swi6 (SPAC664.01c)


Gene Standard Nameswi6 Characterisation Statuspublished
Systematic IDSPAC664.01c Feature Typeprotein coding
SynonymsSPAC824.10c Name Descriptionswitching
ProductHP1 family chromodomain protein Swi6 Product Size328aa, 37.29 kDa
Genomic Location Chromosome I, 1704073-1702406 (1668nt); CDS:1704001-1703015 (987nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
chromatin binding29
methylated histone binding8
Annotation ExtensionEvidenceWith/FromReference
nucleosomal DNA binding1
Annotation ExtensionEvidenceWith/FromReference
nucleosomal histone binding4
protein binding856
RNA binding570
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular protein localization551
Annotation ExtensionEvidenceWith/FromReference
chromatin remodeling156
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere60
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere outer repeat region25
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at silent mating-type cassette35
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at telomere22
Annotation ExtensionEvidenceWith/FromReference
chromosome passenger complex localization to kinetochore4
Annotation ExtensionEvidenceWith/FromReference
donor selection3
Annotation ExtensionEvidenceWith/FromReference
gene conversion at mating-type locus13
Annotation ExtensionEvidenceWith/FromReference
mating type switching21
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid cohesion16
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid segregation185
Annotation ExtensionEvidenceWith/FromReference
protein localization to chromosome, centromeric region21
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
chromosome, centromeric outer repeat region2
Annotation ExtensionEvidenceWith/FromReference
condensed nuclear chromosome, centromeric region68
Annotation ExtensionEvidenceWith/FromReference
mating-type region heterochromatin26
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body216
Annotation ExtensionEvidenceWith/FromReference
nuclear pericentric heterochromatin38
Annotation ExtensionEvidenceWith/FromReference
nucleus2695
Annotation ExtensionEvidenceWith/FromReference
pericentric heterochromatin38
Annotation ExtensionEvidenceWith/FromReference
telomeric heterochromatin13
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
normal growth on thiabendazoleswi6+SV40NLS (SV40 NLS added at N-terminus)Not specified13
swi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)Not specified
sensitive to 4-nitroquinoline N-oxideswi6ΔNull159
sensitive to 5-fluorouracilswi6ΔNull271
sensitive to hydroxyureaswi6ΔNull534
sensitive to thiabendazoleswi6ΔNull211
viable vegetative cell populationswi6ΔNull3795

Cell Phenotype

Term NameAlleleExpressionCount
abnormal mating type switching resulting in duplication or deletion in mating-type regionswi6-115Not specified2
abnormal meiotic recombination at silent mating-type cassetteswi6-115Not specified2
abolished protein localization to centromere28
affecting pds5swi6ΔNull
affecting hrk1swi6ΔNull
abolished protein localization to heterochromatin4
affecting crb3swi6ΔNull
affecting las1swi6ΔNull
affecting ipi1swi6ΔNull
affecting rix1swi6ΔNull
affecting grc3swi6ΔNull
abolished RNA bindingswi6-chromo (1-74, 140-328)Not specified10
swi6-shadow (1-264)Not specified
decreased chromatin silencing at centromere outer repeat regionswi6ΔNull34
decreased chromatin silencing at silent mating-type cassetteswi6-115Not specified19
swi6-S115Not specified
decreased chromatin silencing at telomereswi6ΔNull25
decreased histone H2A phosphorylation at subtelomere during mitotic S phaseswi6ΔNull2
decreased histone H3-K9 dimethylation at silent mating-type cassetteswi6ΔNull1
decreased mating type switchingswi6 mutantNot specified12
decreased mitotic centromeric sister chromatid cohesionswi6ΔNull4
decreased protein localization to centromere37
affecting rad21swi6ΔNull
decreased RNA bindingswi6-KR25A (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A)Not specified10
increased centromeric outer repeat transcript levelunnamed (unrecorded)19
increased chromatin silencing at silent mating-type cassetteswi6+ (wild type)Overexpression1
increased level of heterochromatin-encoded proteinsswi6ΔNull3
increased mating type switchingswi6-115Not specified1
swi6ΔNull
increased meiotic DNA double-strand break formation at silent mating-type cassetteswi6-115Not specified1
increased meiotic recombination at silent mating-type cassetteswi6-115Not specified2
increased protein localization to mating-type region heterochromatin1
affecting swi6swi6+ (wild type)Overexpression
increased RNA level during vegetative growth187
