swi6 (SPAC664.01c)


Gene Standard Nameswi6 Characterisation Statuspublished
Systematic IDSPAC664.01c Feature Typeprotein coding
SynonymsSPAC824.10c Name Descriptionswitching
ProductHP1 family chromodomain protein Swi6 Product Size328aa, 37.29 kDa
Genomic Location Chromosome I, 1704073-1702406 (1668nt); CDS:1704001-1703015 (987nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003723RNA bindingIDAPMID:22683269628
GO:0003682chromatin binding31
at five_prime_UTRIDAPMID:21151114
at ncRNAIDAPMID:21151114
at long_terminal_repeatIDAPMID:21151114
at protein_coding_geneIDAPMID:21151114
at mating_type_regionIDAPMID:21151114
at rRNAIDAPMID:21151114
at tRNAIDAPMID:21151114
at origin_of_replicationIDAPMID:21151114
at pseudogeneIDAPMID:21151114
at telomereIDAPMID:21151114
at regional_centromere_central_coreIDAPMID:21151114
at regional_centromere_inner_repeat_regionIDAPMID:21151114
at regional_centromere_outer_repeat_regionIDAPMID:21151114
GO:0035064methylated histone bindingIDAPMID:227276678
IDAPMID:22683269
GO:0031493nucleosomal histone binding4
binds histone H3.1, initiator methionine removed methylated 1 (fission yeast)IPIhht3PMID:11242054
binds histone H3.2, initiator methionine removed methylated 1 (fission yeast)IPIhht3PMID:11242054
binds fungal histone H3.3, initiator methionine removed methylated 1 (fission yeast)IPIhht3PMID:11242054
GO:0005515protein bindingIPIdfp1PMID:14625560861
IPIswi2PMID:14663140
IPIhsk1PMID:14625560
IPIhus5PMID:16168376
IPIhrk1PMID:20929775
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0034613cellular protein localization552
localizes rad21IMPPMID:11598266
localizes rdp1IMPPMID:15615848
GO:0006338chromatin remodelingNASGO_REF:0000051157
GO:0030702chromatin silencing at centromereIMPPMID:785179553
GO:0030466chromatin silencing at silent mating-type cassetteIMPPMID:820053032
GO:0006348chromatin silencing at telomereIMPPMID:785179522
GO:0072356chromosome passenger complex localization to kinetochoreNASGO_REF:00000014
GO:0007535donor selectionIMPPMID:83756484
GO:0007534gene conversion at mating-type locusIMPPMID:658736313
GO:0007533mating type switching17
requiredIMPPMID:1783290
GO:0007064mitotic sister chromatid cohesion16
requiredIGIrad21PMID:11598266
GO:0045128negative regulation of reciprocal meiotic recombinationIMPPMID:17832903
GO:0071459protein localization to chromosome, centromeric region6
localizes pds5IMPPMID:20929775
localizes hrk1IMPPMID:20929775
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0031934mating-type region heterochromatinIDAGO_REF:000000125
IDAPMID:20929775
GO:0044732mitotic spindle pole bodyIDAPMID:16823372214
GO:0031618nuclear centromeric heterochromatinIDAPMID:2092977538
GO:0005724nuclear telomeric heterochromatinIDAPMID:766012624
IDAPMID:20929775
GO:0005634nucleusIDAPMID:168233722740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000964normal growth on thiabendazoleCell growth assayswi6+SV40NLS (SV40 NLS added at N-terminus)Not specifiedPMID:226832697
Cell growth assayswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)Not specifiedPMID:22683269
FYPO:0001098sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000003Cell growth assayswi6ΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0000088sensitive to hydroxyureaCell growth assayswi6ΔNullPECO:0000137, PECO:0000005PMID:23173672511
FYPO:0000091sensitive to thiabendazoleCell growth assayswi6ΔNullPMID:22683269168
Cell growth assayswi6ΔNullPECO:0000137, PECO:0000005PMID:23173672
competitive growth assay evidenceswi6ΔNullPMID:20537132
FYPO:0002060viable vegetative cell populationMicroscopynot recorded (unrecorded)PMID:82005303730
Microscopyswi6ΔNullPMID:20473289
Microscopyswi6ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0003346abnormal meiotic recombination at silent mating-type cassetteOtherswi6-115Not specifiedPMID:17832901
FYPO:0002133abolished RNA bindingElectrophoretic mobility shift assay dataswi6-shadow (1-264)Not specifiedPMID:226832698
Electrophoretic mobility shift assay dataswi6-chromo (1-74, 140-328)Not specifiedPMID:22683269
FYPO:0000634abolished protein localization to centromere9
has_input pds5Microscopyswi6ΔNullPMID:20929775
has_input hrk1Microscopyswi6ΔNullPMID:20929775
FYPO:0001132abolished protein localization to heterochromatin3
affecting rix1Microscopyswi6ΔNullPMID:21385875
affecting las1Microscopyswi6ΔNullPMID:21385875
affecting crb3Microscopyswi6ΔNullPMID:21385875
