atd1 (SPAC9E9.09c)


Gene Standard Nameatd1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC9E9.09c Feature Typeprotein coding
Synonyms Name DescriptionAceTaldehyde Dehydrogenase
Productaldehyde dehydrogenase (predicted) Product Size503aa, 54.77 kDa
Genomic Location Chromosome I, 4455187-4453280 (1908nt); CDS:4455071-4453560 (1512nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
aldehyde dehydrogenase (NAD) activity2
Annotation ExtensionEvidenceWith/FromReference
aldehyde dehydrogenase [NAD(P)+] activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
acetate biosynthetic process1
Annotation ExtensionEvidenceWith/FromReference
ethanol catabolic process1
Annotation ExtensionEvidenceWith/FromReference
NADPH regeneration4
Annotation ExtensionEvidenceWith/FromReference
pyruvate metabolic process30
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4209
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
mitochondrial matrix153
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to bortezomibatd1ΔNull256
sensitive to doxorubicinatd1ΔNull91
sensitive to hydroxyureaatd1ΔNull534
sensitive to thiabendazoleatd1ΔNull219
viable vegetative cell populationatd1ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable spheroid vegetative cellatd1ΔNull50
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in lkh1 dual specificity protein kinase Lkh1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4455187..4453280
mRNA4455187..4453280
5' UTR4455187..4455072PMID:21511999
CDS4455071..4453560
3' UTR4453559..4453280AU010951
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00171 Pfam IPR015590 Aldehyde dehydrogenase domain 37 493 8
PS00070 Prosite Patterns IPR016160 Aldehyde dehydrogenase, cysteine active site 297 308 5
PS00687 Prosite Patterns IPR029510 Aldehyde dehydrogenase, glutamic acid active site 269 276 7
PTHR11699 HMMPANTHER 1 503 7
PTHR11699:SF46 HMMPANTHER IPR015657 Aminobutyraldehyde dehydrogenase 1 503 1
3.40.605.10 Gene3D IPR016162 Aldehyde dehydrogenase N-terminal domain 21 282 8
3.40.309.10 Gene3D IPR016163 Aldehyde dehydrogenase, C-terminal 283 468 8
SSF53720 SuperFamily IPR016161 Aldehyde/histidinol dehydrogenase 11 497 9

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.88 Da
Charge 1.50
Isoelectric point 6.72
Molecular weight 54.77 kDa
Number of residues 503
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS501 1672
present during mitotic M phase, cellular response to thiabendazoleS501
Annotation ExtensionEvidenceResidueReference
experimental evidence S501 PMID:24763107
present during cellular response to thiabendazole IDA S501 PMID:18257517
present during mitotic M phase experimental evidence S501 PMID:21712547
phosphorylated residue 1927
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
472490during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
455919during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
419783during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
528117during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
478680during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
130580.25during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
56699.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
70during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
8.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
affinity captured byclp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
affinity captured byfar8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
affinity captured bypaa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
affinity captured bysog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
positive genetic interaction withbit61TORC2 subunit Bit61 Positive GeneticPMID:22681890
negative genetic interaction withcaf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
negative genetic interaction withdad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
negative genetic interaction withdam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
negative genetic interaction withdot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
negative genetic interaction withduo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
negative genetic interaction withelp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withhrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:22681890
negative genetic interaction withint6eIF3e subunit Int6 Negative GeneticPMID:22681890
negative genetic interaction withits31-phosphatidylinositol-4-phosphate 5-kinase Its3 Negative GeneticPMID:22681890
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
negative genetic interaction withmcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withmpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
positive genetic interaction withmug81ATP-dependent RNA helicase Slh1, human ASCC3 ortholog (predicted) Positive GeneticPMID:22681890
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
negative genetic interaction withphp5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
negative genetic interaction withpms1MutL family mismatch-repair protein Pms1 Negative GeneticPMID:22681890
negative genetic interaction withprp22ATP-dependent RNA helicase Prp22 Negative GeneticPMID:22681890
negative genetic interaction withptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:22681890
negative genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
negative genetic interaction withrad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
negative genetic interaction withrdl2mitochondrial thiosulfate sulfurtransferase Rdl2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:22681890
positive genetic interaction withsck2serine/threonine protein kinase Sck2 Positive GeneticPMID:24463365
negative genetic interaction withsdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:22681890
negative genetic interaction withset3histone lysine methyltransferase Set3 Negative GeneticPMID:22681890
negative genetic interaction withslx4structure-specific endonuclease subunit Slx4 Negative GeneticPMID:22681890
negative genetic interaction withSPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC2F3.16ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withspc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
negative genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
negative genetic interaction withswc3Swr1 complex subunit Swc3 Negative GeneticPMID:22681890
negative genetic interaction withswd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
negative genetic interaction withtea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
negative genetic interaction withtif38translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
negative genetic interaction withtor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
negative genetic interaction withtrm10tRNA m(1)G methyltransferase Trm10 Negative GeneticPMID:22681890
negative genetic interaction withtsc1hamartin Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
External References
Database Identifier Description
NBRP SPAC9E9.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC9E9.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC9E9.09c BioGRID Interaction Datasets
Expression Viewer SPAC9E9.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC9E9.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC9E9.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC9E9.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC9E9.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC9E9.09c Transcriptome Viewer (Bähler Lab)
GEO SPAC9E9.09c GEO profiles
PInt SPAC9E9.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC9E9.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC9E9.09c Fission yeast phenotypic data & analysis
Cyclebase SPAC9E9.09c.1 Cell Cycle Data
SPD / RIKEN24/24E04Orfeome Localization Data
IntEnz1.2.1.3Integrated relational Enzyme database
Rhea1.2.1.3Annotated reactions database
UniProtKB/SwissProtO14293Putative aldehyde dehydrogenase-like protein C9E9.09c
ModBaseO14293Database of comparative protein structure models
STRINGO14293Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594582aldehyde dehydrogenase (predicted)
RefSeq mRNANM_001020011972h- aldehyde dehydrogenase (predicted) (SPAC9E9.09c), mRNA
European Nucleotide ArchiveD89246ENA EMBL mapping
European Nucleotide ArchiveCAB16407.1ENA Protein Mapping
UniParcUPI000006B297UniProt Archive

Literature for atd1

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015