set13 (SPAC688.14)


Gene Standard Nameset13 Characterisation Statuspublished
Systematic IDSPAC688.14 Feature Typeprotein coding
Synonyms Name Description
Productribosome L32 lysine methyltransferase Set13 Product Size468aa, 54.02 kDa
Genomic Location Chromosome I, 3141223-3143183 (1961nt); CDS:3141463-3143034 (1572nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein-lysine N-methyltransferase activity14
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
peptidyl-lysine methylation38
Annotation ExtensionEvidenceWith/FromReference
peptidyl-lysine monomethylation1
Annotation ExtensionEvidenceWith/FromReference
regulation of cytoplasmic translation in response to stress9
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to hydroxyureaset13ΔNull534
sensitive to methyl methanesulfonateset13ΔNull239
viable vegetative cell populationset13ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyset13ΔNull3094
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3141223..3141603, 3141652..3142329, 3142396..3142667, 3142719..3143183
mRNA3141223..3143183
5' UTR3141223..3141462PMID:21511999
CDS3141463..3141603, 3141652..3142329, 3142396..3142667, 3142719..3143034
3' UTR3143035..3143183PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00856 Pfam IPR001214 SET domain 37 302 12
PS50280 Prosite Profiles IPR001214 SET domain 22 302 13
PTHR13271:SF25 HMMPANTHER 6 465 2
PTHR13271 HMMPANTHER 6 465 5
2h21C01 Gene3D 255 316 5
2h21C01 Gene3D 4 185 5
SSF82199 SuperFamily 4 187 13
SSF82199 SuperFamily 257 320 13
PIRSF011771 PIRSF IPR011383 N-lysine methyltransferase SETD6 1 468 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001327SET domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001327

Protein Properties

Ave. residue weight 115.43 Da
Charge -19.50
Isoelectric point 4.68
Molecular weight 54.02 kDa
Number of residues 468
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS200
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S200 PMID:21712547
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4333during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3776during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3142during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3598during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
3572during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.3during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.35during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999433
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modifiesrpl4260S ribosomal protein L36/L42 Biochemical ActivityPMID:20444689
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
positive genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Positive GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:18818364
positive genetic interaction withpof4elongin-A, F-box protein Pof4 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withppk9serine/threonine protein kinase Ppk9 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
positive genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Positive GeneticPMID:18818364
negative genetic interaction withrxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:25076038
negative genetic interaction withSPAC19A8.11cconserved eukaryotic protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPAC688.14 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC688.14 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC688.14 BioGRID Interaction Datasets
Expression Viewer SPAC688.14 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC688.14 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC688.14 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC688.14 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC688.14 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC688.14 Transcriptome Viewer (Bähler Lab)
GEO SPAC688.14 GEO profiles
PInt SPAC688.14 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC688.14 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC688.14 Fission yeast phenotypic data & analysis
Cyclebase SPAC688.14.1 Cell Cycle Data
SPD / RIKEN25/25B03Orfeome Localization Data
UniProtKB/SwissProtQ9P6L2Ribosomal lysine N-methyltransferase 4
ModBaseQ9P6L2Database of comparative protein structure models
STRINGQ9P6L2Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594072ribosome L32 lysine methyltransferase Set13
RefSeq mRNANM_001019496972h- ribosome L32 lysine methyltransferase Set13 (set13), mRNA
European Nucleotide ArchiveCAB90780.2ENA Protein Mapping
UniParcUPI000228F416UniProt Archive

Literature for set13

Search: Europe PMC or PubMed

Release Version: PomBase:26_53 - 27 May 2015