affecting ipi1Microscopyswi6ΔNullPMID:21385875
affecting grc3Microscopyswi6ΔNullPMID:21385875
FYPO:0002134decreased RNA bindingElectrophoretic mobility shift assay dataswi6-KR25A (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A)Not specifiedPMID:226832696
FYPO:0002611decreased histone H2A phosphorylation at subtelomere during mitotic S phaseChromatin immunoprecipitation experimentswi6ΔNullPMID:206614452
FYPO:0002355decreased histone H3-K9 dimethylation at silent mating-type cassetteChromatin immunoprecipitation experimentswi6ΔNullPMID:226832691
FYPO:0000470decreased mating type switchingCell growth assayswi6 mutantNot specifiedPMID:658736311
Cell growth assayswi6 mutantNot specifiedPMID:24719968
FYPO:0000460decreased mitotic centromeric sister chromatid cohesionMicroscopyswi6ΔNullPMID:209297752
FYPO:0000450decreased protein localization to centromere17
affecting rad21Chromatin immunoprecipitation experimentswi6ΔNullPMID:19454013
FYPO:0000825increased RNA level during vegetative growth132
affecting SO:0000286Transcript expression level evidenceswi6ΔNullPMID:21151114
FYPO:0000220increased centromeric outer repeat transcript levelnot recorded (unrecorded)PMID:127336409
FYPO:0002354increased level of heterochromatin-encoded proteinsWestern blot assayswi6ΔNullPMID:226832693
FYPO:0001383normal DNA contentFlow cytometry dataswi6ΔNullPECO:0000137, PECO:0000005PMID:2317367219
FYPO:0003353normal DNA double-strand break formation at mating-type locusGel electrophoresis evidenceswi6 mutantNot specifiedPMID:65873636
FYPO:0002357normal RNA bindingElectrophoretic mobility shift assay dataswi6-hinge (1-139, 265-328)Not specifiedPMID:226832693
FYPO:0002610normal histone H2A phosphorylation at centromere outer repeatChromatin immunoprecipitation experimentswi6ΔNullPMID:206614451
FYPO:0002613normal histone H2A phosphorylation at mating type locusChromatin immunoprecipitation experimentswi6ΔNullPMID:206614452
FYPO:0002358normal histone H3-K9 dimethylation at silent mating-type cassetteChromatin immunoprecipitation experimentswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)Not specifiedPMID:226832692
FYPO:0002359normal histone H3-K9 dimethylation at telomereChromatin immunoprecipitation experimentswi6-KR25A+SV40NLS (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A, with SV40 NLS added at N-terminus)Not specifiedPMID:226832692
Chromatin immunoprecipitation experimentswi6ΔNullPMID:22683269
FYPO:0002356normal methylated histone residue bindingOtherswi6-KR25A (K143A, R144A, K145A, R146A, R149A, K151A, K152A, K156A, K161A, R163A, K164A, K169A, K172A, K177A, K184A, K187A, K191A, K217A, K222A, K241A, K242A, K243A, K251A, R256A, K261A)Not specifiedPMID:226832691
FYPO:0000416premature mitotic sister chromatid segregationMicroscopyswi6ΔNullPMID:213007813
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyswi6ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in clr3 histone deacetylase (class II) Clr3 PMID:23771057
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:18761674
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:21151114
FYPO affected by mutation in clr4 histone H3 lysine methyltransferase Clr4 PMID:15947136
FYPO affected by mutation in dcr1 dicer PMID:21151114
FYPO affected by mutation in dcr1 dicer PMID:15947136
FYPO affected by mutation in pcf1 CAF assembly factor (CAF-1) complex large subunit Pcf1 PMID:18761674
FYPO affected by mutation in spt6 nucleosome remodeling protein Spt6 PMID:21844224
GO localized by chp1 chromodomain protein Chp1 PMID:10766735
GO localized by clr4 histone H3 lysine methyltransferase Clr4 PMID:11283354
GO substrate of hsk1 Dbf4(Dfp1)-dependent protein kinase Hsk1 PMID:14625560
GO localized by pob3 FACT complex subunit Pob3 PMID:17614284
GO localized by raf1 CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 PMID:16040243
GO localized by raf2 Rik1-associated factor Raf2 PMID:16040243
GO localized by rdp1 RNA-directed RNA polymerase Rdp1 PMID:15615848
GO localized by rik1 silencing protein Rik1 PMID:8937892
GO localized by sir2 Sir2 family histone deacetylase Sir2 PMID:15545655
GO localized by tas3 RITS complex subunit 3 PMID:14704433
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
117040731702406

UTRs

Region Coordinates Reference
three_prime_UTR1703014..1702406PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00385 Pfam IPR023780 Chromo domain 81 133 7
