cyk3 (SPAC9G1.06c)

Gene Standard Namecyk3 ChromosomeI
Systematic IDSPAC9G1.06c Gene Start1982206
Synonyms Gene End1976754
Productcytokinesis protein Cyk3 (predicted) Gene Length5453
Feature Typeprotein coding CDS Start1982107
Name Description CDS End1979364
Characterisation Statusbiological_role_inferred CDS Length2744

Ensembl Gene Location
  1. wis4
  2. rpl3001
  3. oxa101
  4. SPAC9G1.05
  5. cyk3
  6. SPAC9G1.07
  7. SPAC9G1.08c
  8. mzt1
  9. sid1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopycyk3delta (deletion)deletionPMID:20473289
GO Biological Process

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0000910cytokinesisNASGO_REF:0000001
GO Cellular Component

Ontology Graph

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Term IDTerm NameEvidenceWith/FromReference
GO:0005826actomyosin contractile ringNASGO_REF:0000001
GO:0030428cell septumIEASL-0455GO_REF:0000039
GO:0032153cell division siteIDAPMID:16823372
GO:0051286cell tipIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
119822061982041
219819571976754

References

Region Start End Reference
three_prime_UTR19793631976754PMID:21511999
five_prime_UTR19822061982108PMID:21511999
three_prime_UTR19793631976754PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00018 IPR001452 Pfam Src homology-3 domain 12 59 21
SM00326 IPR001452 SMART Src homology-3 domain 9 66 21
SM00460 IPR002931 SMART Transglutaminase-like 528 595 2
PS50002 IPR001452 Prosite Profiles Src homology-3 domain 6 67 21
G3DSA:2.30.30.40 Gene3D 5 65 21
SSF54001 SuperFamily 494 637 30
SSF50044 IPR001452 SuperFamily 5 87 21
PTHR10661:SF52 hmmpanther 10 705 2
PTHR10661 hmmpanther 10 705 4

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.91 Da
Charge 31.50
Isoelectric point 9.75
Molecular weight 98.26 kDa
Number of residues 886
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide4039.5PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide3103.53PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.84PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.1PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc4myosin II light chain Synthetic Growth DefectPMID:22573890
Phenotypic Enhancement
cdc12formin Cdc12 Phenotypic EnhancementPMID:22573890
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Phenotypic EnhancementPMID:22573890
mbx1MADS-box transcription factor Mbx1 Positive GeneticPMID:22681890
chs2chitin synthase homolog Chs2 Phenotypic SuppressionPMID:22573890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
mid1medial ring protein Mid1 Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
myo2myosin II heavy chain Phenotypic EnhancementPMID:22573890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Synthetic Growth DefectPMID:18931302
for3formin For3 Synthetic Growth DefectPMID:18931302
hip4histone promoter control protein Hip4 Positive GeneticPMID:22681890
myo51myosin type V Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
nog1GTP binding protein Nog1 (predicted) Affinity Capture-MSPMID:20603077
clp1Cdc14-related protein phosphatase Clp1/Flp1 Affinity Capture-MSPMID:23297348
apl2AP-1 adaptor complex subunit beta subunit Apl2 Affinity Capture-MSPMID:20603077
rad2514-3-3 protein Rad25 Affinity Capture-MSPMID:20603077
gpd1glycerol-3-phosphate dehydrogenase Gpd1 Affinity Capture-MSPMID:20603077
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Affinity Capture-WesternPMID:20603077
Affinity Capture-MS
pan1actin cortical patch component, with EF hand and WH2 motif Panl (predicted) Affinity Capture-MSPMID:20603077
cdc22ribonucleoside reductase large subunit Cdc22 Affinity Capture-MSPMID:20603077
SPAC6F6.03cribosome export GTPase (predicted) Affinity Capture-MSPMID:20603077
ala1mitochondrial and cytoplasmic alanine-tRNA ligase Ala1 (predicted) Affinity Capture-MSPMID:20603077
shm2serine hydroxymethyltransferase Shm2 (predicted) Affinity Capture-MSPMID:20603077
SPAC1751.03translation initiation factor eIF3m Affinity Capture-MSPMID:20603077
mug64BAR domain protein (predicted) Affinity Capture-MSPMID:20603077
SPBC691.04mitochondrial ATP-dependent RNA helicase Mss116 (predicted) Affinity Capture-MSPMID:20603077
hhf1histone H4 h4.1 Affinity Capture-MSPMID:20603077
SPAC24C9.06caconitate hydratase (predicted) Affinity Capture-MSPMID:20603077
SPAC821.05translation initiation factor eIF3h (p40) Affinity Capture-MSPMID:20603077
nrs1cytoplasmic asparagine-tRNA ligase Nrs1 (predicted) Affinity Capture-MSPMID:20603077
sec21coatomer gamma subunit Sec21 (predicted) Affinity Capture-MSPMID:20603077
ccr4CCR4-Not complex subunit Ccr4 (predicted) Affinity Capture-MSPMID:20603077
myo1myosin type I Affinity Capture-MSPMID:20603077
usp107U1 snRNP-associated protein Usp107 Affinity Capture-MSPMID:20603077
rad2414-3-3 protein Rad24 Affinity Capture-MSPMID:20603077
SPAC23A1.17WIP family cytoskeletal protein (predicted) Affinity Capture-MSPMID:20603077
rps260240S ribosomal protein S26 (predicted) Affinity Capture-MSPMID:20603077
fic1C2 domain protein Fic1 Affinity Capture-WesternPMID:23093943
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External References
Database Identifier Description
NBRP SPAC9G1.06c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAC9G1.06c Retrieval of eukaryotic orthologs
BioGrid SPAC9G1.06c BioGRID Interaction Datasets
Bähler Lab SPAC9G1.06c Cell Cycle Expression Profile
Bähler Lab SPAC9G1.06c Meiosis/Sporulation Expression Profies
Bähler Lab SPAC9G1.06c Pheromone response/mating expression profiles
Bähler Lab SPAC9G1.06c Environmental stress expression profiles
Bähler Lab SPAC9G1.06c Bähler Lab Transcriptome Viewer
Cyclebase SPAC9G1.06c Cell Cycle Data
PInt SPAC9G1.06c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAC9G1.06c Entrez Gene
WikiGene2542740cytokinesis protein Cyk3
Uniprot_genenameCYK3
EntrezGene2542740cytokinesis protein Cyk3
SPD / RIKEN47/47B08Orfeome Localization Data
UniProtKB/SwissProtO14302cytokinesis protein 3
ModBaseO14302Database of comparative protein structure models
Pfam Protein DomainsO14302Pfam Domain Arrangement
RefSeq PeptideNP_593561cytokinesis protein Cyk3
RefSeq mRNANM_001018994972h- cytokinesis protein Cyk3 (cyk3), mRNA
European Nucleotide ArchiveCAB11490ENA Protein Mapping
UniParcUPI000013AB5CUniProt Archive

Literature for cyk3
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013