sen2 (SPAPB17E12.07c)

Gene Standard Namesen2 Characterisation Statusbiological role inferred
Systematic IDSPAPB17E12.07c Feature Typeprotein coding
Synonyms Name Description
ProducttRNA-splicing endonuclease subunit catalytic subunit Sen2 (predicted) Product Size380aa, 44.61 kDa
Genomic Location Chromosome I, 1279149-1277120 (2030nt); CDS:1278974-1277785 (1190nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
tRNA-intron endonuclease activity4
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
tRNA-type intron splice site recognition and cleavage4
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
mitochondrial outer membrane47
Annotation ExtensionEvidenceWith/FromReference
tRNA-intron endonuclease complex4
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationsen2Δ1468

Cell Phenotype

Term NameGenotypesCount
inviable normal volume spheroid vegetative cellsen2Δ48
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1279149..1278140, 1278092..1277120
5' UTR1279149..1278975PMID:21511999
CDS1278974..1278140, 1278092..1277785
3' UTR1277784..1277120PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01974 Pfam IPR006677 tRNA intron endonuclease, catalytic domain-like 251 333 2
TMhelix TMHMM 13 35 950
PTHR21227 HMMPANTHER IPR006676 tRNA-splicing endonuclease 4 380 1
3.40.1350.10 Gene3D IPR011856 tRNA endonuclease-like domain 250 337 3
SSF53032 SuperFamily IPR006677 tRNA intron endonuclease, catalytic domain-like 250 335 3
PIRSF011789 PIRSF IPR016589 tRNA-splicing endonuclease, SEN2 subunit 1 380 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.39 Da
Charge 13.00
Codon Adaptation Index 0.38
Isoelectric point 9.06
Molecular weight 44.61 kDa
Number of residues 380
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for sen2 (SPAPB17E12.07c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.76during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.19during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPAPB17E12.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB17E12.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB17E12.07c BioGRID Interaction Datasets
Expression Viewer SPAPB17E12.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB17E12.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB17E12.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB17E12.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB17E12.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB17E12.07c Transcriptome Viewer (Bähler Lab)
GEO SPAPB17E12.07c GEO profiles
PInt SPAPB17E12.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAPB17E12.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAPB17E12.07c Fission yeast phenotypic data & analysis
Cyclebase SPAPB17E12.07c.1 Cell Cycle Data
UniProtKB/SwissProtQ8TFH7Probable tRNA-splicing endonuclease subunit sen2
ModBaseQ8TFH7Database of comparative protein structure models
STRINGQ8TFH7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_001018222tRNA-splicing endonuclease subunit catalytic subunit Sen2 (predicted)
RefSeq mRNANM_001018702972h- tRNA-splicing endonuclease subunit catalytic subunit Sen2 (predicted) (sen2), mRNA
European Nucleotide ArchiveCAD27500.1ENA Protein Mapping
MetaCycPWY-6689Trna splicing
UniParcUPI000006A3A1UniProt Archive

Literature for sen2

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017