PF01393 Pfam IPR008251 Chromo shadow domain 265 326 2
SM00298 SMART IPR000953 Chromo domain/shadow 80 136 9
SM00300 SMART IPR008251 Chromo shadow domain 261 327 2
PS50013 Prosite Profiles IPR000953 Chromo domain/shadow 81 143 7
PS50013 Prosite Profiles IPR000953 Chromo domain/shadow 267 328 7
PS00598 Prosite Patterns IPR023779 Chromo domain, conserved site 100 121 4
PTHR22812 HMMPANTHER 74 327 3
2.40.50.40 Gene3D 70 135 7
2.40.50.40 Gene3D 264 327 7
SSF54160 SuperFamily IPR016197 Chromo domain-like 74 143 9
SSF54160 SuperFamily IPR016197 Chromo domain-like 263 322 9
Coil ncoils Rabaptin coiled-coil domain 60 81 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001050chromodomain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001050
PBO:0012553HP1/CBX familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0012553

Protein Properties

Ave. residue weight 113.70 Da
Charge -13.50
Isoelectric point 4.87
Molecular weight 37.29 kDa
Number of residues 328
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS203PMID:217125471669
present during mitotic M phase
present during mitotic M phaseS159PMID:21712547
present during cellular response to thiabendazoleIDAS18PMID:18257517
present during cellular response to thiabendazoleIDAS246PMID:18257517
present during mitotic M phaseS246PMID:21712547
present during cellular response to thiabendazoleIDAS24PMID:18257517
present during mitotic M phaseS212PMID:21712547
present during mitotic M phaseS224PMID:21712547
present during mitotic M phaseS24PMID:21712547
present during mitotic M phaseS18PMID:21712547
S18PMID:24763107
S246PMID:24763107
level fluctuates during mitotic cell cycleS212PMID:24763107
S159PMID:24763107
MOD:00047O-phospho-L-threonineT240PMID:21712547689
present during mitotic M phase
present during mitotic M phaseT235PMID:21712547
T240PMID:24763107
present during cellular response to thiabendazoleIDAT240PMID:18257517
MOD:00696phosphorylated residueNASPMID:195477441921
NASPMID:18257517
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
7653during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8917during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8199during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
7981during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2394.42during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
8351during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
3469.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
7during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog579
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
med20mediator complex subunit Med20 Positive GeneticPMID:18818364
pph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
elp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
msh6MutS protein homolog Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Positive GeneticPMID:22681890
atb2tubulin alpha 2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pol1DNA polymerase alpha catalytic subunit Phenotypic EnhancementPMID:6587363
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
ssl3cohesin loading factor Ssl3 Synthetic LethalityPMID:16682348
eme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:18818364
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
dis33'-5' exoribonuclease subunit Dis3 (predicted) Synthetic LethalityPMID:17380189
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Synthetic Growth DefectPMID:18931302
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
csn1COP9/signalosome complex subunit Csn1 Synthetic Growth DefectPMID:18931302
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Positive GeneticPMID:22681890
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
lsc1Lsk1 associated cyclin Negative GeneticPMID:22681890
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
psm1mitotic cohesin complex subunit Psm1 Synthetic LethalityPMID:16682348
ago1argonaute Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
mad2spindle checkpoint protein Mad2 Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:22737087
Negative GeneticPMID:22681890
brc1BRCT domain protein Brc1 Phenotypic EnhancementPMID:23358415
chl1ATP-dependent DNA helicase Chl1 (predicted) Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:11780129
Synthetic LethalityPMID:11598266
mal3EB1 family Mal3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ctp1CtIP-related endonuclease Negative GeneticPMID:22681890
