swi6 (SPAC664.01c)


Gene Standard Nameswi6 Characterisation Statuspublished
Systematic IDSPAC664.01c Feature Typeprotein coding
SynonymsSPAC824.10c Name Descriptionswitching
ProductHP1 family chromodomain protein Swi6 Product Size328aa, 37.29 kDa
Genomic Location Chromosome I, 1704073-1702406 (1668nt); CDS:1704001-1703015 (987nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
cellular protein localization495
Annotation ExtensionEvidenceWith/FromReference
chromatin organization282
Annotation ExtensionEvidenceWith/FromReference
chromatin remodeling154
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere58
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere outer repeat region26
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at silent mating-type cassette36
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at telomere24
Annotation ExtensionEvidenceWith/FromReference
chromosome passenger complex localization to kinetochore4
Annotation ExtensionEvidenceWith/FromReference
donor selection4
Annotation ExtensionEvidenceWith/FromReference
gene conversion at mating-type locus12
Annotation ExtensionEvidenceWith/FromReference
mating type switching22
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid cohesion15
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid segregation187
Annotation ExtensionEvidenceWith/FromReference
protein localization to chromosome, centromeric region21
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
chromosome, centromeric outer repeat region13
Annotation ExtensionEvidenceWith/FromReference
condensed nuclear chromosome, centromeric region70
Annotation ExtensionEvidenceWith/FromReference
mating-type region heterochromatin29
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body220
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin365
nuclear heterochromatin65
Annotation ExtensionEvidenceWith/FromReference
nuclear pericentric heterochromatin42
Annotation ExtensionEvidenceWith/FromReference
nuclear subtelomeric heterochromatin21
Annotation ExtensionEvidenceWith/FromReference
nucleus2700
Annotation ExtensionEvidenceWith/FromReference
pericentric heterochromatin42
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at low temperatureswi6::his195
decreased spore germination frequencyswi6Δ69
normal cell population growth at high temperatureswi6Δ69
normal cell population growth at low temperatureswi6Δ29
normal growth on glucose carbon sourceswi6Δ294
swi6::his1
normal growth on thiabendazoleswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)25
swi6+
swi6+SV40NLS (SV40 NLS added at N-terminus)
sensitive to 4-nitroquinoline N-oxideswi6Δ159
sensitive to 5-fluorouracilswi6Δ307
sensitive to 6-azauracilswi6Δ71
sensitive to carbendazimswi6::his127
sensitive to hydroxyureaswi6Δ594
sensitive to thiabendazoleswi6::his1329
swi6+
swi6Δ
viable vegetative cell populationswi6Δ3850

Cell Phenotype

Term NameGenotypesCount
abnormal chromatin silencing at silent mating-type cassetteswi6Δ34
abnormal mating type switching resulting in duplication or deletion in mating-type regionswi6-1153
abnormal meiotic recombination at silent mating-type cassetteswi6-1152
abnormal protein localization to heterochromatin during vegetative growth24
affects localization of epe1swi6Δ
abnormal sporulation resulting in formation of ascus with fewer than four sporesswi6Δ78
abolished protein localization to centromere during vegetative growth38
affects localization of pds5swi6Δ
affects localization of hrk1swi6Δ
abolished protein localization to heterochromatin during vegetative growth8
affects localization of crb3swi6Δ
affects localization of las1swi6Δ
affects localization of ipi1swi6Δ
affects localization of rix1swi6Δ
affects localization of grc3swi6Δ
abolished RNA bindingswi6-shadow (1-264)10
swi6-chromo (1-74, 140-328)
decreased chromatin silencing at centromere outer repeatswi6Δ48
decreased chromatin silencing at silent mating-type cassetteswi6-11529
swi6-
swi6-S115
decreased chromatin silencing at subtelomereswi6Δ12
decreased chromatin silencing at telomereswi6Δ26
decreased histone H2A phosphorylation at subtelomere during mitotic S phaseswi6Δ2
decreased histone H3-K9 dimethylation at centromereswi6Δ16
decreased histone H3-K9 dimethylation at silent mating-type cassetteswi6Δ6
decreased mating type switchingswi6 mutant16
decreased mitotic centromeric sister chromatid cohesionswi6Δ8
