nxt1 (SPAPB1A10.03)


Gene Standard Namenxt1 Characterisation Statuspublished
Systematic IDSPAPB1A10.03 Feature Typeprotein coding
Synonyms Name Description
ProductmRNA export receptor Nxt1 Product Size115aa, 13.40 kDa
Genomic Location Chromosome I, 1863363-1863762 (400nt); CDS:1863363-1863762 (400nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046982protein heterodimerization activityIPImex67PMID:1496304661
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016973poly(A)+ mRNA export from nucleusIPImex67PMID:1496304617
GO:0000054ribosomal subunit export from nucleusISOSGD:S000001669GO_REF:000002428
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0042272nuclear RNA export factor complexIPImex67PMID:149630462
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001701sensitive to bortezomibCell growth assaynxt1ΔNullPECO:0000005, PECO:0000137PMID:21760946256
expressivity FYPO_EXT:0000002
FYPO:0002060viable vegetative cell populationno_namePMID:149630463755
Microscopynxt1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Microscopynxt1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopynxt1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
118633631863381
218634341863762
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02136 Pfam IPR002075 Nuclear transport factor 2 8 96 3
PS50177 Prosite Profiles IPR018222 Nuclear transport factor 2, eukaryote 7 115 4
PTHR12612 HMMPANTHER 6 98 2
G3DSA:3.10.450.50 Gene3D 1 97 5
SSF54427 SuperFamily 2 97 6

View domain organization at Pfam

Protein Properties

Ave. residue weight 116.48 Da
Charge 0.50
Isoelectric point 7.34
Molecular weight 13.40 kDa
Number of residues 115
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
4728.91during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.49during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.24during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated426
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
SPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
SPBPB10D8.02carylsulfatase (predicted) Positive GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Positive GeneticPMID:22681890
ppk31serine/threonine protein kinase Ppk31 (predicted) Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Positive GeneticPMID:22681890
nup61nucleoporin Nup61 Negative GeneticPMID:22681890
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
usp102U1 snRNP-associated protein Usp102 Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
pab2poly(A) binding protein Pab2 Affinity Capture-MSPMID:19336419
External References
Database Identifier Description
NBRP SPAPB1A10.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1A10.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB1A10.03 BioGRID Interaction Datasets
Expression Viewer SPAPB1A10.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB1A10.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB1A10.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB1A10.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB1A10.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB1A10.03 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPB1A10.03 Cell Cycle Data
GEO SPAPB1A10.03 GEO profiles
PInt SPAPB1A10.03 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2543644mRNA export receptor Nxt1
EntrezGene2543644mRNA export receptor Nxt1
UniProtKB/SwissProtP0CAN8NTF2-related export protein 1
ModBaseP0CAN8Database of comparative protein structure models
StringP0CAN8Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593517mRNA export receptor Nxt1
RefSeq mRNANM_001018951972h- mRNA export receptor Nxt1 (nxt1), mRNA
European Nucleotide ArchiveCAC21476ENA Protein Mapping
UniParcUPI00019B23CCUniProt Archive

Literature for nxt1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014