atd1 (SPAC9E9.09c)

Gene Standard Nameatd1 Characterisation Statusbiological_role_inferred
Systematic IDSPAC9E9.09c Feature Typeprotein coding
Synonyms Name DescriptionAceTaldehyde Dehydrogenase
Productaldehyde dehydrogenase (predicted) Product Size503aa, 54.77 kDa
Genomic Location Chromosome I, 4455187-4453280 (1908nt); CDS:4455071-4453560 (1512nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
aldehyde dehydrogenase (NAD) activity2
Annotation ExtensionEvidenceWith/FromReference
aldehyde dehydrogenase [NAD(P)+] activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
acetate biosynthetic process1
Annotation ExtensionEvidenceWith/FromReference
ethanol catabolic process1
Annotation ExtensionEvidenceWith/FromReference
NADPH regeneration16
Annotation ExtensionEvidenceWith/FromReference
pyruvate metabolic process31
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
mitochondrial matrix154
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to bortezomib256
expressivity FYPO_EXT:0000002atd1ΔNull
sensitive to doxorubicin91
expressivity FYPO_EXT:0000003atd1ΔNull
sensitive to hydroxyureaatd1ΔNull518
sensitive to thiabendazoleatd1ΔNull185
viable vegetative cell populationatd1ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
viable spheroid vegetative cell47
penetrance FYPO_EXT:0000001atd1ΔNull
Target Of
FYPO affected by mutation in lkh1 dual specificity protein kinase Lkh1 PMID:23956636
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00171 Pfam IPR015590 Aldehyde dehydrogenase domain 37 493 8
PS00070 Prosite Patterns IPR016160 Aldehyde dehydrogenase, cysteine active site 297 308 5
PS00687 Prosite Patterns IPR029510 Aldehyde dehydrogenase, glutamic acid active site 269 276 7
PTHR11699:SF46 HMMPANTHER IPR015657 Aminobutyraldehyde dehydrogenase 1 503 1
PTHR11699 HMMPANTHER 1 503 7
3.40.309.10 Gene3D IPR016163 Aldehyde dehydrogenase, C-terminal 283 468 8
3.40.605.10 Gene3D IPR016162 Aldehyde dehydrogenase N-terminal domain 21 282 8
SSF53720 SuperFamily IPR016161 Aldehyde/histidinol dehydrogenase 11 497 9

View domain organization at Pfam

Protein Properties

Ave. residue weight 108.88 Da
Charge 1.50
Isoelectric point 6.72
Molecular weight 54.77 kDa
Number of residues 503

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS501 1670
present during mitotic M phase, cellular response to thiabendazoleS501
Annotation ExtensionEvidenceResidueReference
experimental evidence S501 PMID:24763107
present during cellular response to thiabendazole IDA S501 PMID:18257517
present during mitotic M phase experimental evidence S501 PMID:21712547
phosphorylated residue 1922
Annotation ExtensionEvidenceResidueReference
NAS PMID:18257517
IDA PMID:19547744
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
472490during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
455919during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
419783during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
528117during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
130580.25during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
478680during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
56699.27during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
70during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
8.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
trm10tRNA m(1)G methyltransferase Trm10 Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
bit61TORC2 subunit Bit61 Positive GeneticPMID:22681890
mug81ATP-dependent RNA helicase Slh1, human ASCC3 ortholog (predicted) Positive GeneticPMID:22681890
SPAC2F3.16ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:24957674
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
caf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Negative GeneticPMID:22681890
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
SPAC4H3.07cprotein phosphatase Fmp31 (predicted) Negative GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
tea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
prp22ATP-dependent RNA helicase Prp22 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
sck2serine/threonine protein kinase Sck2 Positive GeneticPMID:24463365
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
pms1MutL family mismatch-repair protein Pms1 Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Negative GeneticPMID:22681890
slx4structure-specific endonuclease subunit Slx4 Negative GeneticPMID:22681890
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:22681890
ptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:22681890
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
int6eIF3e subunit Int6 Negative GeneticPMID:22681890
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
SPAC23A1.02cphosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
its31-phosphatidylinositol-4-phosphate 5-kinase Its3 Negative GeneticPMID:22681890
dot2ESCRT II complex subunit Dot2 Negative GeneticPMID:22681890
clr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
swc3Swr1 complex subunit Swc3 Negative GeneticPMID:22681890
dam1DASH complex subunit Dam1 Negative GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAC9E9.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC9E9.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC9E9.09c BioGRID Interaction Datasets
Expression Viewer SPAC9E9.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC9E9.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC9E9.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC9E9.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC9E9.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC9E9.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC9E9.09c Cell Cycle Data
GEO SPAC9E9.09c GEO profiles
PInt SPAC9E9.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAC9E9.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAC9E9.09c Fission yeast phenotypic data & analysis
SPD / RIKEN24/24E04Orfeome Localization Data
IntEnz1.2.1.3Integrated relational Enzyme database
Rhea1.2.1.3Annotated reactions database
UniProtKB/SwissProtO14293Putative aldehyde dehydrogenase-like protein C9E9.09c
ModBaseO14293Database of comparative protein structure models
STRINGO14293Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594582aldehyde dehydrogenase (predicted)
RefSeq mRNANM_001020011972h- aldehyde dehydrogenase (predicted) (SPAC9E9.09c), mRNA
European Nucleotide ArchiveD89246ENA EMBL mapping
European Nucleotide ArchiveCAB16407.1ENA Protein Mapping
UniParcUPI000006B297UniProt Archive

Literature for atd1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015