fps1 (SPAC6F12.13c)


Gene Standard Namefps1 Characterisation Statuspublished
Systematic IDSPAC6F12.13c Feature Typeprotein coding
Synonyms Name Description
Productgeranyltranstransferase Fps1 Product Size347aa, 39.52 kDa
Genomic Location Chromosome I, 1339942-1338365 (1578nt); CDS:1339700-1338452 (1249nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004161dimethylallyltranstransferase activity2
heterologous_systemIGISGD:S000003703PMID:17596513
GO:0004337geranyltranstransferase activity2
heterologous_systemISOSGD:S000003703PMID:17596513
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO:0005515protein bindingIPIspo9PMID:17596513887
GO:0004660protein farnesyltransferase activity4
contributes_toIMPPMID:17596513
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006995cellular response to nitrogen starvationIMPPMID:1936672893
GO:0006696ergosterol biosynthetic process39
heterologous_systemIGISGD:S000003703PMID:17596513
GO:0045337farnesyl diphosphate biosynthetic process4
heterologous_systemIGISGD:S000003703PMID:17596513
GO:0033384geranyl diphosphate biosynthetic processIEA UniPathway:UPA00259GO_REF:00000412
GO:0008299isoprenoid biosynthetic process14
heterologous_systemISOSGD:S000003703PMID:17596513
GO:0070317negative regulation of G0 to G1 transitionIMPPMID:1936672826
GO:0018342protein prenylationICGO:0004660GO_REF:00000017
GO:0006612protein targeting to membraneICGO:0018342GO_REF:000000130
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000709decreased cell population growth during nitrogen starvationCell growth assayfps1-439PECO:0000004, PECO:0000099PMID:1936672833
FYPO:0002061inviable vegetative cell populationMicroscopyfps1ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopyfps1ΔNullPMID:20473289
no_namePMID:17596513
FYPO:0000082sensitive to heatCell growth assayfps1-439PECO:0000004, PECO:0000099PMID:1936672882

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable sporeMicroscopyfps1ΔNullPECO:0000005, PECO:0000137PMID:23697806447
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
113399421339869
213397001339581
313393751338365

UTRs

Region Start End Reference
five_prime_UTR13399421339869PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00348 Pfam IPR000092 Polyprenyl synthetase 37 306 3
PS00723 Prosite Patterns IPR000092 Polyprenyl synthetase 92 106 3
PS00444 Prosite Patterns IPR000092 Polyprenyl synthetase 227 239 3
PTHR11525 HMMPANTHER 7 347 2
PTHR11525:SF0 HMMPANTHER 7 347 2
G3DSA:1.10.600.10 Gene3D IPR008949 4 347 5
SSF48576 SuperFamily IPR008949 5 346 5
Low complexity (SEG) seg 305 316

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.88 Da
Charge -11.00
Isoelectric point 4.73
Molecular weight 39.52 kDa
Number of residues 347
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
48394.43during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
18670.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
20during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReferenceCount
functionally complements S. cerevisiae ERG20 PMID:175965131
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
spo9farnesyl pyrophosphate synthetase Dosage RescuePMID:17596513
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
spo9farnesyl pyrophosphate synthetase Affinity Capture-WesternPMID:17596513
Two-hybrid
cwf2RNA-binding protein Cwf2 Affinity Capture-MSPMID:21386897
External References
Database Identifier Description
NBRP SPAC6F12.13c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC6F12.13c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC6F12.13c BioGRID Interaction Datasets
Expression Viewer SPAC6F12.13c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC6F12.13c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC6F12.13c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC6F12.13c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC6F12.13c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC6F12.13c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC6F12.13c Cell Cycle Data
GEO SPAC6F12.13c GEO profiles
PInt SPAC6F12.13c Protein-Protein Interaction Predictor (Bähler Lab)
IntEnz2.5.1.10Integrated relational Enzyme database
Rhea2.5.1.10Annotated reactions database
WikiGene2542898geranyltranstransferase Fps1
EntrezGene2542898geranyltranstransferase Fps1
SPD / RIKEN44/44A12Orfeome Localization Data
UniProtKB/SwissProtO14230Farnesyl pyrophosphate synthase
ModBaseO14230Database of comparative protein structure models
StringO14230Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593299geranyltranstransferase Fps1
RefSeq mRNANM_001018729972h- geranyltranstransferase Fps1 (fps1), mRNA
European Nucleotide ArchiveBAA13767ENA Protein Mapping
European Nucleotide ArchiveCAB11097ENA Protein Mapping
UniParcUPI000012ABBAUniProt Archive

Literature for fps1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014