affecting SO:0000286swi6ΔNull
lagging mitotic chromosomesswi6-115Not specified25
swi6ΔNull
meiosis and sporulation in haploidswi6-115Not specified7
normal DNA contentswi6ΔNull22
normal DNA double-strand break formation at mating-type locusswi6 mutantNot specified6
normal histone H2A phosphorylation at centromere outer repeatswi6ΔNull1
normal histone H2A phosphorylation at mating type locusswi6ΔNull2
normal histone H3-K9 dimethylation at silent mating-type cassetteswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)Not specified2
normal histone H3-K9 dimethylation at telomereswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)Not specified2
swi6ΔNull
normal methylated histone residue bindingswi6-KR25A (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A)Not specified1
normal RNA bindingswi6-hinge (1-139, 265-328)Not specified3
normal S-phase DNA damage checkpointswi6ΔNull17
premature mitotic sister chromatid segregationswi6ΔNull4
viable vegetative cell with normal cell morphologyswi6ΔNull3093
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in clr3 histone deacetylase (class II) Clr3 PMID:23771057
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:18761674
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:15947136
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:21151114
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:10766735
FYPO affected by mutation in dcr1 dicer PMID:21151114
FYPO affected by mutation in dcr1 dicer PMID:15947136
FYPO affected by mutation in pcf1 CAF assembly factor (CAF-1) complex large subunit Pcf1 PMID:18761674
FYPO affected by mutation in pol1 DNA polymerase alpha catalytic subunit PMID:11581276
FYPO affected by mutation in pol1 DNA polymerase alpha catalytic subunit PMID:11387218
FYPO affected by mutation in rik1 silencing protein Rik1 PMID:10766735
FYPO affected by mutation in snu4 small nuclear RNA U4 PMID:20018856
FYPO affected by mutation in spt6 nucleosome remodeling protein Spt6 PMID:21844224
FYPO affected by mutation in stc1 LIM-like protein linking chromatin modification to RNAi, Stc1 PMID:20211136
FYPO affected by mutation in swi6 HP1 family chromodomain protein Swi6 PMID:11387218
GO localized by clr4 histone H3 lysine methyltransferase Clr4 PMID:11283354
GO localized by pob3 FACT complex subunit Pob3 PMID:17614284
GO localized by raf1 CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 PMID:16040243
GO localized by raf2 Rik1-associated factor Raf2 PMID:16040243
GO localized by rdp1 RNA-directed RNA polymerase Rdp1 PMID:15615848
GO localized by rik1 silencing protein Rik1 PMID:8937892
GO localized by sir2 Sirtuin family histone deacetylase Sir2 PMID:15545655
GO localized by tas3 RITS complex subunit 3 PMID:14704433
GO substrate of hsk1 Dbf4(Dfp1)-dependent protein kinase Hsk1 PMID:14625560
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1704073..1702406
mRNA1704073..1702406
5' UTR1704073..1704002AU011088
CDS1704001..1703015
3' UTR1703014..1702406PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00385 Pfam IPR023780 Chromo domain 81 133 7
PF01393 Pfam IPR008251 Chromo shadow domain 265 326 2
SM00298 SMART IPR000953 Chromo/chromo shadow domain 80 136 9
SM00300 SMART IPR008251 Chromo shadow domain 261 327 2
PS50013 Prosite Profiles IPR000953 Chromo/chromo shadow domain 81 143 7
PS50013 Prosite Profiles IPR000953 Chromo/chromo shadow domain 267 328 7
PS00598 Prosite Patterns IPR023779 Chromo domain, conserved site 100 121 4
PTHR22812 HMMPANTHER 74 327 3
2.40.50.40 Gene3D 70 135 7
2.40.50.40 Gene3D 264 327 7
SSF54160 SuperFamily IPR016197 Chromo domain-like 263 322 9
SSF54160 SuperFamily IPR016197 Chromo domain-like 74 143 9
Coil ncoils Rabaptin coiled-coil domain 60 81 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050
PBO:0012553HP1/CBX familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0012553

Protein Properties

Ave. residue weight 113.70 Da
Charge -13.50
Isoelectric point 4.87
Molecular weight 37.29 kDa
Number of residues 328
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS224
present during mitotic M phaseS203
present during cellular response to thiabendazole, mitotic M phaseS246
present during mitotic M phaseS159
present during mitotic M phase, cellular response to thiabendazoleS18
S18, S159, S246
present during mitotic M phase, cellular response to thiabendazoleS24
level fluctuates during mitotic cell cycleS212
present during mitotic M phaseS212
Annotation ExtensionEvidenceResidueReference
experimental evidence S18 PMID:24763107
present during mitotic M phase experimental evidence S18 PMID:21712547
present during cellular response to thiabendazole IDA S18 PMID:18257517
