sen2 (SPAPB17E12.07c)

Gene Standard Namesen2 Characterisation Statusbiological_role_inferred
Systematic IDSPAPB17E12.07c Feature Typeprotein coding
Synonyms Name Description
ProducttRNA-splicing endonuclease subunit catalytic subunit Sen2 (predicted) Product Size380aa, 44.61 kDa
Genomic Location Chromosome I, 1279149-1277120 (2030nt); CDS:1278974-1277785 (1190nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000213tRNA-intron endonuclease activityISOSGD:S000004095GO_REF:00000244
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticISOSGD:S000004095GO_REF:000002422
GO:0000379tRNA-type intron splice site recognition and cleavageISOSGD:S000004095GO_REF:00000244
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005741mitochondrial outer membraneISOSGD:S000004095GO_REF:000002441
GO:0000214tRNA-intron endonuclease complexISOSGD:S000004095GO_REF:00000244
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopysen2ΔNullPECO:0000005, PECO:0000137PMID:236978061309

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002187inviable normal volume spheroid vegetative cellMicroscopysen2ΔNullPECO:0000005, PECO:0000137PMID:2369780648
penetrance FYPO_EXT:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01974 Pfam IPR006677 tRNA intron endonuclease, catalytic domain-like 251 333 2
TMhelix TMHMM 13 35 959
PTHR21227 HMMPANTHER 1 380 1
PTHR21227:SF0 HMMPANTHER 1 380 1
G3DSA:3.40.1350.10 Gene3D IPR011856 250 337 3
SSF53032 SuperFamily IPR006677 250 335 3
Low complexity (SEG) seg 113 127
Low complexity (SEG) seg 19 33
PIRSF011789 PIRSF IPR016589 tRNA-splicing endonuclease, SEN2 subunit 1 380 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.39 Da
Charge 13.00
Isoelectric point 9.06
Molecular weight 44.61 kDa
Number of residues 380
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.76during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.19during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAPB17E12.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB17E12.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB17E12.07c BioGRID Interaction Datasets
Expression Viewer SPAPB17E12.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB17E12.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB17E12.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB17E12.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB17E12.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB17E12.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPB17E12.07c Cell Cycle Data
GEO SPAPB17E12.07c GEO profiles
PInt SPAPB17E12.07c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene3361398tRNA-splicing endonuclease subunit catalytic subunit Sen2
EntrezGene3361398tRNA-splicing endonuclease subunit catalytic subunit Sen2
UniProtKB/SwissProtQ8TFH7Probable tRNA-splicing endonuclease subunit sen2
ModBaseQ8TFH7Database of comparative protein structure models
StringQ8TFH7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_001018222tRNA-splicing endonuclease subunit catalytic subunit Sen2
RefSeq mRNANM_001018702972h- tRNA-splicing endonuclease subunit catalytic subunit Sen2 (sen2), mRNA
European Nucleotide ArchiveCAD27500ENA Protein Mapping
UniParcUPI000006A3A1UniProt Archive

Literature for sen2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014