fml1 (SPAC9.05)

Synonyms ChromosomeI
ProductATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Gene Start1470851
Feature Typeprotein coding Gene End1476275
Name Description CDS Start1471060
Characterisation Statuspublished CDS End1473665

Ensembl Gene Location
Tf2-1 > fml1 < SPAC9.06c SPAC9.07c SPNCRNA.742 SPAC9.08c met26
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
114708511472508
214725541473383
314734401476275

Protein Feature Information
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Protein Features

Ensembl protein image with mapped locations of structural domains
Feature ID Database Description Start End Score All Genes
PF00271 Pfam Helicase, C-terminal 474 536 67.3 69
PF00270 Pfam DNA/RNA helicase, DEAD/DEAH box type, N-terminal 77 234 67.5 43
52540 Superfamily 115 559 177.8 295
SM00490 Smart Helicase, C-terminal 446 537 85.4 67
SM00487 Smart Helicase, superfamily 1/2, ATP-binding domain 69 262 117.2 70
PS51192 PROSITE Helicase, superfamily 1/2, ATP-binding domain 80 248 23.738 69
PS51194 PROSITE Helicase, C-terminal 416 582 18.023 69
PS00690 scanprosite DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 191 200 10

Protein Properties

Ave. residue weight 115.77 Da
Charge 24.00
Isoelectric point 9.37
Molecular weight 96.56 kDa
Number of residues 834
Sequence
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Fission Yeast Phenotype

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Term IDDescriptionSourceAll Genes
FYPO:0000102sensitive to cisplatinTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000102
FYPO:0000124viableTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000124
FYPO:0000266sensitive to DNA damaging agentsTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000266
FYPO:0000089sensitive to methyl methanesulfonateTemporary processing gif - replaced by AJAX with count of genes annotated with the term FYPO:0000089

Gene Ontology Annotations

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Biological Process
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0000732strand displacementIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0000732
GO:0006281DNA repairISS SGD:S000001441GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0006281
GO:0031297replication fork processingIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0031297
GO:0033567DNA replication, Okazaki fragment processingISS SGD:S000001441GO_REF:0000024Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0033567
GO:0071932replication fork reversalIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0071932
GO:2000042negative regulation of double-strand break repair via homologous recombinationIMPTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:2000042

Cellular Component
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0005634nucleusISS SGD:S000001441GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005634
IDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year reference
GO:0005730nucleolusIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005730
GO:0005829cytosolIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005829
GO:0071821FANCM-MHF complexISS UniProtKB:A8MT69Temporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0071821

Molecular Function
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GO IDTermEvidenceWith/FromSourceAll Genes
GO:0071821FANCM-MHF complexISS UniProtKB:A8MT69Temporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0071821
GO:0005524ATP bindingIEAGO_REF:0000002Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0005524
IEAGO_REF:0000004
GO:0009378four-way junction helicase activityIDATemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - PubMed ID replaced by AJAX with the autor year referenceTemporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0009378
GO:0043140ATP-dependent 3'-5' DNA helicase activityIC GO:0043138 | GO:0008026GO_REF:0000001Temporary processing gif - replaced by AJAX with count of genes annotated with the term GO:0043140

Disease Association

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DescriptionSourceAll Genes
Fanconi anemia Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with the citation reference [author (year)]Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000994

Protein Family

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DescriptionSourceAll Genes
DEAD/DEAH box helicaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000174

Species Distribution

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DescriptionSourceAll Genes
conserved in FungiTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000057
conserved in VertebratesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000095
conserved in EukaryotesTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000058
predominantly uniformly single copy (one to one)Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000104
conserved in MetazoaTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000094

Manually Curated Orthologs

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SpeciesGeneDescription

Interactions

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Genetic Interactions from BioGRID

Gene Feature Evidence Source
csn1COP9/signalosome complex subunit Csn1 Negative Genetic
rad1checkpoint clamp complex protein Rad1 Negative Genetic
clr4histone H3 methyltransferase Clr4 Negative Genetic
rad17RFC related checkpoint protein Rad17 Negative Genetic
crb2DNA repair protein Rad9 homolog, Rhp9 Negative Genetic
hus1checkpoint clamp complex protein Hus1 Negative Genetic
pdp1PWWP domain protein Pdp1 Negative Genetic
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative Genetic
eme1Holliday junction resolvase subunit Eme1 Negative Genetic
ddb1damaged DNA binding protein Ddb1 Negative Genetic
rik1silencing protein Rik1 Negative Genetic
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative Genetic
par1protein phosphatase regulatory subunit Par1 Negative Genetic
rhp14XP-A family homolog Rhp14 Negative Genetic
ask1DASH complex subunit Ask1 Negative Genetic
dad2DASH complex subunit Dad2 Negative Genetic
raf1Rik1-associated factor Raf1 Negative Genetic
SPCC306.07cU3 snoRNP-associated protein Cic1/Utp30 family (predicted) Positive Genetic
raf2Rik1-associated factor Raf2 Negative Genetic
rad32Rad32 nuclease Negative Genetic


External References

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Database Identifier Description
NBRP SPAC9.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC9.05 Retrieval of eukaryotic orthologs
BioGrid SPAC9.05 BioGRID Interaction Datasets
Bähler Lab SPAC9.05 Cell Cycle Expression Profile
Bähler Lab SPAC9.05 Meiosis/Sporulation Expression Profies
Bähler Lab SPAC9.05 Pheromone response/mating expression profiles
Bähler Lab SPAC9.05 Environmental stress expression profiles
Bähler Lab SPAC9.05 Bähler Lab Transcriptome Viewer
Cyclebase SPAC9.05 Cell Cycle Data
Entrez Gene SPAC9.05 Link to Entrez Gene
SPD / RIKEN38/38F02Orfeome Localization Data
UniProtKB/SwissProtQ9UT23ATP-dependent DNA helicase mfh1
ArrayExpressQ9UT23Link to ArrayExpress
RefSeq PeptideNP_593348ATP-dependent DNA helicase (predicted)
RefSeq mRNANM_001018780972h- ATP-dependent DNA helicase (predicted) (mfh1), mRNA
European Nucleotide ArchiveCU329670ENA EMBL mapping
European Nucleotide ArchiveCAB57423ENA Protein Mapping
UniParcUPI0000683E34UniProt Archive

Literature for fml1

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Search: UK PMC or PubMed