decreased protein level at centromere outer repeat5
affecting cut9swi6Δ
affecting cut4swi6Δ
decreased protein localization to centromere during vegetative growth32
affects localization of rad21swi6Δ
decreased protein localization to heterochromatin at centromere outer repeat11
affects localization of hrp3swi6Δ
affects localization of dsh1swi6Δ
decreased RNA bindingswi6-KR25A (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A)14
increased centromeric outer repeat transcript level31
increased chromatin silencing at silent mating-type cassetteswi6+2
increased level of heterochromatin-encoded proteinsswi6Δ3
increased mating type switchingswi6-1151
swi6Δ
increased meiotic DNA double-strand break formation at silent mating-type cassetteswi6-1151
increased meiotic recombination at silent mating-type cassetteswi6-1152
increased minichromosome loss during vegetative growthswi6::his176
increased protein localization to mating-type region heterochromatin1
affects localization of swi6swi6+
increased RNA level during vegetative growth342
affecting SPBC19C7.04cswi6Δ
affecting hsp16swi6Δ
affecting SO:0000286swi6Δ
lagging mitotic chromosomesswi6Δ41
swi6-115
swi6::his1
meiosis and sporulation in haploidswi6-11510
normal centromere clustering at nuclear peripheryswi6::his17
normal chromatin silencing at centromere outer repeatswi6+16
normal chromatin silencing at silent mating-type cassetteswi6-11522
normal DNA contentswi6Δ26
normal DNA double-strand break formation at mating-type locusswi6 mutant8
normal histone H2A phosphorylation at centromere outer repeatswi6Δ1
normal histone H2A phosphorylation at mating type locusswi6Δ2
normal histone H3-K9 dimethylation at centromere outer repeatswi6+3
normal histone H3-K9 dimethylation at silent mating-type cassetteswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)3
normal histone H3-K9 dimethylation at telomereswi6Δ2
swi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)
normal meiotic telomere clusteringswi6Δ9
normal methylated histone residue bindingswi6-KR25A (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A)1
normal RNA bindingswi6-hinge (1-139, 265-328)5
normal S-phase DNA damage checkpointswi6Δ18
normal spore morphologyswi6Δ18
normal subtelomeric chromatin knob formationswi6Δ3
normal telomere lengthswi6::his135
normal telomere tethering at nuclear peripheryswi6::his13
normal transposable element-derived small RNA levelswi6Δ5
premature mitotic sister chromatid separationswi6Δ6
viable vegetative cell with normal cell morphologyswi6Δ3102

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased cell population growth at high temperatureW804G (W804G), swi6Δ
decreased cell population growth at low temperatureswi6Δ, dis1-288
decreased cell population growth on glucose carbon sourceswi6::his1, nda3-KM311
decreased vegetative cell population growthswi6Δ, sgo2Δ
swi6Δ, bir1-CD (bir1 C-terminus fused to chromodomain), sgo2Δ
inviable vegetative cell populationpsm1-40, swi6+
psc3-3, swi6+
ssl3-103, swi6+
swi6+, psm1-21
normal cell population growth at high temperatureswi6Δ, msc1Δ
msc1Δ, swi6Δ, dis1-288
normal cell population growth at low temperatureswi6Δ, msc1Δ, dis1-288
swi6Δ, msc1Δ
normal growth on glucose carbon sourceswi6Δ, msc1Δ
msc1Δ, swi6Δ, dis1-288
normal growth on thiabendazoleswi6+, dcr1Δ
ago1Δ, swi6+
swi6+, rdp1Δ
sensitive to thiabendazoleswi6Δ, poz1Δ
swi6Δ, msc1Δ
swi6+, clr4Δ
swi6Δ, rap1Δ

Cell Phenotype

Term NameGenotypes
abolished mating type switchingswi3-1, swi6-115
decreased chromatin silencing at centromere outer repeatdcr1Δ, swi6+, clr3Δ
swi6Δ, rap1Δ
swi6+, clr3Δ
swi6Δ, poz1Δ
swi6+, clr4Δ
dcr1Δ, swi6+, sir2Δ
decreased chromatin silencing at silent mating-type cassetteswi6-115, clr5Δ
decreased chromatin silencing at telomeretaz1Δ, swi6+, Rap1-GBD (Rap1 fused to Gal4 DNA-binding domain)
decreased histone H3-K9 dimethylation at silent mating-type cassetteswi6Δ, cid14Δ
decreased histone H4-K16 acetylation at boundary element IRC1Lleo1Δ, swi6Δ
heterochromatin assembly beyond boundary element IRC1Lbdf2Δ, swi6+
heterochromatin assembly beyond boundary element IRC1Rswi6Δ, mst2Δ, epe1Δ
increased histone H3-K9 dimethylationswi6Δ, mst2Δ, epe1Δ
increased level of heterochromatin-encoded proteinsswi6Δ, cid14Δ
increased minichromosome loss during vegetative growthnda3-KM311, swi6::his1
meiosis and sporulation in haploidswi6-115, clr5Δ
