cdc16 (SPAC6F6.08c)

Gene Standard Namecdc16 ChromosomeI
Systematic IDSPAC6F6.08c Gene Start2748180
Synonymsbub2 Gene End2746667
Producttwo-component GAP Cdc16 Gene Length1514
Feature Typeprotein coding CDS Start2748009
Name Description CDS End2746772
Characterisation Statuspublished CDS Length1238

Ensembl Gene Location
  1. SPNCRNA.848
  2. SPNCRNA.205
  3. ost2
  4. rax2
  5. rps13
  6. cdc16
  7. eaf6
  8. arc2
  9. SPAC6F6.11c
  10. SPNCRNA.849
  11. SPAC6F6.12
  12. SPNCRNA.850
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000651increased duration of septationMicroscopycdc16-116 (unknown)unknownEndogenousPECO:0000004PMID:762020
FYPO:0001161decreased aerobic cell population growth on glucose carbon sourceCell growth assaycdc16-116 (unknown)unknownNot specifiedPECO:0000137, PECO:0000102, PECO:0000005PMID:9203579
Cell growth assaycdc16-116 (unknown)unknownNot specifiedPECO:0000102, PECO:0000137, PECO:0000006PMID:9203579
FYPO:0001223binucleate multiseptate cellMicroscopycdc16-116 (unknown)unknownEndogenousPECO:0000004PMID:762020
FYPO:0001224binucleate monoseptate cellMicroscopycdc16-116 (unknown)unknownEndogenousPECO:0000004PMID:762020
FYPO:0001226mononucleate with mislocalized septumMicroscopycdc16-116 (unknown)unknownEndogenousPECO:0000004PMID:762020
FYPO:0001801inviable cell at high temperatureCell growth assaycdc16-116 (unknown)unknownNot specifiedPECO:0000102, PECO:0000137PMID:9203579
FYPO:0002061inviable vegetative cell populationMicroscopycdc16delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005096GTPase activator activity
has_direct_input spg1IGIbyr4PMID:9742395
GO:0005097Rab GTPase activator activityIEAIPR000195GO_REF:0000002
GO:0005515protein bindingIPIcdc11PMID:15062098
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0007094mitotic spindle assembly checkpointIMPPMID:8334988
GO:0010974negative regulation of barrier septum assemblyIMPPMID:762020
GO:0031030negative regulation of septation initiation signaling cascadeIGIbyr4PMID:9742395
GO:0032313regulation of Rab GTPase activityIEAIPR000195GO_REF:0000002
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005816spindle pole bodyIDAPMID:10381387
GO:0005829cytosolIDAPMID:16823372
GO:0044732mitotic spindle pole bodyIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
127481802747509
227474312747341
327472662747119
427469312746667

