bit2 (SPAC6B12.03c)

Gene Standard Namebit2 Characterisation Statusbiological role inferred
Systematic IDSPAC6B12.03c Feature Typeprotein coding
Synonymsbit61 Name Description
ProductHbrB family protein involved in TOR signaling Bit2 (predicted) Product Size302aa, 35.50 kDa
Genomic Location Chromosome I, 2415271-2414051 (1221nt); CDS:2415137-2414229 (909nt)

Ensembl Gene Location
GO Biological Process

GO Slim Terms


Term NameCount
TOR signaling25
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationbit2Δ3815

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell, abnormal cell shape, normal cell sizebit2Δ215
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR2415271..2415138PMID:21511999
3' UTR2414228..2414051PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08539 Pfam IPR013745 HbrB-like 98 250 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.55 Da
Charge 16.50
Codon Adpatation Index 0.36
Isoelectric point 10.03
Molecular weight 35.50 kDa
Number of residues 302
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.052during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3421
conserved in vertebrates3396
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAC6B12.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC6B12.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC6B12.03c BioGRID Interaction Datasets
Expression Viewer SPAC6B12.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC6B12.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC6B12.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC6B12.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC6B12.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC6B12.03c Transcriptome Viewer (Bähler Lab)
GEO SPAC6B12.03c GEO profiles
PInt SPAC6B12.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC6B12.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC6B12.03c Fission yeast phenotypic data & analysis
Cyclebase SPAC6B12.03c.1 Cell Cycle Data
SPD / RIKEN43/43E09Orfeome Localization Data
UniProtKB/SwissProtO14208Uncharacterized protein C6B12.03c
ModBaseO14208Database of comparative protein structure models
STRINGO14208Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593758HbrB family protein
RefSeq mRNANM_001019188972h- HbrB family protein (SPAC6B12.03c), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB11065ENA Protein Mapping
European Nucleotide ArchiveCAB11065.1ENA Protein Mapping
UniParcUPI000013AA30UniProt Archive

Literature for bit2

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015