idp1 (SPAC6G10.08)


Gene Standard Nameidp1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC6G10.08 Feature Typeprotein coding
Synonyms Name Description
Productisocitrate dehydrogenase Idp1 (predicted) Product Size439aa, 49.48 kDa
Genomic Location Chromosome I, 3231335-3232976 (1642nt); CDS:3231536-3232855 (1320nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0051287NAD bindingIEAIPR019818GO_REF:000000223
GO:0004450isocitrate dehydrogenase (NADP+) activityISOSGD:S000002224GO_REF:00000241
GO:0000287magnesium ion bindingIEAIPR019818GO_REF:000000250
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006740NADPH regenerationISOSGD:S000004954GO_REF:000002416
GO:0006537glutamate biosynthetic processISOSGD:S000002224GO_REF:00000249
GO:0006102isocitrate metabolic processISOSGD:S000002224GO_REF:00000243
GO:0006099tricarboxylic acid cycleICGO:0004450GO_REF:000000118
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmISSUniProtKB:P41939GO_REF:00000244205
GO:0005739mitochondrionIDAPMID:16823372758
ISSUniProtKB:P21954GO_REF:0000024
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyidp1ΔNullPECO:0000005, PECO:0000137PMID:236978063759
Microscopyidp1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyidp1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
132313353232976

UTRs

Region Coordinates Reference
five_prime_UTR3231335..3231535PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00180 Pfam IPR024084 Isopropylmalate dehydrogenase-like domain 37 427 5
PS00470 Prosite Patterns IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site 302 321 5
PTHR11822 HMMPANTHER IPR004790 Isocitrate dehydrogenase NADP-dependent 19 439 1
3.40.718.10 Gene3D IPR024084 Isopropylmalate dehydrogenase-like domain 34 434 5
SSF53659 SuperFamily 32 434 5
PIRSF000108 PIRSF IPR004790 Isocitrate dehydrogenase NADP-dependent 32 438 1
TIGR00127 tigrfam IPR004790 Isocitrate dehydrogenase NADP-dependent 33 435 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.71 Da
Charge 14.00
Isoelectric point 9.38
Molecular weight 49.48 kDa
Number of residues 439
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
130892during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
133541during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
123487during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
125464during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
37620.97during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
123752during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
22767.82during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
13during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
cancercancer_census142
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999432
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
trm10tRNA m(1)G methyltransferase Trm10 Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
rsv2transcription factor Rsv2 Negative GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Negative GeneticPMID:22681890
SPBC1105.08EMP70 family Positive GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
csn4COP9/signalosome complex subunit Csn4 Negative GeneticPMID:22681890
rem1meiosis-specific cyclin Rem1 Positive GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
spt2non-specific DNA binding protein Spt2 (predicted) Negative GeneticPMID:22681890
dak1dihydroxyacetone kinase Dak1 Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
cwf20complexed with Cdc5 protein Cwf20 Negative GeneticPMID:22681890
pek1MAP kinase kinase Pek1 Negative GeneticPMID:22681890
SPCC550.11karyopherin (predicted) Negative GeneticPMID:22681890
mlh1MutL family protein Mlh1 (predicted) Positive GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
srp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
csn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:22681890
uap2U2 snRNP-associated protein Uap2 Negative GeneticPMID:22681890
cut14condensin complex subunit Cut14 Positive GeneticPMID:22681890
SPBP4H10.16cphosphatase activator (predicted) Positive GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Positive GeneticPMID:22681890
pmk1MAP kinase Pmk1 Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
nrm1MBF complex corepressor Nrm1 Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
mug58GLYK family kinase of unknown specificity (predicted) Positive GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Positive GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
csn3COP9/signalosome complex subunit Csn3 (predicted) Negative GeneticPMID:22681890
cwf5RNA-binding protein Cwf5 Negative GeneticPMID:22681890
iqw1WD repeat protein, Iqw1 Negative GeneticPMID:22681890
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:22681890
nop10snoRNP pseudouridylase box H/ACA snoRNP complex protein (predicted) Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Positive GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
mkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Positive GeneticPMID:22681890
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
SPBC30B4.02cR3H and G-patch domain, implicated in splicing (predicted) Positive GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:22681890
ckb2CK2 family regulatory subunit Ckb2 (predicted) Positive GeneticPMID:22681890
cxr1mRNA processing factor Positive GeneticPMID:22681890
SPBC21C3.03ABC1 kinase family protein Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Positive GeneticPMID:22681890
int6eIF3e subunit Int6 Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
nap1nucleosome assembly protein Nap1 Positive GeneticPMID:22681890
tma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Positive GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
sap114U2 snRNP subunit Sap114 Negative GeneticPMID:22681890
SPBC18H10.05WD repeat protein, human WDR44 family Positive GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
SPBC8D2.16cDUF171 family protein Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC6G10.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC6G10.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC6G10.08 BioGRID Interaction Datasets
Expression Viewer SPAC6G10.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC6G10.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC6G10.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC6G10.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC6G10.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC6G10.08 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC6G10.08 Cell Cycle Data
GEO SPAC6G10.08 GEO profiles
PInt SPAC6G10.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC6G10.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC6G10.08 Fission yeast phenotypic data & analysis
IntEnz1.1.1.42Integrated relational Enzyme database
Rhea1.1.1.42Annotated reactions database
SPD / RIKEN20/20A10Orfeome Localization Data
KEGGMAP00720KEGG Pathway Database
KEGGMAP00020KEGG Pathway Database
KEGGMAP00480KEGG Pathway Database
UniProtKB/SwissProtO14254Probable isocitrate dehydrogenase [NADP], mitochondrial
ModBaseO14254Database of comparative protein structure models
STRINGO14254Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594105isocitrate dehydrogenase Idp1 (predicted)
RefSeq mRNANM_001019529972h- isocitrate dehydrogenase Idp1 (predicted) (idp1), mRNA
European Nucleotide ArchiveCAB11294.2ENA Protein Mapping
UniParcUPI000228F450UniProt Archive

Literature for idp1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014