atd2 (SPAC922.07c)


Gene Standard Nameatd2 Characterisation Statusbiological role inferred
Systematic IDSPAC922.07c Feature Typeprotein coding
Synonyms Name DescriptionAceTaldehyde Dehydrogenase
Productaldehyde dehydrogenase (predicted) Product Size496aa, 54.03 kDa
Genomic Location Chromosome I, 5488830-5486848 (1983nt); CDS:5488606-5487116 (1491nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
3-chloroallyl aldehyde dehydrogenase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
beta-alanine biosynthetic process1
Annotation ExtensionEvidenceWith/FromReference
cellular aldehyde metabolic process27
Annotation ExtensionEvidenceWith/FromReference
polyamine catabolic process2
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4213
Annotation ExtensionEvidenceWith/FromReference
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationatd2Δ3837

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyatd2Δ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons5488830..5486848
5' UTR5488830..5488607PMID:21511999
3' UTR5487115..5486848PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00171 Pfam IPR015590 Aldehyde dehydrogenase domain 29 488 8
PS00687 Prosite Patterns IPR029510 Aldehyde dehydrogenase, glutamic acid active site 262 269 7
PTHR11699 HMMPANTHER 1 496 7
PTHR11699:SF196 HMMPANTHER 1 496 1
3.40.309.10 Gene3D IPR016163 Aldehyde dehydrogenase, C-terminal 276 463 8
3.40.605.10 Gene3D IPR016162 Aldehyde dehydrogenase N-terminal domain 19 275 8
SSF53720 SuperFamily IPR016161 Aldehyde/histidinol dehydrogenase 14 493 9

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.93 Da
Charge -6.00
Codon Adaptation Index 0.44
Isoelectric point 5.26
Molecular weight 54.03 kDa
Number of residues 496
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for atd2 (SPAC922.07c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
11236during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
12062during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
10850during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
11702during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
4261.4during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
11686during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
23282.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4605
conserved in eukaryotes4515
conserved in bacteria1001
conserved in metazoa3424
conserved in vertebrates3399
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAC922.07c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAC922.07c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withswd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
positive genetic interaction withSPAC1A6.03clysophospholipase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withres2MBF transcription factor complex subunit Res2 Negative GeneticPMID:22681890
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
External References
Database Identifier Description
NBRP SPAC922.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC922.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC922.07c BioGRID Interaction Datasets
Expression Viewer SPAC922.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC922.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC922.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC922.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC922.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC922.07c Transcriptome Viewer (Bähler Lab)
GEO SPAC922.07c GEO profiles
PInt SPAC922.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC922.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC922.07c Fission yeast phenotypic data & analysis
Cyclebase SPAC922.07c.1 Cell Cycle Data
SPD / RIKEN24/24A10Orfeome Localization Data
IntEnz1.2.1.5Integrated relational Enzyme database
Rhea1.2.1.5Annotated reactions database
UniProtKB/SwissProtQ9URW9Putative aldehyde dehydrogenase-like protein C922.07c
ModBaseQ9URW9Database of comparative protein structure models
STRINGQ9URW9Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595007aldehyde dehydrogenase (predicted)
RefSeq mRNANM_001020438972h- aldehyde dehydrogenase (predicted) (SPAC922.07c), mRNA

Literature for atd2

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016