present during cellular response to thiabendazole IDA S24 PMID:18257517
present during mitotic M phase experimental evidence S24 PMID:21712547
experimental evidence S159 PMID:24763107
present during mitotic M phase experimental evidence S159 PMID:21712547
present during mitotic M phase experimental evidence S203 PMID:21712547
level fluctuates during mitotic cell cycle experimental evidence S212 PMID:24763107
present during mitotic M phase experimental evidence S212 PMID:21712547
present during mitotic M phase experimental evidence S224 PMID:21712547
experimental evidence S246 PMID:24763107
present during cellular response to thiabendazole IDA S246 PMID:18257517
present during mitotic M phase experimental evidence S246 PMID:21712547
O-phospho-L-threonine 698
present during mitotic M phaseT235
T240
present during mitotic M phase, cellular response to thiabendazoleT240
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T235 PMID:21712547
experimental evidence T240 PMID:24763107
present during cellular response to thiabendazole IDA T240 PMID:18257517
present during mitotic M phase experimental evidence T240 PMID:21712547
phosphorylated residue 1926
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7653during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8917during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8199during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
7981during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8351during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2394.42during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
3469.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog598
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturesatf1transcription factor, Atf-CREB family Atf1 Affinity Capture-WesternPMID:15292231
affinity capturescdc18MCM loader Affinity Capture-WesternPMID:21239883
forms complex withcdc18MCM loader Reconstituted ComplexPMID:21239883
affinity capturesclr3histone deacetylase (class II) Clr3 Affinity Capture-WesternPMID:16246721
affinity captured byclr3histone deacetylase (class II) Clr3 Affinity Capture-WesternPMID:16246721
affinity captured byclr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:21224386
affinity capturesclr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:21224386
affinity captured bydfp1Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 Affinity Capture-WesternPMID:14625560
forms complex withepe1Jmjc domain chromatin associated protein Epe1 Reconstituted ComplexPMID:18809570
affinity captured byepe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-WesternPMID:18809570
binds activation domain construct withepe1Jmjc domain chromatin associated protein Epe1 Two-hybridPMID:21215368
affinity capturesepe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-WesternPMID:16762840
affinity captured byepe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-WesternPMID:16762840
forms complex withepe1Jmjc domain chromatin associated protein Epe1 Reconstituted ComplexPMID:16762840
binds activation domain construct withers1RNA-silencing factor Ers1 Two-hybridPMID:22474355
binds DNA-binding domain construct withers1RNA-silencing factor Ers1 Two-hybridPMID:22474355
affinity capturesers1RNA-silencing factor Ers1 Affinity Capture-WesternPMID:22474355
forms complex withers1RNA-silencing factor Ers1 Reconstituted ComplexPMID:22733737
affinity captured byers1RNA-silencing factor Ers1 Affinity Capture-WesternPMID:22733737
binds DNA-binding domain construct withers1RNA-silencing factor Ers1 Two-hybridPMID:22733737
(peptide) binds to proteinhht1histone H3 h3.1 Protein-peptidePMID:22727667
forms complex withhht1histone H3 h3.1 Reconstituted ComplexPMID:21211724
binds to peptidehht1histone H3 h3.1 Protein-peptidePMID:20299449
forms complex withhht2histone H3 h3.2 Reconstituted ComplexPMID:21211724
binds to peptidehht2histone H3 h3.2 Protein-peptidePMID:20299449
forms complex withhht3histone H3 h3.3 Reconstituted ComplexPMID:21211724
(peptide) binds to proteinhht3histone H3 h3.3 Protein-peptidePMID:23281010
binds to peptidehht3histone H3 h3.3 Protein-peptidePMID:20299449
affinity captureship1hira protein, histone chaperone Hip1 Affinity Capture-WesternPMID:21211723
affinity captureship3HIRA interacting protein Hip3 Affinity Capture-MSPMID:21211723
affinity captured byhrp3ATP-dependent DNA helicase Hrp3 Affinity Capture-WesternPMID:22990236
modified byhsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Biochemical ActivityPMID:14625560
affinity captured byhsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Affinity Capture-WesternPMID:14625560
