erg25 (SPAC630.08c)


Gene Standard Nameerg25 Characterisation Statusbiological role inferred
Systematic IDSPAC630.08c Feature Typeprotein coding
Synonyms Name Description
ProductC-4 methylsterol oxidase Erg25 (predicted) Product Size300aa, 35.80 kDa
Genomic Location Chromosome I, 361266-359638 (1629nt); CDS:360962-360060 (903nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
C-4 methylsterol oxidase activity1
Annotation ExtensionEvidenceWith/FromReference
iron ion binding17
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ergosterol biosynthetic process45
Annotation ExtensionEvidenceWith/FromReference
fatty acid biosynthetic process29
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum599
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane204
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane966
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationerg25Δ1455

Cell Phenotype

Term NameGenotypesCount
inviable after spore germination, single cell division, abnormal cell shapeerg25Δ49
inviable sporeerg25Δ476
Target Of
OntologyRelationshipGeneProduct
GO regulated by sre1 sterol regulatory element binding protein, transcription factor Sre1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons361266..359638
mRNA361266..359638
5' UTR361266..360963AU010457
CDS360962..360060
3' UTR360059..359638PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04116 Pfam IPR006694 Fatty acid hydroxylase 140 276 5
PTHR11863 HMMPANTHER 23 298 4
PTHR11863:SF22 HMMPANTHER 23 298 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 119.34 Da
Charge 10.00
Codon Adaptation Index 0.73
Isoelectric point 8.07
Molecular weight 35.80 kDa
Number of residues 300
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0071456expression microarray evidencePMID:22235339

Quantitative Gene Expression

View graphical display of gene expression data for erg25 (SPAC630.08c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
88053during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
63481during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
61263during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
59981during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
17421.75during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
62710during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7511.28during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
41during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
9.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPAC630.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC630.08c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC630.08c BioGRID Interaction Datasets
Expression Viewer SPAC630.08c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC630.08c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC630.08c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC630.08c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC630.08c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC630.08c Transcriptome Viewer (Bähler Lab)
GEO SPAC630.08c GEO profiles
PInt SPAC630.08c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC630.08c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC630.08c Fission yeast phenotypic data & analysis
Cyclebase SPAC630.08c.1 Cell Cycle Data
IntEnz1.-.-.-Integrated relational Enzyme database
Rhea1.-.-.-Annotated reactions database
SPD / RIKEN12/12D07Orfeome Localization Data
UniProtKB/SwissProtQ9UUH4Methylsterol monooxygenase
ModBaseQ9UUH4Database of comparative protein structure models
STRINGQ9UUH4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_592903C-4 methylsterol oxidase (predicted)
RefSeq mRNANM_001018303972h- C-4 methylsterol oxidase (predicted) (erg25), mRNA
European Nucleotide ArchiveCAB52730.1ENA Protein Mapping
UniParcUPI000012A0D5UniProt Archive

Literature for erg25

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016