set13 (SPAC688.14)

Gene Standard Nameset13 Characterisation Statuspublished
Systematic IDSPAC688.14 Feature Typeprotein coding
Synonyms Name Description
Productribosome L32 lysine methyltransferase Set13 Product Size468aa, 54.02 kDa
Genomic Location Chromosome I, 3141223-3143183 (1961nt); CDS:3141463-3143034 (1572nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein-lysine N-methyltransferase activity14
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
peptidyl-lysine monomethylation1
Annotation ExtensionEvidenceWith/FromReference
regulation of cytoplasmic translation in response to stress8
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
sensitive to hydroxyureaset13Δ595
sensitive to methyl methanesulfonateset13Δ333
viable vegetative cell populationset13Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyset13Δ3103
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3141223..3141603, 3141652..3142329, 3142396..3142667, 3142719..3143183
Intron3141604..3141651, 3142330..3142395, 3142668..3142718
5' UTR3141223..3141462PMID:21511999
CDS3141463..3141603, 3141652..3142329, 3142396..3142667, 3142719..3143034
3' UTR3143035..3143183PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00856 Pfam IPR001214 SET domain 37 302 12
PS50280 Prosite Profiles IPR001214 SET domain 22 302 12
PTHR13271:SF23 HMMPANTHER 1 209 2
PTHR13271:SF23 HMMPANTHER 258 454 2
PTHR13271 HMMPANTHER 1 209 5
PTHR13271 HMMPANTHER 258 454 5
2h21C01 Gene3D 4 185 5
2h21C01 Gene3D 255 316 5
SSF82199 SuperFamily 257 320 13
SSF82199 SuperFamily 4 187 13
PIRSF011771 PIRSF IPR011383 N-lysine methyltransferase SETD6 1 468 1

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0001327SET domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001327

Protein Properties

Ave. residue weight 115.43 Da
Charge -19.50
Codon Adaptation Index 0.43
Isoelectric point 4.68
Molecular weight 54.02 kDa
Number of residues 468

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2293
present during mitotic M phaseS200
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S200 PMID:21712547
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for set13 (SPAC688.14)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4333during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3776during GO:0000084PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3142during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3598during GO:0000087PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
3572during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.3during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.35during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
gene structure updated PMID:21511999435
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC688.14 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modifiesrpl4260S ribosomal protein L36/L42 Biochemical ActivityPMID:20444689
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC688.14 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withfin1serine/threonine protein kinase, NIMA related Fin1 Positive GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:18818364
positive genetic interaction withpof4elongin-A, F-box protein Pof4 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Positive GeneticPMID:18818364
positive genetic interaction withppk9serine/threonine protein kinase Ppk9 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withirc6clathrin coat adaptor Irc6 Negative GeneticPMID:22681890
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:25076038
negative genetic interaction withptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
negative genetic interaction withrxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
negative genetic interaction witheso1mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
negative genetic interaction withsfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC688.14 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC688.14 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC688.14 BioGRID Interaction Datasets
Expression Viewer SPAC688.14 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC688.14 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC688.14 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC688.14 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC688.14 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC688.14 Transcriptome Viewer (Bähler Lab)
GEO SPAC688.14 GEO profiles
PInt SPAC688.14 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC688.14 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC688.14 Fission yeast phenotypic data & analysis
Cyclebase SPAC688.14.1 Cell Cycle Data
SPD / RIKEN25/25B03Orfeome Localization Data
UniProtKB/SwissProtQ9P6L2Ribosomal lysine N-methyltransferase 4
ModBaseQ9P6L2Database of comparative protein structure models
STRINGQ9P6L2Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594072ribosome L32 lysine methyltransferase Set13
RefSeq mRNANM_001019496972h- ribosome L32 lysine methyltransferase Set13 (set13), mRNA
European Nucleotide ArchiveCAB90780.2ENA Protein Mapping
UniParcUPI000228F416UniProt Archive

Literature for set13

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017