cfr1 (SPAC6G9.12)

Gene Standard Namecfr1 Characterisation Statuspublished
Systematic IDSPAC6G9.12 Feature Typeprotein coding
Synonyms Name Description
ProductChs five related protein Cfr1 Product Size620aa, 67.23 kDa
Genomic Location Chromosome I, 3270191-3272367 (2177nt); CDS:3270235-3272097 (1863nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
cell wall macromolecule catabolic process involved in cytogamy1
Annotation ExtensionEvidenceWith/FromReference
Golgi to plasma membrane transport10
Annotation ExtensionEvidenceWith/FromReference
plasma membrane fusion involved in cytogamy6
Annotation ExtensionEvidenceWith/FromReference
NOT chitin biosynthetic process
Annotation ExtensionEvidenceWith/FromReference
NOT glucan biosynthetic process
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus355
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopycfr1ΔNullPMID:204732893759
Microscopycfr1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000644normal protein localization during vegetative growth127
affecting cfr1MicroscopyΔCT (C terminal deletion)Not specifiedPMID:21113731
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopycfr1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00533 Pfam IPR001357 BRCT domain 171 242 8
SM00060 SMART IPR003961 Fibronectin, type III 79 157 1
SM00292 SMART IPR001357 BRCT domain 169 246 10
PS50172 Prosite Profiles IPR001357 BRCT domain 172 256 13
PS50853 Prosite Profiles IPR003961 Fibronectin, type III 80 166 1
PTHR13561 HMMPANTHER 6 566 3 Gene3D IPR013783 Immunoglobulin-like fold 81 167 3 Gene3D IPR001357 BRCT domain 172 258 13
SSF52113 SuperFamily IPR001357 BRCT domain 171 256 12
SSF49265 SuperFamily IPR003961 Fibronectin, type III 73 168 1
Coil ncoils Rabaptin coiled-coil domain 434 458 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000443BRCT domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000443

Protein Properties

Ave. residue weight 108.44 Da
Charge -64.00
Isoelectric point 4.00
Molecular weight 67.23 kDa
Number of residues 620

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS591PMID:247631071670
experimental evidenceS590PMID:24763107
experimental evidenceS532PMID:24763107
experimental evidenceS490PMID:24763107
experimental evidenceS391PMID:24763107
present during mitotic M phaseexperimental evidenceS532PMID:21712547
present during mitotic M phaseexperimental evidenceS391PMID:21712547
present during mitotic M phaseexperimental evidenceS510PMID:21712547
present during mitotic M phaseexperimental evidenceS403PMID:21712547
present during mitotic M phaseexperimental evidenceS610PMID:21712547
present during mitotic M phaseexperimental evidenceS611PMID:21712547
present during mitotic M phaseexperimental evidenceS490PMID:21712547
MOD:00047O-phospho-L-threonineexperimental evidenceT396PMID:21712547692
present during mitotic M phase
experimental evidenceT569PMID:24763107
present during mitotic M phaseexperimental evidenceT528PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
11536during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
12540during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
11884during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
10977during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
14814.87during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
11916during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
14046.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.91during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
does not functionally complement S. cerevisiae CHS5 PMID:21113731
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi only623
conserved in fungi4600
conserved in eukaryotes4514

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
fus1formin Fus1 Phenotypic EnhancementPMID:16598689
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC6G9.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC6G9.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC6G9.12 BioGRID Interaction Datasets
Expression Viewer SPAC6G9.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC6G9.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC6G9.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC6G9.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC6G9.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC6G9.12 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC6G9.12 Cell Cycle Data
GEO SPAC6G9.12 GEO profiles
PInt SPAC6G9.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC6G9.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC6G9.12 Fission yeast phenotypic data & analysis
SPD / RIKEN26/26C05Orfeome Localization Data
UniProtKB/SwissProtQ92357Cell fusion protein cfr1
ModBaseQ92357Database of comparative protein structure models
STRINGQ92357Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594121Chs five related protein Cfr1
RefSeq mRNANM_001019545972h- Chs five related protein Cfr1 (cfr1), mRNA
European Nucleotide ArchiveCAB03614.1ENA Protein Mapping
UniParcUPI0000127924UniProt Archive

Literature for cfr1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014