binds DNA-binding domain construct withhus5SUMO conjugating enzyme E2 Hus5 Two-hybridPMID:16168376
affinity captureshus5SUMO conjugating enzyme E2 Hus5 Affinity Capture-WesternPMID:16168376
affinity captured bypcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Affinity Capture-WesternPMID:18761674
affinity capturespcr1transcription factor Pcr1 Affinity Capture-WesternPMID:15292231
affinity captured bypol1DNA polymerase alpha catalytic subunit Affinity Capture-WesternPMID:11581276
affinity capturespol1DNA polymerase alpha catalytic subunit Affinity Capture-WesternPMID:11581276
forms complex withpol1DNA polymerase alpha catalytic subunit Reconstituted ComplexPMID:11387218
affinity capturespsc3mitotic cohesin complex, non-SMC subunit Psc3 Affinity Capture-WesternPMID:11780129
binds DNA-binding domain construct withpsc3mitotic cohesin complex, non-SMC subunit Psc3 Two-hybridPMID:11780129
binds activation domain construct withsgo1inner centromere protein, shugoshin, Sgo1 Two-hybridPMID:18716626
binds DNA-binding domain construct withsgo2inner centromere protein, shugoshin Sgo2 Two-hybridPMID:20929775
binds activation domain construct withswi2Swi5 complex subunit Swi2 Two-hybridPMID:15537537
affinity captured byswi2Swi5 complex subunit Swi2 Affinity Capture-WesternPMID:15537537
binds DNA-binding domain construct withswi2Swi5 complex subunit Swi2 Two-hybridPMID:14663140
forms complex withswi6HP1 family chromodomain protein Swi6 Reconstituted ComplexPMID:21211724
affinity capturesswi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:21224386
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withago1argonaute Positive GeneticPMID:18818364
positive genetic interaction withago1argonaute Positive GeneticPMID:22681890
synthetic growth defect withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Synthetic Growth DefectPMID:18252195
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withalp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
negative genetic interaction withalp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:22681890
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
synthetic growth defect withark1aurora-B kinase Ark1 Synthetic Growth DefectPMID:17322402
rescued byark1aurora-B kinase Ark1 Phenotypic SuppressionPMID:22264609
synthetic lethal withark1aurora-B kinase Ark1 Synthetic LethalityPMID:22264609
synthetic growth defect withark1aurora-B kinase Ark1 Synthetic Growth DefectPMID:22264609
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
synthetic growth defect withash2Ash2-trithorax family protein Synthetic Growth DefectPMID:18931302
negative genetic interaction withasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:18818364
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:22681890
synthetic growth defect withbir1survivin, Bir1 Synthetic Growth DefectPMID:17322402
synthetic lethal withbir1survivin, Bir1 Synthetic LethalityPMID:22264609
enhances phenotype ofbrc1BRCT domain protein Brc1 Phenotypic EnhancementPMID:23358415
synthetic growth defect withbub1mitotic spindle checkpoint kinase Bub1 Synthetic Growth DefectPMID:14730319
synthetic lethal withbub1mitotic spindle checkpoint kinase Bub1 Synthetic LethalityPMID:9864354
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:22681890
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withcbp1CENP-B homolog Negative GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcdr2serine/threonine protein kinase Cdr2 Negative GeneticPMID:22681890
negative genetic interaction withcgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
synthetic growth defect withchl1ATP-dependent DNA helicase Chl1 (predicted) Synthetic Growth DefectPMID:18931302
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:18818364
enhances phenotype ofchp1chromodomain protein Chp1 Phenotypic EnhancementPMID:10835380
phenotype enhanced bychp2HP1 family chromodomain protein 2 Phenotypic EnhancementPMID:20421495
phenotype enhanced bychp2HP1 family chromodomain protein 2 Phenotypic EnhancementPMID:23604080
enhances phenotype ofcid14poly(A) polymerase Cid14 Phenotypic EnhancementPMID:22683269
negative genetic interaction withclp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
phenotype enhanced byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:22264609
rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:22264609
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
positive genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
phenotype enhanced byclr5Clr5 protein Phenotypic EnhancementPMID:21253571
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