gtb1gamma-tubulin Gtb1 Synthetic Growth DefectPMID:22737087
mre11Mre11 nuclease Negative GeneticPMID:18818364
SPAC18G6.13sequence orphan Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Positive GeneticPMID:22681890
klp9kinesin-like protein Klp9 Phenotypic SuppressionPMID:22264609
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Synthetic Growth DefectPMID:23050226
Negative Genetic
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
asp1inositol hexakisphosphate kinase/inositol pyrophosphate synthase (predicted) Negative GeneticPMID:22681890
set2histone lysine methyltransferase Set2 Synthetic Growth DefectPMID:18252195
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swi5Swi5 protein Phenotypic SuppressionPMID:22042869
imp1importin alpha Negative GeneticPMID:22681890
psy2protein phosphatase PP4 complex subunit Psy2 (predicted) Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Negative GeneticPMID:22681890
pic1INCENP, Pic1 Synthetic Growth DefectPMID:17322402
Synthetic LethalityPMID:22264609
msd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
gma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
ark1aurora-B kinase Ark1 Synthetic Growth DefectPMID:17322402
Synthetic LethalityPMID:22264609
Phenotypic Suppression
Synthetic Growth Defect
chp2HP1 family chromodomain protein 2 Phenotypic EnhancementPMID:20421495
Phenotypic EnhancementPMID:23604080
psc3mitotic cohesin complex, non-SMC subunit Psc3 Synthetic LethalityPMID:11780129
Synthetic LethalityPMID:16682348
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mst2histone acetyltransferase Mst2 Synthetic Growth DefectPMID:16199868
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Positive GeneticPMID:22681890
clr5Clr5 protein Phenotypic EnhancementPMID:21253571
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Positive GeneticPMID:22681890
clp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
Phenotypic SuppressionPMID:22264609
Phenotypic Enhancement
cid14poly(A) polymerase Cid14 Phenotypic EnhancementPMID:22683269
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
mde4monopolin-like complex subunit Mde4 Phenotypic SuppressionPMID:22264609
bub1serine/threonine protein kinase Bub1 Synthetic Growth DefectPMID:14730319
Synthetic LethalityPMID:9864354
nrm1MBF complex corepressor Nrm1 Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
Positive GeneticPMID:22681890
swi1replication fork protection complex subunit Swi1 Phenotypic EnhancementPMID:6587363
Synthetic Growth DefectPMID:20176980
slm9hira protein Slm9 Synthetic Growth DefectPMID:18931302
fin1serine/threonine protein kinase, NIMA related Fin1 Synthetic Growth DefectPMID:18931302
SPAC750.04cS. pombe specific 5Tm protein family Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Positive GeneticPMID:18818364
lsg1Lsk1 complex gamma subunit (predicted) Negative GeneticPMID:22681890
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
Phenotypic EnhancementPMID:10835380
sgo2inner centromere protein, shugoshin Sgo2 Synthetic Growth DefectPMID:14730319
Negative GeneticPMID:18818364
Synthetic Growth DefectPMID:20929775
Negative GeneticPMID:22681890
alp31tubulin specific chaperone cofactor A, Alp31 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sec28coatomer epsilon subunit (predicted) Positive GeneticPMID:18818364
rad57RecA family ATPase Rad57/Rhp57 Synthetic Growth DefectPMID:18931302
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
sap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
cbp1CENP-B homolog Negative GeneticPMID:18818364
rps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
nda3tubulin beta Nda3 Synthetic Growth DefectPMID:8937982
Synthetic Growth DefectPMID:9722643
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cdr2serine/threonine protein kinase Cdr2 Negative GeneticPMID:22681890
tip41TIP41-like type 2a phosphatase regulator Tip41 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
Phenotypic SuppressionPMID:21189291
SPAC10F6.08cHMG box protein Negative GeneticPMID:22681890
bub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
pmk1MAP kinase Pmk1 Positive GeneticPMID:22681890
swi10DNA repair endonuclease Swi10 Synthetic Growth DefectPMID:18931302
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Synthetic Growth DefectPMID:18252195
bir1survivin, Bir1 Synthetic Growth DefectPMID:17322402
Synthetic LethalityPMID:22264609
