SPAC9G1.05


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPAC9G1.05 Feature Typeprotein coding
Synonyms Name Description
Productactin cortical patch component Aip1 (predicted) Product Size595aa, 65.27 kDa
Genomic Location Chromosome I, 1976706-1979209 (2504nt); CDS:1976902-1979061 (2160nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030042actin filament depolymerizationISOSGD:S000004698GO_REF:00000243
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030479actin cortical patchISOSGD:S000004698GO_REF:000002447
GO:0032153cell division siteIDAPMID:16823372292
GO:0051286cell tipIDAPMID:16823372186
GO:0005737cytoplasmISOSGD:S000004698GO_REF:00000244198
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
ISOSGD:S000004698GO_REF:0000024
GO:0043234protein complexNASGO_REF:00000511468
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000088sensitive to hydroxyureacompetitive growth assay evidenceSPAC9G1.05ΔNullPMID:20537132233
expressivity FYPO_EXT:0000003Cell growth assaySPAC9G1.05ΔNullPECO:0000137, PECO:0000005PMID:19264558
expressivity FYPO_EXT:0000003Cell Growth AssaySPAC9G1.05ΔNullPECO:0000137, PECO:0000102PMID:23697806
FYPO:0002060viable vegetative cell populationMicroscopySPAC9G1.05ΔNullPMID:204732893755
MicroscopySPAC9G1.05ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPAC9G1.05ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
119767061977006
219770681977191
319772621977363
419774041977449
519775561977601
619776511978592
719786391979209

UTRs

Region Start End Reference
five_prime_UTR19767061976901PMID:21511999
three_prime_UTR19790621979209PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00400 Pfam IPR001680 WD40 repeat 222 259 104
PF00400 Pfam IPR001680 WD40 repeat 183 217 104
PF00400 Pfam IPR001680 WD40 repeat 54 86 104
PF00400 Pfam IPR001680 WD40 repeat 474 507 104
PF00400 Pfam IPR001680 WD40 repeat 521 550 104
PF00400 Pfam IPR001680 WD40 repeat 306 343 104
SM00320 SMART IPR001680 WD40 repeat 135 175 121
SM00320 SMART IPR001680 WD40 repeat 347 384 121
SM00320 SMART IPR001680 WD40 repeat 468 507 121
SM00320 SMART IPR001680 WD40 repeat 304 343 121
SM00320 SMART IPR001680 WD40 repeat 511 550 121
SM00320 SMART IPR001680 WD40 repeat 220 259 121
SM00320 SMART IPR001680 WD40 repeat 178 217 121
SM00320 SMART IPR001680 WD40 repeat 47 86 121
SM00320 SMART IPR001680 WD40 repeat 554 592 121
SM00320 SMART IPR001680 WD40 repeat 419 463 121
PS50082 Prosite Profiles IPR001680 WD40 repeat 185 226 100
PS50082 Prosite Profiles IPR001680 WD40 repeat 54 86 100
PS50082 Prosite Profiles IPR001680 WD40 repeat 561 595 100
PS50082 Prosite Profiles IPR001680 WD40 repeat 227 268 100
PS50082 Prosite Profiles IPR001680 WD40 repeat 475 516 100
PS50082 Prosite Profiles IPR001680 WD40 repeat 311 344 100
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 54 595 104
PTHR19856 HMMPANTHER 1 595 1
G3DSA:2.130.10.10 Gene3D IPR015943 54 388 143
G3DSA:2.130.10.10 Gene3D IPR015943 419 593 143
SSF50978 SuperFamily IPR017986 283 389 135
SSF50978 SuperFamily IPR017986 26 343 135
SSF50978 SuperFamily IPR017986 422 593 135
Low complexity (SEG) seg 233 244

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 109.69 Da
Charge 0.00
Isoelectric point 6.50
Molecular weight 65.27 kDa
Number of residues 595
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
19028.57during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
17904.61during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:21931816
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
lub1WD repeat protein Lub1 Negative GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
atp11F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Positive GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
adf1actin depolymerizing factor, cofilin Synthetic LethalityPMID:22024167
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
vps5retromer complex subunit Vps5 Positive GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
SPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Negative GeneticPMID:22681890
res2MBF transcription factor complex subunit Res2 Negative GeneticPMID:22681890
trt1telomerase reverse transcriptase 1 protein Trt1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Positive GeneticPMID:22681890
SPBC21C3.03ABC1 kinase family protein Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cid13poly(A) polymerase Cid13 Affinity Capture-MSPMID:12062100
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
External References
Database Identifier Description
NBRP SPAC9G1.05 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC9G1.05 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAC9G1.05 BioGRID Interaction Datasets
Expression Viewer SPAC9G1.05 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAC9G1.05 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAC9G1.05 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAC9G1.05 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAC9G1.05 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAC9G1.05 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAC9G1.05 Cell Cycle Data
GEO SPAC9G1.05 GEO profiles
PInt SPAC9G1.05 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2542795actin cortical patch component Aip1 (predicted)
EntrezGene2542795actin cortical patch component Aip1 (predicted)
SPD / RIKEN37/37F11Orfeome Localization Data
UniProtKB/SwissProtO14301Uncharacterized WD repeat-containing protein C9G1.05
ModBaseO14301Database of comparative protein structure models
StringO14301Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593560actin cortical patch component Aip1 (predicted)
RefSeq mRNANM_001018993972h- actin cortical patch component Aip1 (predicted) (SPAC9G1.05), mRNA
European Nucleotide ArchiveCAB11489ENA Protein Mapping
UniParcUPI000013AB52UniProt Archive

Literature for SPAC9G1.05

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014