normal chromatin silencing at centromere outer repeatswi6+, dcr1Δ
swi6+, rdp1Δ
ago1Δ, swi6+
normal chromatin silencing at telomeretaz1Δ, swi6+, Rap1-GBD (Rap1 fused to Gal4 DNA-binding domain)
swi6+, poz1W209A (W209A), Rap1-GBD (Rap1 fused to Gal4 DNA-binding domain)
normal histone H3-K9 dimethylation at telomereswi6Δ, cid14Δ
viable elongated vegetative cellswi6Δ, dis1-288
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1704073..1702406
mRNA1704073..1702406
5' UTR1704073..1704002AU011088
CDS1704001..1703015
3' UTR1703014..1702406PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01393 Pfam IPR008251 Chromo shadow domain 268 324 2
PF00385 Pfam IPR023780 Chromo domain 81 133 7
SM00300 SMART IPR008251 Chromo shadow domain 261 327 2
SM00298 SMART IPR000953 Chromo/chromo shadow domain 80 136 9
PS00598 Prosite Patterns IPR023779 Chromo domain, conserved site 100 121 4
PS50013 Prosite Profiles IPR000953 Chromo/chromo shadow domain 267 328 7
PS50013 Prosite Profiles IPR000953 Chromo/chromo shadow domain 81 143 7
PTHR22812:SF95 HMMPANTHER 21 158 2
PTHR22812:SF95 HMMPANTHER 259 328 2
PTHR22812 HMMPANTHER 21 158 3
PTHR22812 HMMPANTHER 259 328 3
2.40.50.40 Gene3D C-C motif chemokine 15 70 135 7
2.40.50.40 Gene3D C-C motif chemokine 15 264 327 7
SSF54160 SuperFamily IPR016197 Chromo domain-like 74 143 9
SSF54160 SuperFamily IPR016197 Chromo domain-like 263 322 9
Coil ncoils Predicted coiled-coil protein (DUF2205) 60 80 1055

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050
PBO:0012553HP1/CBX familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0012553

Protein Properties

Ave. residue weight 113.70 Da
Charge -13.50
Codon Adaptation Index 0.41
Isoelectric point 4.87
Molecular weight 37.29 kDa
Number of residues 328
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
present during mitotic M phase, cellular response to thiabendazoleS18
present during cellular response to thiabendazole, mitotic M phaseS246
present during cellular response to thiabendazole, mitotic M phaseS24
present during mitotic M phaseS203
present during mitotic M phaseS224
present during mitotic M phaseS212
present during mitotic M phaseS159
S18, S24, S159, S212, S246
level fluctuates during mitotic cell cycleS212
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S18 PMID:21712547
present during cellular response to thiabendazole IDA S246 PMID:18257517
present during cellular response to thiabendazole IDA S24 PMID:18257517
present during mitotic M phase experimental evidence S203 PMID:21712547
present during mitotic M phase experimental evidence S246 PMID:21712547
present during cellular response to thiabendazole IDA S18 PMID:18257517
present during mitotic M phase experimental evidence S224 PMID:21712547
present during mitotic M phase experimental evidence S212 PMID:21712547
present during mitotic M phase experimental evidence S24 PMID:21712547
present during mitotic M phase experimental evidence S159 PMID:21712547
experimental evidence S18 PMID:24763107
IDA S212 PMID:25720772
IDA S18 PMID:25720772
level fluctuates during mitotic cell cycle experimental evidence S212 PMID:24763107
experimental evidence S246 PMID:24763107
experimental evidence S159 PMID:24763107
IDA S24 PMID:25720772
O-phospho-L-threonine 1085
present during cellular response to thiabendazole, mitotic M phaseT240
present during mitotic M phaseT235
T240
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA T240 PMID:18257517
present during mitotic M phase experimental evidence T235 PMID:21712547
present during mitotic M phase experimental evidence T240 PMID:21712547
experimental evidence T240 PMID:24763107
IDA T240 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS12,S13,S24, S12,S18,S24, S12,S24, S13,S18,S24, S15,S24, S18,S24, S38,S43,S46, S38,S46,S52, S43,S45,S46, S43,S45,S52, S43,S46,S52, S43,S52, S43,S52,S56, S45,S46,S52, S46,S52, S192,S212, S203,S212, T14,S18,S24, T235,T240 2457
Annotation ExtensionEvidenceResidueReference
IDA S12,S24 PMID:25720772
IDA S38,S46,S52 PMID:25720772
IDA T235,T240 PMID:25720772
IDA S12,S18,S24 PMID:25720772
IDA S43,S52,S56 PMID:25720772
IDA S43,S52 PMID:25720772
IDA S43,S45,S52 PMID:25720772
IDA S18,S24 PMID:25720772
IDA S192,S212 PMID:25720772
IDA S38,S43,S46 PMID:25720772
IDA S46,S52 PMID:25720772
IDA S43,S46,S52 PMID:25720772
IDA S13,S18,S24 PMID:25720772
IDA S203,S212 PMID:25720772
IDA T14,S18,S24 PMID:25720772