synthetic growth defect withcsn1COP9/signalosome complex subunit Csn1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
rescued bycut7kinesin-like protein Cut7 Phenotypic SuppressionPMID:22264609
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
enhances phenotype ofdcr1dicer Phenotypic EnhancementPMID:23572080
synthetic growth defect withdcr1dicer Synthetic Growth DefectPMID:23572080
positive genetic interaction withdcr1dicer Positive GeneticPMID:18818364
enhances phenotype ofdcr1dicer Phenotypic EnhancementPMID:15475954
synthetic lethal withdis33'-5' exoribonuclease subunit Dis3 Synthetic LethalityPMID:17380189
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withelp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:22681890
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
synthetic growth defect witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Synthetic Growth DefectPMID:23050226
synthetic growth defect withfin1serine/threonine protein kinase, NIMA related Fin1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
synthetic growth defect withgtb1gamma-tubulin Gtb1 Synthetic Growth DefectPMID:22737087
negative genetic interaction withhap2HMG box protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
positive genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:18818364
negative genetic interaction withimp1importin alpha Negative GeneticPMID:22681890
negative genetic interaction withklp5kinesin-like protein Klp5 Negative GeneticPMID:22681890
synthetic growth defect withklp6kinesin-like protein Klp6 Synthetic Growth DefectPMID:18931302
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
rescued byklp9kinesin-like protein Klp9 Phenotypic SuppressionPMID:22264609
negative genetic interaction withlsc1Lsk1 associated cyclin Negative GeneticPMID:22681890
negative genetic interaction withlsg1Lsk1 complex gamma subunit Lsg1 Negative GeneticPMID:22681890
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:22681890
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
synthetic growth defect withmad2mitotic spindle checkpoint protein Mad2 Synthetic Growth DefectPMID:22737087
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
negative genetic interaction withmcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
rescuesmde4microtubule-site clamp monopolin complex subunit Mde4 Phenotypic SuppressionPMID:22264609
positive genetic interaction withmed20mediator complex subunit Med20 Positive GeneticPMID:18818364
negative genetic interaction withmis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
rescuesmis4adherin, cohesin loading factor Mis4 Phenotypic SuppressionPMID:21189291
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
positive genetic interaction withmpr1histidine-containing response regulator phosphotransferase Mpr1 Positive GeneticPMID:22681890
synthetic growth defect withmrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
negative genetic interaction withmsd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:18818364
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:22681890
synthetic growth defect withmst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth DefectPMID:18505873
synthetic growth defect withmst2histone acetyltransferase Mst2 Synthetic Growth DefectPMID:16199868
positive genetic interaction withmug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
synthetic growth defect withnda3tubulin beta Nda3 Synthetic Growth DefectPMID:8937982
synthetic growth defect withnda3tubulin beta Nda3 Synthetic Growth DefectPMID:9722643
negative genetic interaction withnht1Ino80 complex HMG box subunit Nht1 Negative GeneticPMID:22681890
negative genetic interaction withnrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
positive genetic interaction withpek1MAP kinase kinase Pek1 Positive GeneticPMID:22681890
synthetic growth defect withpic1INCENP, Pic1 Synthetic Growth DefectPMID:17322402
synthetic lethal withpic1INCENP, Pic1 Synthetic LethalityPMID:22264609
positive genetic interaction withpmk1MAP kinase Pmk1 Positive GeneticPMID:22681890
synthetic growth defect withpof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
phenotype enhanced bypol1DNA polymerase alpha catalytic subunit Phenotypic EnhancementPMID:6587363
negative genetic interaction withpph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withpph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withprp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
synthetic lethal withpsc3mitotic cohesin complex, non-SMC subunit Psc3 Synthetic LethalityPMID:11780129
synthetic lethal withpsc3mitotic cohesin complex, non-SMC subunit Psc3 Synthetic LethalityPMID:16682348
