mpp6 (SPACUNK4.11c)

Gene Standard Namempp6 Characterisation Statusbiological_role_inferred
Systematic IDSPACUNK4.11c Feature Typeprotein coding
Synonyms Name Description
Productnuclear exosome-associated RNA binding protein Mpp6 Product Size188aa, 21.51 kDa
Genomic Location Chromosome I, 2890095-2890887 (793nt); CDS:2890158-2890779 (622nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
nuclear mRNA surveillance4
Annotation ExtensionEvidenceWith/FromReference
polyadenylation-dependent RNA catabolic process17
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nuclear exosome (RNase complex)13
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopympp6ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000478normal meiosisMicroscopympp6ΔNullPMID:16169489139
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopympp6ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF10175 Pfam IPR019324 M-phase phosphoprotein 6 1 107 1
PTHR13582 HMMPANTHER IPR019324 M-phase phosphoprotein 6 1 186 1
Coil ncoils Rabaptin coiled-coil domain 120 141 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.39 Da
Charge 7.50
Isoelectric point 10.02
Molecular weight 21.51 kDa
Number of residues 188

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineexperimental evidenceS167PMID:247631071670
level fluctuates during mitotic cell cycle
present during mitotic M phaseexperimental evidenceS167PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
8102during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
12781during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
9043during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
12649during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
8991during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2098.59during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.9during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.51during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
red1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
pir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
rrp43exosome subunit Rrp43 Affinity Capture-MSPMID:23503588
iss10Mmi1-driven selective elimination factor Iss10 Affinity Capture-MSPMID:24713849
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
SPBPB10D8.02carylsulfatase (predicted) Positive GeneticPMID:22681890
cpd1tRNA (m1A) methyltransferase complex catalytic subunit Cpd1 Positive GeneticPMID:22681890
ubc6ubiquitin conjugating enzyme Ubc6 (predicted) Positive GeneticPMID:22681890
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:22681890
pby1tubulin-tyrosine ligase Pby1 (predicted) Positive GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
rsc4RSC complex subunit Rsc4 Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Positive GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Positive GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Positive GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
plb1phospholipase B homolog Plb1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPACUNK4.11c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPACUNK4.11c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPACUNK4.11c BioGRID Interaction Datasets
Expression Viewer SPACUNK4.11c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPACUNK4.11c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPACUNK4.11c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPACUNK4.11c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPACUNK4.11c Polyadenylation Viewer (Gullerova lab)
pombeTV SPACUNK4.11c Transcriptome Viewer (Bähler Lab)
Cyclebase SPACUNK4.11c Cell Cycle Data
GEO SPACUNK4.11c GEO profiles
PInt SPACUNK4.11c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPACUNK4.11c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPACUNK4.11c Fission yeast phenotypic data & analysis
SPD / RIKEN07/07A07Orfeome Localization Data
UniProtKB/SwissProtO14076Uncharacterized protein UNK4.11c
ModBaseO14076Database of comparative protein structure models
STRINGO14076Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593967M-phase phosphoprotein 6 family protein
RefSeq mRNANM_001019394972h- M-phase phosphoprotein 6 family protein (SPACUNK4.11c), mRNA
European Nucleotide ArchiveCAA20141.1ENA Protein Mapping
UniParcUPI000013AB9CUniProt Archive

Literature for mpp6

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014