IDA S12,S13,S24 PMID:25720772
IDA S43,S45,S46 PMID:25720772
IDA S45,S46,S52 PMID:25720772
IDA S15,S24 PMID:25720772
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for swi6 (SPAC664.01c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7653during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8917during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8199during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7981during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8351during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
2394.42during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
3469.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog600
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC664.01c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturesclr3histone deacetylase (class II) Clr3 Affinity Capture-WesternPMID:16246721
affinity captureshus5SUMO conjugating enzyme E2 Hus5 Affinity Capture-WesternPMID:16168376
affinity captureship1hira protein, histone chaperone Hip1 Affinity Capture-WesternPMID:21211723
affinity capturespcr1transcription factor Pcr1 Affinity Capture-WesternPMID:15292231
affinity capturesclr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:21224386
affinity capturesswi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:21224386
affinity capturesers1RNA-silencing factor Ers1 Affinity Capture-WesternPMID:22474355
affinity capturesepe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-WesternPMID:16762840
affinity capturescdc18MCM loader Affinity Capture-WesternPMID:21239883
affinity captureship3HIRA interacting protein Hip3 Affinity Capture-MSPMID:21211723
affinity capturesatf1transcription factor, Atf-CREB family Atf1 Affinity Capture-WesternPMID:15292231
affinity capturespsc3mitotic cohesin complex, non-SMC subunit Psc3 Affinity Capture-WesternPMID:11780129
affinity capturespol1DNA polymerase alpha catalytic subunit Affinity Capture-WesternPMID:11581276
affinity capturescut9anaphase-promoting complex, TPR lobe subcomplex subunit Cut9/Apc6 Affinity Capture-WesternPMID:19117951
affinity capturescut4anaphase-promoting complex, platform subcomplex scaffold subunit Apc1 Affinity Capture-WesternPMID:19117951
forms complex withcdc18MCM loader Reconstituted ComplexPMID:21239883
forms complex withswi6HP1 family chromodomain protein Swi6 Reconstituted ComplexPMID:21211724
forms complex withepe1Jmjc domain chromatin associated protein Epe1 Reconstituted ComplexPMID:16762840
forms complex withhht1histone H3 h3.1 Reconstituted ComplexPMID:21211724
forms complex withhht2histone H3 h3.2 Reconstituted ComplexPMID:21211724
forms complex withers1RNA-silencing factor Ers1 Reconstituted ComplexPMID:22733737
forms complex withpol1DNA polymerase alpha catalytic subunit Reconstituted ComplexPMID:11387218
forms complex withhht3histone H3 h3.3 Reconstituted ComplexPMID:21211724
binds DNA-binding domain construct withers1RNA-silencing factor Ers1 Two-hybridPMID:22474355
binds DNA-binding domain construct withswi2Swi5 complex subunit Swi2 Two-hybridPMID:14663140
binds DNA-binding domain construct withpsc3mitotic cohesin complex, non-SMC subunit Psc3 Two-hybridPMID:11780129
binds DNA-binding domain construct withhus5SUMO conjugating enzyme E2 Hus5 Two-hybridPMID:16168376
binds DNA-binding domain construct withsgo2inner centromere protein, shugoshin Sgo2 Two-hybridPMID:20929775
affinity captured byswi2Swi5 complex subunit Swi2 Affinity Capture-WesternPMID:15537537
affinity captured byclr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:21224386
affinity captured byhsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Affinity Capture-WesternPMID:14625560
affinity captured byclr3histone deacetylase (class II) Clr3 Affinity Capture-WesternPMID:16246721
affinity captured bydfp1Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 Affinity Capture-WesternPMID:14625560
affinity captured byepe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-WesternPMID:18809570
affinity captured byers1RNA-silencing factor Ers1 Affinity Capture-WesternPMID:22733737
affinity captured bypcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Affinity Capture-WesternPMID:18761674
affinity captured byhrp3ATP-dependent DNA helicase Hrp3 Affinity Capture-WesternPMID:22990236
affinity captured bycut9anaphase-promoting complex, TPR lobe subcomplex subunit Cut9/Apc6 Affinity Capture-WesternPMID:19117951
