erg25 (SPAC630.08c)

Gene Standard Nameerg25 Characterisation Statusbiological_role_inferred
Systematic IDSPAC630.08c Feature Typeprotein coding
Synonyms Name Description
ProductC-4 methylsterol oxidase Erg25 (predicted) Product Size300aa, 35.80 kDa
Genomic Location Chromosome I, 361266-359638 (1629nt); CDS:360962-360060 (903nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000254C-4 methylsterol oxidase activityISSUniProtKB:P53045GO_REF:00000011
GO:0005506iron ion bindingIEAIPR006694GO_REF:000000223
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006696ergosterol biosynthetic processISSUniProtKB:P53045GO_REF:000000139
GO:0006633fatty acid biosynthetic processIEAIPR006694GO_REF:000000229
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0005789endoplasmic reticulum membraneISSUniProtKB:P53045GO_REF:0000001207
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyerg25ΔNullPMID:204732891309
Microscopyerg25ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002420inviable after spore germination, single cell division, abnormal cell shapeMicroscopyerg25ΔNullPECO:0000005, PECO:0000137PMID:2369780646
FYPO:0002151inviable sporeMicroscopyerg25ΔNullPECO:0000005, PECO:0000137PMID:23697806447
Target Of
regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1 PMID:16537923
regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1 PMID:15797383
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04116 Pfam IPR006694 Fatty acid hydroxylase 140 256 5
PTHR11863 HMMPANTHER 1 300 4
PTHR11863:SF4 HMMPANTHER 1 300 1
Low complexity (SEG) seg 289 300

View domain organization at Pfam

Protein Properties

Ave. residue weight 119.34 Da
Charge 10.00
Isoelectric point 8.07
Molecular weight 35.80 kDa
Number of residues 300
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
7511.28during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
17421.75during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
9.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
41during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAC630.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC630.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC630.08c BioGRID Interaction Datasets
Expression Viewer SPAC630.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC630.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC630.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC630.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC630.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC630.08c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC630.08c Cell Cycle Data
GEO SPAC630.08c GEO profiles
PInt SPAC630.08c Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz1.-.-.-Integrated relational Enzyme database
Rhea1.-.-.-Annotated reactions database
WikiGene2543373C-4 methylsterol oxidase (predicted)
EntrezGene2543373C-4 methylsterol oxidase (predicted)
SPD / RIKEN12/12D07Orfeome Localization Data
UniProtKB/SwissProtQ9UUH4Methylsterol monooxygenase
ModBaseQ9UUH4Database of comparative protein structure models
StringQ9UUH4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592903C-4 methylsterol oxidase (predicted)
RefSeq mRNANM_001018303972h- C-4 methylsterol oxidase (predicted) (erg25), mRNA
European Nucleotide ArchiveCAB52730ENA Protein Mapping
UniParcUPI000012A0D5UniProt Archive

Literature for erg25

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014