atp12 (SPAC9.12c)


Gene Standard Nameatp12 Characterisation Statusbiological_role_inferred
Systematic IDSPAC9.12c Feature Typeprotein coding
Synonyms Name Description
Productmitochondrial F1-ATPase chaperone Atp12 (predicted) Product Size291aa, 33.60 kDa
Genomic Location Chromosome I, 1488388-1486827 (1562nt); CDS:1488055-1487131 (925nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
unfolded protein binding41
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
GO Cellular Component
Term NameCount
mitochondrial matrix155
Annotation ExtensionEvidenceWith/FromReference
mitochondrion761
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationatp12ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyatp12ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1488388..1487287, 1487237..1486827
mRNA1488388..1486827
5' UTR1488388..1488056PMID:21511999
CDS1488055..1487287, 1487237..1487131
3' UTR1487130..1486827PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07542 Pfam IPR011419 ATP12, ATPase F1F0-assembly protein 39 168 1
PTHR21013 HMMPANTHER IPR011419 ATP12, ATPase F1F0-assembly protein 33 282 1
2r6iA01 Gene3D 29 94 1
2r31A02 Gene3D IPR023335 Orthogonal Bundle domain in ATP12 101 278 1
SSF160909 SuperFamily 33 277 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.47 Da
Charge 4.00
Isoelectric point 7.61
Molecular weight 33.60 kDa
Number of residues 291
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
10603during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9681during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
10871during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
9710during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
10228during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
1682.55during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.9during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.46during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
ATPAF2 deficiency1
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999432
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
conserved in metazoa3430
conserved in vertebrates3405
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withago1argonaute Negative GeneticPMID:22681890
negative genetic interaction withatg13autophagy associated protein kinase regulatory subunit Atg13 Negative GeneticPMID:22681890
positive genetic interaction withbut1neddylation pathway protein But1 Positive GeneticPMID:22681890
positive genetic interaction withbzz1diacylglycerol binding protein Bzz1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withcdm1DNA polymerase delta subunit Cdm1 Positive GeneticPMID:22681890
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
negative genetic interaction withdsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
negative genetic interaction withdsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
negative genetic interaction withelp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
negative genetic interaction withgsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
positive genetic interaction withhip1hira protein, histone chaperone Hip1 Positive GeneticPMID:22681890
positive genetic interaction withhip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
positive genetic interaction withies2Ino80 complex subunit Ies2 Positive GeneticPMID:22681890
negative genetic interaction withmmb1mitochondrial microtubule binder Mmb1 Negative GeneticPMID:22681890
positive genetic interaction withmug154conserved fungal protein Positive GeneticPMID:22681890
positive genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
negative genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
negative genetic interaction withpmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:22681890
positive genetic interaction withpof9F-box protein Pof9 Positive GeneticPMID:22681890
negative genetic interaction withppe1serine/threonine protein phosphatase Ppe1 Negative GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
negative genetic interaction withpst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
negative genetic interaction withrga3Rho-type GTPase activating protein Rga3 Negative GeneticPMID:22681890
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
positive genetic interaction withset1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
positive genetic interaction withsif1Sad1 interacting factor 1 Positive GeneticPMID:22681890
negative genetic interaction withSPAC25B8.11transcription factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC56F2.08cRNA-binding protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPCC18.13tRNA (guanine-N7-)-methyltransferase subunit Trm82 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
negative genetic interaction withsum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
positive genetic interaction withswd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
negative genetic interaction withtas3RITS complex subunit 3 Negative GeneticPMID:22681890
positive genetic interaction withvps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC9.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC9.12c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC9.12c BioGRID Interaction Datasets
Expression Viewer SPAC9.12c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC9.12c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC9.12c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC9.12c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC9.12c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC9.12c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC9.12c Cell Cycle Data
GEO SPAC9.12c GEO profiles
PInt SPAC9.12c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC9.12c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC9.12c Fission yeast phenotypic data & analysis
SPD / RIKEN12/12H06Orfeome Localization Data
UniProtKB/SwissProtQ9UT16Protein atp12, mitochondrial
ModBaseQ9UT16Database of comparative protein structure models
STRINGQ9UT16Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593355F1-ATPase chaperone Atp12 (predicted)
RefSeq mRNANM_001018787972h- F1-ATPase chaperone Atp12 (predicted) (atp12), mRNA
European Nucleotide ArchiveCAB57430.2ENA Protein Mapping
UniParcUPI000228F40FUniProt Archive

Literature for atp12

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015