cfr1 (SPAC6G9.12)


Gene Standard Namecfr1 Characterisation Statuspublished
Systematic IDSPAC6G9.12 Feature Typeprotein coding
Synonyms Name Description
ProductChs five related protein Cfr1 Product Size620aa, 67.23 kDa
Genomic Location Chromosome I, 3270191-3272367 (2177nt); CDS:3270235-3272097 (1863nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006893Golgi to plasma membrane transportISOSGD:S000004322GO_REF:00000249
GO:0032219cell wall macromolecule catabolic process involved in cytogamyIMPPMID:165986891
different_pathwayIGIfus1PMID:16598689
NOT GO:0006031chitin biosynthetic processIMPPMID:16598689
NOT GO:0009250glucan biosynthetic processIMPPMID:16598689
GO:0032220plasma membrane fusion involved in cytogamyIMPPMID:165986896
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16598689355
IDAPMID:21113731
GO:0005829cytosolIDAPMID:168233722317
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopycfr1ΔNullPECO:0000005, PECO:0000137PMID:236978063755
Microscopycfr1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000644normal protein localization during vegetative growthMicroscopyΔCT (C terminal deletion)Not specifiedPMID:2111373178
affecting cfr1
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopycfr1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
132701913272367

UTRs

Region Start End Reference
three_prime_UTR32720983272367PMID:21511999
five_prime_UTR32701913270234PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00533 Pfam IPR001357 BRCT domain 171 242 8
SM00060 SMART IPR003961 Fibronectin, type III 79 157 1
SM00292 SMART IPR001357 BRCT domain 169 246 12
PS50853 Prosite Profiles IPR003961 Fibronectin, type III 80 166 1
PS50172 Prosite Profiles IPR001357 BRCT domain 172 256 13
PTHR13561 HMMPANTHER 6 566 3
G3DSA:3.40.50.10190 Gene3D IPR001357 172 258 12
G3DSA:2.60.40.10 Gene3D IPR013783 81 167 2
SSF49265 SuperFamily IPR003961 73 168 1
SSF52113 SuperFamily IPR001357 171 256 12
Coil ncoils Rabaptin coiled-coil domain 434 458 975
Low complexity (SEG) seg 469 487
Low complexity (SEG) seg 424 435
Low complexity (SEG) seg 315 338

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000443BRCT domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000443

Protein Properties

Ave. residue weight 108.44 Da
Charge -64.00
Isoelectric point 4.00
Molecular weight 67.23 kDa
Number of residues 620
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
14046.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
14814.87during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.91during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
4.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReferenceCount
does not functionally complement S. cerevisiae CHS5 PMID:211137311
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi only603
conserved in fungi4564
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
fus1formin Fus1 Phenotypic EnhancementPMID:16598689
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAC6G9.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC6G9.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC6G9.12 BioGRID Interaction Datasets
Expression Viewer SPAC6G9.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC6G9.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC6G9.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC6G9.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC6G9.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC6G9.12 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC6G9.12 Cell Cycle Data
GEO SPAC6G9.12 GEO profiles
PInt SPAC6G9.12 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2541978Chs five related protein Cfr1
EntrezGene2541978Chs five related protein Cfr1
SPD / RIKEN26/26C05Orfeome Localization Data
UniProtKB/SwissProtQ92357Cell fusion protein cfr1
ModBaseQ92357Database of comparative protein structure models
StringQ92357Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594121Chs five related protein Cfr1
RefSeq mRNANM_001019545972h- Chs five related protein Cfr1 (cfr1), mRNA
European Nucleotide ArchiveCAB03614ENA Protein Mapping
UniParcUPI0000127924UniProt Archive

Literature for cfr1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014