affinity captured bycut4anaphase-promoting complex, platform subcomplex scaffold subunit Apc1 Affinity Capture-WesternPMID:19117951
affinity captured bypol1DNA polymerase alpha catalytic subunit Affinity Capture-WesternPMID:11581276
binds activation domain construct withsgo1meiotic inner centromere protein, shugoshin, Sgo1 Two-hybridPMID:18716626
binds activation domain construct withswi2Swi5 complex subunit Swi2 Two-hybridPMID:15537537
binds activation domain construct withepe1Jmjc domain chromatin associated protein Epe1 Two-hybridPMID:21215368
binds activation domain construct withers1RNA-silencing factor Ers1 Two-hybridPMID:22474355
modified byhsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Biochemical ActivityPMID:14625560
(peptide) binds to proteinhht1histone H3 h3.1 Protein-peptidePMID:22727667
(peptide) binds to proteinhht3histone H3 h3.3 Protein-peptidePMID:23281010
binds to peptidehht1histone H3 h3.1 Protein-peptidePMID:20299449
binds to peptidehht2histone H3 h3.2 Protein-peptidePMID:20299449
binds to peptidehht3histone H3 h3.3 Protein-peptidePMID:20299449
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC664.01c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
rescuesrpt319S proteasome regulatory subunit Rpt3 (predicted) Phenotypic SuppressionPMID:24710126
rescuesleo1RNA polymerase II associated Paf1 complex (predicted) Phenotypic SuppressionPMID:25972440
rescuesepe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:25972440
rescuesswi5Swi5 protein Phenotypic SuppressionPMID:22042869
rescuesmis4cohesin loading factor (adherin) Mis4 Phenotypic SuppressionPMID:21189291
rescuesmde4microtubule-site clamp monopolin complex subunit Mde4 Phenotypic SuppressionPMID:22264609
synthetic growth defect withsgo2inner centromere protein, shugoshin Sgo2 Synthetic Growth DefectPMID:20929775
synthetic growth defect withark1aurora-B kinase Ark1 Synthetic Growth DefectPMID:17322402
synthetic growth defect withcsn1COP9/signalosome complex subunit Csn1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withdcr1dicer Synthetic Growth DefectPMID:23572080
synthetic growth defect withmrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withslm9hira protein Slm9 Synthetic Growth DefectPMID:18931302
synthetic growth defect withash2Ash2-trithorax family protein Synthetic Growth DefectPMID:18931302
synthetic growth defect withnda3tubulin beta Nda3 Synthetic Growth DefectPMID:8937982
synthetic growth defect withset2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18252195
synthetic growth defect withklp6kinesin-8 family plus-end microtubule motor Klp6 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpic1kinetochore protein, INCENP ortholog Pic1 Synthetic Growth DefectPMID:17322402
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withfin1serine/threonine protein kinase, NIMA related Fin1 Synthetic Growth DefectPMID:18931302
synthetic growth defect witheso1mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Synthetic Growth DefectPMID:23050226
synthetic growth defect withchl1ATP-dependent DNA helicase Chl1 (predicted) Synthetic Growth DefectPMID:18931302
synthetic growth defect withbir1survivin, Bir1 Synthetic Growth DefectPMID:17322402
synthetic growth defect withmad2mitotic spindle checkpoint protein Mad2 Synthetic Growth DefectPMID:22737087
synthetic growth defect withspf30splicing factor Spf30 (predicted) Synthetic Growth DefectPMID:20028739
synthetic growth defect withswi1replication fork protection complex subunit Swi1 Synthetic Growth DefectPMID:20176980
synthetic growth defect withrad57RecA family ATPase Rad57/Rhp57 Synthetic Growth DefectPMID:18931302
synthetic growth defect withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Synthetic Growth DefectPMID:18252195
synthetic growth defect withgtb1gamma-tubulin Gtb1 Synthetic Growth DefectPMID:22737087
synthetic growth defect withmst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth DefectPMID:18505873
synthetic growth defect withswi10DNA repair endonuclease non-catalytic subunit Swi10 Synthetic Growth DefectPMID:18931302
synthetic growth defect withbub1mitotic spindle checkpoint kinase Bub1 Synthetic Growth DefectPMID:14730319
synthetic growth defect withmst2histone acetyltransferase Mst2 Synthetic Growth DefectPMID:16199868
enhances phenotype ofnda3tubulin beta Nda3 Phenotypic EnhancementPMID:8937982