mst1KAT5 family histone acetyltransferase Mst1 Synthetic Growth DefectPMID:18505873
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cut7kinesin-like protein Cut7 Phenotypic SuppressionPMID:22264609
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
top1DNA topoisomerase I Positive GeneticPMID:22681890
spf30splicing factor Spf30 (predicted) Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:20028739
klp5kinesin-like protein Klp5 Negative GeneticPMID:22681890
dcr1dicer Synthetic Growth DefectPMID:23572080
Phenotypic Enhancement
Positive GeneticPMID:18818364
Phenotypic EnhancementPMID:15475954
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
swi2Swi5 complex subunit Swi2 Two-hybridPMID:15537537
Affinity Capture-Western
Two-hybridPMID:14663140
hip1hira protein, histone chaperone Hip1 Affinity Capture-WesternPMID:21211723
clr4histone H3 lysine methyltransferase Clr4 Affinity Capture-WesternPMID:21224386
pcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Affinity Capture-WesternPMID:18761674
pol1DNA polymerase alpha catalytic subunit Reconstituted ComplexPMID:11387218
hus5SUMO conjugating enzyme Hus5 Affinity Capture-WesternPMID:16168376
Two-hybrid
hht2histone H3 h3.2 Protein-peptidePMID:22727667
Reconstituted ComplexPMID:21211724
hht1histone H3 h3.1 Protein-peptidePMID:22727667
Reconstituted ComplexPMID:21211724
ers1RNA-silencing factor Ers1 Two-hybridPMID:22474355
Affinity Capture-Western
Affinity Capture-WesternPMID:22733737
Two-hybrid
Reconstituted Complex
cdc18MCM loader Reconstituted ComplexPMID:21239883
Affinity Capture-Western
hsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Affinity Capture-WesternPMID:14625560
Biochemical Activity
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-WesternPMID:18809570
Reconstituted Complex
Two-hybridPMID:21215368
Reconstituted ComplexPMID:16762840
Affinity Capture-Western
sgo1inner centromere protein, shugoshin, Sgo1 Two-hybridPMID:18716626
atf1transcription factor, Atf-CREB family Atf1 Affinity Capture-WesternPMID:15292231
hip3HIRA interacting protein Hip3 Affinity Capture-MSPMID:21211723
sgo2inner centromere protein, shugoshin Sgo2 Two-hybridPMID:20929775
hrp3ATP-dependent DNA helicase Hrp3 Affinity Capture-WesternPMID:22990236
pcr1transcription factor Pcr1 Affinity Capture-WesternPMID:15292231
swi6HP1 family chromodomain protein Swi6 Reconstituted ComplexPMID:21211724
Affinity Capture-WesternPMID:21224386
dfp1Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 Affinity Capture-WesternPMID:14625560
psc3mitotic cohesin complex, non-SMC subunit Psc3 Affinity Capture-WesternPMID:11780129
Two-hybrid
hht3histone H3 h3.3 Protein-peptidePMID:22727667
Reconstituted ComplexPMID:21211724
Protein-peptidePMID:23281010
clr3histone deacetylase (class II) Clr3 Affinity Capture-WesternPMID:16246721
External References
Database Identifier Description
NBRP SPAC664.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC664.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC664.01c BioGRID Interaction Datasets
Expression Viewer SPAC664.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC664.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC664.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC664.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC664.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC664.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC664.01c Cell Cycle Data
GEO SPAC664.01c GEO profiles
PInt SPAC664.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC664.01c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN14/14C10Orfeome Localization Data
WikiGene2541633chromodomain protein Swi6
EntrezGene2541633chromodomain protein Swi6
UniProtKB/SwissProtP40381Chromatin-associated protein swi6
ModBaseP40381Database of comparative protein structure models
STRINGP40381Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593449chromodomain protein Swi6
RefSeq mRNANM_001018882972h- chromodomain protein Swi6 (swi6), mRNA
ePDB1E0BThe European PDB
PDB1E0BPDB
PDBsum1E0BPDBsum
ePDB2RSOThe European PDB
PDB2RSOPDB
PDBsum2RSOPDBsum
European Nucleotide ArchiveCAA50668ENA Protein Mapping
European Nucleotide ArchiveCAA50668.1ENA Protein Mapping
European Nucleotide ArchiveCAB57340ENA Protein Mapping
European Nucleotide ArchiveCAB57340.1ENA Protein Mapping
UniParcUPI00001362A2UniProt Archive

Literature for swi6

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014