dph3 (SPAC8F11.02c)

Gene Standard Namedph3 ChromosomeI
Systematic IDSPAC8F11.02c Gene Start2855688
Synonyms Gene End2854405
Productdiphthamide biosynthesis protein Dph3 (predicted) Gene Length1284
Feature Typeprotein coding CDS Start2855662
Name Description CDS End2855322
Characterisation Statusbiological_role_inferred CDS Length341

Ensembl Gene Location
  1. spo12
  2. ucp6
  3. SPAC3F10.16c
  4. SPAC3F10.17
  5. rpl4102
  6. dph3
  7. msh3
  8. SPNCRNA.856
  9. SPAC8F11.04
  10. mug130
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopydph3delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0046872metal ion bindingIEAUniProtKB:KW-0479GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0002098tRNA wobble uridine modificationISOSGD:S000007587GO_REF:0000024
GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidineISOSGD:S000007587GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
ISOSGD:S000007587GO_REF:0000024
GO:0005737cytoplasmISOSGD:S000007587GO_REF:0000024
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
128556882855620
228555772855516
328554562855169
428550902854405

References

Region Start End Reference
three_prime_UTR28553212855169PMID:21511999
five_prime_UTR28556882855663PMID:21511999
three_prime_UTR28553212855169PMID:21511999
three_prime_UTR28550902854405PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF05207 IPR007872 Pfam Zinc finger, DPH-type 5 59 2
PS51074 IPR007872 Prosite Profiles Zinc finger, DPH-type 3 59 2
SSF144217 SuperFamily 1 72 1
PTHR21454 hmmpanther 1 65 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0001773zf-CSLTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001773

Protein Properties

Ave. residue weight 112.62 Da
Charge -16.00
Isoelectric point 3.36
Molecular weight 8.90 kDa
Number of residues 79
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide8.4PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2.8PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
par2protein phosphatase regulatory subunit Par2 Negative GeneticPMID:22681890
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Positive GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
tip1CLIP170 family protein Tip1 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Negative GeneticPMID:22681890
usp102U1 snRNP-associated protein Usp102 Positive GeneticPMID:22681890
tea1cell end marker Tea1 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:22681890
sif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
SPBC660.05WW domain containing conserved fungal protein Negative GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
SPCC1223.01ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
ace2transcription factor Ace2 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
ssm4dynactin microtubule-binding subunit, p150-Glued Ssm4 Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
slx9ribosome biogenesis protein Slx9 (predicted) Negative GeneticPMID:22681890
tea4tip elongation aberrant protein Tea4 Negative GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
nrm1negative regulator of MBF Negative GeneticPMID:22681890
mug81ATP-dependent RNA helicase Slh1 (predicted) Negative GeneticPMID:22681890
nop10snoRNP pseudouridylase box H/ACA snoRNP complex protein (predicted) Negative GeneticPMID:22681890
SPBC660.06WW domain containing conserved fungal protein Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Positive GeneticPMID:22681890
SPCC24B10.18human Leydig cell tumor 10 kDa protein homolog Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
sap14U2 snRNP-associated protein SF3B14 Sap14 Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPAC8F11.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC8F11.02c Retrieval of eukaryotic orthologs
BioGrid SPAC8F11.02c BioGRID Interaction Datasets
Bähler Lab SPAC8F11.02c Cell Cycle Expression Profile
Bähler Lab SPAC8F11.02c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC8F11.02c Pheromone response/mating expression profiles
Bähler Lab SPAC8F11.02c Environmental stress expression profiles
Bähler Lab SPAC8F11.02c Bähler Lab Transcriptome Viewer
Cyclebase SPAC8F11.02c Cell Cycle Data
PInt SPAC8F11.02c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC8F11.02c Entrez Gene
SPD / RIKEN02/02A07Orfeome Localization Data
WikiGene2543434diphthamide biosynthesis protein Dph3 (predicted)
Uniprot_genenameDPH3
EntrezGene2543434diphthamide biosynthesis protein Dph3 (predicted)
UniProtKB/SwissProtQ9UT33Diphthamide biosynthesis protein 3
ModBaseQ9UT33Database of comparative protein structure models
Pfam Protein DomainsQ9UT33Pfam Domain Arrangement
RefSeq PeptideNP_593951diphthamide biosynthesis protein Dph3 (predicted)
RefSeq mRNANM_001019378972h- diphthamide biosynthesis protein Dph3 (predicted) (SPAC8F11.02c), mRNA
European Nucleotide ArchiveCAB52163ENA Protein Mapping
UniParcUPI000006AABEUniProt Archive

Literature for dph3
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013