enhances phenotype ofclr3histone deacetylase (class II) Clr3 Phenotypic EnhancementPMID:21253571
enhances phenotype ofbdf2BET family double bromodomain protein Bdf2 Phenotypic EnhancementPMID:25972440
enhances phenotype ofswi1replication fork protection complex subunit Swi1 Phenotypic EnhancementPMID:6587363
enhances phenotype ofdcr1dicer Phenotypic EnhancementPMID:15475954
enhances phenotype ofcid14poly(A) polymerase Cid14 Phenotypic EnhancementPMID:22683269
enhances phenotype ofchp1chromodomain protein Chp1 Phenotypic EnhancementPMID:10835380
enhances phenotype ofbrc1BRCT domain protein Brc1 Phenotypic EnhancementPMID:23358415
phenotype enhanced bypol1DNA polymerase alpha catalytic subunit Phenotypic EnhancementPMID:6587363
phenotype enhanced byclr5Clr5 protein Phenotypic EnhancementPMID:21253571
phenotype enhanced bychp2HP1 family chromodomain protein 2 Phenotypic EnhancementPMID:20421495
phenotype enhanced byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:22264609
synthetically rescuesdis1TOG/XMAP14 microtubule-associated protein Dis1 Synthetic RescuePMID:26510788
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:22681890
negative genetic interaction withbub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withcbp1CENP-B homolog Negative GeneticPMID:18818364
negative genetic interaction withklp6kinesin-8 family plus-end microtubule motor Klp6 Negative GeneticPMID:18818364
negative genetic interaction withryh1GTPase Ryh1 Negative GeneticPMID:22681890
negative genetic interaction withcgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withrps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:18818364
negative genetic interaction withmcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
negative genetic interaction withgma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withmal3EB1 family Mal3 Negative GeneticPMID:18818364
negative genetic interaction withklp5kinesin-8 family plus-end microtubule motor Klp5 Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein Cph2 Negative GeneticPMID:22681890
negative genetic interaction withusp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
negative genetic interaction withypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:18818364
negative genetic interaction withfkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
negative genetic interaction withsgo2inner centromere protein, shugoshin Sgo2 Negative GeneticPMID:18818364
negative genetic interaction withspf30splicing factor Spf30 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withelp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withtip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhap2HMG box protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
negative genetic interaction withpph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction withclp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withnht1Ino80 complex HMG box subunit Nht1 Negative GeneticPMID:22681890
negative genetic interaction withcaf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
negative genetic interaction withasp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmsd1microtubule-anchoring factor Msd1 Negative GeneticPMID:22681890
negative genetic interaction withalp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
negative genetic interaction withmis4cohesin loading factor (adherin) Mis4 Negative GeneticPMID:23050226
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withlsc1Lsk1 associated cyclin Negative GeneticPMID:22681890
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withatb2tubulin alpha 2 Negative GeneticPMID:22681890
negative genetic interaction withlsg1Lsk1 complex gamma subunit Lsg1 Negative GeneticPMID:22681890
negative genetic interaction withcdr2serine/threonine protein kinase Cdr2 Negative GeneticPMID:22681890
negative genetic interaction witheso1mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withprp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
negative genetic interaction withnrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction withrad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
negative genetic interaction withalp14TOG/XMAP14 family protein Alp14 Negative GeneticPMID:18818364
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withimp1importin alpha Negative GeneticPMID:22681890
