mpp6 (SPACUNK4.11c)


Gene Standard Namempp6 Characterisation Statusbiological_role_inferred
Systematic IDSPACUNK4.11c Feature Typeprotein coding
Synonyms Name Description
Productnuclear exosome-associated RNA binding protein Mpp6 Product Size188aa, 21.51 kDa
Genomic Location Chromosome I, 2890095-2890887 (793nt); CDS:2890158-2890779 (622nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0071028nuclear mRNA surveillanceISOSGD:S000005307GO_REF:00000014
GO:0043633polyadenylation-dependent RNA catabolic processISOSGD:S000005307GO_REF:000000117
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000176nuclear exosome (RNase complex)IDAPMID:2350358813
ISOSGD:S000005307GO_REF:0000001
GO:0005730nucleolusIDAPMID:16823372357
GO:0005634nucleusIDAPMID:168233722737
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopympp6ΔNullPMID:204732893751
Microscopympp6ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000478normal meiosisMicroscopympp6ΔNullPMID:16169489131
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopympp6ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
128900952890184
228902402890887
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF10175 Pfam IPR019324 M-phase phosphoprotein 6 1 107 1
PTHR13582 HMMPANTHER IPR019324 M-phase phosphoprotein 6 1 186 1
Coil ncoils Rabaptin coiled-coil domain 120 141 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.39 Da
Charge 7.50
Isoelectric point 10.02
Molecular weight 21.51 kDa
Number of residues 188
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS167PMID:217125471670
present during mitotic M phase
level fluctuates during mitotic cell cycleS167PMID:24763107
MOD:00696phosphorylated residueNASPMID:195477441922
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
8102during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
12781during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
9043during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
12649during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
8991during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2098.59during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.9during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.51during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBPB10D8.02carylsulfatase (predicted) Positive GeneticPMID:22681890
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:22681890
plb1phospholipase B homolog Plb1 Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:22681890
pby1tubulin-tyrosine ligase Pby1 (predicted) Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Positive GeneticPMID:22681890
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Positive GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Positive GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
rrp43exosome subunit Rrp43 Affinity Capture-MSPMID:23503588
External References
Database Identifier Description
NBRP SPACUNK4.11c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPACUNK4.11c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPACUNK4.11c BioGRID Interaction Datasets
Expression Viewer SPACUNK4.11c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPACUNK4.11c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPACUNK4.11c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPACUNK4.11c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPACUNK4.11c Polyadenylation Viewer (Gullerova lab)
pombeTV SPACUNK4.11c Transcriptome Viewer (Bähler Lab)
Cyclebase SPACUNK4.11c Cell Cycle Data
GEO SPACUNK4.11c GEO profiles
PInt SPACUNK4.11c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPACUNK4.11c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN07/07A07Orfeome Localization Data
UniProtKB/SwissProtO14076Uncharacterized protein UNK4.11c
ModBaseO14076Database of comparative protein structure models
STRINGO14076Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593967M-phase phosphoprotein 6 family protein
RefSeq mRNANM_001019394972h- M-phase phosphoprotein 6 family protein (SPACUNK4.11c), mRNA
European Nucleotide ArchiveCAA20141.1ENA Protein Mapping
UniParcUPI000013AB9CUniProt Archive

Literature for mpp6

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014