alp31 (SPAC8E11.07c)

Gene Standard Namealp31 ChromosomeI
Systematic IDSPAC8E11.07c Gene Start3377096
Synonyms Gene End3378081
Producttubulin specific chaperone cofactor A, Alp31 Gene Length986
Feature Typeprotein coding CDS Start3377148
Name Description CDS End3377722
Characterisation Statuspublished CDS Length575

Ensembl Gene Location
  1. nsp1
  2. dph1
  3. SPAC26A3.17c
  4. SPNCRNA.902
  5. SPAC8E11.10
  6. SPAC8E11.12
  7. SPNCRNA.903
  8. SPAC8E11.08c
  9. alp31
  10. SPAC8E11.06
  11. SPAC8E11.05c
  12. SPAC8E11.04c
  13. SPNCRNA.904
  14. dmc1
  15. rad24
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationno_name (unrecorded)unrecordedPMID:10978278
Microscopyalp31delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0048487beta-tubulin bindingISOSGD:S000005791GO_REF:0000024
GO:0051082unfolded protein bindingIEAIPR004226GO_REF:0000002
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006457protein foldingIGInda3PMID:10978278
GO:0007021tubulin complex assemblyIEAIPR004226GO_REF:0000002
GO:0007023post-chaperonin tubulin folding pathwayIMPPMID:10978278
GO:0030951establishment or maintenance of microtubule cytoskeleton polarityIMPPMID:10978278
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005737cytoplasmISOSGD:S000005791GO_REF:0000024
GO:0005829cytosolIDAPMID:16823372
GO:0005874microtubuleIEAUniProtKB:KW-0493GO_REF:0000037
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
133770963377216
233772803377366
333775193378081

References

Region Start End Reference
three_prime_UTR33777233378081PMID:21511999
three_prime_UTR33777233378081PMID:21511999
five_prime_UTR33770963377147PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF02970 IPR004226 Pfam Tubulin binding cofactor A 8 97 1
G3DSA:1.20.58.90 Gene3D 2 104 2
SSF46988 IPR004226 SuperFamily 4 103 1
Coil ncoils Rabaptin coiled-coil domain 92 113 974
PD010430 IPR004226 blastprodom Tubulin binding cofactor A 11 100 1
PTHR21500 IPR004226 hmmpanther Tubulin binding cofactor A 1 111 1
PTHR21500:SF0 hmmpanther 1 111 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.71 Da
Charge -5.00
Isoelectric point 4.86
Molecular weight 13.53 kDa
Number of residues 119
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide9049.14PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.11PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide3.1PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Negative GeneticPMID:22681890
SPAC227.05prefoldin subunit 4 (predicted) Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
mid1medial ring protein Mid1 Negative GeneticPMID:22681890
pmc5mediator complex subunit Pmc5 Negative GeneticPMID:18818364
atb2tubulin alpha 2 Positive GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
atp15F0-ATPase epsilon subunit (predicted) Positive GeneticPMID:22681890
SPCC1919.13cribosome biogenesis protein (predicted) Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
ago1argonaute Negative GeneticPMID:18818364
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
nap1nucleosome assembly protein Nap1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
bdf1Swr1 complex bromodomain subunit Brf1 Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
mgr2mitochondrial membrane protein Mgr2 (predicted) Positive GeneticPMID:22681890
dis2serine/threonine protein phosphatase PP1 Synthetic Growth DefectPMID:21965289
pnk1DNA kinase/phosphatase Pnk1 Positive GeneticPMID:18818364
zrg17cation diffusion family zinc membrane transporter Zrg17 Negative GeneticPMID:22681890
SPAC25B8.05tRNA-pseudouridine synthase (predicted) Negative GeneticPMID:18818364
SPAC227.10prefoldin subunit 2 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
nda3tubulin beta Nda3 Synthetic LethalityPMID:10978278
pst2Clr6 histone deacetylase complex subunit Pst2 Phenotypic EnhancementPMID:19547744
ers1RNA-silencing factor Ers1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
rtf1replication termination factor Rtf1 Positive GeneticPMID:22681890
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
atp10F1-F0 ATPase assembly protein (predicted) Positive GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:18818364
arb1argonaute binding protein 1 Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:18818364
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Positive GeneticPMID:22681890
tco89TORC1 subunit Tco89 Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
tas3RITS complex subunit 3 Negative GeneticPMID:18818364
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Negative GeneticPMID:18818364
SPAPB21F2.02Dopey family protein (predicted) Positive GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
msd1mitotic-spindle disanchored Msd1 Negative GeneticPMID:22681890
sld3DNA replication pre-initiation complex subunit Sld3 Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Positive GeneticPMID:18818364
mca1transcription factor, zf-fungal binuclear cluster type (predicted) Negative GeneticPMID:22681890
ppr8mitochondrial PPR repeat protein Ppr8 Positive GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:18818364
pfd1prefoldin subunit 1 (predicted) Negative GeneticPMID:18818364
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:18818364
cid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
mug147sequence orphan Negative GeneticPMID:22681890
alp21tubulin specific chaperone cofactor E Dosage LethalityPMID:10978278
pac10prefoldin subunit 3 Pac10 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cia1histone chaperone Cia1 Positive GeneticPMID:18818364
SPBC3B8.08Sjogren's syndrome/scleroderma autoantigen 1 family (predicted) Negative GeneticPMID:22681890
SPAC1805.14sequence orphan Negative GeneticPMID:22681890
bub3mitotic spindle checkpoint protein Bub3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rik1silencing protein Rik1 Negative GeneticPMID:18818364
dcr1dicer Negative GeneticPMID:18818364
pab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
SPCC1393.08transcription factor, zf-GATA type (predicted) Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
SPAC2F7.17mitochondrial peptide chain release factor (predicted) Positive GeneticPMID:22681890
pds5cohesin-associated protein Pds5 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
liz1pantothenate transporter Liz1 Negative GeneticPMID:22681890
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
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External References
Database Identifier Description
NBRP SPAC8E11.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC8E11.07c Retrieval of eukaryotic orthologs
BioGrid SPAC8E11.07c BioGRID Interaction Datasets
Bähler Lab SPAC8E11.07c Cell Cycle Expression Profile
Bähler Lab SPAC8E11.07c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC8E11.07c Pheromone response/mating expression profiles
Bähler Lab SPAC8E11.07c Environmental stress expression profiles
Bähler Lab SPAC8E11.07c Bähler Lab Transcriptome Viewer
Cyclebase SPAC8E11.07c Cell Cycle Data
PInt SPAC8E11.07c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC8E11.07c Entrez Gene
WikiGene2543341tubulin specific chaperone cofactor A, Alp31
Uniprot_genenameALP31
EntrezGene2543341tubulin specific chaperone cofactor A, Alp31
SPD / RIKEN06/06B06Orfeome Localization Data
UniProtKB/SwissProtQ9Y703Tubulin-specific chaperone A
ModBaseQ9Y703Database of comparative protein structure models
Pfam Protein DomainsQ9Y703Pfam Domain Arrangement
RefSeq PeptideNP_594162tubulin specific chaperone cofactor A, Alp31
RefSeq mRNANM_001019586972h- tubulin specific chaperone cofactor A, Alp31 (alp31), mRNA
European Nucleotide ArchiveBAA82293ENA Protein Mapping
European Nucleotide ArchiveCAB40194ENA Protein Mapping
UniParcUPI0000136A4AUniProt Archive

Literature for alp31
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013