synthetic lethal withpsm1mitotic cohesin complex subunit Psm1 Synthetic LethalityPMID:16682348
negative genetic interaction withpsy2protein phosphatase PP4 complex subunit Psy2 (predicted) Negative GeneticPMID:22681890
synthetic lethal withrad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:11780129
synthetic lethal withrad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:11598266
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
negative genetic interaction withrad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
synthetic growth defect withrad57RecA family ATPase Rad57/Rhp57 Synthetic Growth DefectPMID:18931302
positive genetic interaction withraf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
positive genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withrps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:22681890
negative genetic interaction withsap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
positive genetic interaction withsec28coatomer epsilon subunit (predicted) Positive GeneticPMID:18818364
synthetic growth defect withset2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18252195
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
synthetic growth defect withsgo2inner centromere protein, shugoshin Sgo2 Synthetic Growth DefectPMID:14730319
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
synthetic growth defect withsgo2inner centromere protein, shugoshin Sgo2 Synthetic Growth DefectPMID:20929775
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:22681890
synthetic growth defect withslm9hira protein Slm9 Synthetic Growth DefectPMID:18931302
negative genetic interaction withSPAC18G6.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
positive genetic interaction withSPAC750.04cS. pombe specific 5Tm protein family Positive GeneticPMID:22681890
negative genetic interaction withspf30splicing factor Spf30 (predicted) Negative GeneticPMID:22681890
synthetic growth defect withspf30splicing factor Spf30 (predicted) Synthetic Growth DefectPMID:20028739
synthetic lethal withssl3cohesin loading factor Ssl3 Synthetic LethalityPMID:16682348
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
enhances phenotype ofswi1replication fork protection complex subunit Swi1 Phenotypic EnhancementPMID:6587363
synthetic growth defect withswi1replication fork protection complex subunit Swi1 Synthetic Growth DefectPMID:20176980
synthetic growth defect withswi10DNA repair endonuclease non-catalytic subunit Swi10 Synthetic Growth DefectPMID:18931302
rescuesswi5Swi5 protein Phenotypic SuppressionPMID:22042869
positive genetic interaction withtas3RITS complex subunit 3 Positive GeneticPMID:18818364
positive genetic interaction withtas3RITS complex subunit 3 Positive GeneticPMID:22681890
negative genetic interaction withtip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
positive genetic interaction withtop1DNA topoisomerase I Positive GeneticPMID:22681890
negative genetic interaction withusp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:18818364
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
positive genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC664.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC664.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC664.01c BioGRID Interaction Datasets
Expression Viewer SPAC664.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC664.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC664.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC664.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC664.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC664.01c Transcriptome Viewer (Bähler Lab)
GEO SPAC664.01c GEO profiles
PInt SPAC664.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC664.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC664.01c Fission yeast phenotypic data & analysis
Cyclebase SPAC664.01c.1 Cell Cycle Data
SPD / RIKEN14/14C10Orfeome Localization Data
UniProtKB/SwissProtP40381Chromatin-associated protein swi6
ModBaseP40381Database of comparative protein structure models
STRINGP40381Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593449chromodomain protein Swi6
RefSeq mRNANM_001018882972h- chromodomain protein Swi6 (swi6), mRNA
ePDB1E0BThe European PDB
PDB1E0BPDB
PDBsum1E0BPDBsum
ePDB2RSOThe European PDB
PDB2RSOPDB
PDBsum2RSOPDBsum
European Nucleotide ArchiveCAA50668.1ENA Protein Mapping
European Nucleotide ArchiveCAB57340.1ENA Protein Mapping
UniParcUPI00001362A2UniProt Archive

Literature for swi6

Search: Europe PMC or PubMed

Release Version: PomBase:26_51 - 07 Apr 2015