atd2 (SPAC922.07c)


Gene Standard Nameatd2 Characterisation Statusbiological_role_inferred
Systematic IDSPAC922.07c Feature Typeprotein coding
Synonyms Name DescriptionAceTaldehyde Dehydrogenase
Productaldehyde dehydrogenase (predicted) Product Size496aa, 54.03 kDa
Genomic Location Chromosome I, 5488830-5486848 (1983nt); CDS:5488606-5487116 (1491nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00040283-chloroallyl aldehyde dehydrogenase activityISOSGD:S000004779GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0019483beta-alanine biosynthetic processISOSGD:S000004779GO_REF:00000241
GO:0006081cellular aldehyde metabolic processICGO:0004028GO_REF:000000116
GO:0006598polyamine catabolic processISOSGD:S000004779GO_REF:00000242
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmISOSGD:S000004779GO_REF:00000244198
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyatd2ΔNullPMID:204732893755
Microscopyatd2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopyatd2ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
154888305486848

UTRs

Region Start End Reference
three_prime_UTR54871155486848PMID:21511999
five_prime_UTR54888305488607PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00171 Pfam IPR015590 Aldehyde dehydrogenase domain 29 488 8
PS00687 Prosite Patterns IPR016160 Aldehyde dehydrogenase, conserved site 262 269 7
PTHR11699:SF46 HMMPANTHER 7 496 2
PTHR11699 HMMPANTHER 7 496 7
G3DSA:3.40.309.10 Gene3D IPR016163 276 463 8
G3DSA:3.40.605.10 Gene3D IPR016162 19 275 8
SSF53720 SuperFamily IPR016161 14 493 9

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.93 Da
Charge -6.00
Isoelectric point 5.26
Molecular weight 54.03 kDa
Number of residues 496
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
23282.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
4261.4during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
2.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC1A6.03cphospholipase (predicted) Positive GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
res2MBF transcription factor complex subunit Res2 Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPAC922.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC922.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC922.07c BioGRID Interaction Datasets
Expression Viewer SPAC922.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC922.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC922.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC922.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC922.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC922.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC922.07c Cell Cycle Data
GEO SPAC922.07c GEO profiles
PInt SPAC922.07c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2543659aldehyde dehydrogenase (predicted)
EntrezGene2543659aldehyde dehydrogenase (predicted)
IntEnz1.2.1.5Integrated relational Enzyme database
Rhea1.2.1.5Annotated reactions database
SPD / RIKEN24/24A10Orfeome Localization Data
UniProtKB/SwissProtQ9URW9Putative aldehyde dehydrogenase-like protein C922.07c
ModBaseQ9URW9Database of comparative protein structure models
StringQ9URW9Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595007aldehyde dehydrogenase (predicted)
RefSeq mRNANM_001020438972h- aldehyde dehydrogenase (predicted) (SPAC922.07c), mRNA
European Nucleotide ArchiveCAB63554ENA Protein Mapping
UniParcUPI000006B5C3UniProt Archive

Literature for atd2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014