negative genetic interaction withSPAC18G6.13Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withpsy2protein phosphatase PP4 complex subunit Psy2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
positive genetic interaction withdcr1dicer Positive GeneticPMID:18818364
positive genetic interaction withypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
positive genetic interaction withtas3RITS complex subunit 3 Positive GeneticPMID:22681890
positive genetic interaction withpek1MAP kinase kinase Pek1 Positive GeneticPMID:22681890
positive genetic interaction withago1argonaute Positive GeneticPMID:18818364
positive genetic interaction withsec28coatomer epsilon subunit (predicted) Positive GeneticPMID:18818364
positive genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
positive genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
positive genetic interaction withSPAC750.04cS. pombe specific 5Tm protein family Positive GeneticPMID:22681890
positive genetic interaction withhrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:18818364
positive genetic interaction withpmk1MAP kinase Pmk1 Positive GeneticPMID:22681890
positive genetic interaction withmed20mediator complex subunit Med20 Positive GeneticPMID:18818364
positive genetic interaction withmpr1histidine-containing response regulator phosphotransferase Mpr1 Positive GeneticPMID:22681890
positive genetic interaction withtop1DNA topoisomerase I Positive GeneticPMID:22681890
positive genetic interaction withraf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
positive genetic interaction withprp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
positive genetic interaction withclg1cyclin Clg1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withrnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:22264609
rescued byklp9kinesin-like protein Klp9 Phenotypic SuppressionPMID:22264609
rescued bycut7kinesin family plus-end microtubule motor Cut7 Phenotypic SuppressionPMID:22264609
rescued byark1aurora-B kinase Ark1 Phenotypic SuppressionPMID:22264609
synthetic lethal withrad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:11780129
synthetic lethal withbub1mitotic spindle checkpoint kinase Bub1 Synthetic LethalityPMID:9864354
synthetic lethal withpsc3mitotic cohesin complex, non-SMC subunit Psc3 Synthetic LethalityPMID:11780129
synthetic lethal withpic1kinetochore protein, INCENP ortholog Pic1 Synthetic LethalityPMID:22264609
synthetic lethal withpsm1mitotic cohesin complex ATPase subunit Psm1/Smc1 Synthetic LethalityPMID:16682348
synthetic lethal withark1aurora-B kinase Ark1 Synthetic LethalityPMID:22264609
synthetic lethal withbir1survivin, Bir1 Synthetic LethalityPMID:22264609
synthetic lethal withdis33'-5' exoribonuclease subunit Dis3 Synthetic LethalityPMID:17380189
synthetic lethal withssl3cohesin loading factor Ssl3 Synthetic LethalityPMID:16682348
External References
Database Identifier Description
NBRP SPAC664.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC664.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC664.01c BioGRID Interaction Datasets
Expression Viewer SPAC664.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC664.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC664.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC664.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC664.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC664.01c Transcriptome Viewer (Bähler Lab)
GEO SPAC664.01c GEO profiles
PInt SPAC664.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC664.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC664.01c Fission yeast phenotypic data & analysis
Cyclebase SPAC664.01c.1 Cell Cycle Data
SPD / RIKEN14/14C10Orfeome Localization Data
UniProtKB/SwissProtP40381Chromatin-associated protein swi6
ModBaseP40381Database of comparative protein structure models
STRINGP40381Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593449chromodomain protein Swi6
RefSeq mRNANM_001018882972h- chromodomain protein Swi6 (swi6), mRNA
ePDB1E0BThe European PDB
PDB1E0BPDB
PDBsum1E0BPDBsum
ePDB2RSOThe European PDB
PDB2RSOPDB
PDBsum2RSOPDBsum
European Nucleotide ArchiveCAA50668.1ENA Protein Mapping
European Nucleotide ArchiveCAB57340.1ENA Protein Mapping
UniParcUPI00001362A2UniProt Archive

Literature for swi6

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016