fas1 (SPAC926.09c)


Gene Standard Namefas1 Characterisation Statuspublished
Systematic IDSPAC926.09c Feature Typeprotein coding
Synonyms Name Description
Productfatty acid synthase beta subunit Fas1 Product Size2073aa, 230.56 kDa
Genomic Location Chromosome I, 3907056-3900130 (6927nt); CDS:3906588-3900367 (6222nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
fatty acid biosynthetic process30
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
fatty acid synthase complex2
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationfas1ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyfas1ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3907056..3900130
mRNA3907056..3900130
5' UTR3907056..3906589PMID:21511999
CDS3906588..3900367
3' UTR3900366..3900130AU011610
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01575 Pfam IPR002539 MaoC-like domain 1558 1667 1
PF00698 Pfam IPR014043 Acyl transferase 1683 2058 2
PF13452 Pfam 1289 1413 1
PF08354 Pfam IPR013565 Domain of unknown function DUF1729 1020 1076 1
SM00827 SMART IPR020801 Polyketide synthase, acyl transferase domain 1684 2040 2
PTHR10982:SF9 HMMPANTHER 26 2068 2
PTHR10982 HMMPANTHER 26 2068 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 1995 2048 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 1675 1738 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 1794 1860 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 154 307 3
3.40.366.10 Gene3D IPR001227 Acyl transferase domain 418 521 3
3.20.20.70 Gene3D IPR013785 Aldolase-type TIM barrel 557 844 35
3.10.129.10 Gene3D IPR029069 HotDog domain 1520 1674 6
3.10.129.10 Gene3D IPR029069 HotDog domain 1292 1422 6
SSF51412 SuperFamily 565 835 2
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 1789 1865 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 1682 1734 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 155 313 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 1996 2042 13
SSF52151 SuperFamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase 420 514 13
SSF54637 SuperFamily IPR029069 HotDog domain 1260 1419 6
SSF54637 SuperFamily IPR029069 HotDog domain 1559 1676 6
PR01483 PRINTS IPR003965 Fatty acid synthase 716 735 1
PR01483 PRINTS IPR003965 Fatty acid synthase 571 591 1
PR01483 PRINTS IPR003965 Fatty acid synthase 696 714 1
PR01483 PRINTS IPR003965 Fatty acid synthase 914 932 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1587 1608 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1852 1873 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1816 1835 1
PR01483 PRINTS IPR003965 Fatty acid synthase 597 615 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1673 1692 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1563 1585 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1014 1038 1
PR01483 PRINTS IPR003965 Fatty acid synthase 1694 1717 1
PIRSF005562 PIRSF IPR016452 Fatty acid synthase, beta subunit, fungi 6 2072 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.22 Da
Charge -6.00
Isoelectric point 6.34
Molecular weight 230.56 kDa
Number of residues 2073
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS2072
S2072, S2073
Annotation ExtensionEvidenceResidueReference
experimental evidence S2072 PMID:24763107
present during mitotic M phase experimental evidence S2072 PMID:21712547
experimental evidence S2073 PMID:24763107
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
227192during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
235558during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
234862during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
236959during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
232031during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
58126.06during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
21696.09during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
43during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
5.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Subunit Composition
DescriptionQualifierReferenceCount
heterododecameric PMID:96930662
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4604
conserved in eukaryotes4516
conserved in bacteria1000
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycdk11serine/threonine protein kinase cdk11 Affinity Capture-MSPMID:23122962
affinity captured byhhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
affinity captured byhhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
affinity captured bysog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Positive GeneticPMID:22681890
negative genetic interaction withcul1cullin 1 Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Positive GeneticPMID:22681890
positive genetic interaction withngg1SAGA complex subunit Ngg1 Positive GeneticPMID:22681890
positive genetic interaction withphp3CCAAT-binding factor complex subunit Php3 Positive GeneticPMID:22681890
positive genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Positive GeneticPMID:22681890
negative genetic interaction withrsv2transcription factor Rsv2 Negative GeneticPMID:22681890
positive genetic interaction withsty1MAP kinase Sty1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC926.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC926.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC926.09c BioGRID Interaction Datasets
Expression Viewer SPAC926.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC926.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC926.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC926.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC926.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC926.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC926.09c Cell Cycle Data
GEO SPAC926.09c GEO profiles
PInt SPAC926.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC926.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC926.09c Fission yeast phenotypic data & analysis
IntEnz2.3.1.38Integrated relational Enzyme database
Rhea2.3.1.38Annotated reactions database
SPD / RIKEN34/34C03Orfeome Localization Data
IntEnz1.3.1.9Integrated relational Enzyme database
Rhea1.3.1.9Annotated reactions database
IntEnz2.3.1.86Integrated relational Enzyme database
Rhea2.3.1.86Annotated reactions database
IntEnz3.1.2.14Integrated relational Enzyme database
Rhea3.1.2.14Annotated reactions database
IntEnz2.3.1.39Integrated relational Enzyme database
Rhea2.3.1.39Annotated reactions database
IntEnz4.2.1.61Integrated relational Enzyme database
Rhea4.2.1.61Annotated reactions database
UniProtKB/SwissProtQ9UUG0Fatty acid synthase subunit beta
ModBaseQ9UUG0Database of comparative protein structure models
STRINGQ9UUG0Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594370fatty acid synthase beta subunit Fas1
RefSeq mRNANM_001019791972h- fatty acid synthase beta subunit Fas1 (fas1), mRNA
European Nucleotide ArchiveD89148ENA EMBL mapping
European Nucleotide ArchiveBAA36384.1ENA Protein Mapping
European Nucleotide ArchiveCAB54157.1ENA Protein Mapping
MetaCycPWY-4381Fatty acid biosynthesis initiation I
MetaCycPWY-5142Acyl-acp thioesterase pathway
MetaCycPWY-5147Oleate biosynthesis I (plants)
MetaCycPWY-5366Palmitoleate biosynthesis II
MetaCycPWY-5367Petroselinate biosynthesis
MetaCycPWY-5966Fatty acid biosynthesis initiation II
MetaCycPWY-5971Palmitate biosynthesis II (bacteria and plants)
MetaCycPWY-5973Cis-vaccenate biosynthesis
MetaCycPWY-5989Stearate biosynthesis II (bacteria and plants)
MetaCycPWY-5994Palmitate biosynthesis I (animals and fungi)
MetaCycPWY-6113Superpathway of mycolate biosynthesis
MetaCycPWY-6282Palmitoleate biosynthesis I
MetaCycPWY-65198-amino-7-oxononanoate biosynthesis I
MetaCycPWY-6799Fatty acid biosynthesis (plant mitochondria)
MetaCycPWY-7096Triclosan resistance
MetaCycPWY-7388Octanoyl-acp biosynthesis (mitochondria, yeast)
KEGG_Enzyme00061+2.3.1.39+4.2.1.59+1.3.1.9+3.1.2.14Fatty acid biosynthesis
KEGG_Enzyme00780+4.2.1.59Biotin metabolism
UniParcUPI000012A53BUniProt Archive

Literature for fas1

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015