References

Region Start End Reference
three_prime_UTR27467712746667PMID:21511999
five_prime_UTR27481802748010PMID:21511999
three_prime_UTR27467712746667PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00566 IPR000195 Pfam Rab-GTPase-TBC domain 45 242 13
SM00164 IPR000195 SMART Rab-GTPase-TBC domain 38 247 13
PS50086 IPR000195 Prosite Profiles Rab-GTPase-TBC domain 41 223 13
G3DSA:1.10.8.270 Gene3D 40 147 12
SSF47923 IPR000195 SuperFamily 159 271 13
SSF47923 IPR000195 SuperFamily 41 181 13
PTHR22957 hmmpanther 24 271 12
PTHR22957:SF85 hmmpanther 24 271 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.68 Da
Charge 10.00
Isoelectric point 8.97
Molecular weight 33.99 kDa
Number of residues 299
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide790.93PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.7PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.81PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:15265986
Phenotypic EnhancementPMID:11683392
tea2kinesin-like protein Tea2 Phenotypic SuppressionPMID:20498706
dma1mitotic spindle checkpoint protein Dma1 Dosage RescuePMID:11271422
Dosage RescuePMID:12479804
Dosage RescuePMID:8978687
Dosage RescuePMID:10924454
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Dosage RescuePMID:10462526
sid1PAK-related GC kinase Sid1 Synthetic RescuePMID:11271422
far11SIP/FAR complex subunit, Far11/Csc2 Synthetic Growth DefectPMID:22119525
lsc1Lsk1 associated cyclin Synthetic RescuePMID:17502918
spg1GTPase Spg1 Synthetic RescuePMID:11271422
Synthetic RescuePMID:9203579
cdc3profilin Phenotypic EnhancementPMID:20805322
byr4two-component GAP Byr4 Dosage RescuePMID:11271422
Phenotypic SuppressionPMID:9638658
Dosage RescuePMID:9742395
Dosage RescuePMID:10924454
sid2NDR kinase Sid2 Synthetic RescuePMID:11271422
Phenotypic SuppressionPMID:20805322
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Synthetic Growth DefectPMID:22267499
tip1CLIP170 family protein Tip1 Phenotypic SuppressionPMID:20498706
csc4SIP/FAR complex subunit, Csc4 Synthetic Growth DefectPMID:22119525
mob1Sid2-Mob1 kinase complex regulatory subunit Mob1 Synthetic Growth DefectPMID:10769201
Synthetic Rescue
Synthetic RescuePMID:11271422
lsg1Lsk1 complex gamma subunit (predicted) Synthetic RescuePMID:21931816
wee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:20805322
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Synthetic RescuePMID:11271422
Synthetic RescuePMID:1527180
zrg17cation diffusion family zinc membrane transporter Zrg17 Negative GeneticPMID:22681890
cdc7serine/threonine protein kinase Cdc7 Synthetic RescuePMID:11271422
Phenotypic SuppressionPMID:9638658
Synthetic RescuePMID:10924454
Dosage Rescue
Synthetic LethalityPMID:1527180
ulp2SUMO deconjugating cysteine peptidase Ulp2 (predicted) Negative GeneticPMID:22681890
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Phenotypic EnhancementPMID:20805322
Phenotypic EnhancementPMID:16687577
Synthetic Growth DefectPMID:1527180
med8mediator complex subunit Med8 Synthetic Growth DefectPMID:10392445
pab1protein phosphatase regulatory subunit Pab1 Synthetic Growth DefectPMID:20876564
paa1protein phosphatase regulatory subunit Paa1 Synthetic Growth DefectPMID:22119525
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Synthetic RescuePMID:15537703
Synthetic RescuePMID:17502918
dsk1SR protein-specific kinase Dsk1 Negative GeneticPMID:22681890
rpb1RNA polymerase II large subunit Rpb1 Synthetic RescuePMID:17502918
myo2myosin II heavy chain Synthetic Growth DefectPMID:11739799
ppa2serine/threonine protein phosphatase Ppa2 Synthetic Growth DefectPMID:22267499
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Dosage RescuePMID:22119525
Phenotypic Enhancement
Synthetic Growth Defect
Synthetic Lethality
far8SIP/FAR complex striatin subunit, Far8/Csc3 Synthetic Growth DefectPMID:22119525
par1protein phosphatase regulatory subunit Par1 Synthetic Growth DefectPMID:11707284
cdc14SIN component Cdc14 Synthetic RescuePMID:11271422
Synthetic LethalityPMID:1527180
myp2myosin II heavy chain Myo3 Synthetic LethalityPMID:9398685
plo1Polo kinase Plo1 Phenotypic SuppressionPMID:11250892
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Negative GeneticPMID:22681890
byr3zinc finger protein Byr3 Dosage RescuePMID:10924454
mal3EB1 family Mal3 Phenotypic SuppressionPMID:20498706
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
byr4two-component GAP Byr4 Two-hybridPMID:9638658
Two-hybridPMID:9742395
Reconstituted Complex
Reconstituted ComplexPMID:10196225
spg1GTPase Spg1 Affinity Capture-WesternPMID:10799520
chs2chitin synthase homolog Chs2 Co-localizationPMID:16772338
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Reconstituted ComplexPMID:15062098
Two-hybrid
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External References
Database Identifier Description
NBRP SPAC6F6.08c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC6F6.08c Retrieval of eukaryotic orthologs
BioGrid SPAC6F6.08c BioGRID Interaction Datasets
Bähler Lab SPAC6F6.08c Cell Cycle Expression Profile
Bähler Lab SPAC6F6.08c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC6F6.08c Pheromone response/mating expression profiles
Bähler Lab SPAC6F6.08c Environmental stress expression profiles
Bähler Lab SPAC6F6.08c Bähler Lab Transcriptome Viewer
Cyclebase SPAC6F6.08c Cell Cycle Data
PInt SPAC6F6.08c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC6F6.08c Entrez Gene
WikiGene2542162two-component GAP Cdc16
Uniprot_genenameCDC16
EntrezGene2542162two-component GAP Cdc16
SPD / RIKEN44/44A11Orfeome Localization Data
UniProtKB/SwissProtP36618Cell division control protein 16
ModBaseP36618Database of comparative protein structure models
Pfam Protein DomainsP36618Pfam Domain Arrangement
RefSeq PeptideNP_593901two-component GAP Cdc16
RefSeq mRNANM_001019331972h- two-component GAP Cdc16 (cdc16), mRNA
European Nucleotide ArchiveCAA50606ENA Protein Mapping
European Nucleotide ArchiveCAB11731ENA Protein Mapping
UniParcUPI0000127214UniProt Archive

Literature for cdc16
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013