtKB:P53045GO_REF:00000241
GO:0005506iron ion bindingIEAIPR006694GO_REF:000000224
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006696ergosterol biosynthetic processISSUniProtKB:P53045GO_REF:000002444
GO:0006633fatty acid biosynthetic processIEAIPR006694GO_REF:000000229
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0005789endoplasmic reticulum membraneISSUniProtKB:P53045GO_REF:0000024205
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyerg25ΔNullPMID:204732891338
Microscopyerg25ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002420inviable after spore germination, single cell division, abnormal cell shapeMicroscopyerg25ΔNullPECO:0000005, PECO:0000137PMID:2369780647
FYPO:0002151inviable sporeMicroscopyerg25ΔNullPECO:0000005, PECO:0000137PMID:23697806465
Target Of
OntologyRelationshipGeneProductReference
GO regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1 PMID:15797383
GO regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1 PMID:16537923
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1361266359638

UTRs

Region Coordinates Reference
three_prime_UTR360059..359638PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04116 Pfam IPR006694 Fatty acid hydroxylase 140 256 5
PTHR11863 HMMPANTHER 1 300 4
PTHR11863:SF4 HMMPANTHER 1 300 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 119.34 Da
Charge 10.00
Isoelectric point 8.07
Molecular weight 35.80 kDa
Number of residues 300
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
88053during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
63481during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
61263during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
59981during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
62710during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
17421.75during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
7511.28during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
41during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
9.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC630.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC630.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC630.08c BioGRID Interaction Datasets
Expression Viewer SPAC630.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC630.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC630.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC630.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC630.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC630.08c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC630.08c Cell Cycle Data
GEO SPAC630.08c GEO profiles
PInt SPAC630.08c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC630.08c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC630.08c Fission yeast phenotypic data & analysis
SPD / RIKEN12/12D07Orfeome Localization Data
IntEnz1.-.-.-Integrated relational Enzyme database
Rhea1.-.-.-Annotated reactions database
UniProtKB/SwissProtQ9UUH4Methylsterol monooxygenase
ModBaseQ9UUH4Database of comparative protein structure models
STRINGQ9UUH4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592903C-4 methylsterol oxidase (predicted)
RefSeq mRNANM_001018303972h- C-4 methylsterol oxidase (predicted) (erg25), mRNA
European Nucleotide ArchiveCAB52730.1ENA Protein Mapping
UniParcUPI000012A0D5UniProt Archive

Literature for erg25

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014