fas1 (SPAC926.09c)


Gene Standard Namefas1 Characterisation Statuspublished
Systematic IDSPAC926.09c Feature Typeprotein coding
Synonyms Name Description
Productfatty acid synthase beta subunit Fas1 Product Size2073aa, 230.56 kDa
Genomic Location Chromosome I, 3907056-3900130 (6927nt); CDS:3906588-3900367 (6222nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00474513-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activityIEA EC:4.2.1.59GO_REF:00000031
GO:00043173-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activityISOSGD:S000001665GO_REF:00000241
GO:0004313[acyl-carrier-protein] S-acetyltransferase activityISOSGD:S000001665GO_REF:00000241
GO:0004314[acyl-carrier-protein] S-malonyltransferase activityISOSGD:S000001665GO_REF:00000242
GO:0004318enoyl-[acyl-carrier-protein] reductase (NADH) activityISOSGD:S000001665GO_REF:00000241
GO:0004312fatty acid synthase activityIDAPMID:96930668
GO:0004321fatty-acyl-CoA synthase activityIEA EC:2.3.1.86GO_REF:00000032
GO:0016295myristoyl-[acyl-carrier-protein] hydrolase activityIEA EC:3.1.2.14GO_REF:00000031
GO:0004320oleoyl-[acyl-carrier-protein] hydrolase activityIEA EC:3.1.2.14GO_REF:00000031
GO:0016296palmitoyl-[acyl-carrier-protein] hydrolase activityIEA EC:3.1.2.14GO_REF:00000031
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006633fatty acid biosynthetic processISOSGD:S000001665GO_REF:000002429
IDAPMID:9693066
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722315
GO:0005835fatty acid synthase complexIDAPMID:96930662
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyfas1ΔNullPECO:0000005, PECO:0000137PMID:236978063759
Microscopyfas1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyfas1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
139070563900130

UTRs

Region Coordinates Reference
five_prime_UTR3907056..3906589PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00698 Pfam IPR014043 Acyl transferase 1683 2058 2
PF08354 Pfam IPR013565 Domain of unknown function DUF1729 1020 1076 1
PF13452 Pfam 1289 1413 1
PF01575 Pfam IPR002539 MaoC-like domain 1558 1667 1
SM00827 SMART IPR020801 Polyketide synthase, acyl transferase domain 1684 2040 2
PTHR10982:SF6 HMMPANTHER 7 2071 1
PTHR10982 HMMPANTHER 7 2071 2
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 154 307 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 418 521 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 1794 1860 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 1995 2048 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 1675 1738 3
3.20.20.70 Gene3D IPR013785 Aldolase-type TIM barrel 557 844 35
3.10.129.10 Gene3D 1292 1422 6
3.10.129.10 Gene3D 1520 1674 6
SSF54637 SuperFamily HotDog domain 1559 1676 6
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 420 514 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 155 313 13
SSF51412 SuperFamily 565 835 2
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 1996 2042 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 1682 1734 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 1789 1865 13
SSF54637 SuperFamily HotDog domain 1260 1419 6
PIRSF005562 PIRSF IPR016452 Fatty acid synthase, beta subunit, fungi 1 2073 1
PR01483 PRINTS IPR003965 Fatty acid synthase 696 714 1
PR01483 PRINTS IPR003965 Fatty acid synthase 571 591 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1587 1608 1
PR01483 PRINTS IPR003965 Fatty acid synthase 597 615 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1673 1692 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1563 1585 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1694 1717 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1014 1038 1
PR01483 PRINTS IPR003965 Fatty acid synthase 914 932 1
PR01483 PRINTS IPR003965 Fatty acid synthase 716 735 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1852 1873 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1816 1835 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.22 Da
Charge -6.00
Isoelectric point 6.34
Molecular weight 230.56 kDa
Number of residues 2073
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS2073PMID:247631071670
present during mitotic M phaseexperimental evidenceS2072PMID:21712547
experimental evidenceS2072PMID:24763107
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
227192during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
235558during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
234862during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
236959during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
232031during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
58126.06during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
21696.09during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
43during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
5.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Subunit Composition
DescriptionQualifierReferenceCount
heterododecameric PMID:96930662
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
rsv2transcription factor Rsv2 Negative GeneticPMID:22681890
atp11F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Positive GeneticPMID:22681890
sty1MAP kinase Sty1 Positive GeneticPMID:22681890
cul1cullin 1 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
cdk11serine/threonine protein kinase cdk11 Affinity Capture-MSPMID:23122962
External References
Database Identifier Description
NBRP SPAC926.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC926.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC926.09c BioGRID Interaction Datasets
Expression Viewer SPAC926.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC926.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC926.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC926.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC926.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC926.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC926.09c Cell Cycle Data
GEO SPAC926.09c GEO profiles
PInt SPAC926.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC926.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC926.09c Fission yeast phenotypic data & analysis
IntEnz2.3.1.38Integrated relational Enzyme database
Rhea2.3.1.38Annotated reactions database
SPD / RIKEN34/34C03Orfeome Localization Data
IntEnz1.3.1.9Integrated relational Enzyme database
Rhea1.3.1.9Annotated reactions database
IntEnz2.3.1.86Integrated relational Enzyme database
Rhea2.3.1.86Annotated reactions database
IntEnz3.1.2.14Integrated relational Enzyme database
Rhea3.1.2.14Annotated reactions database
IntEnz2.3.1.39Integrated relational Enzyme database
Rhea2.3.1.39Annotated reactions database
IntEnz4.2.1.61Integrated relational Enzyme database
Rhea4.2.1.61Annotated reactions database
UniProtKB/SwissProtQ9UUG0Fatty acid synthase subunit beta
ModBaseQ9UUG0Database of comparative protein structure models
STRINGQ9UUG0Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594370fatty acid synthase beta subunit Fas1
RefSeq mRNANM_001019791972h- fatty acid synthase beta subunit Fas1 (fas1), mRNA
European Nucleotide ArchiveD89148ENA EMBL mapping
European Nucleotide ArchiveBAA36384.1ENA Protein Mapping
European Nucleotide ArchiveCAB54157.1ENA Protein Mapping
UniParcUPI000012A53BUniProt Archive

Literature for fas1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014